Effects of residential acaricide treatments on patterns of pathogen coinfection in blacklegged ticks by Richard S. Ostfeld, Sahar Adish, Stacy Mowry, William Bremer, Shannon Duerr, Andrew S. Evans, Ilya R. Fischhoff, Fiona Keating, Jennifer Pendleton, Ashley Pfister, Marissa Teator, Felicia Keesing, Ala Tabor

“…Medically important ixodid ticks often carry multiple pathogens, with individual ticks frequently coinfected and capable of transmitting multiple infections to hosts, including humans. Acquisition of multiple zoonotic pathogens by immature blacklegged ticks (Ixodes scapularis) is facilitated when they feed on small mammals, which are the most competent reservoir hosts for Anaplasma phagocytophilum (which causes anaplasmosis in humans), Babesia microti (babesiosis) and Borrelia burgdorferi (Lyme disease). …”
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Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months by Brenda Asiimwe-Kateera, Nienke Veldhuijzen, Jean Paul Balinda, John Rusine, Sally Eagle, Joseph Vyankandondera, Julie Mugabekazi, Pascale Ondoa, Kimberly Boer, Anita Asiimwe, Joep Lange, Peter Reiss, Janneke van de Wijgert

“…Many patients were coinfected with herpes simplex virus type 2 (79–92%), human papillomavirus (38–53%), and bacterial sexually transmitted infections (STIs) with no differences between groups. …”
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Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison by Yeji Kim, Yeji Kim, Jihyun Kim, Jihyun Kim, Yunji Song, Yunji Song, Keunhwan Jang, Se Eun Kim, Se Eun Kim, Se Eun Kim, Ha-Jung Kim, Ha-Jung Kim

“…Additionally, genes with potential relevance to the clinical characteristics of T-cell lymphoma (TCL), which is characterized by a low treatment response and poor prognosis, were identified through a comparative analysis of different lymphoma subtypes.ResultsWithin the canine lymphoma group, HERC5 showed consistent upregulation, a gene similarly implicated in human acute myeloid leukemia but previously no reports exist. …”
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Association of ambient temperatures with suicide attempts and violence with the future projections under climate change scenarios: a nationwide time-stratified case-crossover study... by Jiwoo Park, Jieun Oh, Whanhee Lee, Yeonsu Kim, Jeong Ho Park, Ho Kim, Seungsik Hwang

“…Abstract Background Both climate change and intentional injuries (suicide attempts and violence) are recognized as crucial factors that affect human health. Previous studies revealed the association between ambient temperatures and deaths due to intentional injuries but mostly about the consequences of severe events. …”
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Anti-SARS-Cov-2 S-RBD IgG Formed after BNT162b2 Vaccination Can Bind C1q and Activate Complement by Anas H. A. Abu-Humaidan, Fatima M. Ahmad, Dima Awajan, Raba’a F. Jarrar, Nader Alaridah

“…The serum samples were incubated with S protein RBD-coated plates. Levels of human IgG, IgA, IgM, C1q, and mannose-binding lectin (MBL) that were bound to the plate, as well as formed C3d, and C5b-9 were compared between different groups of participants. …”
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Predicting academic procrastination of students based on academic self-efficacy and emotional regulation difficulties by Hamidreza Farhadi Rad, Shima Bordbar, Jamshid Bahmaei, Marjan Vejdani, Ali Reza Yusefi

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Gaussian process latent variable models-ANN based method for automatic features selection and dimensionality reduction for control of EMG-driven systems by Maham Nayab, Asim Waris, Muhammad Jawad Khan, Dokhyl AlQahtani, Ahmed Imran, Syed Omer Gilani, Umer Hameed Shah

“…Electromyography (EMG) signals have gained significant attention due to their potential applications in prosthetics, rehabilitation, and human-computer interfaces. However, the dimensionality of EMG signal features poses challenges in achieving accurate classification and reducing computational complexity. …”
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Action Video Game Experience Related to Altered Large-Scale White Matter Networks by Diankun Gong, Weiyi Ma, Jinnan Gong, Hui He, Li Dong, Dan Zhang, Jianfu Li, Cheng Luo, Dezhong Yao

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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model by Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner

“…As guinea pigs exhibit anatomical, physiological, and pharmacological features resembling human airways, including mast cell distribution and mediator release, we evaluated the effect of extracts from two common allergens, house dust mite (HDM) and cat dander (CDE), on histopathological changes and the composition of tryptase- and chymase-positive mast cells in the guinea pig lungs. …”
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A novel high-resolution eco-functional vegetation mapping of coastal dunes by Michele Innangi, Mirko Di Febbraro, Marco Balsi, Ginevra Colonna, Michele Finizio, Federica Pontieri, Maria Laura Carranza

