Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo by Wei Li, Haihong Chen, Hongliang Chen, Ziyin Li, Wei Hu, Qinxuan Zhou, Bing Xu, Yi Wang, Xinhui Xing

“…Intriguingly, ADBP restored the gut microbiome homeostasis in CKD mice, especially with respect to the elevated helpful microbial abundance, and the decreased harmful bacterial abundance. …”
Get full text

Nanofertilizers benefited maize to cope oxidative stress under saline environment by Abbas Shoukat, Zulfiqar Ahmad Saqib, Allah Nawaz, Kashif Zulfiqar Amir, Ilyas Ahmad, Ali Hamza, Karl Hermann Mühling

“…Higher proline content, proteins, relative water and chlorophyll content in plants treated with nano fertilizers demonstrated improved osmoregulation, metabolic homeostasis as well as maintaining water balance and photosynthetic efficiency under stress conditions. …”
Get full text

SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer by Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

“…Abstract Background SLC7A11 is importantly in both ferroptosis and disulfidptosis which participated in human development and homeostasis. By utilizing bioinformatics and in vitro validation, we explored SLC7A11's role in cervical cancer. …”
Get full text

Iron Reduces M1 Macrophage Polarization in RAW264.7 Macrophages Associated with Inhibition of STAT1 by Zhen-Shun Gan, Qian-Qian Wang, Jia-Hui Li, Xu-Liang Wang, Yi-Zhen Wang, Hua-Hua Du

“…Firstly, we characterized the transcription of genes related to iron homeostasis in M1 RAW264.7 macrophages stimulated by IFN-γ. …”
Get full text

Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality by Trevor Simard, Richard G. Jung, Pouya Motazedian, Pietro Di Santo, F. Daniel Ramirez, Juan J. Russo, Alisha Labinaz, Altayyeb Yousef, Brijesh Anantharam, Ali Pourdjabbar, Benjamin Hibbert

“…Among recent promising discoveries, endothelial progenitor cells (EPCs) have garnered considerable interest given an increasing appreciation of their role in vascular homeostasis and their ability to promote vascular repair after stent placement. …”
Get full text

Relevance of Plasma Obestatin and Early Arteriosclerosis in Patients with Type 2 Diabetes Mellitus by Peng-ying Gu, Dong-mei Kang, Wei-dong Wang, Yan Chen, Zhi-hong Zhao, Hui Zheng, Shan-dong Ye

“…We found that higher levels of fasting insulin (Fins), fasting blood glucose, 2 h OGTT glucose, homeostasis model assessment of insulin resistance (HOMA-IR), low density lipoprotein cholesterol, glycated haemoglobin, and C-reactive protein (CRP), as well as lower obestatin level and higher intima-media thickness level (IMT), existed in T2DM group compared with NGT group and IGT group (P<0.01). …”
Get full text

The myometrial transcriptome changes in mares with endometrosis by Ewa Monika Drzewiecka, Tomasz Molcan, Agnieszka Sadowska, Katarzyna Piotrowska-Tomala, Magda Słyszewska, Graça Ferreira Dias, Dariusz Jan Skarżyński, Anna Szóstek-Mioduchowska

“…Evaluated deTARs enriched several KEGG pathways including calcium signaling, cAMP signaling, oxytocin signaling, ECM-receptor interaction, and focal adhesion, and were classified into various GO terms including adaptive immune response, tissue homeostasis, muscle contractions, muscle development, and other. …”
Get full text

Protocol for predicting host-microbe interactions and their downstream effect on host cells using MicrobioLink by Lejla Gul, Anna Julia Elias, Tanvi Tambaku, Marton Olbei, Emily Watters, Balazs Bohar, Dezso Modos, Matthew Madgwick, Tamas Korcsmaros

“…Summary: Analyzing host-microbe interactions is essential for understanding how microbiota changes disrupt host homeostasis. Here, we present a protocol for predicting host-microbe protein-protein interactions and their downstream effects using MicrobioLink. …”
Get full text

Paracetamol metabolism by endothelial cells – Potential mechanism underlying intravenous paracetamol-induced hypotension by Johs Dannesboe, Joakim A. Bastrup, Kathrine Holm Nielsen, Pelle Munck, Morten B. Thomsen, Clare L. Hawkins, Thomas A. Jepps

“…Proteomic analysis of HCAECs exposed to APAP showed upregulation of CYP20A1, together with proteins involved in the pentose phosphate pathway and maintaining redox homeostasis. Proteomic analyses of mesenteric arteries from rats administered intravenous APAP are consistent with a key role of the vascular wall in APAP metabolism, with similar proteomic pathway changes identified in HCAECs. …”
Get full text

