Runs of homozygosity in spontaneous abortions from families with recurrent pregnancy loss by N. A. Skryabin, S. A. Vasilyev, T. V. Nikitina, D. I. Zhigalina, R. R. Savchenko, N. P. Babushkina, M. E. Lopatkina, A. A. Kashevarova, I. N. Lebedev

“…All embryos had normal karyotypes according to metaphase karyotyping and conventional comparative genomic hybridization. SurePrint G3 Human CGH + SNP 4 × 180K microarrays (Agilent Technologies) were used to search for homozygous regions. …”
Get full text

Within-species variation in the gut microbiome of medaka (Oryzias latipes) is driven by the interaction of light intensity and genetic background by Evangelista, Charlotte, Kamenova, Stefaniya, Diaz Pauli, Beatriz, Sandkjenn, Joakim, Vøllestad, Leif Asbjørn, Edeline, Eric, Trosvik, Pål, de Muinck, Eric Jacques

“…Unravelling evolution-by-environment interactions on the gut microbiome is particularly relevant considering the unprecedented level of human-driven disruption of the ecological and evolutionary trajectories of species. …”
Get full text

Predictive factors for axillary pathological complete response to neoadjuvant therapy in elderly breast cancer patients by Yuying Wang, Rui Wang, Di Lu, Yaling Zeng, Xihui Tu, Shiwei Liu, Purong Zhang

“…The univariate analysis results showed that the initial clinical lymph nodes negative(cN0) stage, Human Epidermal Growth Factor Receptor 2(HER2) positivity and breast pathological complete response(bpCR) were significantly correlated with high apCR rates(all P < 0.05). …”
Get full text

Developing a Model for Successful Implementation of Customer Experience Management in Organizations: A Qualitative Study by Payam Mardazad Navi, Kambiz Heidarzadeh Hanzaee, Seyyed Buik Mohammadi, Mohsen Khoon Siavash

“…The explosion of potential touch points and diminishing control over the customer experience requires companies to integrate multiple business functions such as IT, operations of the service, logistics, marketing, human resources, and even external partners and supply chains to create and deliver a positive customer experience. …”
Get full text

Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands by Bárbara Marques, Diogo M. Engrácia, João Franco Machado, Jaime A. S. Coelho, Filipa Mendes, Tânia S. Morais

“…The cytotoxicity of the complexes was evaluated in vitro in several human cancer cell lines, namely melanoma (A375), alveolar adenocarcinoma (A549), epidermoid carcinoma (A431), and breast cancer (MDA-MB 231). …”
Get full text

Perbedaan Daya Hambat Bakteri dari Propolis Cair yang Ada di Pasaran Terhadap Escherichia Coli dan Staphylococcus Aureus Secara In Vitro by Bangun Azhari Yusuf, Aziz Djamal, Asterina

“…The main component of propolis is resin which is collected and mixed with saliva. The human also use propolis as a treatment against various illness such as bacterial infection. …”
Get full text

Mn-doped ZnO thin films as a platform for reagentless uric acid biosensor by Bilasini Devi Naorem, Jatinder Pal Singh, Babita Sharma, Satyam Garg, Athira C, Hashima Sherin, Mahima Momaliya, Muskan, Shubhi Sahu, Arijit Chowdhuri, Mallika Verma, Monika Tomar, Neha Batra

“…The fabricated biosensor exhibits excellent performance in terms of sensitivity (40 µAmM-1cm-2), selectivity with <5 % deviation found in presence of other known markers present in human sera, and shelf life >12 weeks, enabling precise and sensitive uric acid detection. …”
Get full text

Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

Get full text

Hydrochemical assessment of borehole water in Effurun, Delta state Niger Delta, Nigeria: implications for public health and safety by Odunayo Tope Ojo, Chiaka Joy Ike, Adegoke Ige Aladeboyeje, Olayiwola Grace Olaseeni, Olumuyiwa Femi Adewumi

“…The central area exhibited moderate ion concentrations, while the southeastern region had the highest calcium levels, possibly due to geological formations rich in calcium or human activities. The study highlights diverse hydrochemical characteristics of Effurun's borehole water, with some areas showing contamination beyond acceptable limits. …”
Get full text

Diversity and Distribution of <i>Phytophthora</i> Species Along an Elevation Gradient in Natural and Semi-Natural Forest Ecosystems in Portugal by Carlo Bregant, Eduardo Batista, Sandra Hilário, Benedetto Teodoro Linaldeddu, Artur Alves

“…The genus <i>Phytophthora</i> includes a large number of species that are invading forest ecosystems worldwide, chiefly as a consequence of global trade and human activities. This paper reports the results of a survey of <i>Phytophthora</i> diversity in natural and semi-natural forest ecosystems in Portugal along an elevation gradient. …”
Get full text

