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20461
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20463
Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity
Published 2025-01-01“…Mechanically, ex vivo human and mouse Treg cell data and in vivo mouse tumor models suggest that SOAT2 overexpression in Treg cells promotes cholesterol metabolism by activating the SREBP2-HMGCR-GGPP pathway, leading to enhanced Treg suppresser functions but reduced CD8+ T cell proliferation, migration, homeostasis and anti-tumor immunity. …”
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20464
Trait mindfulness in early pregnancy and adverse perinatal outcomes: a prospective cohort study
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20465
Tumour DNA methylation markers associated with breast cancer survival: a replication study
Published 2025-01-01“…Candidate methylation sites (N = 22) and signatures (N = 3) potentially associated with breast cancer survival were identified from five prior studies that used The Cancer Genome Atlas (TCGA) methylation dataset, which shares key characteristics with the MCCS: comparable sample size, tissue type (formalin-fixed paraffin-embedded; FFPE), technology (Illumina HumanMethylation450 array), and participant characteristics (age, ancestry, and disease subtype and severity). …”
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20466
Phenolic and amino acid profiles, and antioxidant properties of third generation snack foods adding Citrus mitis by-products and milk powder: impact of extrusion processing and mic...
Published 2025-02-01“…Total flavonoid content (TFC), hydroxyl radical scavenging activity (HRSA), and inhibition of human LDL oxidation (ILDLox) decreased in PS2 regarding PS1. …”
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20467
Rapid and Efficient Purification of Functional Collectin-12 and Its Opsonic Activity against Fungal Pathogens
Published 2019-01-01“…Furthermore, CL-12 has been shown to be associated with the pathogenesis of human diseases such as Alzheimer’s disease and multiple sclerosis lesion development. …”
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20468
Quality of Life Philosophy IV. The Brain and Consciousness
Published 2003-01-01“…The connectivity seems to imply that the patterns of the human brain are 1000-dimensional. It is our vision that these complicated patterns arise from basic patterns in the quantum matter of which everything is created. …”
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20469
Cell-free DNA release following psychosocial and physical stress in women and men
Published 2025-01-01“…To overcome this, a multiplex quantitative polymerase chain reaction (qPCR) protocol targeting L1PA2 elements, which are prevalent in the human genome, was utilized. The analysis indicated significantly elevated levels of cf-nDNA in both plasma and saliva in all participants, irrespective of gender, following psychosocial and physical stress. …”
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20470
The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin
Published 2016-01-01“…Clostridium perfringens (C. perfringens) beta2 toxin (CPB2) is an important virulent factor of necrotic enteritis in both animals and humans. However, studies of its pathogenic roles and functional mechanisms have been hampered due to the difficulty of purification and lack of specific antibodies against this toxin. …”
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20471
Physical, chemical and biological properties of MTA Angelus and novel AGM MTA: an in vitro analysis
Published 2025-01-01“…Moreover, the cytotoxicity was assessed through the MTT assay on human dental pulp stem cells (hDPSCs) after 24 and 72 h of exposure to the set/fresh status of various dilutions of MTA extracts, following the ISO 10993-12 standard. …”
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20472
Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer
Published 2010-01-01“…We investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. HIF-1, CXCR4, and VEGF high expression levels were correlated positively with TNM stage, lymph node involvement, and distant metastasis Furthermore, we found that combined high expression of any two of the three molecules (P=.028 for HIF-1/CXCR4, P=.007 for HIF-1/VEGF, and P=.004 for CXCR4/VEGF) had stronger correlation with lymph node metastasis than did each alone. …”
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20473
The microbial mechanism of maize residue decomposition under different temperature and moisture regimes in a Solonchak
Published 2025-01-01“…Abstract Soil salinization becomes serious under climate change and human activities. Although the residue decomposition contributes lots to soil carbon storage and fertility, the decomposition process and microbial mechanisms on saline-alkali soils are still vague facing climate change. …”
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20474
Renal and Hematological Effects of CLCF-1, a B-Cell-Stimulating Cytokine of the IL-6 Family
Published 2015-01-01“…We have identified CLCF-1 as a potential injurious factor in the human renal disease focal segmental glomerulosclerosis (FSGS). …”
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20475
Parent-of-origin effects on nuclear chromatin organization and behavior in a Drosophila model for Williams–Beuren Syndrome
Published 2021-09-01“…Simple experimental model systems such as Drosophila help probe the causes and consequences leading to human neurocognitive pathologies. Recently, we have developed a Drosophila model for Williams–Beuren Syndrome (WBS): a mutant agnts3 of the agnostic locus (X:11AB) harboring the dlimk1 gene. …”
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20476
MiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis
Published 2025-01-01“…Validation was conducted using three diverse microbiome/metabolome datasets, including built environments and human gut samples from inflammatory bowel disease (IBD) and COVID-19 studies. …”
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20477
Examining the impact of probiotic Lactiplantibacillus pentosus 6MMI on inhibiting biofilm formation, adhesion, and virulence gene expression in Listeria monocytogenes ATCC 19115
Published 2025-06-01“…Probiotic bacteria improve human health by secreting pro-microbial substances, balancing intestinal flora, binding to the mucous membrane and epithelium, strengthening the intestinal epithelial barrier, and creating interactions between the gastrointestinal microbiota and the immune system. …”
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20478
Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development
Published 2025-01-01“…Abstract Background Ovine pulmonary adenocarcinoma (OPA) is caused by Jaagsiekte sheep retrovirus (JSRV) and is considered an important potential animal model for human lung cancer. The precise mechanisms of OPA oncogenesis are still uncertain. …”
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20479
Frequency of Lower Lung Field Tuberculosis in Diabetes Mellitus Patients Attending Tertiary Care Hospital in Bangladesh: A Cross‐Sectional Study
Published 2025-01-01“…Extrapulmonary tuberculosis and seropositive human immunodeficiency virus (HIV) were excluded from this study. …”
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Occurrence of Enteric Viruses in Surface Water and the Relationship with Changes in Season and Physical Water Quality Dynamics
Published 2020-01-01“…Enteric viruses can affect both human and animal’s health by causing diseases such as gastrointestinal and respiratory infections. …”
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