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26721
Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study
Published 2024-11-01“…Objectives: The aim of this first-in-human study was to investigate whether AUP1602-C is safe and effective in improving wound healing and quality of life (QoL) in patients with non-healing DFU (nhDFU), and to determine the recommended phase II dose. …”
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26722
Siyasetin Meşruluğu Ya Da Meşruiyetin Siyaseti -Politics Legitimate or Legitimacy of Politics
Published 2015-01-01“…This innovation while acknowledging that the sovereignty is divine, also put forward the idea of its tangible manifestation in time and space however carrying human qualities and accomplishing through people. …”
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26723
Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p
Published 2019-01-01“…Induction with Rosiglitazone activated PPAR-γ and promoted its nuclear translocation in cultured human umbilical vein endothelial cells (HUVECs). …”
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26724
The comprehensive assessment of epigenetics changes during skin development
Published 2025-01-01“…The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R (version 4.0.3) software. …”
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26725
Correlation between selenium levels and selenoproteins expression in idiopathic generalized epilepsy: a study from Karachi
Published 2025-01-01“…Selenium, in the form of selenoproteins is an integral part of the human antioxidant defense system. Though a relationship between the altered selenium levels and epilepsy has been reported, limited evidence is available about the expression pattern of selenoproteins in epileptic patients. …”
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26726
The Association between Short-Term PM2.5 Exposure and Long COVID on the Respiratory System
Published 2024-05-01“…During the COVID-19 pandemic, several countries, including Thailand, encountered the issue of PM2.5 pollution, which has had adverse effects on human health. This study was to evaluate the impact of short-term exposure to PM2.5 on the respiratory system and its correlation with the prevalence of Long COVID, while also examining the relevant factors, particularly the presence of PM2.5 exposure. …”
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26727
Renal Transplantation in Secondary Amyloidosis Associated with Tuberculosis
Published 2013-01-01“…She was transplanted with kidney from her 28-year-old brother with 3/6 human leukocyte antigen match. She had immediate good graft function without any perioperative complications (cardiovascular, infections, rejection and delayed graft function). …”
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26728
An Exploration of the Cellular Microenvironment of the Female Pig Urethra: Translational Insights for Urological Research
Published 2025-01-01“…The observed anatomical variations, along with the cellular similarities between pigs and humans, establish the female pig as a crucial translational model for advancing urological research. …”
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26729
Exploring salivary gene expression clusters: A bioinformatics approach for advanced diagnosis and prognosis in head and neck squamous cell carcinoma
Published 2024-06-01“…Materials and methods: A comprehensive keyword search was conducted to extract 74 salivary gland secretion genes from the Human Protein Atlas. GeneMANIA and STRING databases were employed to analyse protein-protein interactions and predict functional partners. …”
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26730
Prospective de novo drug design with deep interactome learning
Published 2024-04-01“…In order to proactively evaluate the deep interactome learning framework for protein structure-based drug design, potential new ligands targeting the binding site of the human peroxisome proliferator-activated receptor (PPAR) subtype gamma are generated. …”
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26731
Estimating avoidable burden of stillbirth attributable to greenness improvement in Iran
Published 2025-01-01“…Introduction: Expanding evidence suggests beneficial impacts of greenspace on human health, yet the relationships between greenness and stillbirth remain unknown. …”
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26732
Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis
Published 2019-01-01“…High concentrations of CX3CL1 in serum are directly proportional to increased concentrations of bone turnover and inflammatory factors in human blood serum (TRACP-5b, NTx, IL-1β, and IL-6). …”
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26733
Water-Soluble Vitamins: Hypo- and Hypervitaminosis in Pediatric Population
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26734
Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice
Published 2019-01-01“…Previous studies demonstrated that both recombinant mice and human IL-35 attenuated atherosclerosis in ApoE-/- mice. …”
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26735
Explainable AI-Based Approach for Age-Related Macular Degeneration (AMD) Detection via Fundus Imaging
Published 2025-01-01“…This work helps clinicians interpret AMD cases and supports decision-making revealing hidden features of AMD that are not visible to the human eye. Future research will focus on improving these systems by expanding the databases in aggregate and incorporating multimodal data.…”
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26736
Role of Subsurface Geo-Energy Pilot and Demonstration Sites in Delivering Net Zero
Published 2022-12-01“…Gaps were identified in two areas: 1) test facilities to aid the design of low cost, high resolution, unobtrusive seismic and other monitoring for a seismically noisy urban environment with a sensitive human population, for example for ATES in urban areas; and 2) a dedicated through-fault zone test site to understand fault transmissivity and reactivation. …”
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26737
Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34pos Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction
Published 2015-01-01“…Here, we investigated a differentiation protocol enabling the generation and selection of human iPSC-derived MSCs exhibiting relevant surface marker expression profiles (CD105 and CD73) and functional characteristics. …”
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26738
The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001
Published 2020-01-01“…Environmental estrogens are mainly derived from human and vertebrate excretion, drugs, and agricultural activities. …”
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26739
Toxicity, antifeedant and repellent activities of five essential oils on adult Cassida vittata Vill. (Coleoptera: Chrysomelidae)
Published 2024-12-01“…Chemical pesticides are considered the most common strategy to control this pest, and their use is extremely harmful to human health and the environment. In this context, the adults of C. vittata were exposed to five essential oils (EOs) obtained from: Artemisia herba alba Asso. …”
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26740
Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite
Published 2016-01-01“…The toxicity effects of all samples were studied using viability assays on human fibroblasts cells (HGF-1) in vitro. The sizes of the crystallites were about 10–70 nm with irregular morphology and present the phase corresponding to the JCPDS card 9–0432 for hydroxyapatite. …”
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