Blue applicability grade index assessment and response surface modelling to synchronous determination of metformin hydrochloride, vildagliptin and dapagliflozin propanediol monohyd... by Pintu Prajapati, Krutika Patil, Dhrumi Naik, Veera Shakar Pulusu, Anzarul Haque, Mohd Abul Kalam, Shailesh Shah

“…Abstract Diabetes mellitus is major chronic disease found in human due to stressful lifestyle and bad food habit. …”
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Magnetic Nanoparticle Based Nonviral MicroRNA Delivery into Freshly Isolated CD105+ hMSCs by Anna Schade, Paula Müller, Evgenya Delyagina, Natalia Voronina, Anna Skorska, Cornelia Lux, Gustav Steinhoff, Robert David

“…Genetic modifications of bone marrow derived human mesenchymal stem cells (hMSCs) using microRNAs (miRs) may be used to improve their therapeutic potential and enable innovative strategies in tissue regeneration. …”
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Portable wide-field digital imaging for screening of neonatal visual impairment causes in Rio de Janeiro, Brazil: a budget impact analysis by Andrea Zin, Lorena M Haefeli, Luiza M Neves, Ana Carolina Carioca Costa, Zilton Farias Meira de Vasconcelos, Marcia Pinto

“…Further health economic evaluations should be performed to verify the affordability of the implementation of this screening strategy in the Brazilian scenario, taking into account scarce human resources.…”
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ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure by Qing Liu, Dan Liu, Yuejiao Wang, Xiaowei Wei, Wei Ma, Hui Gu, Shanshan Jia, Yiwen He, Wenting Luo, Songying Cao, Zhonghua Yang, Anhua Wu, Zhengwei Yuan

“…We demonstrated that ApoM expression was reduced in the spinal cord samples of rat models and human fetuses with NTDs respectively. Specifically, lack of ApoM resulted in reduced cytosolic localization of Elavl2 and caused Nnt mRNA degradation, which further led to impaired cell homeostasis by suppressing PINK1-PRKN-mediated mitophagy and promoting apoptosis and subsequent NTDs formation. …”
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Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders by Vikas R. Dharnidharka, Marianna B. Ruzinova, Chun‐Cheng Chen, Priyanka Parameswaran, Harry O'Gorman, Charles W. Goss, Hongjie Gu, Gregory A. Storch, Kristine Wylie

“…In univariable analysis, death within 5 years of PTLD diagnosis was associated with anellovirus (P = 0.037) and gammapapillomavirus (P = 0.036) detection by MSS, higher tissue qPCR levels of the predominant human anellovirus species torque teno virus (TTV; P = 0.016), T cell type PTLD, liver, brain or bone marrow location. …”
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Oral Fusobacterium nucleatum resists the acidic pH of the stomach due to membrane erucic acid synthesized via enoyl-CoA hydratase-related protein FnFabM by Xiaocong Li, Shipeng Zhang, Huafang Sheng, Yan Zhen, Buling Wu, Zhuang Li, Dingqiang Chen, Hongwei Zhou

“…These results provide novel insights into the mechanisms underlying the oral bacteria survival in acidic environments and their potential to colonize the intestine; thus, shedding light on the oral-gut axis and its implications on human health.…”
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Specificity of psychological readiness for changes and psychological resilience in the employees of the State Criminal-Executive Service of Ukraine by O. V. Mitroshkina

“…Bardier) and questionnaire of human resilience (O. O. Rylska) were applied to solve empirical problems. …”
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Advances in Cardiovascular Multimodality Imaging in Patients with Marfan Syndrome by Marco Alfonso Perrone, Sara Moscatelli, Giulia Guglielmi, Francesco Bianco, Deborah Cappelletti, Amedeo Pellizzon, Andrea Baggiano, Enrico Emilio Diviggiano, Maria Ricci, Pier Paolo Bassareo, Akshyaya Pradhan, Giulia Elena Mandoli, Andrea Cimini, Giuseppe Caminiti

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Dynamic Variation in Hippocampal Metabolism after Acute Stress Exposure: An In Vivo Proton Magnetic Resonance Spectroscopy Study at 9.4 T by Yoon Ho Hwang, Min-Hee Lee, Chang-Soo Yun, Yong-Tae Kim, Hyeon-Man Baek, Bong Soo Han, Dong Youn Kim

