Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers by Sofia V Krasik, Ekaterina A Bryushkova, George V Sharonov, Daria S Myalik, Elizaveta V Shurganova, Dmitry V Komarov, Irina A Shagina, Polina S Shpudeiko, Maria A Turchaninova, Maria T Vakhitova, Igor V Samoylenko, Dimitr T Marinov, Lev V Demidov, Vladimir E Zagaynov, Dmitriy M Chudakov, Ekaterina O Serebrovskaya

“…To explore the manifestation of this influence, we used deep unbiased immunoglobulin profiling and systematically characterized the relationships between B cells in circulation, draining lymph nodes (draining LNs), and tumors in 14 patients with three human cancers. We demonstrated that draining LNs are differentially involved in the interaction with the tumor site, and that significant heterogeneity exists even between different parts of a single lymph node (LN). …”
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Dietary sodium-to-potassium ratio as a risk factor for stroke, cardiovascular disease and all-cause mortality in Japan: the NIPPON DATA80 cohort study by Hirofumi Ohnishi, Yoshitaka Murakami, Katsuyuki Miura, Koji Tamakoshi, Hirotsugu Ueshima, Akira Okayama, Tomonori Okamura, Takayoshi Ohkubo, Toshiyuki Ojima, Yoshihiro Miyamoto, Maryam Zaid, Aya Kadota, Akira Fujiyoshi, Yosikazu Nakamura, Naoyuki Takashima, Atsushi Hozawa, Shigeyuki Saitoh, Yutaka Kiyohara, Fumiyoshi Kasagi, Nagako Okuda, Takehito Hayakawa, Hiroshi Akasaka, Yusuke Arai, Katsushi Yoshita, Kiyomi Sakata, Nobuo Nishi, Toru Izumi, Yasuhiro Matsumura, Hideaki Nakagawa, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Kazunori Kodama

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Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

“…The anticoagulation assay showed that the four P2′ single-point mutants still had apparent inhibitory anticoagulation activity that selectively inhibited the human intrinsic coagulation pathway and had no influence on the extrinsic coagulation pathway or common coagulation pathway, which indicated that the single-point mutants had minimal effects on the anticoagulation activity of BF9-N17K. …”
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Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma by Dirk Hose, Seemun Ray, Sina Rößler, Ulrich Thormann, Reinhard Schnettler, Kim de Veirman, Thaqif El Khassawna, Christian Heiss, Anne Hild, Daniel Zahner, Francisca Alagboso, Anja Henss, Susanne Beck, Martina Emde-Rajaratnam, Jürgen Burhenne, Juliane Bamberger, Eline Menu, Elke de Bruyne, Michael Gelinsky, Marian Kampschulte, Marcus Rohnke, Sabine Wenisch, Karin Vanderkerken, Thomas Hanke, Anja Seckinger, Volker Alt

“…The material’s anti-myeloma activity was assessed using ten human myeloma cell lines (HMCLs) and eight primary myeloma cell samples including four patients refractory to systemic bortezomib treatment. …”
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Stability Analysis of Dry Yield of Z. multiflora Boiss. under Drought Stress and Mycorrhizal Fungi Symbiosis by Ashraf Aghababapoor Dehkordi, Sadollah Houshmand, Shahram Mohammady

“…Extended Abstract Background: In recent years, the use of medicinal plants has increased due to the side effects, lower cost, patient compatibility to these drugs, and the harmful effects of chemical drugs on human health. Zataria multiflora Boiss. is an important medicinal plant species in the Lamiaceae family, native to Iran, Pakistan, and Afghanistan. …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…However, the use of fungicides results in increased costs and harm to the environment and human health. Therefore, the utilization of biocompatible chemical compounds is regarded as an innovative and effective strategy for integrated product management and combating various stressors. …”
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Performance evaluation of four cascade impactors for airborne ultrafine-particle (UFP) collection: the influence of particle type, concentration, mass, and chemical nature by E. Eckenberger, A. Mittereder, N. Gawlitta, N. Gawlitta, J. Schnelle-Kreis, J. Schnelle-Kreis, M. Sklorz, D. Brüggemann, R. Zimmermann, R. Zimmermann, A. C. Nölscher

