Comprehensive characterization of tobacco-induced changes in enamel surface topography by Tamanna Kaur, Ramya Ramadoss, Nitya Krishnasamy, Sandhya Sundar, Suganya Panneer Selvam, Hema Shree K

“…Materials and methods: This study analyzed human enamel samples, including one unstained sample (Grade 0) and three tobacco-stained samples (Grades 1–3) according to Modified Lobene Stain Index (MLSI), to investigate the impact of tobacco exposure on enamel structure. …”
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A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes) by Tamás Visnovitz, Dorina Lenzinger, Anna Koncz, Péter M Vizi, Tünde Bárkai, Krisztina V Vukman, Alicia Galinsoga, Krisztina Németh, Kelsey Fletcher, Zsolt I Komlósi, Csaba Cserép, Ádám Dénes, Péter Lőrincz, Gábor Valcz, Edit I Buzas

“…We previously found evidence that human colorectal cancer cells in vivo release large multivesicular body-like structures en bloc. …”
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Feedback of aggregate patient-reported outcomes (PROs) data to clinicians and hospital end users: findings from an Australian codesign workshop process by Monique F Kilkenny, Dominique A Cadilhac, Shaun L Hancock, Violet Marion, Paulette Kelly, Sibilah Breen, Benjamin Clissold, Lauren Sanders, Olivia Francis Ryan, Penina Gunzburg, Shae Cooke, Lauren Guy

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Designing and Explaining the Competence Model of Knowledge Engineers in Municipalities (Study Case: Tehran Municipality) by Amin Seyyed Nosrati, Zahra Foroutani, Atyieh Bohrani

“…The results are expected to enhance the quality of knowledge management processes by ensuring the effective utilization of human resources. Moreover, the competencies identified in this study can inform the development of training programs and development initiatives in the field of knowledge management within municipalities, thereby increasing the effectiveness and impact of these programs.…”
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Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial by Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

“…MethodsWe conducted a low-intervention, nonexternally funded clinical trial using the human and material resources available on site. We managed our trial in a clinical trial unit where there were staff, sources, and ongoing commercial clinical trials. …”
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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

“…Interrogation of temporal and signalling-specific gene expression in this atlas, evaluated against cell type-specific gene expression in human complex trait data highlights the WNT-inhibitor gene TMEM88 as a regulator of mesendodermal lineages influencing cardiovascular and anthropometric traits. …”
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Effects of Environmental Factors on Carbon Stocks of Dry Evergreen Afromontane Forests of the Choke Mountain Ecosystem, Northwestern Ethiopia by Fikirte Asrat, Teshome Soromessa, Tesefaye Bekele, Rama Mohan Kurakalva, Sravya Sai Guddeti, David Russel Smart, Kristine Steger

“…The average carbon stock throughout the whole plots investigated in Anshirava forest (protected) was 180.18 t·ha−1 (53%) in AGB, 111.43 t·ha−1 (33%) in soil, 36.43 t·ha−1 (11%) in BGB, 6.09 t·ha−1 (2%) in USB, 2.69 t·ha−1 (1%) in litter, and 1.36 t·ha−1 (less than 1%) in DW. In Ziba forest (high human intervention), the average carbon stock was 106.71 t·ha−1 (44%) in AGB, 100.07 t·ha−1 (42%) in soil, 21.34 t·ha−1 (9%) in BGB, 5.41 t·ha−1 (2%) in USB, 4.82 t·ha−1 (2%) in litter, and 2.00 t·ha−1 (1%) in DW. …”
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Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease by Jean Dallongeville, Carlos Iribarren, Jean Ferrières, Liisa Lyon, Alun Evans, Alan S. Go, Dominique Arveiler, Stephen P. Fortmann, Pierre Ducimetière, Mark A. Hlatky, Philippe Amouyel, Audrey Southwick, Thomas Quertermous, Aline Meirhaeghe

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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model by Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Maria Krutakova, Josef Skoda, Azam Rashidian, Ivona Pavkova, Kryštof Škach, Jana Hricová, Michaela Chocholouskova, Lucie Smutna, Rajamanikkam Kamaraj, Miloš Hroch, Martin Leníček, Stanislav Mičuda, Dirk Pijnenburg, Rinie van Beuningen, Michal Holčapek, Libor Vítek, Magnus Ingelman-Sundberg, Oliver Burk, Thales Kronenberger, Radim Nencka, Petr Pavek

“…Through comprehensive analyses utilizing lipidomics, bile acid metabolomics, and transcriptomics in humanized PXR-CAR-CYP3A4/3A7 mice fed high-fat and high-cholesterol diets, we demonstrate that MI-883 significantly reduces plasma cholesterol levels and enhances fecal bile acid excretion. …”
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Compatibility and antimicrobial activity of silver nanoparticles synthesized using Lycopersicon esculentum peels by Esraa Ali, Samah H. Abu-Hussien, Esraa Hesham, Shimaa Ahmed, Habiba Mostafa, Ahmed Gamal, Salwa M. El-Sayed, Bahaa Hemdan, Ashraf Bakry, Naglaa M. Ebeed, Hesham Elhariry, Ahmed Galal, Basma T. Abd-Elhalim

