Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer by Alejandra M. Scursoni, Laura Galluzzo, Sandra Camarero, Jessica Lopez, Fabiana Lubieniecki, Claudia Sampor, Valeria I. Segatori, Mariano R. Gabri, Daniel F. Alonso, Guillermo Chantada, María Teresa G. de Dávila

“…The N-glycolylated ganglioside NeuGc-GM3 has been described in solid tumors such as breast carcinoma, nonsmall cell lung cancer, and melanoma, but is usually not detected in normal human cells. Our aim was to evaluate the presence of NeuGc-GM3 in pediatric neuroectodermal tumors by immunohistochemistry. …”
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Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function by Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon

“…To determine the role of Fc effector function in therapeutic efficacy against Venezuelan equine encephalitis virus (VEEV), we compared the potently neutralizing anti-VEEV human IgG F5 (hF5) Ab with intact Fc function (hF5-WT) or containing the loss of function Fc mutations L234A and L235A (hF5-LALA) in the context of VEEV infection. …”
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Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT... by Huizhen Xing, Xinwei Bai, Xiaoying Pei, Yuqi Zhang, Xueying Zhang, Shujun Chen, Dan Li, Bin Lv, Xiaoying Wang, Xiaoli Wu

“…The chlorogenic acid, a polyphenol commonly found in herb, had been effectively conjugated with human serum albumin and coated on selenium nanoparticles (Se NPs) to create CHSe NPs. …”
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Determination of the Contents of Antioxidants and Their Degradation Products in Sodium Chloride Injection for Blood Transfusion by Bo Tao, Gang Wang, Zongning Yin, Xiaocong Pu, Yan Jiang, Luohong Zhang, Jie Cheng, Yong Li, Jiayu Zhang

“…Because of the potential harm of antioxidants to human body, it is necessary to limit the amount of antioxidants migrating to the pharmaceutical solutions. …”
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Association between Abdominal Fat (DXA) and Its Subcomponents (CT Scan) before and after Weight Loss in Obese Postmenopausal Women: A MONET Study by Caroline Y. Doyon, Martin Brochu, Virginie Messier, Marie-Ève Lavoie, May Faraj, Éric Doucet, Rémi Rabasa-Lhoret, Isabelle J. Dionne

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Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review by Petra P. Larsen, MD, PhD, Virginie Dinet, PhD, Cécile Delcourt, PhD, Catherine Helmer, MD, PhD, Morgane Linard, MD, PhD

“…In total, 40 articles were included, among which 30 on human data, 9 animal studies, 6 in vitro experiments, and 1 hypothesis paper (sometimes with several data types in the same article). …”
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A Review of the Effects of Major Atmospheric Pollutants on Pollen Grains, Pollen Content, and Allergenicity by Hélène Sénéchal, Nicolas Visez, Denis Charpin, Youcef Shahali, Gabriel Peltre, Jean-Philippe Biolley, Franck Lhuissier, Rémy Couderc, Ohri Yamada, Audrey Malrat-Domenge, Nhân Pham-Thi, Pascal Poncet, Jean-Pierre Sutra

“…The effects of polluted pollen grains, subparticles, and derived aeroallergens in animal models, in in vitro cell culture, on healthy human and allergic patients are described. Combined effects of atmospheric pollutants and pollen grains-derived biological material on allergic population are specifically discussed. …”
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Child Injury in Israel: Emergency Room Visits to a Children's Medical Center by Michal Hemmo-Lotem, Claudia Jinich-Aronowitz, Liri Endy-Findling, Michal Molcho, Michal Klein, Yehezkel Waisman, Yehuda L. Danon, Joav Merrick

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In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biom... by Malak Zirari, Marouane Aouji, Wissal Baghdad, Mohammed Er-rajy, Hamada Imtara, Feras Abujaber, Otmane Elharrati, Omar M. Noman, Mahmoud Tarayrah, Driss Hmouni, Nouredine El Mejdoub

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An association between type A porcine endogenous retrovirus copy number and hematological parameters and gender in miniature pigs by R. B. Aitnazarov, S. V. Nikitin, G. V. Kontsevaya, M. I. Voevoda, N. S. Yudin

“…Pig is the most promising species for transplantation of organs and cells into humans, although implementation of xenotransplantation in clinical practice has been hindered by the risk of infecting the recipient with zoonotic infectious diseases. …”
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Isolation and Characterization of Colistin-Resistant <i>Enterobacteriaceae</i> from Foods in Two Italian Regions in the South of Italy by Rosa Fraccalvieri, Angelica Bianco, Laura Maria Difato, Loredana Capozzi, Laura Del Sambro, Stefano Castellana, Adelia Donatiello, Luigina Serrecchia, Lorenzo Pace, Donatella Farina, Domenico Galante, Marta Caruso, Maria Tempesta, Antonio Parisi

“…The emergence of colistin-resistant <i>Enterobacteriaceae</i> in food products is a growing concern due to the potential transfer of resistance to human pathogens. This study aimed to assess the prevalence of colistin-resistant <i>Enterobacteriaceae</i> in raw and ready-to-eat food samples collected from two regions of Italy (Apulia and Basilicata) and to evaluate their resistance phenotypes and genetic characteristics. …”
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Characterisation of EfbA from the Endodontic Pathogen Enterococcus faecalis and Prediction of Immunodominant EfbA Epitope Peptides: An In-vitro and In-silico Study by Dev Arora, AS Smiline Girija, J Vijayashree Priyadharsini

