The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer by Runzhi Huang, Jiaqi Zhang, Mingxiao Li, Penghui Yan, Huabin Yin, Suna Zhai, Xiaolong Zhu, Peng Hu, Jiaxin Zhang, Ling Huang, Man Li, Zehui Sun, Tong Meng, Daoke Yang, Zongqiang Huang

“…The functions of the PPAR family (PPARA, PPARD, and PPARG) and their coactivators (PPARGC1A and PPARGC1B) in maintenance of lipid and glucose homeostasis have been unveiled. However, the roles of PPARs in cancer development remain elusive. …”
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Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion by Lu Wang, Jia-Qi Ma, Li-Jia Song, Xiao-Peng Qu, Yue Zhang, Hai-Ming Fan, Chao Wang, Long-Long Zheng, Guo-Dong Gao, Yan Qu, Liang-Liang Shen, Bei Liu

“…Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis of the internal environment in patients with chronic diseases. …”
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Gut microbiota remodeling drived by dietary millet protein prevents the metabolic syndrome by Shuhua Shan, Ruopeng Yin, Jiangying Shi, Lizhen Zhang, Jiaqi Zhou, Qinqin Qiao, Xiushan Dong, Wenjing Zhao, Zhuoyu Li

“…Metabolic syndrome (MetS) is a chronic disease associated with the disturbance of gut microbiota homeostasis. Metabolites derived from gut microbes play essential roles in MetS prevention and therapy. …”
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Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration by Yu Wang, Shanshan Jin, Yaru Guo, Yilong Lu, Xuliang Deng

“…Altogether, our study indicated that the multi-pronged approach is promising to promote the periodontal bone regeneration in periodontitis condition by reducing the inflammation-induced stem cell senescence and maintaining bone homeostasis.…”
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Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation by Paraskevas Zampas, Zhen Li, Antonia Katsouda, Aimilia Varela, Stelios Psarras, Constantinos H. Davos, David J. Lefer, Andreas Papapetropoulos

“…Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that occur concurrently and increase the risk of cardiovascular disease. 3-mercaptopyruvate sulfurtransferase (MPST) is a cysteine-catabolizing enzyme that yields pyruvate and hydrogen sulfide (H2S) and plays a central role in the regulation of energy homeostasis. Herein, we seek to investigate the role of MPST/H2S in MetS and its cardiovascular consequences using a mouse model of the disease. …”
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Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systematic review and meta-analysis by Idrees A. Shah, Rabiya Rashid, Haroon Rashid, Abid Bhat, Mohd Ashraf Ganie

“…The expression and hepatic clearance of insulin and subsequent glucose homeostasis are mediated by TCF7L2 via Wnt signaling. …”
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Metabolic phenotype of adult mice offspring obtained from different variants of embryo transfer by M. V. Anisimova, Ya. Gong, N. S. Yudin, Yu. M. Moshkin, L. A. Gerlinskaya

“…Stable deviations of body compositions and glucose homeostasis indices detected in experimental groups of progenies indicate the phenotypic significance of the embryo transplantations per se.…”
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Oxidative stress caused by 3-monochloro-1,2-propanediol provokes intestinal stem cell hyperproliferation and the protective role of quercetin by Zongzhong Liu, Yanfei He, Yuhan Wang, Kefeng Ren, Pengpeng Xia, Binbin Xie, Tian Wei

“…Our findings uncover a mechanism whereby suppression of undesirable ISC hyperproliferation, caused by 3-MCPD-induced oxidative stress, maintains intestinal homeostasis, and provide a theoretical basis for exploiting quercetin, a natural antioxidant, as a dietary antidote against the intestinal hazards posed by environmental toxicants.…”
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Insight into the role of antioxidant in microbial lignin degradation: Ascorbic acid as a fortifier of lignin-degrading enzymes by Aipeng Li, Weimin Wang, Shuqi Guo, Changzhi Li, Xinying Wang, Qiang Fei

“…Antioxidants are crucial for maintaining redox homeostasis in living cells, which can impact the efficiency of enzymes. …”
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Metagenomic analysis of gut microbiota diversity in poultry before and after antibiotic administration by O. V. Prasolova, N. I. Malik, I. A. Timofeeva, N. A. Kirsanova, E. V. Krylova, E. V. Malik, I. A. Rusanov, N. A. Chupakhina

