Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator by Rahma Aly, Shoukath Sulthana, Robert Beaudoin, Ayman K. Hamouda, Santosh Aryal

“…These NPs were found to be highly biocompatible when challenged against the human embryonic kidney-293 (HEK-293) cell line that stably expressed α4β2 (HEK-α4β2) nAChRs in a wide range of concentrations. …”
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in... by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

“…For our in vitro investigations, we employed the LX-2 human hepatic stellate cell line. Our procedures included cultivating these cells, employing SAMM50-rs2073080 plasmid techniques to enhance the expression of recently discovered SNPs, and conducting biochemical assays. …”
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PRMT1 Promotes the Self‐renewal of Leukemia Stem Cells by Regulating Protein Synthesis by Min Zhou, Yi Huang, Ping Xu, Shuyi Li, Chen Duan, Xiaoying Lin, Shilai Bao, Waiyi Zou, Jingxuan Pan, Chang Liu, Yanli Jin

“…It is found that PRMT1 promotes the survival and serially plating abilities of human primary CML LSCs. Genetic deletion of Prmt1 significantly delays the leukemogenesis and impairs the self‐renewal of LSCs in BCR‐ABL–driven CML mice. …”
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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence by Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa

“…A negligible hemolytic effect of celastrol against human erythrocytes was observed. In the in vivo model of VVC, the combination of FLZ and celastrol in vaginal gel revealed a drastic reduction in the fungal burden with apparently normal vaginal tissue. …”
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Development of a novel instrument to measure Japanese psychiatric nurses’ technological competency as caring in nursing by Yoshiyuki Takashima, Hirokazu Ito, Gil P. Soriano, Yuko Yasuhara, Kyoko Osaka, Savina Schoenhofer, Tetsuya Tanioka

“…Results: The developed instrument comprises 22 items with a 4-factor structure: competency to practice caring and person-centered care (Factor 1); competency to recognize and respond to ethical issues in psychiatry (Factor 2); competency to utilize technology in psychiatry (Factor 3); and competence to practice care for the preservation of human dignity and shared decision making (Factor 4). …”
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CompositIA: an open-source automated quantification tool for body composition scores from thoraco-abdominal CT scans by Raffaella Fiamma Cabini, Andrea Cozzi, Svenja Leu, Benedikt Thelen, Rolf Krause, Filippo Del Grande, Diego Ulisse Pizzagalli, Stefania Maria Rita Rizzo

“…However, their manual calculation is time-consuming and prone to human error. This study aims to develop and validate CompositIA, an automated, open-source pipeline for quantifying body composition scores from thoraco-abdominal computed tomography (CT) scans. …”
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Inhibition of id-1 reduces osteosarcoma growth and metastasis through mediation of snail by Rongbing Shu, Zhuanyi Yu, Jianmin Wu, Qiuxin Cheng, Zhihao Peng, Huaqiang Zhou, Min Zhao

“…In cell-based experiments, four osteosarcoma cell lines (Saos-2, U2OS, MG-63, and 143B) and the human osteoblast cell line hFOB 1.19 were cultured. …”
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Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction by Fang Lyu, Yuxin Zhong, Qingliu He, Wen Xiao, Xiaoping Zhang

“…Analyses of immune infiltration, human leukocyte antigen (HLA) expression, immune checkpoint expression, immunophenoscore (IPS), tumor immune dysfunction and exclusion (TIDE) scores, and responses to six targeted therapies were conducted across different risk groups. …”
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Assessment of ecological environment quality and their drivers in urban agglomeration based on a novel remote sensing ecological index by Fangyuan Lu, Chen Zhang, Haoyu Cao, Xibin Wang, Tong Zheng, Zhenfang Huang

“…This index comprehensively characterizes key environmental factors, including greenness, heat, wetness, air quality, and human activity. The NRSEI is then used to assess the Ecological Environmental Quality (EEQ) of the Yangtze River Delta Urban Agglomeration (YRDUA) over the period from 2012 to 2021. …”
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Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…This study analyzed their expression in human ccRCC cell lines and patient tumor biopsies. …”
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Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation by Seiki Tajima, Shigeyuki Yamamoto, Masaaki Tanaka, Yosky Kataoka, Masao Iwase, Etsuji Yoshikawa, Hiroyuki Okada, Hirotaka Onoe, Hideo Tsukada, Hirohiko Kuratsune, Yasuomi Ouchi, Yasuyoshi Watanabe

