A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases by Claudia-Andreea Moldoveanu, Maria Tomoaia-Cotisel, Alexandra Sevastre-Berghian, Gheorghe Tomoaia, Aurora Mocanu, Csaba Pal-Racz, Vlad-Alexandru Toma, Ioana Roman, Madalina-Anca Ujica, Lucian-Cristian Pop

“…In summary, this review provides a comprehensive overview of molecular pathways involved in interactions of curcumin and its metabolites, and brain vascular homeostasis. This review explores cellular and molecular current aspects, of curcumin-based effects with an emphasis on curcumin’s metabolism and its impact on pathological conditions, such as neurodegenerative diseases, schizophrenia, and cerebral angiopathy. …”
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Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male by Silvia Migliaccio, Davide Francomano, Roberto Bruzziches, Emanuela A. Greco, Rachele Fornari, Lorenzo M. Donini, Andrea Lenzi, Antonio Aversa

“…Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis model assessment of insulin resistance (HOMA-IR), and body composition in 86 obese (mean BMI = 34) male subjects (18–69 yr old). …”
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Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency by Yunting Zhou, Junming Zhou, Yumin Zhang, Jun Tang, Bo Sun, Wei Xu, Xiaohang Wang, Yang Chen, Zilin Sun

“…Here, we explored whether and how intestinal microbiota affects glucose homeostasis in VA-deficient diet-fed mice. Methods. …”
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Efficacy of myrrh extract against Eimeria labbeana-like experimental infection in Columba livia domestica: in vivo study by Shurug Albasyouni, Afra Alharbi, Esam Al-Shaebi, Saleh Al Quraishy, Rewaida Abdel-Gaber

“…MyE facilitates the disruption of intestinal homeostasis caused by E. labbeana-like infection, specifically concerning carbohydrates and proteins. …”
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Lipid analysis of tear fluid as a diagnostic tool for meibomian gland dysfunction by L.R. Takhauova, A.A. Guseva, A.A. Krylova, O.I. Krivosheina

“…Krivosheina¹ </p> <p> ¹Siberian State Medical University, Tomsk, Russian Federation </p> <p> ²Seversk Biophysical Scientific Center of the Federal Medical Biological Agency of Russia, &nbsp;&nbsp;Seversk, Russian Federation </p> <p> The tear film lipid layer plays a crucial role in maintaining ocular surface homeostasis by preventing excessive evaporation of the aqueous layer and reducing heat transfer from the corneal and conjunctival surface. …”
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Dietary secoisolariciresinol diglucoside ameliorates high-fat diet-induced atherosclerosis via regulating immunological inflammation and reshaping gut microbiota in ApoE-/- mice by Yiwei Li, Jing Wang, Jian Liu, Ting Wang, Yuanyuan Liu, Yajuan Liu, Li Guo, Zhixia Bai, Wenke Shen, Ru Yan, Huiyan Ma, Juan Liu, Hao Wang, Xiaoxia Zhang

“…Collectively, dietary SDG ameliorates HFD-induced AS mice via suppressing inflammation and reshaping gut homeostasis.…”
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Lactobacillus plantarum J26 alleviates alcohol-induced oxidative liver injury by regulating the Nrf2 signaling pathway by Hongxuan Li, Shasha Cheng, Yuhong Wang, Yilin Sun, Jiaxin Zhang, Mingshuang Sun, Chaoxin Man, Yu Zhang, Yujun Jiang

“…In addition, pre-intake L. plantarum J26 can improve the level of short-chain fatty acids (SCFAs) in the intestines in mice, short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2 (Nrf2) signaling pathway to alleviate liver oxidative stress, and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy, thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.…”
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Effects of hypoxia on the heart of the juvenile four-finger threadfin (Eleutheronema tetradactylum) based on physiological indicators and transcriptome analysis by Yi Lu, Eric Amenyogbe, Ye- Yang, Zhong-liang Wang, Zhong-liang Wang, Zhong-liang Wang, Jing-hui Jin, Rui-tao Xie, Eric Kwabena Droepenu, Jian-sheng Huang, Jian-sheng Huang, Jian-sheng Huang

“…HIF-1 signaling regulates oxygen homeostasis, with HIF-1α stabilizing hypoxia-responsive genes such as VEGFA, which promotes vascular remodeling and enhances oxygen delivery. …”
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The molecular mechanism by which heat stress during the grain filling period inhibits maize grain filling and reduces yield by Xiaohu Li, Shilin Zhuge, Jiyuan Du, Peng Zhang, Xingyu Wang, Tianjian Liu, Donghui Li, Haoran Ma, Xinzheng Li, Yongxin Nie, Changjian Liao, Haiping Ding, Zhiming Zhang

“…Transcriptome analysis showed that heat stress disrupted starch biosynthesis and hormonal homeostasis, notably affecting abscisic acid and auxin pathways. …”
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Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma by Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu, Ying Wang

