Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4 by Ming Zhang, Chun-Mei Wang, Jing Li, Zhao-Jie Meng, Sheng-Nan Wei, Ji Li, Richard Bucala, Yu-Lin Li, Li Chen

“…The aim of this study was to investigate the protective effect and mechanism of berberine on palmitate-induced endothelial dysfunction in human umbilical vein endothelial cells (HUVECs). …”
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Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil by Joao Leandro Paula Ferreira, Rosangela Rodrigues, Andre Minhoto Lança, Valeria Correia de Almeida, Simone Queiroz Rocha, Taisa Grotta Ragazzo, Denise Lotufo Estevam, Luis Fernando de Macedo Brigido

“…Human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) is an important public health issue. …”
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Triatomine Fauna and Recent Epidemiological Dynamics of Chagas Disease in an Endemic Area of Northeast Brazil by Cláudia M. Melo, Ana Carla F. G. Cruz, Antônio Fernando V. A. Lima, Luan R. Silva, Rubens R. Madi, Veronica de Lourdes S. Jeraldo, Ruben Mercado

“…The distribution of triatomines exhibits an expanding south-central to northern dispersion, with a preference for semiarid and agreste areas and occasional observations in humid coastal areas due to anthropogenic actions reflected in the environment. Of the human cases analyzed from 2012 to 2016, 8.3% (191/2316) presented positive serology for Trypanosoma cruzi, and this proportion showed a gradual increase in the southern center of the state and new notifications in coastal regions. …”
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Evaluation of prescribing practices and treatment failure for purulent skin and soft tissue infections in patients with obesity by Mackenzie L. Miller, Destiny M. Hughson, Noah D. Blower, Andrew P. Jameson, Lisa E. Dumkow

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IMRAS-Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS. by Martha Sedegah, Michael R Hollingdale, Harini Ganeshan, Maria Belmonte, Jun Huang, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Bradley Hickey, Nimfa Teneza-Mora, Joanne Lumsden, Sharina Reyes, Jo Glenna Banania, Anatalio Reyes, Ivelese Guzman, Thomas L Richie, Judith E Epstein, Eileen Villasante

“…<h4>Background</h4>Immunization with radiation-attenuated sporozoites (RAS) by mosquito bites provides >90% sterile protection against Plasmodium falciparum malaria in humans. We conducted a clinical trial based on data from previous RAS clinical trials that suggested that 800-1200 infected bites should induce ~50% protective vaccine efficacy (VE) against controlled human malaria infection (CHMI) administered three weeks after the final immunization. …”
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Metagenomic exploration and computational prediction of novel enzymes for polyethylene terephthalate degradation by Donya Afshar Jahanshahi, Mohammad Reza Rezaei Barzani, Mohammad Bahram, Shohreh Ariaeenejad, Kaveh Kavousi

“…As a global environmental challenge, plastic pollution raises serious ecological and health concerns owing to the excessive accumulation of plastic waste, which disrupts ecosystems, harms wildlife, and threatens human health. Polyethylene terephthalate (PET), one of the most commonly used plastics, has contributed significantly to this growing crisis. …”
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Agro Climatic Feasibility Rosa damascena mill Cultivation in Climate Change Condition in northern part of Isfahan Province Zahra sadat Jalali Chiomeh by zahra sadat Jalali Chimeh, Amir Gandomkar, Morteza Khodagholi, Hossein Battoli

“…Agriculture, as one of the most important human economic activities, is closely related to the climatic conditions, and any changes in the climatic conditions can have dramatic changes in agriculture. …”
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Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis by Bonnie Hei Man Liu, Yuezhen Lin, Xi Long, Sze Wan Hung, Anna Gaponova, Feng Ren, Alex Zhavoronkov, Frank W. Pun, Chi Chiu Wang

“…GBP2, HCK, and ITGB2 are upregulated in human endometriotic specimens. siRNA‐mediated knockdown of GBP2 and HCK significantly reduced cell viability and proliferation while stimulating apoptosis in endometrial stromal cells. …”
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Impact of COVID-19 on the Air Quality over China and India Using Long-term (2009–2020) Multi-satellite Data by Manish Soni, Sunita Verma, Hiren Jethava, Swagata Payra, Lok Lamsal, Priyanshu Gupta, Janhavi Singh

“…Therefore, it is important to further strengthen environmental policies to tackle air quality, human health, and climate change in this part of the world.…”
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Effect of Fusion to the LTB Carrier Protein on Coronavirus Spike Protein Vaccine Candidates Produced in Maize by Erin Egelkrout, Magdalena Maj, Rodrigo Manjarin, Gina Fake, Muneaki Watanabe, Jenna Williams, Nate Blanchard, John Walker, Celine Hayden, John Howard

