The Promising Effect of Tocilizumab on Chronic Antibody-Mediated Rejection (cAMR) of Kidney Transplant by Łukasz Świątek, Miłosz Miedziaszczyk, Dominik Lewandowski, Filip Robakowski, Piotr Tyburski, Marta Jakubowska, Marek Karczewski, Ilona Idasiak-Piechocka

“…One of the recent promising methods of cAMR treatment is a recombinant humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody referred to as Tocilizumab (TCZ). …”
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Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparo... by Miranda Davies-Tuck, Emily Callander, Mary Sharp, Scott W White, Dorota A Doherty, Jane Warland, Zoe Bradfield, Lesley Kuliukas, Monique Rose, Amber Pettitt, Kylie Ekin, JA Keelan

“…All data will be analysed by intention to treat.Ethics and dissemination The study is approved by the Western Australia Health Central Human Research Ethics Committee (RGS0000006283). …”
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ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury by Xuechan Bi, Min Li, Yiming Guo, Mengyao Hu, Yujie Chen, Ni Lian, Sihan Chen, Min Li, Heng Gu, Xu Chen

“…We observed that the key molecules of GSDMD-mediated pyroptosis, apoptosis, and necroptosis, which are N-terminal GSDMD, cleaved caspase-3/PARP, and phosphorylated MLKL, respectively, were elevated in keratinocytes of UVB-challenged mice and human skin tissue. Through keratinocyte-specific gene knockout or using corresponding inhibitors, we found that individual inhibition of GSDMD-mediated pyroptosis, caspase-3-mediated apoptosis, or MLKL-mediated necroptosis did not reduce the overall level of keratinocyte death after UVB exposure, and that the other two pathways maintained the activation. …”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Results: The limits of detection of the multiplexed PCR were in the range of 5–100 CFU/mL for fungal spiked human blood samples. Against the clinical diagnosis of proven or probable IFDs, the findings show that the LFA system produced a high specificity of 99.4 % while the sensitivity was only moderate at 47.8 % due to the difficulty of extracting fungal DNA from blood samples. …”
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Position Paper by Canadian Dental Sleep Medicine Professionals Regarding the Role of Different Health Care Professionals in Managing Obstructive Sleep Apnea and Snoring with Oral A... by Luc Gauthier, Fernanda Almeida, Patrick Arcache, Catherine Ashton-McGregor, David Côté, Helen Driver, Kathleen Ferguson, Gilles Lavigne, Philippe Martin, Jean-François Masse, Florence Morisson, Jeffrey Pancer, Charles Samuels, Maurice Schachter, Frédéric Sériès, Glendon Sullivan

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Digital interactive experience- and game-based fall interventions for community-dwelling healthy older adults: a cross-disciplinary systematic review by Celina Ciemer, Celina Ciemer, Lisa Kröper, Thomas Jürgen Klotzbier, Sabiha Ghellal, Nadja Schott

“…It focuses on integrating Human Movement Science and User Experience & Game Design perspectives, emphasizing the cross-disciplinary nature of this research.MethodsWe employed a cross-disciplinary literature search framework, searching the databases ACM-DL, IEEE-Xplore, ScienceDirect, PubMed, Scopus, and Web of Science. …”
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Integrating Explainable Artificial Intelligence With Advanced Deep Learning Model for Crowd Density Estimation in Real-World Surveillance Systems by Sultan Refa Alotaibi, Hanan Abdullah Mengash, Mohammed Maray, Faiz Abdullah Alotaibi, Abdulwhab Alkharashi, Ahmad A. Alzahrani, Moneerah Alotaibi, Mrim M. Alnfiai

“…It detects crowded areas, manages crowd flow, and combines automated analysis with human oversight for improved public safety and early intervention. …”
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Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study—INTERACT MESO by Job P van Kooten, Jacobus W A Burger, Cornelis Verhoef, Joachim G J V Aerts, Eva V E Madsen, Alexandra R M Brandt-Kerkhof, Stijn L W Koolen, Ron H J Mathijssen, Michelle V Dietz, Niels A D Guchelaar

“…Through this PAC, 8–16 weekly cycles of intraperitoneal chemotherapy will be administered.Ethics and dissemination The Central Committee on Research Involving Human Subjects (CCMO, The Hague, The Netherlands) and the Medical Research Ethics Committee (METC, Rotterdam, The Netherlands) have granted permission to carry out this study protocol. …”
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Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study by Gang Wei, Cheng Zhang, Feng-Jie Shen, Hua-Qi Guo, Lin Liu

“…This study aims to investigate the cause-and-effect relationship of FH with risk of intestinal vascular diseases in human. Methods: A Mendelian randomization (MR) analysis was performed by extracting summary-level datasets for FH or FH concurrently with ischemic heart disease (IHD) and intestinal vascular diseases from the FinnGen study including 329,115, 316,290 and 350,505 individuals. …”
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Rabies re-emergence after long-term disease freedom (Amur Oblast, Russia) by A. D. Botvinkin, I. D. Zarva, I. V. Meltsоv, S. A. Chupin, E. M. Poleshchuk, N. G. Zinyakov, S. V. Samokhvalov, I. V. Solovey, N. V. Yakovleva, G. N. Sidorov, I. A. Boyko, V. G. Yudin, E. I. Andaev, A. Ye. Metlin

