Exome sequencing of UK birth cohorts [version 2; peer review: 2 approved, 1 approved with reservations] by Petr Danecek, Amy Hough, John Wright, Karen Ho, Nicholas J. Timpson, Sarah J. Lindsay, Davide Bonfanti, Daniel S. Malawsky, Rafaq Azad, Deborah Plowman, Sara Widaa, Gemma Shireby, Emla Fitzsimons, David Bann, Matthew E. Hurles, Hilary C. Martin, Susan M. Ring, Dan Mason, Michael A. Quail, Wei Huang, Vivek Iyer, Mahmoud Koko, Iaroslav Popov, Laurie Fabian, Gennadii Zakharov, Ruth Y. Eberhardt, Emma E. Wade, Qin Qin Huang

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Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group by Alessia Cavazza, Francisco J. Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem, Špela Malenšek, Peter Pečan, Annalisa Santini, Paula Heredia, Araceli Aguilar-González, Houria Boulaiz, Qianqian Ni, Marina Cortijo-Gutierrez, Kristina Pavlovic, Inmaculada Herrera, Berta de la Cerda, Emilio M. Garcia-Tenorio, Eva Richard, Sergio Granados-Principal, Arístides López-Márquez, Mariana Köber, Marijana Stojanovic, Melita Vidaković, Irene Santos-Garcia, Lorea Blázquez, Emily Haughton, Dongnan Yan, Rosario María Sánchez-Martín, Loubna Mazini, Gloria Gonzalez Aseguinolaza, Annarita Miccio, Paula Rio, Lourdes R. Desviat, Manuel A.F.V. Gonçalves, Ling Peng, Cecilia Jiménez-Mallebrera, Francisco Martin Molina, Dhanu Gupta, Duško Lainšček, Yonglun Luo, Karim Benabdellah

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Predicting Interplanetary Shock Occurrence for Solar Cycle 25: Opportunities and Challenges in Space Weather Research by Denny M. Oliveira, Robert C. Allen, Livia R. Alves, Séan P. Blake, Brett A. Carter, Dibyendu Chakrabarty, Giulia D’Angelo, Kevin Delano, Ezequiel Echer, Cristian P. Ferradas, Matt G. Finley, Bea Gallardo‐Lacourt, Dan Gershman, Jesper W. Gjerloev, John Bosco Habarulema, Michael D. Hartinger, Rajkumar Hajra, Hisashi Hayakawa, Liisa Juusola, Karl M. Laundal, Robert J. Leamon, Michael Madelaire, Miguel Martínez‐Ledesma, Scott M. McIntosh, Yoshizumi Miyoshi, Mark B. Moldwin, Emmanuel Nahayo, Dibyendu Nandy, Bhosale Nilam, Katariina Nykyri, William R. Paterson, Mirko Piersanti, Ermanno Pietropaolo, Craig J. Rodger, Trunali Shah, Andy W. Smith, Nandita Srivastava, Bruce T. Tsurutani, S. Tulasi Ram, Lisa A. Upton, Bhaskara Veenadhari, Sergio Vidal‐Luengo, Ari Viljanen, Sarah K. Vines, Vipin K. Yadav, Jeng‐Hwa Yee, James W. Weygand, Eftyhia Zesta

“…Such effects can pose considerable threats to human assets in space and on the ground, including satellites in the upper atmosphere and power infrastructure. …”
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Editorial by Michael Rose, Jonathan M. Hoffmann

“…Second, Melissa Ihlow and Maria Lenk (Stuttgart) review “Humans in the Global Ecosystem”, edited by Pierre L. …”
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The establishment of blue-sky index: how to quantify the aerosol optical impacts on sky color by Sunan Shen, Jiandong Wang, Chao Liu, Jia Xing, Jiaping Wang, Jing Cai, Zeyuan Tian, Peng Wang, Guangjie Zheng, Yuzhi Jin, Chenggang Wang, Le Cao, Zhouyang Zhang, Bin Wang, Aijun Ding, Shuxiao Wang

“…Color of the sky serves as a direct indicator of haze, while also exerting substantial influence on human physiological and psychological well-being, as well as the overall environmental scenery. …”
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Enhancing clinical and public health interpretation of accelerometer-assessed physical activity with age-referenced values based on UK Biobank data by Alex V. Rowlands, Andrew P. Kingsnorth, Bjørge H. Hansen, Stuart J. Fairclough, Lynne M. Boddy, Benjamin D. Maylor, Henrik R. Eckmann, Borja del Pozo Cruz, Nathan P. Dawkins, Cameron Razieh, Kamlesh Khunti, Francesco Zaccardi, Tom Yates

