Comparative experimental anesthesia efficacy study of epidural injection at the sacrococcygeal space using ultrasound guidance versus blindness technique in Egyptian donkeys (Equus... by Mohamed A. Hamed, Hazem Hamouda, Mohammed Elmetwally, Foad Farrag, Mohamed Abdo Rizk, Mohamed M. A. Abumandour, Yamen Mohammed Hegazy, Alaa Samy

“…In the first group, we used ten cadaver donkeys that were humanely euthanized. In the second group, we used 10 live, healthy adult donkeys to assess the efficacy and time of analgesia onset for blind and ultrasound-guided epidural injections at the sacrococcygeal region. …”
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Exposure to perchlorate via drinking water from eight major water basins in China and its health risks across different age groups by Jia Lyu, Yongyan Chen, Lan Zhang, Xu Yan, Muyesaier Tudi

“…Considering the endocrine-disrupting properties of perchlorate, the possibility of perchlorate exposure to humans through drinking water has become a public health concern. …”
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Spatial Variability of Metals in Surface Water and Sediment in the Langat River and Geochemical Factors That Influence Their Water-Sediment Interactions by Wan Ying Lim, Ahmad Zaharin Aris, Mohamad Pauzi Zakaria

“…These results are important when making crucial decisions in determining potential hazardous levels of these metals toward humans.…”
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Novel candidate genes and genetic basis analysis of kernel starch content in tropical maize by Xiaoping Yang, Ranjan K. Shaw, Linzhuo Li, Fuyan Jiang, Xingming Fan

“…Abstract Background Starch is the most abundant carbohydrate in maize grains, serving as a primary energy source for both humans and animals, and playing a crucial role in various industrial applications. …”
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Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations by Joel Heisler, Daniel Kovner, Saeed Izadi, Jonathan Zarzar, Paul J. Carter

“…Here, we studied the effect of a panel of common and clinically validated Fc mutations on the viscosity of two closely related humanized IgG1, κ antibodies, omalizumab (anti-IgE) and trastuzumab (anti-HER2). …”
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Antimicrobial Usage in Smallholder Poultry Production in Nigeria by Oladeji Bamidele, Tunde A. Amole, Oluwafikayo A. Oyewale, Olayinka O. Bamidele, Abdulmojeed Yakubu, Uduak E. Ogundu, Folasade O. Ajayi, Waheed A. Hassan

“…The indiscriminate use of antimicrobials in livestock production is of increasing concern due to the threat of antimicrobial resistance in both humans and animals. Much emphasis has been placed on intensively managed poultry production systems, which routinely use antimicrobials as against smallholder poultry production systems (SPPS). …”
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Chitosan Nanoparticles for Enhanced Immune Response and Delivery of Multi-Epitope <i>Helicobacter pylori</i> Vaccines in a BALB/c Mouse Model by Rita Amaral, Tomás Concha, Jorge Vítor, António J. Almeida, Cecília Calado, Lídia M. Gonçalves

“…<b>Conclusions</b>: These findings indicate that both pDNA and recombinant protein vaccines encapsulated into chitosan nanoparticles are promising candidates for eradicating <i>H. pylori</i> and mitigating associated gastric diseases in humans.…”
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Development and Application of Physiologically-Based Pharmacokinetic Model to Predict Systemic and Organ Exposure of Colorectal Cancer Drugs by Sara Peribañez-Dominguez, Zinnia Parra-Guillen, Iñaki F. Troconiz

“…This project has the goal of characterizing the systemic and tissue exposure of four anti-cancer drugs in humans using a PBPK platform fed with data from the literature. …”
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Antibiogram Profile of Patients Having Urinary Tract Infection Treated with Most Commonly Used Antibiotics by Bilal Ahmad, Faleesha Gul, Said Hassan, Haseeba Arif, Amber Javaid, Shawkat Ali

“… Background: Urinary tract infections (UTIs) are the most common infections in humans, primarily caused by bacteria, with Escherichia coli (E. coli) responsible for 75-90% of cases. …”
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Numerical Analysis on the Storage of Nuclear Waste in Gas-Saturated Deep Coal Seam by Teng Teng, Yuming Wang, Xiaoyan Zhu, Xiangyang Zhang, Sihai Yi, Guowei Fan, Bin Liu

“…Nuclear power has contributed humanity a lot since its successful usage in electricity power generation. …”
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Safe-and-sustainable-by-design redox active molecules for energy storage applications by Clemens Wolf, Janine Maier, Julia Wenger, Georg Rudelstorfer, Christian Leypold, Julia Voglhuber-Höller, Matiss Reinfelds, Andrea Weiner, Arantza Muriana, Susanne Lux, Claudia Mair-Bauernfeind, Andreas Falk, Stefan Spirk

