Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

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Cooperation Between <i>Rhodococcus qinshengii</i> and <i>Rhodococcus erythropolis</i> for Carbendazim Degradation by Roosivelt Solano-Rodríguez, Fortunata Santoyo-Tepole, Mario Figueroa, Voleta Larios-Serrato, Nora Ruiz-Ordaz, Abigail Pérez-Valdespino, Everardo Curiel-Quesada

“…Excessive use of this xenobiotic causes environmental deterioration and affects human health. Microbial metabolism is one of the most efficient ways of carbendazim elimination. …”
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Odor-active aroma compounds in traditional fermented dairy products: The case of mabisi in supporting food and nutrition security in Zambia by Thelma W. Sikombe, Anita R. Linnemann, Himoonga B. Moonga, Stefanie Quilitz, Sijmen E. Schoustra, Eddy J. Smid, Anna Alekseeva

“…A unique combination of specific compounds detectable by human olfactory senses creates the distinct odor profile of fermented products. …”
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Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux by Mélanie R. Tardif, Julie Andrea Chapeton-Montes, Alma Posvandzic, Nathalie Pagé, Caroline Gilbert, Philippe A. Tessier

“…Chemotactic agents, cytokines, and particulate molecules were used to stimulate human neutrophils. MSU crystals, PMA, and H2O2 induced the release of S100A8, S100A9, and S100A12 homodimers, as well as S100A8/A9 heterodimer. …”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…In vitro experiments, human aortic smooth muscle cells were extracted, and an in vitro dissection model was constructed with angiotensin II. siRNA silencing studies were performed to investigate the effects of MR-1 and ROCK1 on the development of AD and their interconnections.Results: Analysis of aortic tissues revealed significantly elevated levels of MR-1 and ROCK1 in AD patients, and meanwhile the inflammatory indexes showed the same trend. …”
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Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants by Nikos Stratakis, Augusto Anguita-Ruiz, Lorenzo Fabbri, Léa Maitre, Juan R. González, Sandra Andrusaityte, Xavier Basagaña, Eva Borràs, Hector C. Keun, Lida Chatzi, David V. Conti, Jesse Goodrich, Regina Grazuleviciene, Line Småstuen Haug, Barbara Heude, Wen Lun Yuan, Rosemary McEachan, Mark Nieuwenhuijsen, Eduard Sabidó, Rémy Slama, Cathrine Thomsen, Jose Urquiza, Theano Roumeliotaki, Marina Vafeiadi, John Wright, Mariona Bustamante, Martine Vrijheid

“…Leveraging extensive multi-omics profiling (methylome, miRNome, transcriptome, proteins and metabolites) and a rich phenotypic characterization across two parts of Europe within the population-based Human Early Life Exposome project, we unravel the molecular landscape of childhood obesity and associated metabolic dysfunction. …”
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Power Transmission for Millimeter-Wave Indoor/Outdoor Wearable IoT Devices Using Grounded Coplanar Waveguide-Fed On-Body Antenna by Fuad Erman, Slawomir Koziel, Alhareth Zyoud, Leifur Leifsson, Ubaid Ullah, Shaker Alkaraki

“…A prototype of the proposed antenna is fabricated and validated experimentally for both cases on a human volunteer arm/chest and in the free space. …”
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Genetic characteristics of influenza A and B viruses circulating in Russia in 2019–2023 by Svetlana B. Yatsyshina, Anna A. Artamonova, Maria A. Elkina, Anna V. Valdokhina, Victoria P. Bulanenko, Aleksandra A. Berseneva, Vasily G. Akimkin

“…All influenza A(H1N1)pdm09 viruses in the 2022–2023 season had a previously unknown mutation E224A in HA, which increases its affinity for α-2,3 sialic acids — receptors localized in the human lungs, to which the virus binds via HA. 2 and 3% of influenza A(H1N1)pdm09 viruses in 2019–2020 and 2022–2023, respectively, had the D222N mutation in the receptor-binding site of HA, which is associated with more severe disease. …”
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The Mechanisms of Guaranteeing the Right to Clean Air in Iran and International Documents by Fatemeh Hamidi, Maryam Afshari, Ali Mashhadi

“…The municipal law approved in 1955 has also not been able to play a significant role in the realization of the guarantee of the human right to clean air due to the lack of executive guarantees and up-to-dateness. …”
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Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells by Caitlin M. Tressler, Kanchan Sonkar, Menglin Cheng, Vinay Ayyappan, Ruoqing Cai, Kristine Glunde