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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context by Deborah R. Gustafson, Xuantao Li, Alison E. Baird, Henrik Zetterberg, Kaj Blennow, Jinbing Zhang, Amanda Blair Spence, Pauline Maki, Anjali Sharma, Kathleen Weber, Recai Yucel

“…The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Institute of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). …”
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Advanced Restriction Imaging and Reconstruction Technology for Prostate Magnetic Resonance Imaging (ART-Pro): A Study Protocol for a Multicenter, Multinational Trial Evaluating Bip... by Madison T. Baxter, Christopher C. Conlin, Aditya Bagrodia, Tristan Barrett, Hauke Bartsch, Anja Brau, Matthew Cooperberg, Anders M. Dale, Arnaud Guidon, Michael E. Hahn, Mukesh G. Harisinghani, Juan F. Javier-DesLoges, Sophia C. Kamran, Christopher J. Kane, Joshua M. Kuperman, Daniel J.A. Margolis, Paul M. Murphy, Nabih Nakrour, Michael A. Ohliger, Rebecca Rakow-Penner, Ahmed Shabaik, Jeffry P. Simko, Clare M. Tempany, Natasha Wehrli, Sean A. Woolen, Jingjing Zou, Tyler M. Seibert

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Endocrine disruptors and cancers. [Perturbateurs endocriniens et cancers] by Souhila AOUICHAT BOUGUERRA, Saliha BOUMAZA, Khouloud HEMILA, Samia NEGGAZI, Nadjiba HAMLAT, Sihem BERDJA, Leïla SMAIL, Besma MOHAMMEDI, Kenza REGUOUAT, Amina BOUDJLIDA, Sofiane KACI, Fatima BOUACHRIA-BOUSMAHA

“…These compounds are present in our environment, carried by air, water, soil and their toxicity is proven because they interact with the hormones synthesis, degradation, transport and mode of action. Exposure of humans and animals to ED through food and/or domestic use is currently a hot topic. …”
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Contribution à l’histoire de la boulangerie romaine : étude de « pains/galettes » découverts en Gaule by Andreas G. Heiss, Véronique Matterne, Nicolas Monteix, Margaux Tillier, Camille Noûs

“…In the same vein as the previous considerations, we follow the idea that a dish or a drink represent artefacts, in the current definition as objects “predominantly shaped by human action”. We therefore consider it legitimate to evaluate processed foods, and their archaeological remains, as material witnesses to an ancient culinary heritage and we interpret them as such. …”
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…Introduction: Gut microbiome–derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest as promising tools for studying the link between the gut microbiome and human health. The diverse composition of bEVs, including their proteins, mRNAs, metabolites, and lipids, makes them useful for investigating diseases such as cancer. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…Identified pathways were validated by perturbation studies in human hepatocytes and PTPRD substrates by pull-down assays. …”
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Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost by Bo Zhang, Youyi Fong, Lauren Dang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Daniel S. Graciaa, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Chenchen Yu, Craig A. Magaret, Cindy Molitor, Bhavesh Borate, Sydney Busch, David Benkeser, Antonia Netzl, Derek J. Smith, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martín Bäcker, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Seema U. Nayak, Paul C. Roberts, Peter B. Gilbert, Dean Follmann, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

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Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017Research in context by Yi-Fan Wei, Li Ning, Yi-Lin Xu, Jing Ma, Dong-Run Li, Zan-Fei Feng, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Peng Li, Yong-Pei Yu, Dong-Hui Huang, Xiao-Ying Li, Song Gao, Chun-Qing Lin, Ting-Ting Gong, Qi-Jun Wu, Jing-He Lang

“…Findings: The incidence of OC displayed marked disparities across regions and Human Development Index (HDI), with the highest ASRs in Eastern and Central Europe and very high HDI regions, and the lowest in Africa, Asia, and medium HDI regions. …”
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First assessment of biofouling assemblages in the northern Red Sea, an important region for marine non-indigenous species transfer by Juan Sempere-Valverde, Juan Sempere-Valverde, Eva Aylagas, Vitaly Syomin, Vitaly Syomin, Marcos A. L. Teixeira, Glafira D. Kolbasova, Glafira D. Kolbasova, Sofía Ruiz-Velasco, Sahar Chebaane, Arthur Anker, João Curdia, Ronald Cadiz, Dylan M. Cottrell, Andrea Desiderato, Luiz F. Andrade, Chakkiath Paul Antony, Carolina Bocanegra-Castano, Matilde Marzucchi, Angelo Poliseno, Doaa Baker, Basmah Alabdulaziz, Flor Torres, Ameer A. Eweida, Ameer A. Eweida, Susana Carvalho, Susana Carvalho