Nanomolar detection of essential amino acid in dairy products using a novel electrochemical sensor based on zinc cobaltite nanoflowers embedded porous 3D reduced graphene oxide by Neethu Sebastian, Wan-Chin Yu, Deepak Balram, Ashish Patel, Deepak Kumar, Virendra Kumar Yadav

“…L-tryptophan (L-Trp) is a vital amino acid that sways neuronal function, immunity, and gut homeostasis, and its accurate detection in food samples is crucial. …”
Get full text

Efficacy of Manual Hemostasis for Percutaneous Axillary Artery Intra-Aortic Balloon Pump Removal by Rajiv Tayal, Michael DiVita, Christoph W. Sossou, Alexis K. Okoh, Kelly Stelling, James M. McCabe, Amir Kaki, Najam Wasty, David A. Baran

“…Results. 29 of 46 patients (63%) achieved axillary artery homeostasis via manual compression. The median duration of IABP implantation was 12 days (range 1–54 days). …”
Get full text

Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease by Megan C. Bakeberg, Maddeson Riley, Michelle Byrnes, Alexa Jefferson, Souyma Ghosh, Malcom K. Horne, Sarah McGregor, Rick Stell, Sue Walters, Tess Evans, Katherine Roberts, Frank L. Mastaglia, Ryan S. Anderton

“…To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP. …”
Get full text

Promising LOX proteins for cartilage-targeting osteoarthritis therapy by Luca Morici, Eric Allémann, Olivier Jordan, Ines Nikolić

“…Among the pathways involved in cartilage homeostasis, “LOX” proteins (referring to three distinct protein families, very often confused in the literature) play a prominent role. …”
Get full text

Influence of the biologically active dietary supplement Floravit® on the skin and hair structure in sable (Martes zibellina) by N. N. Loenko, I. E. Chernova, T. S. Kunitsina

“…It is important to search for new highly effective multicomponent compounds that are able to influence several of animals’ homeostasis systems simultaneously to improve the physiological adaptation of fur animals to different conditions of nutrition. …”
Get full text

Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential by Yijie Huang, Ying Tang, Ruiqi Zhang, Xiao Wu, Li Yan, Xiling Chen, Qianqi Wu, Yiyan Chen, Yingtao Lv, Yuan Su

“…In healthy periodontal tissues, PDLFs maintain the homeostasis of periodontal soft and hard tissues as well as the local immune microenvironment. …”
Get full text

Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity by Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi

“…Androgens are generated inside this gland and are crucial for its tissue-homeostasis. However, there is no data showing the presence of androgens in meibum, implying local conversion/deactivation into unknown metabolites. …”
Get full text

Biomimic Nanodrugs Overcome Tumor Immunosuppressive Microenvironment to Enhance Cuproptosis/Chemodynamic‐Induced Cancer Immunotherapy by Hangyi Wu, Xiaoyu Lu, Yuhan Hu, J. Baatarbolat, Zhihao Zhang, Yiping Liang, Youwen Zhang, Ye Liu, Huixia Lv, Xin Jin

“…Abstract Elesclomol (ES) as an efficient Cu ionophore can specifically transport Cu into mitochondria and disrupt intracellular Cu homeostasis. Extra intracellular Cu induces cuproptosis and chemodynamic therapy (CDT), which further cascades immunogenic cell death (ICD) and activates antitumor immune responses. …”
Get full text

Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential by Tohada M. AL-Noshokaty, Rehab Abdelhamid, Nourhan M. Abdelmaksoud, Aya Khaled, Mariam Hossam, Razan Ahmed, Toka Saber, Shahd Khaled, Shereen Saeid Elshaer, Ahmed I. Abulsoud

“…This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, and satiety. We examine the compelling evidence supporting GLP-1 receptor agonists (GLP-1RAs) in managing type 2 diabetes (T2D), obesity, and other diseases. …”
Get full text

Faecalibacterium prausnitzii regulates carbohydrate metabolic functions of the gut microbiome in C57BL/6 mice by Peiling Geng, Ni Zhao, Yufan Zhou, Reuben S. Harris, Yong Ge

“…Multiomic approaches were used to profile the impact of UT1 on the gut microbiome and associated metabolic activity of C57BL/6 mice at homeostasis. Both 16S rRNA and metagenomic sequencing demonstrated that oral administration of UT1 resulted in profound microbial compositional changes including a significant enrichment of Lactobacillus, Bifidobacterium, and Turicibacter. …”
Get full text

A randomized controlled trial to assess the efficacy of standardized tai chi in prefrail older adults with immunosenescence: design and protocol by Wen Zhong, Wei Huang, Hua Deng, Shuang Qiu, Qiyue Yang, Huanan Jia

“…Aims With the newly emerged concept of muscle-immune homeostasis, this study focused on determining the efficacy of tai chi prefrail older adults who develop immunosenescence. …”
Get full text