Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…Patients with obesity and low hepatic PTPRD expression exhibit increased levels of metabolic risk factors.Conclusion Our data revealed an important regulatory role of the hepatic PTPRD-STAT3 axis in maintaining glucose/lipid homeostasis, which is recapitulated in clinical manifestations of metabolic liver disease.…”
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Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer by Eeshrita Jog, Ashwin Kumar Jainarayanan, Alessandro La Ferlita, Arnab Chakraborty, Afiya Dalwai, Showket Yahya, Anusha Shivashankar, Bhagya Shree Choudhary, Aakash Chandramouli, Mufaddal Kazi, Darshan Jain, Nileema Khapare, Akshaya B, Bushra K. Khan, Poonam Gera, Prachi Patil, Rahul Thorat, Nandini Verma, Lalit Sehgal, Avanish Saklani, Siddhesh S. Kamat, Sorab N. Dalal, Nazia Chaudhary

“…Blocking the conversion of free fatty acids into LDs by treatment with statins or inhibiting lipin1 expression disrupts lipid homeostasis, leading to lipotoxicity and ferroptotic cell death in both DTPs and patient-derived organoids (PDOs) in vitro. …”
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Exploring the potential of an oyster (Saccostrea mordax) in oligotrophic seas: Effects of starvation on physiological and molecular regulation by Shuming Guo, Liqiang Zhao, Yuexin Zhao, Zohaib Noor, Xiaogang Yang, Shiwei Fu, Zhen Zhao, Weitao Wan, Jinkuan Wei, Yanping Qin, Haitao Ma, Ziniu Yu, Jun Li, Yuehuan Zhang

“…Moreover, the down-regulation of the expression of immune-related genes, such as the IAP gene family, MYD88, and CDC42, indicated that the homeostasis between apoptosis and cell proliferation was disrupted, which was in agreement with the results of sections with the enlarged lumen of the digestive gland and apoptosis of digestive cells. …”
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Specific Antibody Production by Blood B Cells is Retained in Late Stage Drug-naïve HIV-infected Africans by Lydie Béniguel, Evelyne Bégaud, Fabrice Cognasse, Philippe Gabrié, Christophe D. Mbolidi, Mary A. Marovich, Céline Cazorla, Frédéric Lucht, Christian Genin, Olivier Garraud

“…This suggests that the in vitro antibody production by drug-naïve individuals' PBMCs resulted from the maturation of already envelope and core antigen-primed, differentiated B cells, presumably pre-plasma cells, which are not known to circulate at homeostasy. As in vitro produced Abs retained the capacity of binding antigen and forming complexes, this study provides pre-clinical support for functional humoral responses despite major HIV- and other tropical pathogen-induced B cell perturbations.…”
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