Nicotinamide Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice through Its Anti-Inflammatory Properties and Modulates the Gut Microbiota by Kai Kang, Yue Sun, Dan Pan, Bing Chang, Li-Xuan Sang

“…Vitamin B (nicotinamide (NAM)), one of the most important nutritional components for humans, exerts anti-inflammatory activity. This study was aimed at investigating the effect of NAM on the gut microbiota and short-chain fatty acids (SCFAs) in mice with chronic colitis. …”
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Increasing exposure of cotton growing areas to compound drought and heat events in a warming climate by Shengli Liu, Wei Zhang, Tongtong Shi, Tong Li, Hui Li, Guanyin Zhou, Zhanbiao Wang, Xiongfeng Ma

“…Cotton (Gossypium hirsutum L.) is a critical source of natural fiber and cottonseed oil for humans, yielding substantial economic benefits globally. …”
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Prediction of Future Terrorist Activities Using Deep Neural Networks by M. Irfan Uddin, Nazir Zada, Furqan Aziz, Yousaf Saeed, Asim Zeb, Syed Atif Ali Shah, Mahmoud Ahmad Al-Khasawneh, Marwan Mahmoud

“…Terrorism not only disturbs the law and order situations in a society but also affects the quality of lives of humans and makes them suppressed physically and emotionally and deprives them of enjoying life. …”
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High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome by Tao Hong, Jiao-Yang Li, Ya-Di Wang, Xiao-Yan Qi, Zhe-Zhen Liao, Poonam Bhadel, Li Ran, Jing Yang, Bin Yan, Jiang-Hua Liu, Xin-Hua Xiao

“…This study aimed to investigate serum asprosin levels in MetS as well as their association with various metabolic parameters in humans. Methods. A total of 131 consecutive patients with MetS, and 162 age-matched, healthy subjects were recruited for this study. …”
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Potential Technosignature from Anomalously Low Deuterium/Hydrogen in Planetary Water Depleted by Nuclear Fusion Technology by David C. Catling, Joshua Krissansen-Totton, Tyler D. Robinson

“…Deuterium–deuterium (DD) fusion is viewed as an ideal energy source for humanity in the far future, given a vast seawater supply of D. …”
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Occurrence and Exposure Assessment of Zearalenone in the Zhejiang Province, China by Zijie Lu, Ronghua Zhang, Pinggu Wu, Dong Zhao, Jiang Chen, Xiaodong Pan, Jikai Wang, Hexiang Zhang, Xiaojuan Qi, Qin Weng, Shufeng Ye, Biao Zhou

“…This study aims to examine the hazards of zearalenone (ZEN) to humans and assess the risk of dietary exposure to ZEN, particularly in relation to precocious puberty in children from the Zhejiang Province. …”
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Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

“…The temporal trends in clinical trial activity after CTA enactment were examined.Results A total of 577 CTA-compliant specified clinical trials (ie, studies funded by pharmaceutical companies or studies evaluating the efficacy and safety of off-label drugs or devices in humans) were registered in the jRCT. During the same period, 5068 clinical trials were registered in the UMIN-CTR. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans. In vitro biotransformation of tolterodine by HepG2 cells overexpressing CYP3A4, CYP2D6 or CYP2C9 was investigated by LC-MS analysis of cell culture supernatant for the non-volatile metabolite, N-dealkylated tolterodine, and PTR-ToF-MS analysis of the headspace for acetone. …”
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The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study by Cheryl R.Z. See, Annabel X. Tan, Lucia R. Valmaggia, Matthew J. Kempton

“…Animal studies have shown evidence of gray matter (GM) reductions associated with stress, and previous work has found similar associations in humans. However longitudinal studies investigating the association between stress and changes in brain structure are limited. …”
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Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus by Fangyu Li, Rui Li, Hongjun Deng

“…Similarly, serum levels of RDH10 were significantly lower in MASLD and T2DM model mice and humans than in controls.ConclusionOur study suggests that RDH10 is a common diagnostic marker for MASLD and T2DM and provides new research directions for the prevention and treatment of MASLD and T2DM.…”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