“…As UFPs potentially impact human and environmental health, their chemical composition is of interest. …”
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Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction by Tanya M. Spruill, PhD, Chorong Park, PhD, RN, Jolaade Kalinowski, EdD, Milla E. Arabadjian, PhD, RN, Yuhe Xia, MSc, Amanda J. Shallcross, ND, MPH, Pallavi Visvanathan, PhD, Nathaniel R. Smilowitz, MD, MS, Anaïs Hausvater, MD, Sripal Bangalore, MD, MHA, Hua Zhong, PhD, Ki Park, MD, Puja K. Mehta, MD, Dwithiya K. Thomas, MD, Jeffrey Trost, MD, Kevin R. Bainey, MD, Bobak Heydari, MD, Janet Wei, MD, Victoria Vaughan Dickson, PhD, RN, Gbenga Ogedegbe, MD, MPH, Jeffrey S. Berger, MD, MS, Judith S. Hochman, MD, Harmony R. Reynolds, MD

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Enterococcus and Eggerthella species are enriched in the gut microbiomes of COVID-19 cases in Uganda by Carolina Agudelo, David Patrick Kateete, Emmanuel Nasinghe, Rogers Kamulegeya, Christopher Lubega, Monica Mbabazi, Noah Baker, Kathryn Y. Lin, Chang C. Liu, Arthur Shem Kasambula, Edgar Kigozi, Kevin Komakech, John Mukisa, Kassim Mulumba, Patricia Mwachan, Brenda Sharon Nakalanda, Gloria Patricia Nalubega, Julius Nsubuga, Diana Sitenda, Henry Ssenfuka, Giana T. Cirolia, Jeshua T. Gustafson, Ruohong Wang, Moses Luutu Nsubuga, Fahim Yiga, Sarah A. Stanley, Bernard Ssentalo Bagaya, Alison Elliott, Moses Joloba, Ashley R. Wolf

“…Abstract Background Infection with the COVID-19-causing pathogen SARS-CoV-2 is associated with disruption in the human gut microbiome. The gut microbiome enables protection against diverse pathogens and exhibits dysbiosis during infectious and autoimmune disease. …”
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Effects of 24 Weeks of Growth Hormone Treatment on Bone Microstructure and Volumetric Bone Density in Patients with Childhood-Onset Adult GH Deficiency by Hongbo Yang, Kemin Yan, Yuping Xu, Linjie Wang, Qi Zhang, Fengying Gong, Huijuan Zhu, Weibo Xia, Hui Pan

“…Effects of recombinant human growth hormone (rhGH) on bone microarchitecture in CO AGHD were insufficiently evaluated. …”
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Longitudinal analysis of lifestyle risk factors, nutrition status and drivers of food choice among urban migrants in Ulaanbaatar, Mongolia, and Almaty, Kazakhstan: a formative stud... by Sabri Bromage, Shamil Tazhibayev, Xin Zhou, Chang Liu, Enkhtsetseg Tserenkhuu, Oksana Dolmatova, Munkhbat Khishignemekh, Leyla Musurepova, Wusigale, Soninkhishig Tsolmon, Enkhjargal Tsendjav, Davaasambuu Enkhmaa, Rajesh Kumar Rai, Bayarmaa Enkhbat, Bilige Menghe, Davaasambuu Ganmaa

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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…Combined with other inertias integral to the climate system, the bulk of the expected harm to humans from climate change will be felt by future generations…”
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A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti by Bacot, Tiphaine, Haberkorn, Chloe, Guilliet, Joseph, Cattel, Julien, Kefi, Mary, Nadalin, Louis, Filee, Jonathan, Boyer, Frederic, Gaude, Thierry, Laporte, Frederic, Tutagata, Jordan, Vontas, John, Dusfour, Isabelle, Bonneville, Jean-Marc, David, Jean-Philippe