“…However, sites in the Sharma lagoon showed high human pressure levels and comparatively higher coverage of cryptogenic bryozoans on panels.DiscussionThis study provides the first detailed assessment of biofouling communities in NEOM, establishing a baseline and contributing to a regional species reference library for non-indigenous and cryptogenic species. …”
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Genetic determinants of COVID-19 severity and mortality: ACE1 Alu 287 bp polymorphism and ACE1, ACE2, TMPRSS2 expression in hospitalized patients by João Locke Ferreira de Araújo, Átila Duque Rossi, Jessica Maciel de Almeida, Hugo José Alves, Isabela de Carvalho Leitão, Renata Eliane de Ávila, Anna Carla Pinto Castiñeiras, Jéssica da Silva Oliveira, Rafael Mello Galliez, Marlon Daniel Lima Tonini, Débora Souza Faffe, Shana Priscila Coutinho Barroso Barroso, Gustavo Gomes Resende, Cássia Cristina Alves Gonçalves, Terezinha Marta Pereira Pinto Castiñeiras, Amilcar Tanuri, Mauro Martins Teixeira, Renato Santana Aguiar, Cynthia Chester Cardoso, Renan Pedra de Souza

“…Background The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. …”
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Effect of Sucrose Spray on some Phytochemical Characteristics of Stevia (Stevia rebaudiana Bertoni) under Field Conditions by Vahid Akbarpour, Hossein Aruei, Kambiz Mashayekhi, Majid Azizi Arani, Mohammad Ali Bahmanyar

