Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated by Michele Ammendola, Rosario Sacco, Giuseppe Sammarco, Giuseppe Donato, Valeria Zuccalà, Roberto Romano, Maria Luposella, Rosa Patruno, Carlo Vallicelli, Giorgio Maria Verdecchia, Davide Cavaliere, Severino Montemurro, Girolamo Ranieri

“…Angiogenesis is a complex process involved in both growth and progression of several human and animal tumours. Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis. …”
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Exploring the decline in health index of the Qarhan salt lake region in Qinghai Province, China: A 40-year assessment by Pengfei Ji, Qian Shen, Ru Wang, Yue Yao, Bing Zhang, Wenting Xu, Yuting Zhang, Wenqi Kou, Wenxin Li

“…In this study, we develop a Salt Lake Health Index (SLHI), suitable for assessing salt lake regions affected by human activities, using the Analytic Hierarchy Process and remote sensing technology. …”
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MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production by Xinrui Yang, Jing Liu, Yaru Yin, Luxun Yang, Mingquan Gao, Zifei Wu, Binghui Lu, Shenglin Luo, Weidong Wang, Rong Li

“…In this study, we investigate the therapeutic potential of human umbilical cord-derived mesenchymal stem cell exosomes (MSC-EXs) in mice exposed to DU. …”
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Machine vision-based detection of key traits in shiitake mushroom caps by Jiuxiao Zhao, Jiuxiao Zhao, Wengang Zheng, Wengang Zheng, Yibo Wei, Yibo Wei, Qian Zhao, Qian Zhao, Jing Dong, Jing Dong, Xin Zhang, Xin Zhang, Mingfei Wang, Mingfei Wang

“…In practical applications, this method improves the breeding process by rapidly and non-invasively assessing key traits such as the size and color of shiitake mushroom caps, which helps in efficiently screening strains and reducing human errors. Firstly, an edge detection model was established. …”
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Longitudinal genetic studies of cognitive characteristics by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova

“…The content, quantity and arrangement of transposable elements in human genome, which do not affect changes in nucleotide sequences of protein encoding genes, but affect their expression, can be transmitted to the next generation.…”
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Prognostic significance of p27 in colorectal cancer: a meta-analysis and bioinformatics analysis by Jing Zou, Dong Wang, Gaoping Yin, Kexiang Lu, Kaibin Chang, He Li

“…In addition, we used Gene Expression Profiling Interactive Analysis (GEPIA), University of Alabama at Birmingham’s Cancer Data Analysis Portal (UALCAN), and the Human Protein Atlas (HPA) to validate our results.ResultsThrough an extensive examination of four prominent databases, a total of 21 original articles encompassing a cohort of 3,378 patients were identified. …”
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Fabrication of tin nanoparticles with functionalized platinum nanodendrites on ITO electrode for simultaneous detection of Cd2+, Pb2+, and Cu2+ ions by Nurul Hidayah Ramli, Noorhashimah Mohamad Nor, Zainovia Lockman, Khairunisak Abdul Razak

“…The industrial discharge of heavy metals led to the accumulation in food chains, causing significant risks to human health and the environment. The detection of heavy metals is crucial for monitoring heavy metal contamination. …”
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Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…The SAE1 overexpression was significantly associated with the tumor size, tumor-node-metastasis stage, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and whether or not it was a triple-negative BC. …”
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MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

“…Methods We first collected dura matter (DM) samples from CICD patients and examined the expression of cuproptosis-related genes (DLAT, FDX1, and SDHB) to confirm the inhibitory effect of CPO on angiogenesis. Then, we treated human umbilical vein endothelial cells (HUVECs) with different concentrations of elesclomol and CuCl2 to determine the optimal concentration for inducing CPO. …”
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Water, Sanitation and Hygiene in a Conflict Area: A Cross-Sectional Study in South Kordofan, Sudan by Rofida Asmally, Abdelmalik A. Imam, Abdullatif Eissa, Abubakr Saeed, Ahmed Mohamed, Eahaa Abdalla, Mariam Alazraa M. Esmaeel, Mariam Elbashir, Mohamed H. Elbadawi, Mohammed Omer, Raghad Eltayeb, Ranya Mohammed, Tibyan Abdalhamed, Tina Merghani

“…Abstract Background The UN General Assembly recognised the human right to water and sanitation through the sixth SDG in 2010. …”
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Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats by Hui-Hua Liu, Xiao-Kuo He, Hsin-Yung Chen, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Hao-Li Liu, Yung-Hsiao Chiang, Jia-Yi Wang, Xiao-Jun Feng, Ying-Zu Huang, Tsung-Hsun Hsieh