“…Conclusion Taken together, the modified designs led to safer and more sustainable redox active materials for both humans and the environment at lab scale. Implementing the results mentioned above to further expedite the technology will ultimately pave the way to more sustainable energy storage applications. …”
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Leaflet: Operative Steps for Interventional Studies in Neuroscience by Maria Meringolo, Sergio Delle Monache, Giuseppina Martella, Antonella Peppe

“…Clinical trials are designed to assess the effects of drugs on humans, focusing on determining safety profiles, appropriate modes of administration, and comparative efficacy against placebos. …”
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The Effects of Alpha Interferon on the Development of Autoimmune Thyroiditis in the NOD H2h4 Mouse by Yael Oppenheim, Grace Kim, Yoshiyuki Ban, Pamela Unger, Erlinda Concepcion, Takao Ando, Yaron Tomer

“…Alternatively, it is possible that αIFN did not induce thyroiditis in mice because, unlike in humans, in mice αIFN does not induce Th1 switching.…”
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Aberrant methylation of placental development genes in chorionic villi of spontaneous abortions with trisomy 16 by О. Yu. Vasilyeva, E. N. Tolmacheva, A. E. Dmitriev, Ya. A. Darkova, E. A. Sazhenova, T. V. Nikitina, I. N. Lebedev, S. A. Vasilyev

“…In humans, aneuploidy is incompatible with the birth of healthy children and mainly leads to the death of embryos in the early stages of development in the first trimester of pregnancy. …”
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Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India’s combat against vector-borne diseases by Kuldeep Singh, Amit Sharma, Manju Rahi, Sanjeev Kumar Gupta, Gaurav Kumar, Rajendra Baharia, Sam Joy

“…The promising new vector control tools are insecticide-treated nets with synergist and/or pyrrole chlorfenapyr, alternatives/additions to synthetic pyrethroids like neonicotinoids, clothianidin for indoor residual spray, newer formulations such as Bacillus sphaericus for use in larvicides, attractive toxic sugar baits, especially to curtail outdoor transmission, endectocides like ivermectin for use in animals/humans, insecticidal paints, spatial repellents, insecticide-treated wearables and others. …”
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Genetic Analysis of Cytokine Promoters in Nonhuman Primates: Implications for Th1/Th2 Profile Characteristics and SIV Disease Pathogenesis by Pavel Bostik, Melanie Watkins, Francois Villinger, Aftab A. Ansari

“…The shift from a predominant synthesis of prototype Th1 cytokines to Th2 or Th0 type of cytokines by antigen activated PBMC's from HIV infected humans and SIV infected disease susceptible rhesus macaques (RM) has been shown to be associated with disease progression. …”
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Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies. by Peter R McIlroy, Le Thanh Mai Pham, Thomas Sheffield, Maxwell A Stefan, Christine E Thatcher, James Jaryenneh, Jennifer L Schwedler, Anupama Sinha, Christopher A Sumner, Iris K A Jones, Stephen Won, Ryan C Bruneau, Dina R Weilhammer, Zhuoming Liu, Sean Whelan, Oscar A Negrete, Kenneth L Sale, Brooke Harmon

“…Previously, we designed a next-generation synthetic humanized nanobody (Nb) phage display library and demonstrated that this library could be used to rapidly identify highly specific and potent neutralizing heavy chain-only antibodies (HCAbs) with prophylactic and therapeutic efficacy in vivo against the original SARS-CoV-2. …”
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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Antigen-specific therapies using islet autoantigens for restoring immune tolerance have emerged as promising approaches for the treatment of T1D but have been unsuccessful in humans. Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (iNKT) cells, and insulin B chain 9–23 peptide, which is an epitope for CD4+ T cells, could induce the accumulation of regulatory T cells (Tregs) in islets in a peptide-dependent manner, followed by the remarkable prevention of diabetes onset in nonobese diabetic (NOD) mice. …”
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In situ natural radioactivity and radiological hazard assessments of granite gneiss outcrops in parts of the Southwestern Basement Complex of Nigeria by Adedibu Sunny Akingboye, Omowumi Ademila

“…Radioactive emission (gamma ray) emanating from rock materials constitutes threats to humans and their environment. Hence, the natural radioactivity and radiological hazard indices of some granite gneiss outcrops with their residual soils from two different localities within the Southwestern Basement Complex of Nigeria were assessed using Gamma-ray spectrometry. …”
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Development of a neural network for diagnosing the risk of depression according to the experimental data of the stop signal paradigm by M. O. Zelenskih, A. E. Saprygin, S. S. Tamozhnikov, P. D. Rudych, D. A. Lebedkin, A.  N. Savostyanov

“…An architecture was developed and a system was implemented for testing motor control indicators in humans, then it was tested in real experiments. A comparison of neural network technologies and methods of mathematical statistics was carried out. …”
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