Differences in Transcriptional Activation by the Two Allelic (L162V Polymorphic) Variants of PPARα after Omega-3 Fatty Acids Treatment by Iwona Rudkowska, Mélanie Verreault, Olivier Barbier, Marie-Claude Vohl

“…To examine the functional difference of the two allelic variants on receptor activity, transient co-transfections were performed in human hepatoma HepG2 cells activated with EPA, DHA and EPA:DHA mixtures. …”
Get full text

Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer by Mikito Inokuchi, Yoshitaka Fujimori, Sho Otsuki, Yuya Sato, Masatoshi Nakagawa, Kazuyuki Kojima

“…Many molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed, and monoclonal antibodies targeting human epidermal growth factor receptor 2 (HER2) have become standard therapy for HER2-positive GC. …”
Get full text

Community stakeholder perspectives for empowering EJ initiatives through Public Participation Geographic Information Systems (PPGIS) by Jacelyn Rice-Boayue, Laurie Garo, Elisabeth Ilboudo Nebie

Get full text

Assessment of Nitrogen Ceilings for Dutch Agricultural Soils to Avoid Adverse Environmental Impacts by Wim de Vries, Hans Kros, Oene Oenema, Jan Willem Erisman

“…This leads to a series of environmental impacts, including: (1) nitrate (NO3) contamination of drinking water, (2) eutrophication of freshwater lakes, (3) acidification and biodiversity impacts on terrestrial ecosystems, (4) ozone and particle formation affecting human health, and (5) global climate change induced by emissions of N2O. …”
Get full text

The Unignorable Near-ground PM2.5, UFP, PAHs, and BC Levels around a Traffic Prohibited Night Market by Sheng-Lun Lin, Hongjie Zhang, Ming-Yeng Lin, Shih-Wei Huang

“…Abstract In some special densely populated areas, the background atmospheric fine particulate matter (PM2.5) concentration is very high, which makes near-ground (NG) exposure a major problem endangering human health. In our study, the night market in Chiayi City was selected as the research object and collected the 24-hour PM2.5 samples through the federal reference method (FRM), characterizing the mass concentration, water-soluble ionic components, carbon specious, metal compositions and source contributions of PM2.5. …”
Get full text

Sheikh al-Qaraḍāwī’s Independent Reasoning (Ijtihād) in Reformulating Contemporary Islamic Criminal Jurisprudence within the Framework of the Modern State by Gaber Mohamed

“…He believes that Islamic punitive measures primarily aim at promoting values and upholding human rights principles without discrimination based on religion, race, colour, or gender. …”
Get full text

Geospatial clustering and correlates of deaths during the Ebola outbreak in Liberia: a Bayesian geoadditive semiparametric analysis of nationally representative cross-sectional sur... by Fiifi Amoako Johnson, Barbara Sakyi

“…The community-level development indicators (global human footprint, gross cell production and population density) had a non-linear associative effect with the observed spatial clustering. …”
Get full text

In Vitro Characterization of Multilamellar Fibers with Uniaxially Oriented Electrospun Type I Collagen Scaffolds by Alireza Hooshmand-Ardakani, Tahereh Talaei-Khozani, Mehdi Sadat-Shojai, Soghra Bahmanpour, Nehleh Zarei-fard

“…In vitro cell culture, using human adipose tissue-derived mesenchymal stem cells (hAT-MSCs) on cross-linked scaffold, showed improvement in cell proliferation, attachment, migration, and intercellular junction with a flattened morphology. …”
Get full text

Subseasonal Prediction of Heat‐Related Mortality in Switzerland by Maria Pyrina, Ana M. Vicedo‐Cabrera, Dominik Büeler, Sidharth Sivaraj, Christoph Spirig, Daniela I. V. Domeisen

“…Abstract Heatwaves pose a range of severe impacts on human health, including an increase in premature mortality. …”
Get full text

GWAS of a soybean breeding collection from South East and South Kazakhstan for resistance to fungal diseases by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, Y. Turuspekov

“…In Kazakhstan the area under soybean is increasing every year, helping to solve the problem of protein deficiency in human nutrition and animal feeding. One of the main problems of soybean production is fungal diseases causing yields losses of up to 30 %. …”
Get full text

Peripheral Blood Derived Mononuclear Cells Enhance the Migration and Chondrogenic Differentiation of Multipotent Mesenchymal Stromal Cells by Niina Hopper, John Wardale, Daniel Howard, Roger Brooks, Neil Rushton, Frances Henson

“…The aim of this study was to evaluate the effect of peripheral blood derived mononuclear cell (PBMC) stimulation on mesenchymal stromal cells (MSCs) derived from the infrapatellar fat pad of human OA knee. Cell migration was measured using an xCELLigence electronic migration chamber system in combination with scratch assays. …”
Get full text

