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Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation
Published 2025-01-01“…Here, we found that Apaf-1-like molecules from lancelets, fruit flies, mice, and humans have conserved DNA sensing functionality. Mechanistically, mammalian Apaf-1 recruits receptor-interacting protein 2 (RIP2, also known as RIPK2) via its WD40 repeat domain and promotes RIP2 oligomerization to initiate NF-κB-driven inflammation upon cytoplasmic DNA recognition. …”
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24222
Alleviation of Brain Injury-Induced Cerebral Metabolic Depression by Amphetamine: A Cytochrome Oxidase Histochemistry Study
Published 2000-01-01“…The ability of D-amphetamine to alleviate depressed cerebral oxidative metabolism following cortical injury may be one mechanism by which drugs increasing noradrenaline release accelerate functional recovery in both animals and humans.…”
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24223
Neurophysiology of Drosophila Models of Parkinson’s Disease
Published 2015-01-01“…Given the neurological impact of disease causing mutations within these same genes in humans the phenotypes observed in fly are of significant interest. …”
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24224
Heavy metals impact environmental capacity of oasis soils in Qinghai-Tibet Plateau dry zone
Published 2025-01-01“…However, the overexploitation of resources by humans for production and living has affected the quality of soils in the Qinghai-Tibet region, whereby the environmental capacity is decreasing. …”
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24225
Toxoplasma gondii in Slaughtered Sheep in High- and Low-Humidity Regions in the South of Iran: Molecular Prevalence and Genotype Identification
Published 2021-01-01“…Toxoplasma gondii is one of the most common meat-born zoonoses that infect all warm-blooded animals and humans. Sheep (Ovis aries) is one of the main reservoirs of T. gondii worldwide, and the infections induce various sequels, such as abortion and stillbirth. …”
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24226
Pathology Survey on a Captive-Bred Colony of the Mexican Goodeid, Nearly Extinct in the Wild, Zoogoneticus tequila (Webb & Miller 1998)
Published 2013-01-01“…Encountered diseases included the following: 7 cases of scoliosis (2 males and 5 females); 2 fish with a similar congenital deviation of ocular axis; 1 adult male with left corneal opacity, presumably of traumatic origin; 1 female fish with a large subocular fluid-filled sac, histologically referable to a lymphatic cyst, similarly to the eye sacs of a Goldfish variety (Carassius auratus) called bubble eye; and 1 female fish with recurrent abdominal distension consequent to distal bowel dilation and thinning, associated with complete mucosal atrophy, and comparable to intestinal pseudo-obstruction syndromes described in humans and various animal species. The absence of infectious or parasitic diseases, as well as the low incidence of diseases potentially related to environmental alterations or nutritional disorders such as spinal deformities, suggests the adequacy of breeding management techniques of Z. tequila for its conservation and reintroduction in to the original habitat in the near future.…”
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24227
Acrylamide Induces Antiapoptotic Autophagy and Apoptosis by Activating PERK Pathway in SH-SY5Y Cells
Published 2025-01-01“…Acrylamide (ACR) is a commonly used organic compound that exhibits evident neurotoxicity in humans. Our previous studies showed that the mechanisms of ACR-caused neurotoxicity included apoptosis, PERK-mediated endoplasmic reticulum stress, and autophagy, but the relationships among them were still unclear. …”
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24228
Asymptomatic cholecystitis and its controversial issues in biliary surgery
Published 2025-02-01“…That is why most cases of postcholecystectomy syndrome occur in patients operated on for asymptomatic cholecystitis.The unwillingness to discover the secret of stone formation and asymptomatic cholecystitis in humans when concretions in the gallbladder are detected without reference to surgery, to indicate the trajectory of the examination, leads to a number of tactical errors, preserving the risk of PES, and erasing practical recommendations for the management of such patients. …”
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24229
CroALa
Published 2012-02-01“…The documentation of these solutions serves a twofold pedagogical purpose: first, to help newcomers find their way around the immense potential enabled by the TEI encoding scheme and, second, to encourage other humanities scholars to become makers—or, at least, adapters—of TEI-based digital tools. …”
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24230
Energy Expenditure in Infants in Health and Disease
Published 1997-01-01“…Measurement of energy balance represents a basic theoretical concept in the determination of nutritional and fluid requirements in humans in health and disease. Infants have special nutrient requirements, more limited reserves and relative immaturity of organ function. …”
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Recognition of features of the entrance of Pahlavi period buildings in Zahedan City
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Structure of symbolic capital in the modern communication environment: digital network progression
Published 2023-06-01Get full text
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24234
Extraction of Spatial Distribution Characteristics of Jiangnan Urban Landscape under the Influence of Geomorphology
Published 2021-01-01“…From the perspective of spatial variability, the main features of traditional landscape construction in Jiangnan are analyzed through three levels: the characteristics of the process of humanized landscapes evolving into natural landscapes, the comparative analysis of similarities and differences in the construction of cities and towns, and the characteristics of the system of regional landscape construction. …”
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24238
POSTGRADUATE PROGRAMS AND DOCTORAL STUDIES IN MODERN CONDITIONS AND A DESTINY OF SKILLS RAISING SYSTEM: ROUND TABLE DISCUSSION
Published 2016-12-01“…., Sholokhov Moscow State University for the Humanities), Kondrat’ev V.V. (Prof.,Kazan National Research Technological University), Senashenko V.S. …”
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24239
Analyzing dead core formation in catalyst pellets of various geometries under non-isothermal conditions
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