“…The diversity of gut microbiota is an important ecological resource that plays a key role in maintenance of the host homeostasis. It is extremely important to preserve the existing gut microbiota diversity, which ensures its resistance to the negative effects of abiotic factors, while the study of the antibiotic role in the disturbance of microbiota diversity is a fundamental basis used not only to identify aspects responsible for microbiota-associated poultry diseases, but also to learn techniques of microbiota management. …”
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Autophagy-Enhancing Properties of <i>Hedyotis diffusa</i> Extracts in HaCaT Keratinocytes: Potential as an Anti-Photoaging Cosmetic Ingredient by Qiwen Zheng, Xiangji Jin, Trang Thi Minh Nguyen, Eun-Ji Yi, Se-Jig Park, Gyeong-Seon Yi, Su-Jin Yang, Tae-Hoo Yi

“…The decline in autophagy disrupts homeostasis in skin cells, leading to oxidative stress, energy deficiency, and inflammation—all key contributors to skin photoaging. …”
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Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity by Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu, Jianqing Wu

“…Mechanically, ex vivo human and mouse Treg cell data and in vivo mouse tumor models suggest that SOAT2 overexpression in Treg cells promotes cholesterol metabolism by activating the SREBP2-HMGCR-GGPP pathway, leading to enhanced Treg suppresser functions but reduced CD8+ T cell proliferation, migration, homeostasis and anti-tumor immunity. Our study thus identifies a potential mechanism responsible for altered Treg function in the context of immune aging, and also implicates SOAT2 as a potential target for tumor immunotherapy.…”
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Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPARα by Sujuan Xu, Edward Lee, Zhaoxing Sun, Xiaoyan Wang, Ting Ren, Zhouping Zou, Jifu Jin, Jie Li, Jian Zhang, Yingxiang Li, Qiang Yang, Yang Zhang, Man Guo, Yi Fang, Xiaoqiang Ding

“…Renal proximal tubular cells are susceptible to oxidative stress, and the dysregulation of renal proximal tubular cellular homeostasis can damage cells via apoptotic pathways. …”
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Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition by Shuangqian Yan, Panpan Xue, Ying Sun, Tingjie Bai, Sijie Shao, Xuemei Zeng

“…Transcriptomic analysis validates Cu‐HPB/C's impact on cholesterol homeostasis and reveals cell death mechanisms including oxidative stress, ferroptosis, cuproptosis, and apoptosis. …”
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Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy by Yuan Lin, Ye-cheng Xiao, Hong Zhu, Qing-yan Xu, Lei Qi, Yu-bin Wang, Xiu-juan Li, Ma-li Zheng, Rui-sheng Zhong, Yi Zhang, Xiang-dong Xu, Bo-le Wu, Zhu-mei Xu, Xiang-hong Lu

“…In the patient group there was a significant positive correlation between FGF21, insulin level, and homeostasis model assessment index. Serum FGF21 concentrations in patients with proliferative diabetic retinopathy or nonproliferative diabetic retinopathy were significantly higher than those in patients without diabetic retinopathy. …”
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Butyric Acid Modulates Gut Microbiota to Alleviate Inflammation and Secondary Bone Loss in Ankylosing Spondylitis by Ke You, Lianjun Yang, Zhihai Su, Jun Shen, Xinyang Fan, Yuanqing Guo, Zhen Yuan, Hai Lu

“…<b>Conclusions:</b> These beneficial effects were attributed to the modulation of gut microbiota, anti-inflammatory properties, and the maintenance of skeletal metabolic homeostasis. This study contributes new evidence supporting the relationship between gut microbiota and bone health.…”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Results: GIP108 treatment led to weight loss and improved glucose homeostasis in mice. Prolonged exposure to GIPR agonists produced homologous functional GIPR desensitisation in isolated islets. …”
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Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients at... by Samik Pramanik, Jimmy Barua, Lokanathan V, Sharmistha Roy

“…There was a significant association between BMI, insulin resistance measured by homeostasis model assessment-estimated insulin resistance (HOMA-IR), and grade of fatty liver of the patients (P<0.0001). …”
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Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21 by Sora Han, Jong Dai Kim, Sunyi Lee, Ae Lee Jeong, Jeong Su Park, Hyo Jeong Yong, Ariundavaa Boldbaatar, Hye In Ka, Eun-Jung Rhee, Won-Young Lee, Young Yang

“…CTRP1 was correlated with homeostasis model assessment-β (HOMA-β), but no correlation was observed with HOMA-insulin resistance. …”
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A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes by Elizabeth Rendina-Ruedy, Kelsey D. Hembree, Angela Sasaki, McKale R. Davis, Stan A. Lightfoot, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith

“…The C57BL/6 mouse model of diet-induced obesity has been used to study the mechanisms by which altered glucose homeostasis affects bone mass and quality, but genetic variations in substrains of C57BL/6 may have confounded data interpretation. …”
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