The world’s most venomous spider is a species complex: systematics of the Sydney funnel-web spider (Atracidae: Atrax robustus) by Stephanie F. Loria, Svea-Celina Frank, Nadine Dupérré, Helen M. Smith, Braxton Jones, Bruno A. Buzatto, Danilo Harms

“…Pickard-Cambridge, 1877 is an iconic Australian species and considered among the most dangerously venomous spiders for humans. Originally described in 1877 from a single specimen collected in “New Holland”, this spider has a complex taxonomic history. …”
Get full text

Mannitol and the blood-labyrinth barrier by Trung N. Le, Brian W. Blakley

“…Methods Permeability of the BLB and the blood brain barrier (BBB) to gentamicin with and without mannitol was studied by collecting 175 samples from 44 guinea pigs using concentrations relevant to human clinical situations. Samples were taken from two groups of 22 animals, with each animal undergoing sampling at a different time after administration of either 10 mg/ml gentamicin (4 mg/kg) (Gardena, CA) alone or gentamicin with 20% mannitol (250 mg/kg) (Mallinckrodt Inc., KY). …”
Get full text

Gaps in Capacity in Primary Care in Low-Resource Settings for Implementation of Essential Noncommunicable Disease Interventions by S. Mendis, Igbal Al Bashir, Lanka Dissanayake, Cherian Varghese, Ibtihal Fadhil, Esha Marhe, Boureima Sambo, Firdosi Mehta, Hind Elsayad, Idrisa Sow, Maltie Algoe, Herbert Tennakoon, Lai Die Truong, Le Thi Tuyet Lan, Dismond Huiuinato, Neelamni Hewageegana, Naiema A. W. Fahal, Goitom Mebrhatu, Gado Tshering, Oleg Chestnov

“…The survey included questions on the availability of human resources, equipment, infrastructure, medicines, utilization of services, financing, medical information, and referral systems. …”
Get full text

Essential Role of Thioredoxin 2 in Mitigating Oxidative Stress in Retinal Epithelial Cells by Eriko Sugano, Namie Murayama, Maki Takahashi, Kitako Tabata, Makoto Tamai, Hiroshi Tomita

“…In the present study, oxidative stress was induced in the human RPE cell line (ARPE-19) using 4-hydroxynonenal (4-HNE) or C2-ceramide. …”
Get full text

Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review by Rahul G. Matnani, Rachel L. Stewart, Joseph Pulliam, Chester D. Jennings, Melissa Kesler

“…The neoplastic cells were negative for Epstein-Barr virus (EBV) or Human Herpes Virus 8 (HHV-8). At the time of diagnosis, the PET scan demonstrated hypermetabolic neoplastic cells involving the left axilla, bilateral internal jugular areas, mediastinum, right hilum, bilateral lungs, and spleen. …”
Get full text

Team Assembly Mechanisms and the Knowledge Produced in the Mexico’s National Institute of Geriatrics: A Network Analysis and Agent-Based Modeling Approach by Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Augusto Cabrera-Becerril, David Fajardo-Ortiz

“…Mexico’s National Institute of Geriatrics (INGER) is the national research center of reference for matters related to human aging. INGER scientists perform basic, clinical, and demographic research which may imply different scientific cultures working together in the same specialized institution. …”
Get full text

The effectiveness of community-wide screening for pulmonary tuberculosis: a systematic review by Susanna S. van Wyk, Ntombifuthi Blose, Lester Kapanda-Phiri, Mareli Claassens, Taryn Young

Get full text

VisGraphVar: A benchmark generator for Assessing Variability in Graph Analysis Using Large Vision-Language Models by Camilo Chacon Sartori, Christian Blum, Filippo Bistaffa

“…Geometric structures, particularly graphs with their inherent flexibility and complexity, serve as an excellent benchmark for evaluating these models’ predictive capabilities. While human observers can readily identify subtle visual details and perform accurate analyses, our investigation reveals that state-of-the-art LVLMs exhibit consistent limitations in specific visual graph scenarios, especially when confronted with stylistic variations. …”
Get full text

Causes of the exceptionally high number of fatalities in the Ahr valley, Germany, during the 2021 flood by B. Rhein, B. Rhein, H. Kreibich

“…Specific recommendations for disaster management are (1) that in the event of such extreme flash floods, the warning messages must focus on saving human lives – i.e. those at risk must be advised to move to safe places, e.g. to the upper floors, instead of trying to save belongings – and (2) evacuations must be initiated in good time, especially where flooding of the ground floor with high water levels is to be expected, paying particular attention to the safety of the elderly and people with limited mobility.…”
Get full text