Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…This bacterial complex is reflected as an attractive target for drug development due to its presence in disease-causing microorganisms and concurrent absence in humans. The objective of this research was to identify certain promising drug candidates that could excessively stimulate the HslV protease, leading to uncontrolled protein breakdown in the pathogens. …”
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Identification of two new genetic loci for high-resolution genotyping of Enterocytozoon bieneusi by Meng Xinan, Ou Yonglin, Jiang Wen, Guo Yaqiong, Xiao Lihua, Feng Yaoyu, Li Na

“…., the public health significance of E. bieneusi in animals, and sources of E. bieneusi infections in humans.…”
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Prevalence and Subtypes Distribution (ST10, ST14, ST25, ST26) of Blastocystis spp. in Anatolian Water Buffalo (Bubalus bubalis) in Van, Türkiye by Adnan Ayan, Burcak Aslan Celik, Ozgur Yasar Celik, Ali Bilgin Yilmaz, Ozlem Orunc Kilinc, Ozge Oktay Ayan

“…ABSTRACT Background Blastocystis spp. is one of the most common protozoa worldwide, living in the gastrointestinal tract of humans and many other animals. On the basis of the genetic heterogeneity of small subunit ribosomal RNA, at least 28 subtypes (ST1‐ST17, ST21 and ST23–ST32) are reported to exist in mammals and birds. …”
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Post-treatment of rat aflatoxicosis by camel milk and silymarin by Nahla H. Hassaneen, Shabaan A. Hemeda, Abeer F. El Nahas, Ghadeer M. Albadrani, Muath Q. Al-Ghadi, Zuhair M. Mohammedsaleh, Sabreen E. Fadl, Eman M. El-Diasty, Hader I. Sakr, Hader I. Sakr

“…BackgroundAflatoxins are highly potent mycotoxins that can seriously harm the health of humans and a variety of animal species. On the other hand, camel milk and silymarin offer a variety of positive effects for many animal species. …”
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Nematode controlling effects and safety tests of Duddingtonia flagrans biological preparation in sheep by Yuan Ma, Lili Jiang, Zhaobin Fan, Luyao Hao, Zhengyi Li, Yanni Zhang, Qiannan Li, Rui Wang, Hongliang Luo

“…Although many researchers have examined the safety of this fungus for humans, animals, and the environment, few reports have discussed the safety of nematode-trapping D. flagrans biologics for animals. …”
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Comparing Campylobacter jejuni to three other enteric pathogens in OligoMM12 mice reveals pathogen-specific host and microbiota responses by Mathias K.-M. Herzog, Audrey Peters, Nizar Shayya, Monica Cazzaniga, Kardokh Kaka Bra, Trisha Arora, Manja Barthel, Ersin Gül, Luca Maurer, Patrick Kiefer, Philipp Christen, Katharina Endhardt, Julia A. Vorholt, Gad Frankel, Markus M. Heimesaat, Stefan Bereswill, Cormac G. M. Gahan, Marcus J. Claesson, Xavier Domingo-Almenara, Wolf-Dietrich Hardt

“…Additionally, our comparative approach successfully identifies pathogen-specific responses, including the detection of genes uniquely associated with C. jejuni infection in humans. These findings underscore the potential of the OligoMM12 model as a versatile tool for advancing our understanding of food-borne pathogen interactions.…”
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H. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition by Nabil M. Selim PhD, Seham S. El-Hawary PhD, Soheir M. El Zalabani PhD, Rehab Nabil Shamma PhD, Nariman El Sayed Mahdy PhD, Noheir H. Sherif PhD, Khayrya A. Youssif PhD, Usama Ramadan Abdelmohsen PhD, Mai H. Mekkawy PhD, Hanan A. Fahmy PhD

“…Objectives: Hepatocellular carcinoma (HCC) represents the third-most prevalent cancer in humans worldwide. The current study’s objective is to search for the potentiality of Washingtonia robusta H. …”
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Occurrence and Multi-Locus Genotyping of <i>Giardia duodenalis</i> in Black Goats from Fujian Province, China by Shou-Xiao Huang, Kai Hu, Peng-Fei Fu, Si-Ang Li, Yang Liu, Zhipeng Niu, Dong-Hui Zhou

“…<i>Giardia duodenalis</i> is a zoonotic parasite that causes gastrointestinal diseases in both humans and animals. To evaluate the prevalence and genetic diversity of <i>G. duodenalis</i> in black goats, we collected 539 fecal samples from nine districts in Fujian Province, China. …”
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Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy by Fangzhou He, Jiuhui Xu, Fanwei Zeng, Boyang Wang, Yi Yang, Jie Xu, Xin Sun, Tingting Ren, Xiaodong Tang