“…Docking of the epitopes with reference to Human Leukocyte Antigens (HLA) alleles was assessed using the ClusPro server, and the results were evaluated for the T-cell dominant epitopes. …”
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TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers by Kimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Alice Tsai, Minjie Zhang, Douglas A. Whittington, Wenhai Zhang, Steven A. Lombardo, Satoshi Yoda, Erik W. Wilker, Samuel R. Meier, Yi Yu, Teng Teng, Alan Huang, John P. Maxwell

“…MTAP deletion occurs in 10–15 % of all human cancer representing multiple histologies. MTA is a negative regulator of PRMT5 that accumulates as a result of MTAP deletion. …”
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Bridging past and present: exploring Cannabis traditions in Armenia through ethnobotanical interviews and bibliographic prospecting by Manica Balant, Teresa Garnatje, Daniel Vitales, Marine Oganesian, Joan Vallès, Nina Stepanyan-Gandilyan, Airy Gras

“…(Cannabaceae) has been widely used by humans throughout its history for a variety of purposes (medicinal, alimentary and other uses). …”
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Medical students’ attitudes toward AI in education: perception, effectiveness, and its credibility by Abdul Sami, Fateema Tanveer, Khadeejah Sajwani, Nafeesa Kiran, Muhammad Ahsan Javed, Dilber Uzun Ozsahin, Khalid Muhammad, Yasir Waheed

“…We recommend developing dedicated AI tools for medical education and their formal integration into medical curricula, along with appropriate regulatory oversight to ensure AI can enhance human abilities rather than acting as a replacement for humans.…”
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Population-Level SARS-CoV-2 RT–PCR Cycle Threshold Values and Their Relationships with COVID-19 Transmission and Outcome Metrics: A Time Series Analysis Across Pandemic Years by Judith Carolina De Arcos-Jiménez, Ernestina Quintero-Salgado, Pedro Martínez-Ayala, Gustavo Rosales-Chávez, Roberto Miguel Damian-Negrete, Oscar Francisco Fernández-Diaz, Mariana del Rocio Ruiz-Briseño, Rosendo López-Romo, Patricia Noemi Vargas-Becerra, Ruth Rodríguez-Montaño, Ana María López-Yáñez, Jaime Briseno-Ramirez

“…The study further observed a weakening association in later pandemic stages, likely influenced by the emergence of new variants, hybrid immunity, changes in human behavior, and diagnostic shifts. These findings underscore the value of Ct values as scalable tools for public health surveillance and highlight the importance of contextualizing their analysis within specific epidemiological and temporal frameworks. …”
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Comparative evaluation of four exome enrichment solutions in 2024: Agilent, Roche, Vazyme and Nanodigmbio by Vera Belova, Iuliia Vasiliadis, Zhanna Repinskaia, Alina Samitova, Anna Shmitko, Natalya Ponikarovskaya, Oleg Suchalko, Valery Cheranev, Shatalov Peter, Shegai Peter, Kaprin Andrey, Denis Rebrikov, Dmitriy Korostin

“…This study compares available to date four exome enrichment kits: Agilent SureSelect Human All Exon v8, Roche KAPA HyperExome, Vazyme VAHTS Target Capture Core Exome Panel, and Nanodigmbio NEXome Plus Panel v1. …”
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Artificial Intelligence–Powered Training Database for Clinical Thinking: App Development Study by Heng Wang, Danni Zheng, Mengying Wang, Hong Ji, Jiangli Han, Yan Wang, Ning Shen, Jie Qiao

“… Abstract BackgroundWith the development of artificial intelligence (AI),ntered the era of intelligent medicine ObjectiveThis study aimed to introduce an app named “XueYiKu,” which includes consultations, physical examinations, auxiliary examinations, and diagnosis, incorporating AI and actual complete hospital medical records to build an online-learning platform using human-computer interaction. MethodsThe “XueYiKu” app was designed as a contactless, self-service, trial-and-error system application based on actual complete hospital medical records and natural language processing technology to comprehensively assess the “clinical competence” of residents at different stages. …”
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Investigating the Feasibility of Behavioral Nudges to Reduce the Phenomenon of Escape from Responsibility in Public Sector by Seyed Kamal Vaezi, Mahboubeh Hosseini

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Bone Marrow Stromal Cells Generate a Pro-Healing Inflammasome When Cultured on Titanium–Aluminum–Vanadium Surfaces with Microscale/Nanoscale Structural Features by David J. Cohen, Christine M. Van Duyn, Jingyao Deng, Musaddiq K. Lodi, Michelle B. Gallagher, James T. Sugar, Jeremy J. Rawlinson, Preetam Ghosh, Barbara D. Boyan, Zvi Schwartz

“…The surface topography and chemistry of titanium–aluminum–vanadium (Ti6Al4V) implants play critical roles in the osteoblast differentiation of human bone marrow stromal cells (MSCs) and the creation of an osteogenic microenvironment. …”
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