Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia by Massimo Mapelli, Elisabetta Salvioni, Irene Mattavelli, Cristina Banfi, Stefania Ghilardi, Arianna Greco, Maria Luisa Biondi, Sara Rovai, Elisabetta Mancini, Sergio Harari, Piergiuseppe Agostoni

“…Background The COVID-19 pandemic has led to significant concern due to its impact on human health, particularly through pneumonia-induced lung damage. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…ASCs were isolated from healthy voluntary donors, expanded using a human platelet lysate in bioreactors, and cryopreserved as per clinical use. …”
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Delineating urban flooding when incorporating community stormwater knowledge by Madeline Scolio, Peleg Kremer, Virginia Smith, Achira Amur, Bridget Wadzuk, Kate Homet, Eric Devlin, Md Abdullah Al Mehedi, Laura Moore

“…Given the complexity of flooding, there is no single method to fully encompass the impacts on both human well-being and the environment. Through the co-creation of flood risk knowledge, community members are empowered and play a critical role in fostering resilience in their neighborhoods. …”
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Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC by Chenxuan Li, En-di Zhang, Rui Yu, Bo Yuan, Yunxin Yang, Zhong Zeng, Hanfei Huang

“…Methods: Explored CDC6 mRNA and protein expression in normal human tissues and tumors using TCGA, GTEx, and HPA. …”
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Prevalence, Antimicrobial Susceptibility Pattern of Bacterial Isolates, and Associated Factors of Urinary Tract Infections among HIV‐Positive Patients at Hiwot Fana Specialized Uni... by Dadi Marami, Senthilkumar Balakrishnan, Berhanu Seyoum

“…Its prevalence is fueled by human immunodeficiency virus (HIV) infection. The emergence of antimicrobial resistance is now widespread and poses a serious clinical threat. …”
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TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets by Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets

“…We identified MC2/A2 and MA3/DP4-specific TCR-Vα3/Vβ28 and TCR-Vα38/Vβ2 chains and validated these TCRs in vitro upon gene transfer into primary human T cells. The MC2 and MA3 TCR were surface-expressed and mediated CD8 T-cell functions towards melanoma cell lines and CD4 T-cell functions towards dendritic cells, respectively. …”
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A Genome-Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients by Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen

“…Further analysis showed that 61.28% of the novel lncRNAs were conserved in humans. A set of 12 lncRNAs were selected for qPCR validation, and 9 of 12 lncRNAs were confirmed to show significant differential expression between the T1D and control validation cohorts. …”
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Study protocol for a Prospective Observational study of Safety Threats and Adverse events in Trauma (PrO-STAT): a pilot study at a level-1 trauma centre in Canada by Melissa McGowan, Charles Keown-Stoneman, Brodie Nolan, Teodor Grantcharov, Eliane M Shore, Anisa Nazir

“…A synchronised data capture and analysis platform will comprehensively assess AEs, errors and human and environmental factors during trauma resuscitations. …”
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A consort‐guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses by Emma Santosuosso, Renaud Léguillette, Sierra Shoemaker, Ryan Baumwart, Sierra Temple, Kaneesha Hemmerling, Tessa Kell, Warwick Bayly

“…Heart rate variability (HRV) can be used to monitor human athlete's training, but its value is unknown in horses. …”
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Possible accumulation of emerging contaminants of concern in treated wastewater on the soil plant system of a processing tomato-wheat succession by Giuseppe Gatta, Federica Carucci, Anna Gagliardi, Michele Perniola, Michele Denora, Francesco De Mastro, Gennaro Brunetti, Sapia Murgolo, Cristina De Ceglie, Alfieri Pollice, Marcella Michela Giuliani

“…However, continued monitoring and further research are essential to fully understand the long-term effects of ECCs on agricultural systems and ensure the protection of both human health and the environment.…”
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qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements by Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser, Athina Vidaki

