Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production by Yan Tian, Chenxia Zhou, Qun Yan, Ziyi Li, Da Chen, Bo Feng, Jun Song

“…Renal function, tissue pathology, mitochondrial morphology and function, and lipid peroxidation biomarkers (lipid peroxidation [LPO], malondialdehyde [MDA], glutathione peroxidase 4 [GPX4], glutathione [GSH], and cystine transporter solute carrier family 7 member 11 [SLC7A11]) were evaluated. Human proximal tubule cells (HK2 cells) were exposed to high glucose alone or in combination with dapagliflozin. …”
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Evaluation of Siemens Healthineers’ StrokeSegApp for automated diffusion and perfusion lesion segmentation in patients with ischemic stroke by Lynnet-Samuel J. Teichmann, Ahmed A. Khalil, Kersten Villringer, Jochen B. Fiebach, Stefan Huwer, Eli Gibson, Ivana Galinovic

“…Out of 56 subjects meeting DEFUSE 2/3 criteria in the cohort, it correctly identified mechanical thrombectomy candidates with a sensitivity of 82.1% (95% CI: 63.1–93.9%) and a specificity of 96.4% (95% CI: 81.7–99.9%).ConclusionThe Siemens Healthineers’ StrokeSegApp provides accurate automated segmentation of ischemic stroke lesions, comparable to human experts as well as similar commercial software, and shows potential as a reliable tool in clinical decision-making for stroke treatment.…”
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Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2): protocol for a historical cohort study by David Jenkins, Mark H Stoler, Anne Hammer, Torben Steiniche, Lone Kjeld Petersen, Patti E Gravitt, Rikke Kamp Damgaard, Maurits NC de Koning, Wim GV Quint, John Doorbar, Johnny Kahlert

“…The combination of the novel biomarker human papillomavirus (HPV) E4 with p16INK4a targets steps in the transition from a productive oncogenic HPV infection (CIN1) to a transformed lesion (CIN3) within CIN2. …”
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Exploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations by Amany Belal, Aly Abdou, Samar F. Miski, Mohamed A. M. Ali, Heba I. Ghamry, Ahmad J. Obaidullah, Ahmad J. Obaidullah, Mohamed Y. Zaky, Ahmed H. E. Hassan, Ahmed H. E. Hassan, Eun Joo Roh, Eun Joo Roh, Ahmed A. Al-Karmalawy, Ahmed A. Al-Karmalawy, Mona H. Ibrahim

“…Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections represent critical global health challenges due to the high morbidity and mortality associated with co-infections. …”
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Genomic landscape of head and neck cancer in Asia: A comprehensive meta-analysis of 1016 samples by Srikanth S. Manda, Nafisa Arfa, Neha Sharma, Aparna R. Parikh, Thomas J. Roberts, Sewanti Limaye, Venkataraman Ramachandran, Kumar Prabhash, Moni A. Kuriakose, Prashant Kumar

“…Head and neck cancer (HNC) is a diverse group of malignancies arising in the mucosal linings of the oral cavity, pharynx, and larynx, influenced by factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. This study conducts a comprehensive meta-analysis of the mutational landscape of HNC across Asian cohorts, encompassing India, Korea, Japan, China, Singapore, and Saudi Arabia. …”
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Food-Induced Adverse Reactions: A Review of Physiological Food Quality Control, Mucosal Defense Mechanisms, and Gastrointestinal Physiology by Dongdong Guo, Chang Liu, Hongkang Zhu, Yuliang Cheng, Xiang Huo, Yahui Guo, He Qian

“…Antitoxin defenses also come with costs and may fail due to insufficiencies, exaggerations, or misdirected actions, ultimately leading to adverse food reactions. With the changes in human diet and lifestyle, the failure of defense mechanisms has contributed to the rising incidence of food intolerances. …”
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Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…In this view, considering the higher potential for neonatal plasticity within the brain in human beings as compared to other species, long-term consequences of prenatal stress might not be as inexorable as suggested in animal-based studies published to date.…”
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Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management by Eleonora Spinozzi, Marta Ferrati, Cecilia Baldassarri, Paolo Rossi, Guido Favia, Giorgio Cameli, Giovanni Benelli, Angelo Canale, Livia De Fazi, Roman Pavela, Luana Quassinti, Cristiano Giordani, Fabrizio Araniti, Loredana Cappellacci, Riccardo Petrelli, Filippo Maggi

“…The EO non-target toxicity on Daphnia magna Straus (LC50 = 4.51 μL/L) and its cytotoxicity on a human kidney cell line (HEK293) (IC50 of 14.38 μg/mL) were also assessed. …”
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New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease by Ting Fang, Qiaoyan Liu, Xinxin Huangfu, Hongkai Zhu, Hongwen Sun, Liming Chen

“…The results indicated statistically significant regulation of most core targets by TPHP and DPHP in MPC5, MES13, and human kidney-2 cells.…”
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Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review by Maria Júlia Bento Martins Parreira, Bruna Trazzi Pagani, Matheus Bento Medeiros Moscatel, Daniela Vieira Buchaim, Carlos Henrique Bertoni Reis, Beatriz Flávia de Moraes Trazzi, Acácio Fuziy, Rogerio Leone Buchaim

“…After analyzing the selected articles, it was possible to observe several reports on hyperostosis or even changes in the formation of bone structures in human patients. Concerning animals, the largest number of studies addressed the changes caused in the formation or development of bone structures by the systemic administration of Isotretinoin. …”
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A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipi... by Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende

