Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…Gene annotation analysis was performed to identify genes over-expressed in these regions by using the Allen Human Brain Atlas, followed by a set of gene functional feature analyses. 19 studies (1333 patients and 1174 healthy controls) were included in this meta-analysis. …”
Get full text

Healthcare Costs and Resource Use Associated With Cervical Intraepithelial Neoplasia and Cervical Conization: A Retrospective Study of German Statutory Health Insurance Claims Data by Anna-Janina Stephan, Miriam Reuschenbach, Kunal Saxena, Vimalanand S. Prabhu, Christian Jacob, Kim M. Schneider, Wolfgang Greiner, Regine Wölle, Monika Hampl

“…**Background:** Cervical intraepithelial neoplasia (CIN) can be a consequence of human papillomavirus (HPV) infection. High-grade CIN (CIN2/CIN3) may develop from persistent HPV infection and progress to cervical cancer if left untreated. …”
Get full text

Mercury Vapour Long-Lasting Exposure: Lymphocyte Muscarinic Receptors as Neurochemical Markers of Accidental Intoxication by E. Roda, A. Giampreti, S. Vecchio, P. Apostoli, T. Coccini

Get full text

Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis by Denis Poddubnyy, Torsten Diekhoff, Sevtap Tugce Ulas, Fabian Proft, Valeria Rios Rodriguez, Judith Rademacher, Juliane Greese, Katharina Ziegeler, Carolina Dominguez Aleixo, Maximilian Lindholz

“…Classification of back pain as inflammatory (=IBP), human leucocyte antigen-B27 positivity, family history, disease activity according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), symptom duration, elevated acute phase reactants, peripheral and extramusculoskeletal manifestations were evaluated. …”
Get full text

The Effects of Three Methods of Luteal Phase Support on Pregnancy Outcomes in Poor Ovarian Responders: A Randomized Clinical Trial by Tahereh Madani, Arezoo Arabipoor, Fariba Ramezanali, Shabnam Khodabakhshi, Zahra Zolfaghary

“…This study aimed to compare the effectiveness of variousluteal phase support (LPS) methods, including progesterone alone, human chorionic gonadotropin (hCG) alone,and the combination of progesterone with hCG, in these patients.Materials and Methods: In this randomized clinical trial, 375 patients diagnosed with POR based on the Bolognacriteria underwent intracytoplasmic sperm injection-embryo transfer (ET) cycles at the Royan Institute betweenNovember 2015 and June 2019. …”
Get full text

CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury by Zhu Zhang, Jinqi Hao, Qinghong Qiao, Junting Song, Yanqin Yu

“…In this study, the role and mechanism of circHIPK2 in MIRI were evaluated. Methods Human cardiac myocytes (HCM) were cultured under Hypoxia/Reoxygenation (H/R) condition to establish a MIRI model in vitro. …”
Get full text

Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway by Jia Yan, Linglin Zhang, Qingyu Zeng, Yitao Qian, Ke Li, Xiaojing Liu, Yun Wu, Yu Yan, Haiyan Zhang, Szeman Cheung, Jia Liu, Ronald Sroka, Xiuli Wang, Lei Shi

“…In this study, we investigated the impact of ALA-PDT on lipid metabolism in an acne-like mouse model and in immortalized human sebocytes (XL-i-20), focusing on the role of the OLR1-Wnt/β-catenin pathway. …”
Get full text

Idea občana – válečníka a „moderní“ maskulinní identita: modelová studie z dějin Spojených států by Jiří Hutečka

“…Although it is not very surprising considering the “state of the art” in both fields here, it must be surprising in any other way, because there is a hardly any more “gendered” human endeavor than warfare – a fact generally acknowledged by theorists and thinkers from Bourdieu to Virginia Woolfe. …”
Get full text

Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization by Junpei Fukumoto, Minako Yoshida, Suzumi M. Tokuoka, Eri Saki H. Hayakawa, Shinya Miyazaki, Takaya Sakura, Daniel Ken Inaoka, Kiyoshi Kita, Jiro Usukura, Hideo Shindou, Fuyuki Tokumasu

“…These findings highlight PfLPLAT1 as a potential target for antimalarial therapy, particularly due to its unique role and divergence from human orthologs.…”
Get full text

LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling by Marlene N. Thaitumu, Daniel Marques De Sá e Silva, Philippine Louail, Johannes Rainer, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Georgios Theodoridis, Helen Gika

“…<b>Results:</b> BµS devices, especially Mitra and Capitainer, provided equal or even superior information on the metabolic profiling of human blood based on the number and intensity of features and the precision and stability of some annotated metabolites compared to plasma. …”
Get full text