“…We sought to further investigate these clinical observations at the molecular level by combining metabolic and transcriptomic studies in two human TNBC cell lines treated with six different chemotherapeutic agents. …”
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Defining Nocturnal Polyuria in Adolescents by Tasmia Promi, Anthony Brooks, Gulzhan Tologonova, Marie-Claire Roberts, Sarita Dhuper, Meseret Tena, Oluwatoyin Bamgbola, Monique Hanono, Jeffrey P. Weiss, Karel Everaert, Tine DeBacker, Thomas F. Monaghan, Louis Salciccioli, Stephen Wadowski, Elka Jacobson-Dickman, Jason M. Lazar

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KATALIKYBĖ IR VISUOMENĖ TARPUKARIO LIETUVOJE by Valdas Pruskus

“…Protesting against too active wardship of an individual and a distrust in his (her) ability to make an independent choice and conscious self-determination, which dominated in the practice of the Churc of that times, the modernists defended the necessity to revitalize the authentic faith, deeply hidden in a human, to strengthen his (her) religious aspirations and in such way to cherish a spirituality, because no conscious and morally responsible activities are not able without it. …”
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Caffeinated chewing gum enhances maximal strength and muscular endurance during bench press and back squat exercises in resistance-trained men by Li Ding, Jue Liu, Yi Yao, Li Guo, Bin Chen, Yinhang Cao, Olivier Girard

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Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression by Fang T, Hu L, Chen T, Li F, Yang L, Liang B, Wang W, Zeng F

“…We aimed to explore the roles of LDHA and LDH5 isoenzyme activity in BC, which provides a new insight into LDHA for the treatment of BC.Methods: The expression of LDHA in BC and its relationship with clinicopathological features were obtained from various databases including The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), Breast Cancer-Gene Expression Miner (bc-GenExMiner), TNMplot, UALCAN. …”
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Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer by Sara M Tolaney, Tianyu Li, Edward T Richardson, Judith Agudo, Elizabeth A Mittendorf, Beth Overmoyer, Eric P Winer, Adrienne G Waks, Tanya E Keenan, Nabihah Tayob, Gerburg M Wulf, Victoria Attaya, Leilani Anderson, Ian E Krop, Eliezer M Van Allen

“…The safety and tolerability of trastuzumab emtansine (T-DM1) combined with pembrolizumab is unknown.Methods This was a single-arm phase Ib trial (registration date January 26, 2017) of T-DM1 plus pembrolizumab in metastatic, human epidermal growth factor receptor 2 (HER2)-positive breast cancer. …”
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…Currently approved human epidermal growth factor receptor 2 (HER2)-targeted antibody therapies are largely derived from trastuzumab, including trastuzumab-chemotherapy combinations, fixed-dose trastuzumab-pertuzumab combinations, and trastuzumab antibody-drug conjugates. …”
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Using Health Utility Index (HUI) for Measuring the Impact on Health-Related Quality of Life (HRQL) Among Individuals with Chronic Diseases by Frank Mo, Bernard C.K. Choi, Felix C.K. Li, Joav Merrick

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Mechanism of the blood-brain barrier modulation by cadherin peptides by Elinaz Farokhi, Ahmed L. Alaofi, Vivitri D. Prasasty, Filia Stephanie, Marlyn D. Laksitorini, Krzysztof Kuczera, Teruna J. Siahaan

“…Aim: This study was aimed at finding the binding site on the human E-cadherin for Ala-Asp-Thr Cyclic 5 (ADTC5), ADTC7, and ADTC9 peptides as blood-brain barrier modulator (BBBM) for determining their mechanism of action in modulating the blood-brain barrier (BBB). …”
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East Asian Welfare Regimes 東アジア福祉制度 by Joseph Wong, Andrew DeWit, Ito Peng

“…At the same time, a focus on spurring economic development saw social policy subordinated to a larger productivist emphasis on fostering human capital while protecting the prerogatives of capital over labor.The authors draw insights from these lines of analysis, but view the region itself as a place of diversity. …”
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In vitro modeling of feline gut fermentation: a comprehensive analysis of fecal microbiota and metabolic activity by Qianle Ren, Qianle Ren, Yuling Li, Mingmei Duan, Jinjun Li, Fangshu Shi, Yun Zhou, Wanjing Hu, Junfu Mao, Xiaoqiong Li

“…The in vitro fermentation model of the fecal GM serves as a valuable complement to food and health research in both humans and animals. Despite advancements in standardized protocols for culturing human GM, research concerning animals—particularly companion animals—remains limited. …”
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