“…Further studies confirmed that thiotert effectively disrupts cellular redox homeostasis, as evidenced by elevated intracellular reactive oxygen species (ROS) levels, increased MnSOD, accelerated DNA impairment, and activated apoptosis signal. …”
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A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy by Ling Wang, Yuzhong Zhang, Shenglin Geng, Lan Ma, Yiran Wang, Dongxu Han, Guojuan Fan, Weifen Zhang, Weifen Zhang, Weifen Zhang, Yanna Lv, Jinlong Ma, Jinlong Ma, Jinlong Ma

“…Importantly, it resulted in improved skin lesion scores, scratching behavior, eosinophil infiltration, swelling and inflammation levels, immune homeostasis, and histopathological changes in rats with acute eczema. …”
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SLC22A1 rs622342 Polymorphism Predicts Insulin Resistance Improvement in Patients with Type 2 Diabetes Mellitus Treated with Metformin: A Cross-Sectional Study by Kunrong Wu, Xiaoli Li, Yuedong Xu, Xiaoqian Zhang, Ziwan Guan, Shufang Zhang, Yan Li

“…The homeostatic indexes of IR (HOMA-IR) and beta-cell function (HOMA-BCF) were determined according to the homeostasis model assessment. Results. Fasting plasma glucose (FPG) levels, HbA1c levels, and HOMA-IR were significantly higher in patients with the rs622342 AA genotype than in those with C allele (P<0.05). …”
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The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights by Zhuo Huang, Zhuo Huang, Qinyan Yao, Qinyan Yao, Shuang Ma, Shuang Ma, Jinjie Zhou, Jinjie Zhou, Xiaoxuan Wang, Xiaoxuan Wang, Qingguo Meng, Qingguo Meng, Yaxin Liu, Yaxin Liu, Zihan Yu, Zihan Yu, Xin Chen, Xin Chen

“…The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and metabolic homeostasis. Recent research highlights the intricate interactions between gut microbiota and RNA, especially non-coding RNAs, in regulating metabolic processes. …”
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Diagnosis and Treatment of Sepsis in a Fourteen-year-old Patient: A case study of pulmonary inflammatory discharge without typical features of respiratory tract infection by Bartłomiej Żaczek, Jakub Kozłowski, Alicja Kamińska, Wojciech Kupczak, Kinga Bujak, Aleksandra Kocjan, Ismael Alsoubie, Natalie Papachristoforou, Wojciech Kaźmierski, Mateusz Ziomek, Paulina Lis, Marta Czubaj-Kowal

“…Sepsis is a set of symptoms caused by the body’s uncontrolled inflammatory response to infection, leading to damage to more than one organ and homeostasis disorders. Symptoms of sepsis in children may be non-specific, making it difficult to diagnose quickly and effectively. …”
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Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging by Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C. Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong, Jie Zhuang, Xinglu Huang

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Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology by Xin Chen, Xing Ji, Zhaobai Lao, Bin Pan, Yu Qian, Wanlei Yang

“…Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), key regulators of bone homeostasis, are instrumental in this process. Emerging research highlights bone cells' ability to sense various mechanical stimuli and relay these signals intracellularly. …”
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The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats by T.A. Voroshylova, V.I. Shepitko, Ye.V. Stetsuk, N.V. Boruta, O.V. Vilkhova, M.V. Rud, G.S. Puzyryov, O.V. Sych, А.A. Miahkokhlib

“…Testosterone plays an important role in the intracellular homeostasis of the heart. Quercetin is an organic substance belonging to the flavonoid family with a wide range of medicinal properties. …”
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Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis by Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng

“…Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator with emerging beneficial roles in lipid homeostasis. We investigated the impact of FGF21 in experimental colitis-induced epididymal white adipose tissue (eWAT) lipolysis. …”
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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases by Li Zhu, Yong-Ping Liu, Yuan-Wang, Bo-Xuan Sun, Yu-Ting Huang, Ji-Kai Zhao, Jian-Feng Liu, Li-Ming Yu, Hui-Shan Wang

“…Numerous studies conducted in recent years indicate that mammalian E3 ubiquitin ligases serve as key regulators in the maintenance of cellular homeostasis by targeting the ubiquitination of substrate proteins and activating downstream signaling pathways. …”
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The Aryl Hydrocarbon Receptor (AhR) Is a Novel Gene Involved in Proper Physiological Functions of Pancreatic β-Cells by Shuhd Bin Eshaq, Jalal Taneera, Shabana Anjum, Abdul Khader Mohammed, Mohammad H. Semreen, Karem H. Alzoubi, Mohamed Eladl, Yasser Bustanji, Eman Abu-Gharbieh, Waseem El-Huneidi

“…The Kynurenine pathway is crucial in metabolizing dietary tryptophan into bioactive compounds known as kynurenines, which have been linked to glucose homeostasis. The aryl hydrocarbon receptor (AhR) has recently emerged as the endogenous receptor for the kynurenine metabolite, kynurenic acid (KYNA). …”
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