“…Porcine epidemic diarrhea virus (PEDV) is a devastating swine disease and SARS-CoV-2 is the latest coronavirus to infect the human population. Both viruses display a similar spike protein on the surface that is a target of vaccine development. …”
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Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice by Yifan Lu, Lu Jiang, Wanlu Li, Meijie Qu, Yaying Song, Xiaosong He, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang

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Elevated SAMD3 expression in T cells predicts improved survival in pancreatic ductal adenocarcinoma patients by Lingyi Fu, Enliang Zhou, Shuo Li, Ziteng Li, Liyan Wu, Xinxin Zhou, Lang Tian, Bokang Cui

“…Design We investigated the heterogeneity and gene expression profiles of T cells using a single-cell RNA sequencing (sc-RNA-seq) dataset comprised of human PDAC samples. SAMD3 mRNA expression was further evaluated in a tumor-specific OT-I/ovalbumin (OVA) mouse model. …”
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Liquid–Solid Triboelectric Nanogenerator‐Based DNA Barcode Detection Biosensor for Species Identification by Wenlong Ma, Jiawei Li, Xiaolin Qu, Shao‘e Sun, Yanan Zhou, Yitong Liu, Peng Wang, Zhongli Sha

“…Abstract DNA barcode detection method is widely applied for species identification, which is imperative to evaluate the effect of human economic activities on the biodiversity of ecosystem. …”
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Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE−/− mice by Yaze Wang, Hifumi Ohishi, Rongji Wu, Hui Liu, Rong Xu

“…Abstract Background Atherosclerosis (AS) is a major contributor to vascular disorders and represents a significant risk to human health. Currently, first-line pharmacotherapies are associated with substantial side effects, and the development of atherosclerosis is closely linked to dietary factors. …”
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Individual Differences in Behavioural Despair Predict Brain GSK-3beta Expression in Mice: The Power of a Modified Swim Test by Tatyana Strekalova, Nataliia Markova, Elena Shevtsova, Olga Zubareva, Anastassia Bakhmet, Harry M. Steinbusch, Sergey Bachurin, Klaus-Peter Lesch

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Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions by Marina G. Gobbo, Nishtman Dizeyi, Per-Anders Abrahamsson, Per-Anders Bertilsson, Viviane Sanches Masitéli, Eloisa Zanin Pytlowanciv, Sebastião R. Taboga, Rejane M. Góes

“…The effect of MLT (500 µM, 5 mM, and 10 mM) on androgen-dependent (22Rv1) and androgen-independent (PC3) cancer cells and human prostate epithelial cells (PNTA1) under normal and hyperglycemic conditions (HG, 450 mg/dL) was analyzed. …”
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Hubungan Tingkat Pengetahuan Ibu dan Tingkat Ekonomi Keluarga Nelayan dengan Status Gizi Balita di Kelurahan Air Tawar Barat Kota Padang by Pipit Amelia Burhani, Fadil Oenzil, Gusti Revilla

“…</p><p><strong>Kata kunci:</strong> status gizi, balita, tingkat pengetahuan ibu, tingkat ekonomi keluarga</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>Nutritional status has a profound influence in individual’s health that affecting the quality of human resources in the future. Nutritional status depends on food intake, mother’s knowledge, family economics, mother’s education, nurturing pattern and food availability. …”
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Genetic diversity atlas of Brucella melitensis strains from Sichuan Province, China by Wenbo Li, Linzi Zeng, Rongmei Yuan, Teng Qi, Hongyu Liao, Yuhangxi Cao, Shu Huang, Zhiguo Liu, Zhenjun Li

“…Abstract Human brucellosis is a re-emerging disease in Sichuan Province, China. …”
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Helminth diversity of nutria (Myocastor coypus) across the Morava basin in the Czech Republic by Michal Benovics, Eva Nosková, Anna Klimešová, Lucie Škorpíková, Ema Jaššová, Jakub Drimaj, Jan Slováček, Ondřej Mikulka

“…Although the nutria is a relatively new species in local fauna, its synanthropic behaviour raises concerns about potential threats to human health, underscoring the importance of exercising caution when handling these animals.…”
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Pengembangan Knowledge Management System Ukiran Kayu Khas Bali Berbasis Artificial Intelligence by I Putu Restu Indrawan Prabawa, Ariq Cahya Wardhana

“…In facilitating and increasing understanding of human resource management who are members of the Begeh Carving UKM through KMS which aims so that knowledge can continue in the next generation. …”
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