An optimized method for counting viral particles using electron microscopy by B. N. Zaitsev, O. S. Taranov, N. B. Rudometova, N. S. Shcherbakova, A. A. Ilyichev, L. I. Karpenko

“…The developed approach results in increased sensitivity, accuracy, and reproducibility of quantitative analysis of various samples containing animal, plant or human viruses using electron microscopy.…”
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The effect of AKT inhibition in α-synuclein-dependent neurodegeneration by Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Sokol V. Todi, Peter A. LeWitt, Peter A. LeWitt, Peter A. LeWitt, Wei-Ling Tsou

“…We observed that administration of the AKT inhibitor, A-443654 led to mild improvements in both survival and motor function in flies expressing human α-Syn. Genetic studies revealed that reduction of AKT levels decreased α-Syn protein levels, concomitant with improved physiological outcomes. …”
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Does welfare technology contribute to security, activity, participation and independence within municipal elder care? A qualitative study protocol by Ingrid Hellström, Johannes Österholm, Åsa Larsson Ranada, Katarina Baudin, Vedrana B Baric

“…As the ageing population continues to rise, the strain on welfare resources both, human and financial, intensifies. The adoption of WT holds promise for enhancing the well-being of older persons, their significant others, organisations and caregiving staff. …”
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Influence of time-of-day on neuromuscular performance in team sport athletes: a systematic review and meta-analysis by Julio Martin-López, Alberto Pérez-López, David Varillas-Delgado, Álvaro López-Samanes

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Forest Fire Risk Modeling Using Logistic Regression and Geographic Information Systems: A Case Study in Muğla - Milas by İlker Atmaca, Özge Işık Pekkan, Mehtap Özenen Kavlak, Yavuz Selim Tunca, Saye Nihan Çabuk

“…Forest fires are an important environmental problem, they negatively affect the entire ecosystem and human and animal life in it. In Turkey 192.734 hectares of forest area has been damaged in 46.669 forest fires in the last 20 years. …”
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Gap Junctions Are Involved in the Rescue of CFTR-Dependent Chloride Efflux by Amniotic Mesenchymal Stem Cells in Coculture with Cystic Fibrosis CFBE41o- Cells by Annalucia Carbone, Roberto Zefferino, Elisa Beccia, Valeria Casavola, Stefano Castellani, Sante Di Gioia, Valentina Giannone, Manuela Seia, Antonella Angiolillo, Carla Colombo, Maria Favia, Massimo Conese

“…We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial cells (CFBE41o- line, CFBE) on Transwell® filters acquired an epithelial phenotype and led to the expression of a mature and functional CFTR protein. …”
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…Tyrosine kinase inhibitors (TKIs) targeting ALK have improved disease outcomes, but resistance mechanisms are common. This first-in-human trial evaluates ESK-440, a dual inhibitor of ALK and focal adhesion kinase, as a novel strategy for cancers with resistance to ALK-targeting TKIs. …”
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Quality of Life as Medicine: A Pilot Studyof Patients with Chronic Illness and Pain by Soren Ventegodt, Joav Merrick, JØrgen Anderson

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Practical Calling Approach for Exome Array-Based Genome-Wide Association Studies in Korean Population by Tae-Joon Park, Lyong Heo, Sanghoon Moon, Young Jin Kim, Ji Hee Oh, Sohee Han, Bong-Jo Kim

“…To address these shortcomings, we present a practical approach for accurate genotype calling using the Illumina Infinium HumanExome BeadChip. We present comparison results and a statistical summary of our genotype data sets. …”
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重组人内皮抑素对胃肠间质瘤血管形成及生长的抑制作用

“…【目的】 研究重组人内皮抑素(recombinant human endostatin,rhES)能否抑制胃肠间质瘤(gastrointestinal stromal tumor,GIST)裸鼠移植肿瘤血管生成及生长,探讨抑制血管形成作为GIST治疗方法的可行性65377;【方法】 随机将20只荷瘤裸鼠分为实验组与对照组65377;对照组瘤周注射生理盐水,实验组瘤周注射rhES,连用10 d65377;自用药开始,每5 d测量肿瘤体积,直至用药结束后5 d65377;计算抑瘤率和肿瘤缩小率65377;比较实验组与对照组肿瘤体积65380;微血管密度(microvascular density,MVD)65380;bcl-2阳性表达率65380;凋亡指数(AI)及实验组治疗前后肿瘤体积差异是否具有显著性65377;【结果】 用药前实验组与对照组肿瘤体积无差别(P = 0.628)65377;用药后实验组肿瘤体积逐渐减小65377;用药结束后5 d,实验组肿瘤体积与用药前及对照组相比均明显缩小(P = 0.000),抑瘤率86.5%,肿瘤缩小率为55.5%65377;所有瘤株CD117均为阳性表达65377;实验组MVD低于对照组(P = 0.020)65377;实验组bcl-2阳性表达率均低于对照组(P = 0.023)65377;实验组AI高于对照组(P = 0.020)65377; 【结论】 rhES抑制GIST血管生成65380;促进肿瘤细胞凋亡及遏制肿瘤生长,有可能成为治疗GIST的有效方法之一65377;…”
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Music Drama as a Christian Parable: Mozart’s <i>Idomeneo</i> by Nils Holger Petersen