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Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease by Su Yan, Jun Lu, Bingfang Duan, Hongquan Zhu, Tian Tian, Yuanyuan Qin, Yuanhao Li, Wenzhen Zhu

“…Then we performed gene-category enrichment and spatial correlation analyses to evaluate the specific correspondence between cortical alteration in PD and genetic expression from the Allen Human Brain Atlas and normative neurotransmitter atlases from Neuromaps. …”
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Rapid and Specific Detection of Escherichia coli O157:H7 in Ground Beef Using Immunomagnetic Separation Combined with Loop-Mediated Isothermal Amplification by Qin Yu, Puthiyakunnon Santhosh, Zhang Yiduo, Wu Xianbo, Boddu Swapna, Luo Binde, Fan Hongying

“…Escherichia coli O157:H7 is well known for many foodborne outbreaks that lead to fatal infections in human being worldwide. The objective of this study was to develop a rapid and sensitive method for detection of EHEC O157:H7 from ground beef using a method that combined immunomagnetic separation (IMS) with loop-mediated isothermal amplification (LAMP). …”
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Antibacterial Efficacy Comparison of Electrolytic and Reductive Silver Nanoparticles Against <i>Propionibacterium acnes</i> by Suparno Suparno, Rita Prasetyowati, Khafidh Nur Aziz, Anggarwati Rahma, Eka Sentia Ayu Lestari, Siti Chaerani Nabiilah, Deby Grace

“…<b>Background:</b> The aim of this study was to develop an electrolysis system to produce silver nanoparticles free from toxic gases, as the most common reduction and electrolysis techniques produce nitrogen dioxide (NO₂) as a byproduct, which is harmful to human health. The new electrolysis system used two identical silver plate electrodes, replacing silver and carbon rods, and used water as the electrolyte instead of silver nitrate (AgNO₃) solution since AgNO₃ is the source of NO₂. …”
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Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust by Brian E. Crucian, Heather Quiriarte, Chiu-wing Lam, Mayra Nelman, Audrie A. Colorado, Douglass M. Diak, John T. James

“…Very little is known regarding the toxicity of lunar dust on human physiology. This study assessed airborne lunar dust exposure in rats on localized pulmonary and systemic immune parameters.MethodsRats were exposed to 0 (air only), 20.8 (low), and 60.6 (high) mg/m3 of respirable-size lunar dust for 4 weeks (6 h/day, 5 days/week). …”
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Prevalence of Obesity and Its Association with Socioeconomic Factors in Elderly Iranians from Razavi-Khorasan Province by Mohsen Nematy, Ali Sakhdari, Parnian Ahmadi-Moghaddam, Maliheh Aliabadi, M. Kimiagar, A. A. Ilaty, M. Azimi-Nezhad, M. T. Shakeri, M. Ghayour-Mobarhan, A. Sahebkar, G. Ferns

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Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality by Yalan Wu, Xiangrong Feng, Jinmei Li, Mengjun Li, Yao Wang, Weihui Lu, Huanhuan Luo

“…These findings suggest that exacerbated dyslipidemia caused by long-term HTH environment exposure may be a key risk factor for CVD-related mortality in middle-aged and elderly individuals and suggest research directions into the effects of HTH environments on human health.…”
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Corporate accreditation system of PJSC Gazprom as a tool for ensuring uniformity of measurements of organization by R. T. Saetova, I. A. Battalov, Ya. V. Denisova

“…Protection of the interests of the consumer and the rights of the supplier is ensured by the accuracy of determining the quantity and quality indicators of the supplied products established in technical regulations, standards and by minimizing risks to life, human health and the environment on the basis of reliable measurements. …”
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Clinical and Epidemiological Characteristics of <i>Staphylococcus caprae</i> Infections in Catalonia, Spain by Javier Díez de los Ríos, María Navarro, Judit Serra-Pladevall, Sònia Molinos, Emma Puigoriol, Noemi Párraga-Niño, Glòria Pedemonte-Parramón, Luisa Pedro-Botet, Óscar Mascaró, Esteban Reynaga

“…<i>Staphylococcus caprae</i> is a coagulase-negative staphylococcus commonly associated with animals which can also be a zoonotic human pathogen. To date, there is little data available on <i>S. caprae</i> infections. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Finally, immunofluorescence staining for CD8, CD45, and CXCR4 was performed on human GC tissue samples. Results A total of 1,298 GC patients were included in this comprehensive analysis. …”
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