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Spatial and temporal predictability drive foraging movements of coastal birds by Madeleine Foley, Kimberly A. Lato, Matthew Fuirst, Richard R. Veit, Robert M. Cerrato, Lesley H. Thorne

“…Herring gulls in urban environments foraged more on Fridays and weekends, possibly due to increased or altered human activities on these days. Conclusions Our results demonstrate the importance of spatial memory and spatiotemporal predictability of gull foraging habitats and highlight the extent to which gulls adjust their movements based on their foraging habitats.…”
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Spatiotemporal dynamics and prevention strategies of cervical cancer incidence in Addis Ababa, Ethiopia: an ecological study by Mathewos Assefa, Eva Johanna Kantelhardt, Teferi Gedif Fenta, Tariku Shimels

“…To address these challenges, the implementation of school-based human papillomavirus vaccination programmes, alongside targeted interventions, active campaigns and sustained surveillance, is critical. …”
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A multi-stage weakly supervised design for spheroid segmentation to explore mesenchymal stem cell differentiation dynamics by Arash Shahbazpoor Shahbazi, Farzin Irandoost, Reza Mahdavian, Seyedehsamaneh Shojaeilangari, Abdollah Allahvardi, Hossein Naderi-Manesh

“…Abstract There is a growing interest in utilizing 3D culture models for stem cell and cancer cell research due to their closer resemblance to in vivo environments. In this study, human mesenchymal stem cells (MSCs) were cultured using adipocytes and osteocytes as differentiative mediums on varying concentrations of chitosan substrate. …”
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Production-living-ecological functions measurement and spatio-temporal evolution of the coastal zone under the perspective of land-sea coordination: a case study of Liaoning Coasta... by Lina Ke, Lei Wang, Quanming Wang, Zhiyu Ren, Yao Lu, Shusheng Yin, Yu Zhao, Qin Tan, Yibo Li

“…The acceleration of urbanization and development of marine resources has led to the imbalance of land structure, which threatens the sustainable development of the human living environment. Exploring the spatial distribution patterns of land-sea and its spatio-temporal evolution characteristics is an important initiative to resolve conflicts and optimise the spatial structure of land-sea use. …”
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Effect of the Addition of Apple Pomace and Erythritol on the Antioxidant Capacity and Antidiabetic Properties of Shortbread Cookies by Ewa Raczkowska, Aneta Wojdyło, Paulina Nowicka

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Event Detection and Identification of Influential Spreaders in Social Media Data Streams by Leilei Shi, Yan Wu, Lu Liu, Xiang Sun, Liang Jiang

“…However, traditional event detection models require human intervention to detect the number of topics to be explored, which significantly reduces the efficiency and accuracy of event detection. …”
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Poor COVID-19 Preventive Practice among Healthcare Workers in Northwest Ethiopia, 2020 by Belayneh Ayanaw Kassie, Aynishet Adane, Eskeziaw Abebe Kassahun, Amare Simegn Ayele, Aysheshim Kassahun Belew

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RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells by Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M

“…Nonetheless, the specific influence of SPP86 on autophagy, particularly its mechanisms in the context of DNA damage and apoptosis in human melanoma cells, remains inadequately understood. …”
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Lidocaine Shows Significant Antimicrobial Effects Against <i>Staphylococcus</i> Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injecta... by Stephan Heller, Ricarda Johanna Seemann, Rainer Burgkart, Andreas Obermeier, Hermann Locher

“…Additional tests were conducted on <i>Staphylococcus epidermidis</i> and methicillin-resistant Staphylococcus aureus (MRSA), as well as on <i>S. aureus</i> in human synovial fluid. Results: Lidocaine showed a concentration-dependent antimicrobial effect, with greater inhibition at higher concentrations and lower bacterial densities. …”
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The Ukrainian war and the pandemic: the impact on public health and the need for new health digital tools and the next level of intelligence by M. Geanta, B. Cucos, A. Boata, A.C. Nuta, F.M. Nuta, V.V. Semenov

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Development and validation of a questionnaire for table tennis teaching in physical education by Miguel Ángel Ortega-Zayas, Antonio José Cardona-Linares, Alberto Quílez, Alejandro García-Giménez, Miguel Lecina, Francisco Pradas

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