“…For EGFR-positive tumor targeting, humanized antigen-binding domains of therapeutic antibody cetuximab were used. …”
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Prevalence of gastrointestinal nematode parasites of dogs and associated risk factors in Gondar town, Northwest Ethiopia by Tsedalu Yirsa, Amare Bihone, Getenew Teshager, Yimer Muktar, Abebe Berihun

“…Intestinal parasites commonly infect dogs and can potentially spread to humans globally. Regrettably, numerous dog owners do not give priority to managing their pets' health, often ignoring treatment unless the animal is already ill. …”
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Genomic changes during the evolution of the Coxiella genus along the parasitism-mutualism continuum by Santos-Garcia, Diego, Morel, Olivier, Henri, Hélène, El Filali, Adil, Buysse, Marie, Noël, Valérie, McCoy, Karen D., Gottlieb, Yuval, Klasson, Lisa, Zenner, Lionel, Duron, Olivier, Vavre, Fabrice

“…Among them, Coxiella burnetii is a well-known pathogen causing Q fever in humans. This bacterium presents both intracellular (parasitic) and environmental (resistant) forms. …”
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Clothianidin and Thiacloprid Mixture Administration Induces Degenerative Damage in the Dentate Gyrus and Alteration in Short-Term Memory in Rats by Alejandra Mora-Gutiérrez, Jorge Guevara, Carmen Rubio, Minerva Calvillo-Velasco, Daniela Silva-Adaya, Socorro Retana-Márquez, Blanca Espinosa, Carmen Martínez-Valenzuela, Moisés Rubio-Osornio

“…Chronic exposure to neonicotinoids in humans is related to autism, memory loss, and finger tremor. …”
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Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats by Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar

“…Overall, CVE may play a significant therapeutic role in the management of DOX-induced cardiotoxicity in humans.…”
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Microbiological Safety of Leafy Vegetables Produced at Houeyiho and Sèmè-Kpodji Vegetable Farms in Southern Benin: Risk Factors for Campylobacter spp. by Sylvain Daton Kougblénou, Alidéhou Jerrold Agbankpé, Justin Gbèssohélé Béhanzin, Tamègnon Victorien Dougnon, Alidah Victonie Aniambossou, Lamine Baba-Moussa, Honoré Sourou Bankolé

“…Foodborne infections, mainly those attributable to Campylobacter, are one of the most common causes of intestinal diseases, of bacterial origin in humans. Although the vehicle of transmission is not always identified, the most common vehicles are poultry, poultry products, and contaminated water. …”
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Health literacy and influencing factors in university students across diverse educational fields in Kazakhstan by Zhaniya Dauletkaliyeva, Zhanerke Bolatova, Nurbek Yerdessov, Karina Nukeshtayeva, Olzhas Zhamantayev, Aliya Takuadina, Gaukhar Kayupova

“…The highest HL score was in students of Health Sciences field (88.22 ± 17.53), whereas mean HL score in students of Engineering field of study was 83.27 ± 20.07, and it was 86.13 ± 18.11 for the Humanities and Social sciences field of study. The factors negatively associated with HL were region of origin, health information searching, lack of basic life support skills, smoking, self-assessment of health as bad, and missing study days. …”
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Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization by Brenden N Moeun, Florent Lemaire, Alexandra M Smink, Hamid Ebrahimi Orimi, Richard L Leask, Paul de Vos, Corinne A Hoesli

“…So far, the results have been less promising when transitioning to humans and larger animal models due to challenges in oxygenation and insulin delivery. …”
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The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis by Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

“…The respective mice respond similarly to lipid-lowering and antidiabetic drugs as humans. The objective of this study was to evaluate/characterize the APOE∗3-Leiden.glucokinase+/− (E3L.GK+/−) mouse as a novel disease model to study the metabolic syndrome and diabetic complications. …”
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The Strength of a Story: Partnering With a Community Organization to Destigmatize Substance Use Disorder by Noah Sorkow, Cameron Lauf, Stephen H. Berns

“…Community members expressed how the session helped humanize health care providers and had interest in participating in future sessions. …”
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