“…In the results, analogous to those observed in humans, the present study demonstrates long-term potentiation- (LTP-) and long-term depression- (LTD-) like plasticity can be induced by tDCS protocol in anesthetized rats. …”
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Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

“…Exosomes (Exo53, Exo301, or Exo702) were isolated from conditioned media of human or murine pancreatic cancer cell lines (Panc-1, MiaPaCa-2, and PAN02) after treatment with Ad-p53, OBP-301, or OBP-702. …”
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Extraction of collagen from by-products of Amazonian fish tambaqui, Colossoma macropomum and pirarucu Arapaima gigas by Alexandre Augusto Barai, Antônio José Inhamuns, Tiago Cabral Nóbrega, Cristiane Cunha Guimarães, Lígia dos Santos Mourão, Antonio Fabio Lopes de Souza, Fagnaldo Braga Pontes, Flávia Dayane Félix Farias, Joana Maia Mendes, João Paulo Ferreira Rufino, Adriano Teixeira de Oliveira

“…Several high-value commercial products, such as collagen, have been developed from by-products of the fish processing industry due to their wide range of applications and importance for human health. This study aimed to extract, determine the yield, and characterize the collagen obtained from the scales of Colossoma macropomum and Arapaima gigas. …”
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Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients by He Huang, Shilei Xu, Aidong Chen, Fen Li, Jiezhong Wu, Xusheng Tu, Kunpeng Hu

“…Functions of prognostic genes were predicted based on the interaction proteins and the correlation with tumor-infiltrating immune cells. The Human Protein Atlas (HPA) tool was utilized to validate the protein expression levels. …”
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A first study on sperm sexing in water buffalo through magnetic nanoparticles by Syed Murtaza Hassan Andrabi, Muhammad Hammad Fayyaz, Muhammad Shafiq Haider, Ghulam Muhammad Ali

“…Each aliquot of 50 million sperm was diluted in 1 mL of modified human tubal fluid (mHTF). Three ali-quots (sexed groups) were incubated with 0.67 ml of negatively charged MNPs suspension. …”
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Exploring the neural mechanisms underlying cooperation and competition behavior: Insights from stereo-electroencephalography hyperscanning by Xiaojun Qiao, Rui Li, Huimin Huang, Yang Hong, Xiaoran Li, Ziyue Li, Siyi Chen, Lizhi Yang, ShengTeng Ong, Yi Yao, Fengpeng Wang, Xiaobin Zhang, Kao-Min Lin, Yongna Xiao, Mingxiang Weng, Junsong Zhang

“…Summary: Cooperation and competition are essential social behaviors in human society. This study utilized hyperscanning and stereo-electroencephalography (SEEG) to investigate intra- and inter-brain neural dynamics underlying these behaviors within the insula and inferior frontal gyrus (IFG), regions critical for executive function and mentalizing. …”
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Impact of post-breeding administration of hCG and flunixin meglumine on luteal function and pregnancy rates in anestrous Nili-Ravi buffaloes by Ejaz Ahmad, Muhammad Muzammal Niaz, Muhammad Saleem Akhtar, Muhammad Rizwan Yousuf, Muhammad Zahid Tahir, Tanveer Ahmad

“… This study was conducted to determine the impact of post-breeding administration of human chorionic gonadotropin hormone (hCG) and flunixin meglumine on luteal function and pregnancy rates in postpartum anoestrous Nili-Ravi buffaloes synchronized through a CIDR-GnRH based protocol during low breeding season. …”
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Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia by Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang, Nam-Kyung Lee

“…We identified a Tie2-agonistic antibody T11 that cross-reacted with the extracellular domain of human and mouse Tie2, and evaluated its ability to increase endothelial cell survival and tube formation. …”
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Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine by Monika Wojtyłko, Ariadna B. Nowicka, Anna Froelich, Mirosław Szybowicz, Tobiasz Banaszek, Dorota Tomczak, Wiesław Kuczko, Radosław Wichniarek, Irena Budnik, Barbara Jadach, Oliwia Kordyl, Antoni Białek, Julia Krysztofiak, Tomasz Osmałek, Dimitrios A. Lamprou

“…The optimized formulations were subjected to spectroscopic and rheological characterization and mechanical tests, as well as tested for release through an artificial membrane and permeation through human skin ex vivo. Both hydrogels were found to have suitable parameters for coating microneedles using the dip-coating method, including the stability of the substance at the process temperature, shear-thinning behavior, and appropriate textural parameters such as adhesion or hardness. …”
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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…Introduction A quarter of breast cancers show human epidermal growth factor-2 (HER2) overexpression, where targeted therapy dramatically improves survival. …”
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