The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death by Margarida T. Grilo Ruivo, Ji-hun Shin, Todd Lenz, Stephanie Y. Matsuno, Katherine Olivia Yanes, Arnault Graindorge, Maguy Hamie, Laurence Berry-Sterkers, Mathieu Gissot, Hiba El Hajj, Karine G. Le Roch, Melissa B. Lodoen, Maryse Lebrun, Diana Marcela Penarete-Vargas

“…ΔROP55 infection also induced RIPK3-dependent necroptosis in human and mouse primary macrophages. Moreover, ΔROP55 parasites were significantly impaired in virulence in female mice and prevented NF-κB activation and parasite clearance in mBMDM. …”
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Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…Gene annotation analysis was performed to identify genes over-expressed in these regions by using the Allen Human Brain Atlas, followed by a set of gene functional feature analyses. 19 studies (1333 patients and 1174 healthy controls) were included in this meta-analysis. …”
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Healthcare Costs and Resource Use Associated With Cervical Intraepithelial Neoplasia and Cervical Conization: A Retrospective Study of German Statutory Health Insurance Claims Data by Anna-Janina Stephan, Miriam Reuschenbach, Kunal Saxena, Vimalanand S. Prabhu, Christian Jacob, Kim M. Schneider, Wolfgang Greiner, Regine Wölle, Monika Hampl

“…**Background:** Cervical intraepithelial neoplasia (CIN) can be a consequence of human papillomavirus (HPV) infection. High-grade CIN (CIN2/CIN3) may develop from persistent HPV infection and progress to cervical cancer if left untreated. …”
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Proposed framework for the integration of refractive error services into the eye health ecosystem in Kenya via social enterprise by Shadrack Muma, Kovin Shunmugam Naidoo, Rekha Hansraj

“…It is anticipated that through engagement of social enterprises, integration of critical aspects such as human resources, awareness/education, cost efficiency, research and service delivery could potentially be enhanced.…”
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Mercury Vapour Long-Lasting Exposure: Lymphocyte Muscarinic Receptors as Neurochemical Markers of Accidental Intoxication by E. Roda, A. Giampreti, S. Vecchio, P. Apostoli, T. Coccini

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Potential Clinical Application of Analysis of Bisphenols in Pericardial Fluid from Patients with Coronary Artery Disease with the Use of Liquid Chromatography Combined with Fluores... by Tomasz Tuzimski, Szymon Szubartowski, Janusz Stążka, Kamil Baczewski, Daria Janiszewska, Viorica Railean, Bogusław Buszewski, Małgorzata Szultka-Młyńska

“…Bisphenols may negatively impact human health. In this study, we propose the use of HPLC–FLD for the simultaneous determination of bisphenols in pericardial fluid samples collected from patients with coronary artery disease undergoing coronary artery bypass surgery. …”
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Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis by Denis Poddubnyy, Torsten Diekhoff, Sevtap Tugce Ulas, Fabian Proft, Valeria Rios Rodriguez, Judith Rademacher, Juliane Greese, Katharina Ziegeler, Carolina Dominguez Aleixo, Maximilian Lindholz

“…Classification of back pain as inflammatory (=IBP), human leucocyte antigen-B27 positivity, family history, disease activity according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), symptom duration, elevated acute phase reactants, peripheral and extramusculoskeletal manifestations were evaluated. …”
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Novel Electrochemiluminescence Sensor for Dopamine Detection Based on Perylene Diimide/CuO Nanomaterials by Qirong Tian, Xinyang Sun, Chuan Li, Lei Shang, Rongna Ma, Xiaojian Li, Liping Jia, Shuijian He, Qian Zhang, Wei Zhang, Huaisheng Wang

“…In addition, the novel ECL sensor in this work showed good practicability in a human serum sample.…”
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The Effects of Three Methods of Luteal Phase Support on Pregnancy Outcomes in Poor Ovarian Responders: A Randomized Clinical Trial by Tahereh Madani, Arezoo Arabipoor, Fariba Ramezanali, Shabnam Khodabakhshi, Zahra Zolfaghary

“…This study aimed to compare the effectiveness of variousluteal phase support (LPS) methods, including progesterone alone, human chorionic gonadotropin (hCG) alone,and the combination of progesterone with hCG, in these patients.Materials and Methods: In this randomized clinical trial, 375 patients diagnosed with POR based on the Bolognacriteria underwent intracytoplasmic sperm injection-embryo transfer (ET) cycles at the Royan Institute betweenNovember 2015 and June 2019. …”
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CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury by Zhu Zhang, Jinqi Hao, Qinghong Qiao, Junting Song, Yanqin Yu

“…In this study, the role and mechanism of circHIPK2 in MIRI were evaluated. Methods Human cardiac myocytes (HCM) were cultured under Hypoxia/Reoxygenation (H/R) condition to establish a MIRI model in vitro. …”
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Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway by Jia Yan, Linglin Zhang, Qingyu Zeng, Yitao Qian, Ke Li, Xiaojing Liu, Yun Wu, Yu Yan, Haiyan Zhang, Szeman Cheung, Jia Liu, Ronald Sroka, Xiuli Wang, Lei Shi