“…Resistance of mosquitoes to insecticides is one example of rapid adaptation to anthropogenic selection pressures having a strong impact on human health and activities. Target-site modification and increased insecticide detoxification are the two main mechanisms underlying insecticide resistance in mosquitoes. …”
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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

“…Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. …”
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Molecular assessment of splicing variants in a cohort of patients with inborn errors of immunity: methodological approach and interpretation remarks by Laura Miguel Berenguel, Carla Gianelli, Carla Gianelli, Carla Gianelli, Elisabet Matas Pérez, Teresa del Rosal, Ana Méndez Echevarría, Ángel Robles Marhuenda, Marta Feito Rodríguez, Maria Teresa Caballero Molina, Maria Teresa Caballero Molina, Lorena Magallares García, Brenda Sánchez Garrido, Samantha Hita Díaz, Luis Allende Martínez, Luis Allende Martínez, Pilar Nozal Aranda, Pilar Nozal Aranda, Pilar Nozal Aranda, Carmen Cámara Hijón, Carmen Cámara Hijón, Carmen Cámara Hijón, Eduardo López Granados, Eduardo López Granados, Eduardo López Granados, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, María Bravo García-Morato, María Bravo García-Morato, María Bravo García-Morato

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Genomic insights into the specialisation and selection of the Jinding duck by H. Chen, Y. Huang, J. Xue, K. luo, H. Tang, S. Zheng, Y. Xiong, Y. Wu, J. Li, R. Xuan, R. Xiong, Y. Gong, X. Fang, L. Wang, J. Miao, J. Zhou, H. Tan, Y. Wang, L. Wu, J. Ouyang, Y. Shen, X. Yan

“…The domestication of ducks represents a pivotal evolutionary shift from the unguided propagation of wild species to deliberate human-mediated selection, culminating in distinct behavioural, morphological, and physiological traits that differentiate domesticated ducks from their wild counterparts. …”
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Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6Research in context by James D. Sargent, Kristin Lauten, Kathryn C. Edwards, Susanne E. Tanski, Todd A. MacKenzie, Laura M. Paulin, Mary F. Brunette, Maciej L. Goniewicz, Amanda Malasky, Debra Stark, Fernando B. de Moura, Holly Griffin, Kimberly H. Nguyen, Eric Backlund, Heather L. Kimmel, John H. Kingsbury, Jenny E. Ozga, K Michael Cummings, Andrew Hyland

“…Funding: This manuscript is supported with Federal funds from the National Institute on Drug Abuse (NIDA) at the National Institutes of Health (NIH), and the Center for Tobacco Products (CTP) at the Food and Drug Administration (FDA), Department of Health and Human Services, under contract to Westat (contract nos. …”
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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecie... by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

“…The Sponsor was involved in protocol development, trial conduct, including data monitoring and analysis, and the preparation of this manuscript in line with the Medicines for Human Use (Clinical Trials) Regulations 2004 and amendments.…”
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Analysis on Flavor Quality of Brassica rapa L. from Different Varieties by MAERHABA·Paerhati, Zhanteng SONG, Ruina YANG, Jing LI, Jing AN, Min LIU, Zhenzhen XU, Jingrong ZHU

“…Results showed that the amino acids in 4 different varieties of Brassica rapa L. were all of various kinds, all containing 17 amino acids measured, including 7 essential amino acids for human body. The umami amino acids of SFB accounted for a relatively high proportion, and the sweet amino acids of KPZ accounted for a relatively high proportion. …”
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Phasic and periodic change of drought under greenhouse effect by Yang Li, Zhicheng Zheng, Yaochen Qin, Haifeng Tian, Zhixiang Xie, Peijun Rong

“…It can lead to crop reduction and even pose a threat to human survival in environmentally sensitive areas of China (ESAC). …”
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