“…Mozart’s <i>Idomeneo</i> may work in a modern cultural context because it functions as a parable, easily understandable also in a modern political or social context, because of its deep human (psychological) insight and the empathy brought to bear on all the characters of the opera.…”
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Validation of a Finite Element Simulation for Predicting Individual Knee Joint Kinematics by Elin Theilen, Anna Rorich, Thomas Lange, Sebastian Bendak, Cora Huber, Hagen Schmal, Kaywan Izadpanah, Joachim Georgii

“…<italic>Methods:</italic> Our 3D FE modeling approach for individual human knee joints is based on segmentation of anatomical structures extracted from routine static magnetic resonance (MR) images. …”
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Knowledge, attitudes and practices of rural and suburban areas about brucellosis in Central Bosnia by Sabina Šečić-Selimović, Emsel Papić, Aida Katica, Mohammad Abou El Ardat, Zarema Obradović

“…In the period 2003-2012, 539 cases in humans and 7508 infected animals were registered. …”
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Impact of Gastrointestinal In Vitro Digestion and Deficit Irrigation on Antioxidant Activity and Phenolic Content Bioaccessibility of “Manzanilla” Table Olives by Lucía Sánchez-Rodríguez, Marina Cano-Lamadrid, Ángel A. Carbonell-Barrachina, Francisca Hernández, Esther Sendra

“…Approximately, 12% of the polyphenols of table olives were bioaccessible for human absorption. Saving water techniques influence neither the final polyphenol content and antioxidant potential of table olives nor the bioaccessibility of polyphenols. …”
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Benzo[1,2-b:6,5-b’]dithiophene-4,5-diamine: A New Fluorescent Probe for the High-Sensitivity and Real-Time Visual Monitoring of Phosgene by Yingzhen Zhang, Jun Xiao, Ruiying Peng, Xueliang Feng, Haimei Mao, Kunming Liu, Zhenzhong Liu, Chunxin Ma

“…The detection of highly toxic chemicals such as phosgene is crucial for addressing the severe threats to human health and public safety posed by terrorist attacks and industrial mishaps. …”
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Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells. by Raven M Osborn, Justin Leach, Michelle Zanche, John M Ashton, ChinYi Chu, Juilee Thakar, Stephen Dewhurst, Sonia Rosenberger, Martin Pavelka, Gloria S Pryhuber, Thomas J Mariani, Christopher S Anderson

“…We then tested the dissociation and methanol-acetone inactivation method on primary human lung epithelial cells that had been differentiated on an air-liquid interface. …”
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Community-based culturally tailored education programmes for black adults with cardiovascular disease, diabetes, hypertension and stroke: a systematic review protocol of primary em... by Hardeep Singh, Michelle LA Nelson, Joseph IV Fulton, Oya Pakkal, Elizabeth M Uleryk

“…The aggregated data will be presented through textual descriptions of programme characteristics and outcomes.Ethics and dissemination This systematic review protocol does not require ethics approval without the inclusion of human participants and will use studies that have previously obtained informed consent. …”
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Research and Discussion on the Relationships between Noise-Induced Hearing Loss and ATP2B2 Gene Polymorphism by Suhao Zhang, Enmin Ding, Haoyang Yin, Hengdong Zhang, Baoli Zhu

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Insights into the transmission cycle of cutaneous leishmaniasis from an endemic community in rural Guatemala by Yaimie Lopez, Aitor Casas-Sanchez, Byron Arana, Nidia Rizzo, Erick Duran, Norma Padilla, Andrea de la Vega, Esteban Bustamante, Álvaro Acosta-Serrano, Renata Mendizabal-Cabrera

“…Blood-meal analysis revealed human and pig blood in engorged Ny. ylephiletor collected inside and in the proximity of the households. …”
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In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis by Georgi Momekov, Dilyan Ferdinandov, Spiro Konstantinov, Sonja Arpadjan, Daniela Tsekova, Galina Gencheva, Panayot R. Bontchev, Margarita Karaivanova

“…A comparative assessment of both agents against the human kidney cell line 293T has shown that [Au(II)Hp-2H.…”
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