Narrow Dietary Niche With High Overlap Between Snow Leopards and Himalayan Wolves Indicates Potential for Resource Competition in Shey Phoksundo National Park, Nepal by Sandesh Lamichhane, Bikram Shrestha, Bhumi Prakash Chaudhary Tharu, Raj Kumar Koirala, Bishnu Prasad Bhattarai, Pratigyan Poudel, Binaya Adhikari, Gopal Khanal

“…Nevertheless, the region's low prey richness means that, with increasing human influence, any reduction in wild prey or increase in livestock could intensify competition between snow leopards and wolves, which could have implications for livestock depredation.…”
Get full text

Huge splenomegaly, a rare presentation of multicentric Castleman’s disease in an HIV-infected patient: a case report and literature review by Malihe Hasannezad, Abdolkarim Haji Ghadery, Sara Ghaderkhani, Armin Vazirian, Fereshteh Ameli, Farid Azmoudeh-Ardalan, Mohammad Reza Rafiian Naini, Ladan Abbasian

“…Nowa­days, multicentric CD is most commonly observed in individuals infected with human immunodeficiency virus (HIV) type 1, in association with Kaposi’s sarcoma. …”
Get full text

A Rare Case of Spontaneous Heterotopic Pregnancy at 12&nbsp;weeks of Gestation Following Natural Conception With Literature Review by Wang F, Xu Y, Dong X, Jiang P, Yu QQ

“…The complexity of clinical and laboratory findings complicates its diagnosis, necessitating a high index of suspicion for prompt intervention.Case Presentation: We reported the case of a 36-year-old woman diagnosed with heterotopic pregnancy at 12 weeks of gestation following spontaneous conception, who presented with severe abdominal pain. Initial beta-human chorionic gonadotropin (β-hCG) levels were 57,278.00 mIU/mL. …”
Get full text

High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression by Jie Qi, Qichao Wu, Qian Cheng, Xiangyuan Chen, Minmin Zhu, Changhong Miao

“…Our previous study indicated that SET domain-containing protein 8 (SETD8) downregulation is involved in high glucose-mediated endothelial inflammation in human umbilical vein endothelial cells (HUVECs). …”
Get full text

Influence of Regional Pollution Outflow on Particle Number Concentration and Particle Size in Airshed of Guangzhou, South China by Hing Cho Cheung, Chengyu Nie, Mintao Huang, Tingting Yang, Hao Wang, Celine Siu Lan Lee, Chenglei Pei, Jun Zhao, Baoling Liang

“…There is a strong local emission (mainly vehicular emissions) in both urban and suburban areas which was significantly lowered during the CNY period due to reduced human activities. The PM pollution was found to be significantly influenced by local emissions (dominated by Aitken mode particles) and new particle formation (NPF) process (dominated by nucleation mode particles). …”
Get full text

Sub-District Level Spatiotemporal Changes of Carbon Storage and Driving Factor Analysis: A Case Study in Beijing by Yirui Zhang, Shouhang Du, Linye Zhu, Tianzhuo Guo, Xuesong Zhao, Junting Guo

“…In future carbon storage prediction, the ecological protection scenario will contribute to achieving the goals of carbon peak and carbon neutrality. (3) Among the various driving factors, slope has the strongest impact on the overall carbon storage in Beijing, followed by Human Activity Intensity (HAI) and Nighttime Light Data (NTL). …”
Get full text

Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing by Mengyang Liu, Manisha Sharma, Guoliang Lu, Zhiwen Zhang, Wenting Song, Jingyuan Wen

“…The hydrogel significantly improved antioxidant capacity, protecting human fibroblasts from UVA-induced oxidative stress and enhancing cell viability. …”
Get full text

Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

“…Summary: Antimicrobial resistance poses a severe threat to human health and Pseudomonas aeruginosa stands out among the pathogens responsible for this emergency. …”
Get full text

The Risk Assessment of Pesticide Ingestion with Fruit and Vegetables for Consumer’s Health by Gordana Jurak, Jasna Bošnir, Domagoj Đikić, Ana Mojsović Ćuić, Iva Pavlinić Prokurica, Aleksandar Racz, Tomislav Jukić, David Stubljar, Andrej Starc

“…Postharvest control stands out, especially when it comes to products imported from distant countries, resulting in increased concentration of pesticides and risk to human health consuming such products. In this study, analyses of pesticide residues were performed on 200 samples of fruits and vegetables. …”
Get full text

‘If one doesn't happen, the other will’: forensic mental health service patients’ experiences of co-occurring self-harm and aggression by Matina Shafti, Peter Taylor, Andrew Forrester, Louise Robinson, Sandeep Mathews, Daniel Pratt

Get full text