“…These studies are part of a larger, collaborative initiative seeking to address antibody reproducibility by characterizing commercially available antibodies for human proteins and publishing the results openly as a resource for the scientific community. …”
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Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease by Jill O’Sullivan, Shriram Patel, Gabriel E. Leventhal, Rachel S. Fitzgerald, Emilio J. Laserna-Mendieta, Chloe E. Huseyin, Nina Konstantinidou, Erica Rutherford, Aonghus Lavelle, Karim Dabbagh, Todd Z. DeSantis, Fergus Shanahan, Andriy Temko, Shoko Iwai, Marcus J. Claesson

“…Our multi-omics machine learning approach was also able to predict relapse when combining features from the microbiome and human host. Therefore multi-omics, rather than single omics, better predicts relapse within 4 years of colonoscopy, while a patient’s succinotype is associated with a higher frequency of relapses.…”
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Assessing Health Disparities in Digital Services and Technologies During and After the COVID-19 Pandemic: A Pooled Cross-Sectional Analysis Using HINTS Data by Shih HJ, Min H, Chang J

“…Huan-Ju Shih,1 Hua Min,1 Jongwha Chang2 1Department of Health and Human Services, George Mason University, Fairfax, VA, USA; 2Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI, USACorrespondence: Jongwha Chang, Wayne State University, School of Medicine, Department of Internal Medicine, Detroit, MI, 48201, USA, Tel +1313-966-9687, Email jochang@umich.eduIntroduction: Digital health techniques were adopted faster during COVID-19, but the gap remains. …”
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miR-1233-3p Inhibits Angiopoietin-1-Induced Endothelial Cell Survival, Migration, and Differentiation by Veronica Sanchez, Sharon Harel, Anas Khalid Sa’ub, Dominique Mayaki, Sabah N. A. Hussain

“…Our high-throughput screening of miRNAs regulated by Ang-1 exposure in human umbilical vein endothelial cells (HUVECs) has identified miR-1233-3p as a mature miRNA whose cellular levels are significantly downregulated in response to Ang-1 exposure. …”
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Employing the concept of stacking ensemble learning to generate deep dream images using multiple CNN variants by Lafta Alkhazraji, Ayad R. Abbas, Abeer S. Jamil, Zahraa Saddi Kadhim, Wissam Alkhazraji, Sabah Abdulazeez Jebur, Bassam Noori Shaker, Mohammed Abdallazez Mohammed, Mohanad A. Mohammed, Basim Mohammed Al-Araji, Abdulkareem Z. Mohmmed, Wasiq Khan, Bilal Khan, Abir Jaafar Hussain

“…Such approaches can also be useful for promoting interest in human artwork, particularly surrealist images. Accordingly, in the present, a stacking ensemble Deep Dream model was developed that aids psychiatrists and psychologists in addressing the challenge of mimicking hallucinations. …”
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A comparative cohort study of post-COVID-19 conditions based on physical examination records in ChinaResearch in context by Zhong Liu, Boqiang Hu, Tao Zeng, Cuiping You, Nan Li, Yongjing Liu, Jie Zhang, Chenbing Liu, Piaopiao Jin, Xiaoxi Feng, Jun Chen, Jinyan Huang

“…Standard physical examination data, comprising evaluations of nearly a hundred indicators, were investigated for a comprehensive assessment of COVID-19’s effect on human health. Findings: The results suggested that most indicators remained stable or changed within a permissible range after the COVID-19 outbreak in December 2022, but several specific indicators presented abnormal patterns of varying durations. …”
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Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts by Rhowell Navarro Tiozon, Rhowell Navarro Tiozon, Erstelle Pasion-Uy, Saleh Alseekh, Saleh Alseekh, Kristel June D. Sartagoda, Shem Gempesaw, Joel H. G. Tolentino, Alisdair R. Fernie, Alisdair R. Fernie, Nese Sreenivasulu

“…This study offers valuable insights into the health-promoting potential of germinated rice sprouts as a rich dietary source of antioxidants beneficial to human health.…”
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Novel Electrochemical Treatment of Spent Caustic from the Hydrocarbon Industry Using Ti/BDD by Alejandro Medel, Erika Méndez, José L. Hernández-López, José A. Ramírez, Jesús Cárdenas, Roberto F. Frausto, Luis A. Godínez, Erika Bustos, Yunny Meas

“…The results show that the hydrocarbon industry spent caustics can be mineralized to CO2 and water, driving the use of ET and of the Ti/BDD to solve a real problem, whose potential and negative impact on the environment and on human health is and has been the environmental agencies’ main focus.…”
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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial protocol by Danielle Mazza, Angela Taft, Kevin McGeechan, Kirsten Black, Heather McKay, Marion Haas, Jayne Lucke, Jeffery F Peipert

“…The costs and outcomes of the intervention and control will be compared in a cost-effectiveness analysis.Ethics and dissemination The ACCORd study has been approved by the Monash University Human Research Ethics Committee: CF14/3990-2014002066 and CF16/188-2016000080. …”
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Advancements and challenges in agriculture: a comprehensive review of machine learning and IoT applications in vertical farming and controlled environment agriculture by Binoy Sasmal, Gobinda Das, Preeti Mallick, Sneha Dey, Suman Ghorai, Subrata Jana, Chiranjibe Jana

“…In VF, aeroponics consumes 98% less water than conventional farming. Human health, comfort, and productivity directly correlate with the indoor climate. …”
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