“…After 2018, the epizootic spread within the forest-steppe landscapes of the Zeya-Bureya Plain, where human and animal rabies cases had been earlier reported (until 1972). …”
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Water Management Practices Affect Arsenic and Cadmium Accumulation in Rice Grains by Liming Sun, Manman Zheng, Hongyan Liu, Shaobing Peng, Jianliang Huang, Kehui Cui, Lixiao Nie

“…Cadmium (Cd) and arsenic (As) accumulation in rice grains is a great threat to its productivity, grain quality, and thus human health. Pot and field studies were carried out to unravel the effect of different water management practices (aerobic, aerobic-flooded, and flooded) on Cd and As accumulation in rice grains of two different varieties. …”
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Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries by Mansoureh Bijani, Amrollah Mostafazadeh, Mina Motallebnejad, Ali Bijani, Roghiyeh Pourbagher, Samaneh Gharekhani

“…As dental caries is a bacterial infectious disease, the host immune system parameters including soluble human leukocyte antigen-G (sHLA-G) are essential factors in estimating dental caries. …”
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The Ethical Challenges of Gamification in Iran: Uncovering the Dark Side by Mona Jami Pour, Hamideh Binaei

“…ObjectiveThe popularity of gamification in business, in areas such as marketing, sales, human resources, and education is growing rapidly. …”
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Regional Differences of Digital Rural Construction in China and Driving Factors by Zeng Yongming, Zhong Zikang

“…In addition, the four sub-dimensional indexes—rural digital infrastructure, rural economic digitalization, rural governance digitalization, and rural life digitalization—show evident spatial differentiation characteristics, with the "Hu Huanyong Line" as the boundary. 3) Regarding mechanism, the spatial panel model was used to verify that government functions, economic foundations, digital foundations, and human capital were important driving factors for the construction of county-level digital rural areas. …”
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Space-time Characteristics of 16 PM2.5-bound Phthalates (PAEs) in Ambient Air from Shanghai: Profiles, Sources, Meteorological Effects, and Exposure Risks by Janvier Munyaneza, Md Faysal Hossain, Qilong Jia, Yusen Duan, Guangli Xiu

“…They occur in both particle and gas phases in the air causing threats to human health. In the study in hands, LC-MS/MS was employed for the analysis of PM2.5-PAEs in 128 ambient PM2.5 samples from nine locations (urban, sub-urban and coastal) in Shanghai between February 2015 and September 2021. …”
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Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway by Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li

“…This study aimed to explore the mechanism by which adipose-derived stem cells (ADSCs) repair intestinal barrier damage. The human colon adenocarcinoma cell line Caco-2 and rats were treated with lipopolysaccharide (LPS) to establish in vitro and in vivo models, respectively, of intestinal barrier damage. …”
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Draft genome sequence of a co-harbouring blaNDM-5 and mcr-1.1 Escherichia coli phylogroup A isolate associated with patient colonisation in Ireland by Anna Tumeo, Francesca McDonagh, Aneta Kovarova, Kate Ryan, Christina Clarke, Georgios Miliotis

“…We report the draft genome of a rare instance of carbapenem, fosfomycin and colistin resistant E. coli phylogroup-A, isolated as part of routine screening of a human patient in a clinical setting in Ireland. Methods: E. coli E230738 was identified using MALDI-ToF/MS. …”
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Fiber-tip photonic crystal for real-time referenced biosensing in serum by Mathias Dolci, Paco Dreverman, Mildred S. Cano-Velázquez, Arthur L. Hendriks, Emiel Veth, P.J. van Veldhoven, Andrea Fiore, Peter Zijlstra

“…These referenced fiber-tip PhC biosensors may pave the way for fluidic integrated systems in environmental, industrial, and healthcare applications, and open up the possibility of biosensing in the human body by integrating them into catheters.…”
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Tracing Aquatic Macrophyte Development in Nansi Lake, Northern China's Largest Freshwater Lake: Plant Macrofossils From 1855 to Present by Qinghui Zhang, Yufei Wu, Liwei Yang, Zekun Li, Zonglei Li, Yuying Yang, Shiyue Chen, Enfeng Liu

“…Multiple factor analysis was employed to investigate the correlation between these shifts and changes in paleolimnological indicators (invertebrates, geochemistry, and grain size), as well as documented records related to hydrology, climate changes, and human activities. The results confirmed our hypothesis that climatically and anthropogenically induced hydrological alterations were likely the primary drivers influencing macrophyte composition alteration and succession dynamics in the lake. …”
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Phenolic Content and Antioxidant and Antimicrobial Activities of Malva sylvestris L., Malva oxyloba Boiss., Malva parviflora L., and Malva aegyptia L. Leaves Extract by Khalid A. Shadid, Ashok K. Shakya, Rajashri R. Naik, Nidal Jaradat, Husni S. Farah, Naeem Shalan, Nooman A. Khalaf, Ghaleb A. Oriquat

“…As such, it is emerging as a promising therapeutic agent for the treatment of various neurodegenerative diseases and many types of human infectious diseases.…”
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