“…Abstract Background Human DNA methylation profiling offers great promises in various biomedical applications, including ageing, cancer and even forensics. …”
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Increased Kappa/Lambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis by Lang Yi, Mingju Hao, Tian Lu, Guigao Lin, Lida Chen, Ming Gao, Gaowei Fan, Dong Zhang, Guojing Wang, Xin Yang, Yulong Li, Kuo Zhang, Rui Zhang, Yanxi Han, Lunan Wang, Jinming Li

“…The κ/λ hybrid antibodies in normal human serum were reported recently, but their clinical relevance has not yet been explored. …”
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Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review by Shulin Hou, Zeyao Shi, Xiaowen Li, Ru Yang, Yan Song, Zhaolan Zeng

“…NPWT was mainly performed to promote granulation and accelerated healing. Recombinant human basic fibroblast growth factor (Rh-bFGF) was used to heal the wound. …”
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Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation by Sarvatit Patel, Kai Ellis, Kai Ellis, Corey A. Scipione, Jason E. Fish, Jason E. Fish, Jason E. Fish, Jason E. Fish, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe

“…This study determined how senescent ECs communicate with monocytes, whether extracellular vesicles (EVs) released from senescent ECs affect monocyte functions, and investigated the potential for epigallocatechin-3-gallate (EGCG), a flavonoid in green tea, to reverse these effects. Human umbilical vein endothelial cells (HUVECs) were treated with Etoposide (10 µM, 24 h) to induce senescence, followed by EGCG (100 µM, 24 h) treatment to evaluate its potential as a senotherapeutic agent. …”
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FTO attenuates TNF-α-induced damage of proximal tubular epithelial cells in acute pancreatitis-induced acute kidney injury via targeting AQP3 in an N6-methyladenosine-dependent man... by Xinghui Li, Qi Liang, Lu Liu, Shujun Chen, Yong Li, Yu Pu

“…Therefore, the aim of this study is to explore the association of FTO and AQP3 on proximal tubular epithelial cell damage in SAP-induced AKI.Methods An in-vitro AKI model was established in human proximal tubular epithelial cells (PTECs) HK-2 via tumor necrosis factor-α (TNF-α) induction (20 ng/mL), after which FTO and AQP3 expression was manipulated and quantified by quantitative real-time PCR and Western blotting. …”
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Continuous ambulatory peritoneal dialysis technique failure in adult patients treated at a tertiary hospital in central South Africa: a retrospective analytical study by Tshifhiwa B. Sikhipha, Claire Barrett, Nicoline van Zyl, Cornel van Rooyen, Feziwe B. Bisiwe

“…Hypertension was the leading cause of ESKD (n = 47; 51.6%), followed by human immunodeficiency virus- (HIV-) associated conditions (n = 18; 19.8%). …”
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Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model by Marloes IJff, Xionge Mei, Enzo M. Scutigliani, Hans M. Rodermond, Gregor G. W. van Bochove, Przemek M. Krawczyk, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Johannes Crezee, Arlene L. Oei

“…For the in vivo study, human cervical cancer (SiHa) cells were injected in the right hind leg of athymic nude mice. …”
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Real-World Experience with Dolutegravir-Based Two-Drug Regimens by Douglas Ward, Moti Ramgopal, David J. Riedel, Cindy Garris, Shelly Dhir, John Waller, Jenna Roberts, Katie Mycock, Alan Oglesby, Bonnie Collins, Megan Dominguez, James Pike, Joseph Mrus

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Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…In order to identify potential genes related to poorly/well-controlled patients with T2D, our strategy of investigation included a primary screen by microarray (Human Genome U133) in a small group of individuals followed by an independent validation in a greater group using RT-qPCR. …”
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Phytotoxicity and phytoremediation potential of Lemna minor exposed to perfluorooctanoic acid by Azam Noori, Lorena Corbelli, Erin Lincoln, Sara Thomas, Jasmine Jones, Sara L. Nason, Jason C. White, Riley Lewis, Christy L. Haynes

“…Perfluorooctanoic acid (PFOA) is one of the highly toxic compounds which was phased out of application in consumer products in 2015 due to its harmful effects on human and environmental health. However, this chemical was in use for many years and is still found in water resources. …”
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