The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice by Rui Luo, Yiding Zhang, Katsushi Kumata, Lin Xie, Yusuke Kurihara, Masanao Ogawa, Tomomi Kokufuta, Nobuki Nengaki, Feng Wang, Ming-Rong R. Zhang

“…Moreover, remodelin has been found to enhance healthspan in an animal model of the human accelerated ageing syndrome. In this study, we synthesized C-11-labelled remodelin ([11C]remodelin) for the first time as a positron emission tomography (PET) probe and assessed its biodistribution in mice using PET. …”
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Effects of Calliandra and Sesbania on Daily Milk Production in Dairy Cows on Commercial Smallholder Farms in Kenya by D. N. Makau, J. A. VanLeeuwen, G. K. Gitau, S. L. McKenna, C. Walton, J. Muraya, J. J. Wichtel

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Modeling the impact of pandemic on the urban thermal environment over megacities in China: Spatiotemporal analysis from the perspective of heat anomaly variations by Jianfeng Gao, Qingyan Meng, Linlin Zhang, Xinli Hu, Die Hu, Jiangkang Qian

“…Influenced by lockdown policies and anomalies in human activities, emergencies such as pandemic significantly altered the urban thermal environment. …”
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High power impulse magnetron sputtering deposited virucide and antibacterial CrN-Cu films and the durability of the antimicrobial activity by Santiago Domínguez-Meister, Janire Mediavilla, Anastasia Dianova, Noelia Álvarez, Sara Insausti, Edurne Rujas, Jose L. Nieva, Marta Brizuela, Iñigo Braceras

“…The coatings have been deposited by reactive high power impulse magnetron sputtering (HiPIMS) technology, on stainless steel and glass, materials used profusely in high human traffic environments. The microstructural and mechanical properties of the coatings have been evaluated, their antiviral (VSV-G) and antibacterial (S. …”
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The water quality of the Upper Citarum: Applying the overall index of pollution, Said-WQI, and pollution index methods by Mariana Marselina, Nurul Aulia Rahmi, Siti Ai Nurhayati

“…Water is a crucial natural resource, integral to sustaining human life and environmental equilibrium. However, water quality remains a critical issue issue due to prevailing contamination. …”
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The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors by Yang Jiao, Linlin Wang, Lin Lu, Jianjun Liu, Xin Li, Hongbo Zhao, Zongliu Hou, Bingrong Zheng

“…Our previous study showed that the factors secreted by human umbilical cord MSCs (hUCMSCs) induced pyroptosis in the breast cancer cell line MCF7 and our RNA sequencing studies revealed an increase in the expression of the pyroptosis-related gene caspase-4 (CASP4) and nucleotide-binding, leucine-rich repeat pyrin domain-containing protein 1 (NLRP1) in pyroptotic MCF7 cells. …”
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Exploration and implication of green macroalgal proliferation in the Nanhui-east-tidal-flat: an investigation of post-reclamation mudflat wetlands by Jinlin Liu, Zhangyi Xia, Yinqing Zeng, Jing Xia, Jing Xia, Peimin He

“…The Nanhui-east-tidal-flat (NETF), the largest marginal shoal in the Yangtze River of China, is significantly impacted by human activities. Prior research has not detected the presence of green macroalgae in the NETF, nor has it explored the effects of reclamation on the distribution of macroalgae. …”
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Caractérisation éthologique de l’émotivité chez le cercopithèque de Brazza (Cercopithecus neglectus) by Helene Meunier, Philippe Bec, Catherine Blois-Heulin

“…We conducted this study on a species of non human primates, De Brazza’s monkey (Cercopithecus neglectus), which tends to be very gregarious and reacting a lot to social isolation (Joly 2000). …”
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Role of Cathepsin S in Periodontal Inflammation and Infection by S. Memmert, A. Damanaki, A. V. B. Nogueira, S. Eick, M. Nokhbehsaim, A. K. Papadopoulou, A. Till, B. Rath, S. Jepsen, W. Götz, C. Piperi, E. K. Basdra, J. A. Cirelli, A. Jäger, J. Deschner

