Earth Detecting Earth: At What Distance Could Earth’s Constellation of Technosignatures Be Detected with Present-day Technology? by Sofia Z. Sheikh, Macy J. Huston, Pinchen Fan, Jason T. Wright, Thomas Beatty, Connor Martini, Ravi Kopparapu, Adam Frank

“…This work highlights the growing range of ways that exoplanet technosignatures may be expressed, the growing complexity and visibility of the human impact upon our planet, and the continued importance of the radio frequencies in SETI.…”
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Women Empowered to Connect With Addiction Resources and Engage in Evidence-Based Treatment (WE-CARE)—an mHealth Application for the Universal Screening of Alcohol, Substance Use, D... by Krystyna Isaacs, Autumn Shifflett, Kajal Patel, Lacey Karpisek, Yi Cui, Maayan Lawental, Golfo Tzilos Wernette, Brian Borsari, Katie Chang, Tony Ma

“…Individuals were recruited using flyers, academic listserves, and a commercial human subject recruiting company (Prolific). Upon completion of the screening instruments, women explored the educational and linkage to care features of the app and filled out a System Usability Scale to evaluate the mobile health app’s usability and acceptability. …”
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Assessing and predicting Bojiang lake area and LULC changes from 2000 to 2045 by Muhammad Naeem, Yongqiang Zhang, Xiaoqiang Tian, Ping Miao, Congcong Li, Zhenwu Xu, Longhao Wang, Faisal Mumtaz, Zixuan Tang, Shaoyang He

“…Study focus: While the global significance of lake ecosystems is well established, few studies have investigated the long-term dynamics of Bojiang Lake, particularly the interplay between human activities and climate change. This study assesses lake area fluctuations and land use/land cover changes in the Bojiang Lake Basin from 2000 to 2023 and provides projections for 2024–2045 using the CA-ANN model. …”
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The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target by Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich

“…We further showed that the structure of the ligand-binding pocket of the fungal enzyme differs significantly from its human counterpart, suggesting that specific inhibitors can be designed. …”
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Longitudinal associations between air pollution and incident dementia as mediated by MRI-measured brain volumes in the UK Biobank by Rhiannon Thompson, Xinning Tong, Xueyi Shen, Jinjun Ran, Shengzhi Sun, Xiaoxin Iris Yao, Chen Shen

“…Background: Although there is increasing evidence that environmental exposures are associated with the risk of neurodegenerative conditions, there is still limited mechanistic evidence evaluating potential mediators in human populations. Methods: UK Biobank is a large long-term study of 500,000 adults enrolled from 2006 to 2010 age 40–69 years. …”
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The lingering menace: How legacy organochlorine pesticides still threaten our rivers and food chains by Wenping Xie, Guangjun Wang, Ermeng Yu, Jun Xie, Wangbao Gong, Zhifei Li, Kai Zhang, Yun Xia, Jingjing Tian, Hongyan Li

“…The bioaccumulation of organochlorine pesticides (OCPs) in aquatic organisms has been extensively explored in recent years due to associated ecological risks and potential threats to human health through food. This study aims to assess the bioaccumulation of organochlorine pesticides (OCPs) in 18 freshwater fish species from the Pearl River Delta, China. …”
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Lactic acid in the vaginal milieu modulates the Candida-host interaction by Diletta Rosati, Marisa Valentine, Mariolina Bruno, Arnab Pradhan, Axel Dietschmann, Martin Jaeger, Ian Leaves, Frank L. van de Veerdonk, Leo A.B. Joosten, Sumita Roy, Mark H. T. Stappers, Neil A.R. Gow, Bernhard Hube, Alistair J.P. Brown, Mark S. Gresnigt, Mihai G. Netea

“…We examined how lactic acid abundance in the vaginal niche impacts the interaction between C. albicans and the human immune system using an in vitro culture in vaginal simulative medium (VSM). …”
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Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…Methods The impact of fraxinellone (FRA) on the proliferation and migration capacity of human hypertrophic scar-derived fibroblasts (HSFs) was assessed by EdU proliferation, wound healing and transwell assays. …”
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A novel agricultural drought index based on multi-source remote sensing data and interpretable machine learning by Hao Chen, Ni Yang, Xuanhua Song, Chunhua Lu, Menglan Lu, Tan Chen, Shulin Deng

“…Drought is a frequent, destructive, and complex natural hazard, and seriously threatens eco-environment, socio-economy, and the health of human. Previous studies suggested that integrated multi-source remote sensing drought indices have the potential to comprehensively monitor drought conditions, however most existing integrated drought indices still have several limitations. …”
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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…TH-CRE rats (N = 47; 24 females and 23 males) received either AAV carrying pseudophosphorylated human tau (htauE14) or a control virus at 3 months of age. …”
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International REACH forgiveness intervention: a multisite randomised controlled trial by Tyler J Vanderweele, Nicole Rodriguez, Richard G Cowden, Man Yee Ho, Everett L Worthington, Andrea Ortega Bechara, Zhuo Job Chen, Elly Yuliandari Gunatirin, Shaun Joynt, Viacheslav V Khalanskyi, Hennadii Korzhov, Ni Made Taganing Kurniati, Anastasiya Anastasiya Salnykova, Liudmyla Shtanko, Sergiy Tymchenko, Vitaliy L Voytenko, Anita Zulkaida, Maya B Mathur