“…Extended Abstract Background: Sugars are one of the important components in the human diet, along with fats and proteins, which provide about 60-70% of their energy. …”
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Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning. by Elizabeth A Cromwell, Joshua C P Osborne, Thomas R Unnasch, Maria-Gloria Basáñez, Katherine M Gass, Kira A Barbre, Elex Hill, Kimberly B Johnson, Katie M Donkers, Shreya Shirude, Chris A Schmidt, Victor Adekanmbi, Olatunji O Adetokunboh, Mohsen Afarideh, Ehsan Ahmadpour, Muktar Beshir Ahmed, Temesgen Yihunie Akalu, Ziyad Al-Aly, Fahad Mashhour Alanezi, Turki M Alanzi, Vahid Alipour, Catalina Liliana Andrei, Fereshteh Ansari, Mustafa Geleto Ansha, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Benjamin F Arnold, Marcel Ausloos, Martin Amogre Ayanore, Atif Amin Baig, Maciej Banach, Aleksandra Barac, Till Winfried Bärnighausen, Mohsen Bayati, Krittika Bhattacharyya, Zulfiqar A Bhutta, Sadia Bibi, Ali Bijani, Somayeh Bohlouli, Mahdi Bohluli, Oliver J Brady, Nicola Luigi Bragazzi, Zahid A Butt, Felix Carvalho, Souranshu Chatterjee, Vijay Kumar Chattu, Soosanna Kumary Chattu, Natalie Maria Cormier, Saad M A Dahlawi, Giovanni Damiani, Farah Daoud, Aso Mohammad Darwesh, Ahmad Daryani, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Hoa Thi Do, Maysaa El Sayed Zaki, Maha El Tantawi, Demelash Abewa Elemineh, Anwar Faraj, Majid Fasihi Harandi, Yousef Fatahi, Valery L Feigin, Eduarda Fernandes, Nataliya A Foigt, Masoud Foroutan, Richard Charles Franklin, Mohammed Ibrahim Mohialdeen Gubari, Davide Guido, Yuming Guo, Arvin Haj-Mirzaian, Kanaan Hamagharib Abdullah, Samer Hamidi, Claudiu Herteliu, Hagos Degefa de Hidru, Tarig B Higazi, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Olayinka Stephen Ilesanmi, Milena D Ilic, Irena M Ilic, Usman Iqbal, Seyed Sina Naghibi Irvani, Ravi Prakash Jha, Farahnaz Joukar, Jacek Jerzy Jozwiak, Zubair Kabir, Leila R Kalankesh, Rohollah Kalhor, Behzad Karami Matin, Salah Eddin Karimi, Amir Kasaeian, Taras Kavetskyy, Gbenga A Kayode, Ali Kazemi Karyani, Abraham Getachew Kelbore, Maryam Keramati, Rovshan Khalilov, Ejaz Ahmad Khan, Md Nuruzzaman Nuruzzaman Khan, Khaled Khatab, Mona M Khater, Neda Kianipour, Kelemu Tilahun Kibret, Yun Jin Kim, Soewarta Kosen, Kris J Krohn, Dian Kusuma, Carlo La Vecchia, Van Charles Lansingh, Paul H Lee, Kate E LeGrand, Shanshan Li, Joshua Longbottom, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Afshin Maleki, Abdullah A Mamun, Ali Manafi, Navid Manafi, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Walter Mendoza, Endalkachew Worku Mengesha, Desalegn Tadese Mengistu, Seid Tiku Mereta, Tomislav Mestrovic, Ted R Miller, Mohammad Miri, Masoud Moghadaszadeh, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Shafiu Mohammed, Salahuddin Mohammed, Masoud Moradi, Rahmatollah Moradzadeh, Paula Moraga, Jonathan F Mosser, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Gurudatta Naik, Ionut Negoi, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Trang Huyen Nguyen, Rajan Nikbakhsh, Bogdan Oancea, Tinuke O Olagunju, Andrew T Olagunju, Ahmed Omar Bali, Obinna E Onwujekwe, Adrian Pana, Hadi Pourjafar, Fakher Rahim, Mohammad Hifz Ur Rahman, Priya Rathi, Salman Rawaf, David Laith Rawaf, Reza Rawassizadeh, Serge Resnikoff, Melese Abate Reta, Aziz Rezapour, Enrico Rubagotti, Salvatore Rubino, Ehsan Sadeghi, Abedin Saghafipour, S Mohammad Sajadi, Abdallah M Samy, Rodrigo Sarmiento-Suárez, Monika Sawhney, Megan F Schipp, Amira A Shaheen, Masood Ali Shaikh, Morteza Shamsizadeh, Kiomars Sharafi, Aziz Sheikh, B Suresh Kumar Shetty, B Suresh Kumar Shetty, Jae Il Shin, K M Shivakumar, Biagio Simonetti, Jasvinder A Singh, Eirini Skiadaresi, Amin Soheili, Shahin Soltani, Emma Elizabeth Spurlock, Mu'awiyyah Babale Sufiyan, Takahiro Tabuchi, Leili Tapak, Robert L Thompson, Alan J Thomson, Eugenio Traini, Bach Xuan Tran, Irfan Ullah, Saif Ullah, Chigozie Jesse Uneke, Bhaskaran Unnikrishnan, Olalekan A Uthman, Natalie V S Vinkeles Melchers, Francesco S Violante, Haileab Fekadu Wolde, Tewodros Eshete Wonde, Tomohide Yamada, Sanni Yaya, Vahid Yazdi-Feyzabadi, Paul Yip, Naohiro Yonemoto, Hebat-Allah Salah A Yousof, Chuanhua Yu, Yong Yu, Hasan Yusefzadeh, Leila Zaki, Sojib Bin Zaman, Maryam Zamanian, Zhi-Jiang Zhang, Yunquan Zhang, Arash Ziapour, Simon I Hay, David M Pigott

“…National onchocerciasis elimination programmes may wish to consider prioritising these IUs for mapping surveys as human resources, laboratory capacity, and programmatic schedules may constrain survey implementation, and possibly delaying MDA initiation in areas that would ultimately qualify.…”
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Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer by Wen Wen, Sen Zhao, Yiwen Jiang, Chengzhu Ou, Changyuan Guo, Ziqi Jia, Jiayi Li, Yansong Huang, Hengyi Xu, Pengming Pu, Tongxuan Shang, Lin Cong, Xiang Wang, Nan Wu, Jiaqi Liu

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The graded heat-health risk forecast and early warning with full-season coverage across China: a predicting model development and evaluation studyResearch in context by Qing Wang, Chen Chen, Huaiyue Xu, Yuanyuan Liu, Yu Zhong, Jing Liu, Menghan Wang, Mengxue Zhang, Yiting Liu, Jing Li, Tiantian Li

“…Summary: Background: Due to global climate change, high temperature and heatwaves have become critical issues that pose a threat to human health. An effective early warning system is essential to mitigate the health risks associated with high temperature and heatwaves. …”
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