“…The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions elicited by interleukin-1β and Fusobacterium nucleatum, respectively. …”
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Trace element concentrations, multivariate analysis and health risk potential of soils from urban and peri-urban agriculture by K.M. Hawrami, A.K. Baset

“…BACKGROUND AND OBJECTIVES A rapidly increasing human population has resulted in the expansion of urban areas and an associated increase in the demand for food.  …”
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Personally-oriented models of development of musically gifted children by N. G. Tagiltseva, L. V. Matveyeva, М. А. Byzova

“…Nowadays, the development of national competitiveness depends on many factors, but the quality of human capital is first of all. One of priority tasks of education system in Russian Federation is search and support of gifted children and teenagers: creation of conditions for their productive education, full upbringing and optimum development of their abilities providing further maximum self-realisation of a person. …”
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…Maximizing translation should be central to animal research on human diseases, guiding researchers in study design and animal model selection. …”
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Pilates exercise in pregnancy: a systematic review and meta-analysis by Yuxuan Li, Heran Lu, Liuwei Zhang, Yijia Ren, Xiaotong Dai, Lin Lin

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The effect of caregiver opinion leaders to increase demand for evidence-based practices for youth anxiety: A cluster randomized controlled trial by Margaret E. Crane, Marc S. Atkins, Sara J. Becker, Jonathan Purtle, Gillian C. Dysart, Sydney Keller, Olivia Brauer, Sirina E. Tiwari, Thomas M. Olino, Lara Baez, John Lestino, Philip C. Kendall

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The ideals of student youth in relation to the present, possible and anti-ideal by I. A. Nikolaeva

“…Ideals are a component of a single image of the world; they are interrelated with the actual (present), possible/impossible and anti-ideal as fundamental modes of human existence. The correlation of ideals with these categories reveals their functionality as regulators of social behaviour. …”
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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The three most active compounds: 4e (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-nitrobenzamide), 4f (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-chlorobenzamide) and 4g (4-bromo-N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)benzamide), were evaluated for anticancer activity against human OS cancer cell line (MG-63), liver cancer cell line (HepG2), lung cancer cell line (A549) and cervical cancer (HeLa), using MTT assay. …”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

“…Although underscored by animal studies, the endotypes of human RDEB are poorly understood. To fill this gap, we apply systems immunology approaches using single-cell high-dimensional techniques to capture the signature of peripheral immune cells and the diversity of metabolic profiles in RDEB adults, sampled outside of any opportunistic infection and active cancer. …”
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Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study by Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li

“…Abstract Background This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to December 2022, in Beijing Friendship Hospital, Capital Medical University, and participants were randomly assigned (1:1) to either the inosine (trial) or non‐inosine (control) group that received inosine (dosage: 0.2 g, three times/day) + PD‐1/PD‐L1 inhibitor or only PD‐1/PD‐L1 inhibitor ± targeted ± chemotherapy, respectively. …”
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All‐Inorganic Perovskite Quantum‐Dot Optical Neuromorphic Synapses for Near‐Sensor Colored Image Recognition by Yung‐Chi Yao, Chia‐Jung Lee, Yong‐Jun Chen, Jun‐Zhi Feng, Hongseok Oh, Chin‐Shan Lue, Jinn‐Kong Sheu, Ya‐Ju Lee

“…The ONS device exhibits distinct wavelength responses essential for emulating colored image recognition capability inherent in the human visual system. Additionally, the seamless integration of electronics and photonics within a unified material system establishes a novel paradigm for optical retrieval, enabling real‐time perception of the encoded status of the ONS device. …”
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Exploring the landscape of entrepreneurship in Pakistan: a comparative analysis of perceptions, challenges, and the need for psychoeducational interventions in the academic sector by Khurram Mehboob, Muhammad Ali, Noor Hassan, Zeeshan Mehboob, Muhammad Faisal Mushtaq, Rana Hamad Ullah, Muhammad Zahid Akhtar, Muhammad Akram Tariq, Khalida Parveen, Riffat Mehboob

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