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Climate change risks illustrated by the Intergovernmental Panel on Climate Change (IPCC) “burning embers” by P. Marbaix, P. Marbaix, P. Marbaix, A. K. Magnan, A. K. Magnan, A. K. Magnan, V. Muccione, V. Muccione, P. W. Thorne, Z. Zommers

“…<p>The completion of the Sixth Assessment Cycle of the Intergovernmental Panel on Climate Change (IPCC) provides a unique opportunity to understand where the world stands on climate-change-related risks to natural and human systems at the global level, as well as for specific regions and sectors. …”
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Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

“…N -Acetylneuraminic acid (Neu5Ac) is a negatively charged nine-carbon amino sugar that is often the peripheral sugar in human cell-surface glycoconjugates. Some bacteria scavenge, import, and metabolize Neu5Ac or redeploy it on their cell surfaces for immune evasion. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Here, we demonstrate that fibronectin type III domain-containing protein 5 (FNDC5), the precursor protein for myokine irisin, is depleted in the hearts of human cancer patients or mice exposed to chemotherapeutics. …”
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Early tolerance and late persistence as alternative drug responses in cancer by Simona Punzi, Davide Cittaro, Guido Gatti, Gemma Crupi, Oronza A. Botrugno, Antonino Alex Cartalemi, Alon Gutfreund, Caterina Oneto, Valentina Giansanti, Chiara Battistini, Giovanni Santacatterina, Lucrezia Patruno, Ilaria Villanti, Martina Palumbo, Daniel J. Laverty, Francesca Giannese, Alex Graudenzi, Giulio Caravagna, Marco Antoniotti, Zachary Nagel, Ugo Cavallaro, Luisa Lanfrancone, Timothy A. Yap, Giulio Draetta, Nathalie Balaban, Giovanni Tonon

“…While resistance and persistence have been described, whether drug-induced tolerance exists in cancer cells remains largely unknown. Here, we show that human cancer cells elicit a tolerant response when exposed to commonly used chemotherapy regimens, propelled by the pervasive activation of autophagy, leading to the comprehensive activation of DNA damage repair pathways. …”
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Secular trends of physical fitness for college students in Anhui Province over the past decade by Jianzhong Sun, Hui Liang, Lei Wang, Zhongju Chen, Cunjian Bi, Feng Zhang

“…In the final year of 2019, a global COVID-19 pandemic emerged and persisted for three years, causing a significant diminution in human physical well-being. This article aims to delve into the changes in the physical fitness of college students over the past decade and anticipates future trends. …”
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Novel image registration algorithm for scene-matching navigation by Hongrui YANG, Qiju ZHU, Peixian CAO, Hao GU, Dongdong ZHAO

“…High-precision positioning and navigation technology are crucial for the autonomous operation of unmanned aerial vehicles (UAVs), enabling them to determine their location and navigate to predetermined destinations without human intervention. In scenarios where satellite navigation is unavailable, image matching–based visual navigation technology becomes essential owing to its simple device structure and high accuracy in passive positioning. …”
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2-Heptanone Produces Sensorial-Emotional Changes, Depending on Length of Exposure / La 2-heptanona produce cambios sensorio-emocionales, dependiendo del tiempo de exposición by Ana Gloria Gutiérrez-García, Carlos M. Contreras, María Remedios Mendoza-López

“… Abstract: 2-Heptanone is an alarm pheromone contained in some human fluids, but its role is unknown in chemical communication. …”
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Exploring the genotypic potential of perilla (Perilla frutescens L.) for climate-resilient agriculture in the North Eastern Himalayas by Meraj Alam Ansari, Meraj Alam Ansari, Amit Kumar, T. P. Ahammed Shabeer, Alok Kumar, Subhra Saikat Roy, Subhra Saikat Roy, Majhrool Hak Ansari, Raghavendra Singh, Raghavendra Singh, Moirangthem Sangeeta, Jayanta Layek, Narendra Prakash, Vinay K. Mishra

“…Large-scale cultivation of perilla improves food security and offers numerous health benefits, including cardiovascular support and disease prevention, thereby enhancing human wellbeing. However, the genetic complexity of its fatty acid composition, nutrient content, and yield-associated agronomic traits remains poorly understood. …”
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A comparative bio-mechanical performance assessment of additively manufactured bone scaffolds using different beta Ti alloys and Gyroid based cellular structure by Mudassar Rehman, Yanen Wang, Kashif Ishfaq, Ray Tahir Mushtaq, Aqib Mashood Khan, Mohammed Alkahtani, Aamer Nazir, Maimoona Afzal

“…An exponential rise in demand for artificial implants has emphasized the need for novel biomaterials with good biocompatibility and mechanical properties comparable to human cortical and cancellous bone, to mitigate stress shielding and other post implantation challenges. …”
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