“…In this study, we investigated the impact of ALA-PDT on lipid metabolism in an acne-like mouse model and in immortalized human sebocytes (XL-i-20), focusing on the role of the OLR1-Wnt/β-catenin pathway. …”
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Weighted gene co-expression network analysis reveals key stromal prognostic markers in pancreatic cancer by G. Mantini, A. Agostini, M. Tufo, S. Rossi, M. Kulesko, C. Carbone, L. Salvatore, G. Tortora, G. Scambia, L. Giacò

“…Importantly, HPGDS was found to be stromal-specific in the TMA cohort of Human Protein Atlas. Single sample GSEA showed that the stromal module is enriched for stromal signature of Moffitt and Puleo. …”
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Preparation of Iron Oxide and Titania-Based Composite, Core-Shell Populated, Nanoparticulates Material by Two-Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer A... by Hasan H. Bahjat, Raid A. Ismail, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Mohsen Al-Omar, Salman A. A. Mohammed, Riaz A. Khan

“…The flow cytometry analyses confirmed the NPs’ cytotoxic impacts against the human lung cancer A549 cell lines through the initiation of apoptosis and promotion of the cell cycle arrest at the G1 phase of cell division. …”
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Idea občana – válečníka a „moderní“ maskulinní identita: modelová studie z dějin Spojených států by Jiří Hutečka

“…Although it is not very surprising considering the “state of the art” in both fields here, it must be surprising in any other way, because there is a hardly any more “gendered” human endeavor than warfare – a fact generally acknowledged by theorists and thinkers from Bourdieu to Virginia Woolfe. …”
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A mixed method exploration of job morale of physicians working in public healthcare settings in Kazakhstan during the COVID-19 pandemic by Alina Kuandyk, Mariya Dmitriyeva, Nazerke Toleukhanova, Maev Conneely, Timur Suleimenov, Dauren Sarssenov, Raimzhan Mamytkhan, Madiyar Sakhayev, Arman Tleubergenov, Medet Toleubayev

“…The Warr-Cook-Wall scale, Maslach Burnout Inventory Human Services Survey for Medical Personnel, and Beck Depression Inventory were used to measure job morale indicators. …”
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Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization by Junpei Fukumoto, Minako Yoshida, Suzumi M. Tokuoka, Eri Saki H. Hayakawa, Shinya Miyazaki, Takaya Sakura, Daniel Ken Inaoka, Kiyoshi Kita, Jiro Usukura, Hideo Shindou, Fuyuki Tokumasu

“…These findings highlight PfLPLAT1 as a potential target for antimalarial therapy, particularly due to its unique role and divergence from human orthologs.…”
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LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling by Marlene N. Thaitumu, Daniel Marques De Sá e Silva, Philippine Louail, Johannes Rainer, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Georgios Theodoridis, Helen Gika

“…<b>Results:</b> BµS devices, especially Mitra and Capitainer, provided equal or even superior information on the metabolic profiling of human blood based on the number and intensity of features and the precision and stability of some annotated metabolites compared to plasma. …”
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STUDY OF THE EFFECT OF METHIONINE HYPERHOMOCYSTEINEMIA AND ITS CORRECTION WITH CHOLINE AND VITAMIN D ON THE CONDITION OF THE PERIODONTIUM, SMALL INTESTINE, AND LIVER OF RATS by Oleh Kutelmakh, Yulia Chumakova, Lina Kovalchuk, Yulia Odnorih, Olexandra Kutelmakh, Anastasiya Spodaruk

“…In recent years, there have been reports of a clinical relationship between periodontitis, intestinal and liver diseases of the human body, the so-called "oral-intestinal-hepatic axis", although the causal mechanism of such an "association" is still unclear. …”
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Development of the Whole Day Matters Toolkit for Primary Care: a consensus-building study to mobilize national public health guidelines in practice by Tamara L. Morgan, Michelle S. Fortier, Rahul Jain, Kirstin N. Lane, Kaleigh Maclaren, Taylor McFadden, Jeanette Prorok, Jill Robison, Zachary J. Weston, Jennifer R. Tomasone

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Narrow Dietary Niche With High Overlap Between Snow Leopards and Himalayan Wolves Indicates Potential for Resource Competition in Shey Phoksundo National Park, Nepal by Sandesh Lamichhane, Bikram Shrestha, Bhumi Prakash Chaudhary Tharu, Raj Kumar Koirala, Bishnu Prasad Bhattarai, Pratigyan Poudel, Binaya Adhikari, Gopal Khanal

“…Nevertheless, the region's low prey richness means that, with increasing human influence, any reduction in wild prey or increase in livestock could intensify competition between snow leopards and wolves, which could have implications for livestock depredation.…”
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