“…The cytotoxicity effect was observed at a half-maximal inhibitory concentration (IC50) of 200.53 μg/ml on human colon NCM460D normal cells.…”
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Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for skin infections, microneedles (MNs) have demonstrated superiority mainly because of their merits in enhancing drug delivery efficiency and reducing microbial resistance. …”
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Klasifikasi Tingkat Stress dari Data Berbentuk Teks dengan Menggunakan Algoritma Support Vector Machine (SVM) dan Random Forest by Naufal Fathirachman Mahing, Alifi Lazuardi Gunawan, Ahmad Foresta Azhar Zen, Fitra Abdurrachman Bachtiar, Satrio Agung Wicaksono

“…Monitoring stress levels is important for humans. High levels of stress can have a negative impact on human health. …”
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Parejas heterosexuales serodiscordantes en Chiapas, México. La influencia del género en la expresión de la agencia/Heterosexual HIV-Discordant Couples in Chiapas, Mexico. The Influ... by Francisco Chong-Villareal, Teresa Margarita Torres-López

“…English  Heterosexual men and women with Human Immunodeficiency Virus (HIV) face personal challenges (e.g. fear of infecting others and rejection) and social ones (real rejection). …”
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Anti-inflammatory and antioxidant properties of Camellia sinensis L. extract as a potential therapeutic for atopic dermatitis through NF-κB pathway inhibition by Min Jung Kim, Ye Jin Yang, Ga-Yul Min, Ji Woong Heo, Jae Dong Son, Young Zoo You, Hun Hwan Kim, Gon Sup Kim, Hu-Jang Lee, Ju-Hye Yang, Kwang Il Park

“…Exposure of TNF-α/IFN-γ- stimulated human keratinocytes (HaCaT) cells to CSE resulted in a 200 µg/mL dependent inhibition of p65 and signal transducer and activator of transcription 1 (STAT-1) translocation from the cytosol to the nucleus, as confirmed through immunofluorescence (IF) staining. …”
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Identification of novel autoantibodies in Sjögren’s disease by Fiona Engelke, Petra Budde, Salvatore De Vita, Thomas Dörner, Diana Ernst, Jan Gras, Harald Heidecke, Annika Loredana Kilian, Katja Kniesch, Ann-Sophie Lindemann, Luca Quartuccio, Jacob Ritter, Kai Schulze-Forster, Benjamin Seeliger, Hans-Dieter Zucht, Torsten Witte

“…We aimed to identify novel autoantibodies in SjD that may facilitate the diagnostic procedure for Ro/SSA negative SjD.MethodsIgG and IgA autoantibody reactivity of 94 potential candidate autoantigens for SjD, selected from a discovery screen of 1,629 human antigens coupled to Luminex beads and prior knowledge about potential biological relevance, were examined in serum of SjD patients (n=347) using Luminex and ELISA technology. …”
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Unraveling the spatiotemporal trends and source attribution of polycyclic aromatic hydrocarbons and oxygenated derivatives in Guangzhou agricultural ditch sediment by Shaomin Li, Weisong Chen, Yichen Liu, Haoyu Wang, Yongtao Li, Zhen Zhang, Xingjian Yang

“…Spatially, Pearson correlation and path analysis disclosed a linkage between OPAHs and high-molecular-weight PAHs and adjacent agricultural practices, whereas low-molecular-weight PAHs were associated with human and industrial operations. This disparity was linked to the restricted mobility of high-molecular-weight PAHs, rendering them particularly susceptible to proximal sources. …”
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Status of seawater intrusion in Mexico: A review by Xiaoxiao Zha, Jesús Horacio Hernández Anguiano, Francisco Padilla Benítez, Arturo Cruz-Falcón, Raul Miranda-Avilés, Manuel E. Mendoza Cantú, Jorge Adrian Perera-Burgos, Xu Liao, Juan Manuel Navarro-Céspedes, Miguel Angel Acosta-Reyes, Yanmei Li

“…This synthesis of seawater intrusion highlights the role of climate change, which directly links to human-induced pressures. The findings offer insights into coastal regions worldwide grappling with similar challenges from climate change and increasing water demand.…”
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Intensified monsoonal rainstorm events over westerly-dominated Asian interior during the warm mid-Holocene by Peixian Shu, Weijian Zhou, Aaron E. Putnam, Baosheng Li, Shugang Kang, Yingying Sha, Zhengguo Shi, Guodong Ming, Hong Wang, Youbin Sun, David K. Wright, Weiguo Liu, Xiaodong Liu, Peng Cheng, Yougui Song, Dongfeng Niu, John R. Dodson, Hua Du, Jiaju Zhao, Zeke Zhang, Yahui Qiu, Zhisheng An

“…Abstract Hydroclimatic change in the Asian interior plays a key role in regulating regional environmental sustainability, water security, and human-nature relationships. However, the influence of the summer monsoon and westerly circulation on the evolution of hydroclimate over the arid Asian interior remains controversial. …”
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High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report by Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto

“…We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. …”
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A flood resilience assessment method of green-grey-blue coupled urban drainage system considering backwater effects by Yue Liu, Xiang Zhang, Jie Liu, Yao Wang, Haifeng Jia, Shiyong Tao

“…Currently, the increasing frequency of urban floods—driven by extreme rainfall resulting from climate change, human-induced urbanization, and inadequacies in urban drainage systems—has heightened interest in resilient cities. …”
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