“…Methods Since novel immunotherapies may address this need, we performed an integrative analysis involving single-cell RNA sequencing, cell function experiments, and humanized models to dissect the immunoregulatory interactions in EwS and identify strategies for optimizing immunotherapeutic efficacy. …”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Understanding whether pancreatic GIPR desensitisation affects the long-term benefits of GIPR agonists in humans is vital to design effective metabolic pharmacotherapies.…”
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Study on Seroprevalence and Leptospiral Antibody Distribution Among Livestock Breeders and Farmers in Golestan Province by Malihe Naderi, Vahideh Hamidi Sofiani, Reza Hoseinpour, Amir Mohammad Alborzi, Seyed Amir Soltani

“…ABSTRACT Background The high prevalence of leptospirosis in humans is of great public health concern, particularly in tropical and subtropical regions. …”
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The mirror preference test: A reverse translational approach to study anomalous subjective experience in rats by Daria Chestnykh, Liubov S. Kalinichenko, Stephan von Hörsten, Johannes Kornhuber, Christian P. Müller

“…Symptoms related to the misinterpretation of reality are crucial for diagnosis but pose challenges for preclinical research. In humans, a Mirror-Gazing test is used to examine abnormal self-experience and to predict the risk of schizophrenia. …”
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Evaluation of a compressed air foam system to clean quail rearing facilities by Jill Wright Skrobarczyk, David James Caldwell, Kenneth Scott McKenzie, Ashley Charles Blankenburg, James Allen Byrd, Morgan Brian Farnell

“…This is especially important in cases of salmonellosis where there is a risk of disease transmission to humans. Compressed air foam systems (CAFS) may serve as an alternative carrier for foaming agents to clean and sanitize agricultural surfaces following an outbreak. …”
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Equipping our public health nutrition workforce to promote planetary health: a case example of tertiary education co-designed with students by Ka Po Chau, Wing Chong, Raquel Londono, Beau Cubillo, Julia McCartan, Liza Barbour

“…Students’ descriptions of what planetary health means to them were focused on humans’ role in protecting and preserving the ecosystem, the responsible and sustainable use of natural resources and a need to sustain a healthy life for future generations. …”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. …”
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Filterable PM2.5, Metallic Elements, and Organic Carbon Emissions from the Exhausts of Diesel Vehicles by Yuan-Chung Lin, Ya-Ching Li, Kassian T. T. Amesho, Feng-Chih Chou, Pei-Cheng Cheng

“…Abstract Urban air pollution in the form of fine particulate matter (PM2.5) poses a substantial health threat to humans via inhalation. To assess the risks from this pollutant, we characterized and quantified the PM2.5 exhausted by 15 diesel vehicles ranging from 28,306 to 883,374 km (an average of 525,854 km) in total mileage and varying in manufacturer and model year (1988–2005). …”
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Identifying Zoonotic Parasites in Domiciled and Non‐Domiciled Dogs (Canis lupus familiaris) Within an Urban Zone of the Eastern State of Mexico by José Salcedo‐Jiménez, Yazmín Alcala‐Canto, Julio Segura‐Tinoco, Ernestina Valadez‐Moctezuma, Juan José Pérez‐Rivero

“…Interactions among non‐domiciled dogs, domiciled dogs and humans heighten the risk of transmission. Implementing prevention, control and awareness strategies is crucial to reduce the spread of these parasites.…”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…Typhimurium, ST) is a food-borne pathogen that can be transmitted from animals to humans and causes symptoms such as diarrhea, fever, and vomiting. …”
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Emotional and physical experiences of people with neovascular age-related macular degeneration during the injection process in Germany: a qualitative study by Oliver Zeitz, Martina Breuning, Christine Holmberg, Christian Wolfram, Anne Thier

“…Furthermore, they narrated negative injection experiences in association with their interactions with medical staff and doctors.Conclusion Although time in the medical setting is limited, efficient and good doctor-patient relationships seem crucial for satisfying care experiences. A respectful and humane relationship may be one key to achieving treatment adherence.…”
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Transfer of Organochlorine Pesticide Residues during Household and Industrial Processing of Ginseng by Peiling Wu, Mengying Gu, Yujie Wang, Jian Xue, Xiaoli Wu

“…Different ginseng processing methods resulted in variable transfer rates of pesticides, as well as a diverse exposure risk of pesticides to humans. Consequently, it is necessary to concern about the transfer rates of pesticide residues during ginseng processing.…”
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