The Level of Heavy Metal Contamination in Selected Vegetables and Animal Feed Grasses Grown in Wastewater Irrigated Area, around Asmara, Eritrea by Goitom Kfle, Ghebray Asgedom, Tedros Goje, Felema Abbebe, Lula Habtom, Hagos Hanes

“…Soils irrigated with wastewater are by and large contaminated with heavy metals, and consumption of vegetables and animal feed grasses grown in contaminated soils have been a major food chain route for human exposure and pose a health hazard. A study was conducted in three sites to assess the accumulation of heavy metals in farms irrigated with wastewater between two and five decades in and around Asmara, Eritrea. …”
Get full text

Australian children’s foot, ankle and leg problems in primary care: a secondary analysis of the Bettering the Evaluation and Care of Health (BEACH) data by Hylton B Menz, Christopher Harrison, Peter A Lazzarini, Cylie M Williams, Julie Gordon

Get full text

MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling by Wenshuai He, Limin Zhao, Pengfei Wang, Maojia Ren, Yunfei Han

“…Methods An in vitro AS cell model was established by exposing human umbilical vein endothelial cells (HUVECs) to 100 µg/mL ox-LDL for 24 h. …”
Get full text

Changes in and Potential Mechanisms of Circulating IgA+CD27-Class-Switched Memory B Cells in Patients With Allergic Rhinitis by Zheng H, Xu S, Yang R, Jiao WE, Qiao YL, Liu JY, Fan HM, Zhou YT, Ni HF, Chen J, Deng YQ, Chen SM

“…After AIT, the number of circulating IgA+CD27- class-switched memory B cells in AR patients was significantly positively correlated with the number of Treg cells and IL-10 and significantly negatively correlated with the VAS score (P < 0.05).Conclusion: The IgA+CD27- class-switched memory cell subset in human peripheral blood may serve as a potential biomarker for evaluating AR symptoms and treatment efficacy. …”
Get full text

Iron deficiency anaemia and its associated risk factors among lactating mothers in Ghana by Mensah K, Abbam G, Gadzeto FF, Marfo L, Daud S, Kuntah S, Bani SB, Dzamesi HK, Apodola FA, Badu A, Chukwurah FE

“…ackground: Anaemia is one of the most common conditions affecting human physiology. Iron deficiency, with or without anaemia, reduces the working capacity of individuals and the entire population. …”
Get full text

Nitrous Oxide Emissions from Smallholders’ Cropping Systems in Sub-Saharan Africa by Shaankua E. Lemarpe, Collins M. Musafiri, Joseph M. Macharia, Milka N. Kiboi, Onesmus K. Ng’etich, Chris A. Shisanya, Jeremiah Okeyo, Elizabeth A. Okwuosa, Felix K. Ngetich

“…Ozone layer depletion allows penetration of ultraviolet radiations, which are hazardous to human health. Climate change culminates in reduced food productivity. …”
Get full text

Computer analysis of co-localization of transcription factor binding sites in genome by ChIP-seq data by A. I. Dergilev, A. M. Spitsina, I. V. Chadaeva, A. V. Svichkarev, F. M. Naumenko, E. V. Kulakova, E. R. Galieva, E. E. Vityaev, M. Chen, Y. L. Orlov

“…The computer program of the statistical data processing of gene location and chromatin domains that analyzes experimental data of site localization obtained by ChIP-seq in the mouse genome and the human genome has been developed. The presence of preferences at position of transcription factor binding sites of various types has been revealed, the distances between the nearest groups of TF binding sites Oct4, Nanog, Sox2 and TF binding sites n-Myc and c-Myc have been calculated using this program. …”
Get full text

TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Background: Despite treatment advances for patients with early-stage triple-negative breast cancer (TNBC) and hormone receptor (HR)-low/human epidermal growth factor receptor 2-negative (HER2−) breast cancer, treatments that improve clinical outcomes while mitigating toxicity are needed. …”
Get full text

Evaluation for an Open Society: Then and Now by Robert Picciotto

“…The dominance of an international order grounded in democracy, human rights, and the rule of law is giving way to a world in which leaders are pursuing narrow nationalist and vested interests. …”
Get full text

Feline Papillomatosis by Herman Egberink, Katrin Hartmann, Ralf Mueller, Maria Grazia Pennisi, Sándor Belák, Séverine Tasker, Karin Möstl, Diane D. Addie, Corine Boucraut-Baralon, Tadeusz Frymus, Regina Hofmann-Lehmann, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Margaret J. Hosie

“…Besides cat-specific PVs, DNA sequences most closely related to human and bovine PVs have been detected in feline skin lesions. …”
Get full text