“…Coastal dune landscapes are dynamic systems shaped by complex biotic-abiotic interactions and impacted by human disturbances. This study focuses on Mediterranean coastal dunes, analyzing spatial distribution and ecological characteristics of their plant communities through an innovative approach that integrates vegetation functional traits with UAV-based remote sensing. …”
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G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication by Ryoya Sekine, Kouki Takeda, Tsukasa Suenaga, Satsuki Tsuno, Takumi Kaiya, Maki Kiso, Seiya Yamayoshi, Yoshihide Takaku, Shiho Ohno, Yoshiki Yamaguchi, Seiichi Nishizawa, Kazuhiro Sumitomo, Kazufumi Ikuta, Teru Kanda, Yoshihiro Kawaoka, Hidekazu Nishimura, Shusuke Kuge

“…Here we show that when directly added to a cell culture, 12mer guanine RNA (G12) and its phosphorothioate-linked derivatives (G12(S)), rapidly entered cytoplasm and suppressed the propagation of human coronaviruses and influenza A viruses to between 1/100 and nearly 1/1000 of normal virus infectivity without cellular toxicity and induction of innate immunity. …”
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Assessing dynamic coastal vulnerability to climate hazards: A geospatial approach in Kakinada District, Andhra Pradesh, India by Ganni Satya Venkata Sai Aditya Bharadwaz, Indrajit Pal, Chitrini Mozumder, Mokbul Morshed Ahmad

“…Overall, 598.32 km2 out of 1647.68 km2 exhibited moderate to very high vulnerability, highlighting the threats from coastal erosion and human encroachment. Significant coastal erosion was identified, with shoreline changes ranging from 604.35 to 1016.25 m over the past two decades, particularly in the southern district. …”
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Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation by Daniel Czyzyk, Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi, Shinji Furuzono, David M. Turner, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu

“…Abstract Mutations in RAS and PI3Kα are major drivers of human cancer. Their interaction plays a crucial role in activating PI3Kα and amplifying the PI3K-AKT-mTOR pathway. …”
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Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country by Shahan Waheed, Ayaz Ghouse Kalsekar, Ayeesha Kamran Kamal, Nathan S. Bryan, Asad I. Mian

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655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations by Stefania Tommasi, Vita Fedele, Rosanna Lacalamita, Michele Bruno, Francesco Schittulli, David Ginzinger, Gery Scott, Serenella Eppenberger-Castori, Daniele Calistri, Silvia Casadei, Ian Seymour, Salvatore Longo, Gianluigi Giannelli, Brunella Pilato, Giovanni Simone, Christopher C. Benz, Angelo Paradiso

“…Human ERBB2 presents several SNPs. One of these, Ile655Val, introduces a structural change in the transmembrane region of ERBB2 and has been the focus of debate over its potential role as a susceptibility marker for breast cancer risk. …”
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Polyphenolic Compounds in Fabaceous Plants with Antidiabetic Potential by Lucia Guerrero-Becerra, Sumiko Morimoto, Estefania Arrellano-Ordoñez, Angélica Morales-Miranda, Ramón G. Guevara-Gonzalez, Ana Angélica Feregrino-Pérez, Consuelo Lomas-Soria

“…To integrate these herbal remedies into modern medicine, further research on phenolic compound type, doses, efficacy, and safety in the human population is needed.…”
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Detection of Invasive Species (Siam Weed) Using Drone-Based Imaging and YOLO Deep Learning Model by Deepak Gautam, Zulfadli Mawardi, Louis Elliott, David Loewensteiner, Timothy Whiteside, Simon Brooks

“…The study demonstrates the feasibility of using YOLO models to detect invasive species in natural landscapes, providing a safe alternative to the current method involving human spotters in helicopters. Future research will focus on developing tools to merge duplicates, gather georeference data, and report detections from large image datasets more efficiently, providing valuable insights for practical applications in environmental management at the catchment scale.…”
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Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02 by Gwendolin S. Simper, Gia-Gia T. Hò, Alexander A. Celik, Trevor Huyton, Joachim Kuhn, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding

“…Genetically engineered human B-lymphoblastoid cells expressing soluble HLA-B∗15:02 molecules were treated with the drug or its metabolite. …”
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Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection by Haoyu Ran, Changying Li, Syed M. Musa Rizvi, Ruiqin Zhou, Lingwen Kong, Sun Shuangling, Yue Shao, Kejia Wu, Changzhu Duan, Jun Luo, Haoming Shi, Qingchen Wu, Cheng Zhang

“…Through genome-wide association studies, expression quantitative trait locus (eQTL) analysis, and human plasma protein profiling, we identified DBNL, NPC2, SUMF2, and TFPI as high-risk genes and CCN3, PRKCSH, TEX264, and TGFBR3 as low-risk genes for AD. …”
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Effective treatment of severe acute pancreatitis and COVID-19 pneumonia with tocilizumab by Piotr Zielecki, Magdalena Kaniewska, Mariusz Furmanek, Tomasz Bulski, Grażyna Rydzewska

“…One study showed that TCZ might reduce mortality in patients with severe COVID-19 pneumonia [14], but to date there have been no human studies evaluating tocilizumab in the treatment of acute pancreatitis. …”
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