NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats by Ablikim Abliz, Chen Chen, Wenhong Deng, Weixing Wang, Rongze Sun

“…PCBs, widespread endocrine disruptors, cause the disturbance of thyroid hormone (TH) homeostasis in humans and animals. However, the exact mechanism of thyroid dysfunction caused by PCBs is still unknown. …”
Get full text

Creatine and pregnancy outcomes, a prospective cohort study in low-risk pregnant women: study protocol by Deborah L De Guingand, Stacey J Ellery, Miranda L Davies-Tuck, Hayley Dickinson

“…This prospective study aims to overcome some of the limitations associated with the previous study and thoroughly characterise creatine homeostasis throughout gestation in a low-risk pregnant population.Methods and analysis This study is recruiting women with a singleton low-risk pregnancy who are attending Monash Health, in Melbourne, Australia. …”
Get full text

Research Advances in the Role of Cereal Dietary Fiber in Modulating Glucose and lipid Metabolism via the Gut Microbiota-Bile Acid by DONG Hong-wang, QI Wen-tao, PENG Wen-ting, SONG Ge, FANG Wei

“…Recent studies suggest that dietary fiber intake regulates glucose and lipid homeostasis by modulating bile acid metabolism. This process is closely associated with gut microbiota. …”
Get full text

Blood transcriptome resources of chinstrap () and gentoo () penguins from the South Shetland Islands, Antarctica by Bo-Mi Kim, Jihye Jeong, Euna Jo, Do-Hwan Ahn, Jeong-Hoon Kim, Jae-Sung Rhee, Hyun Park

“…In the blood transcriptomes, KEGG analyses detected many essential genes involved in the major innate immunity pathways, which are key metabolic pathways for maintaining homeostasis against exogenous infections or toxins. …”
Get full text

Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment by Chengyang Zhu, Zun Fan, Zhijie Cheng, Jun Yin, Lei Qin, Xin Zhao

“…Both in-vitro and in-vivo experiments demonstrate that NMs with Cu-Cur MPNs encapsulation (Cu-Cur-NMs) can restore redox homeostasis, reduce inflammatory response, and promote blood vessel formation, thus remodeling the regenerative microenvironment to greatly improve the repair quality of CSTDs. …”
Get full text

Altered mitochondrial unfolded protein response and FGF21 secretion in MASLD progression and the effect of exercise intervention by Xinmeng Yuan, Wen Sun, Ye Xu, Mengqi Xiang, Yaran Gao, Wanyu Feng, Hongjian Xiao, Liumei Zhang, Qiang Tang, Jiao Lu, Yuan Zhang

“…Additionally, the exercise intervention acts as a regulator to optimize UPRmt signal transduction and to enhance mitochondrial homeostasis by improving mitochondrial function, reversing the UPRmt activation pattern, and increasing FGF21 secretion, which plays a pivotal role in delaying the occurrence and development of MASLD.…”
Get full text

Shallow-water mussels (Mytilus galloprovincialis) adapt to deep-sea environment through transcriptomic and metagenomic insights by Luyang Sun, Xiaolu Liu, Li Zhou, Hao Wang, Chao Lian, Zhaoshan Zhong, Minxiao Wang, Hao Chen, Chaolun Li

“…Results reveal complex gene expression adjustments in stress response, immune defense, homeostasis, and energy metabolism pathways during adaptation. …”
Get full text

Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance by Hana Alzamil

“…Insulin resistance and beta-cell function were assessed using the homeostasis model assessment (HOMA-IR and HOMA-B). Results. …”
Get full text

Lactobacillus from fermented bamboo shoots prevents inflammation in DSS-induced colitis mice via modulating gut microbiome and serum metabolites by Xiangru Liu, Xiaoling Lu, Hao Nie, Jing Yan, Zhiwen Ma, Hailin Li, Shixin Tang, Qi Yin, Jingfu Qiu

“…Consequently, these results demonstrated that Lactobacillus spp. isolates derived from FBS showed promising probiotic activity based on the gut microbiome homeostasis modulation, anti-inflammation and intestinal barrier protection in UC mice.…”
Get full text

Acute Genetic Damage Induced by Ethanol and Corticosterone Seems to Modulate Hippocampal Astrocyte Signaling by Ana Laura Reyes-Ábalos, Magdalena Álvarez-Zabaleta, Silvia Olivera-Bravo, María Vittoria Di Tomaso

“…Astrocytes maintain CNS homeostasis but also critically contribute to neurological and psychiatric disorders. …”
Get full text

Isolation of <i>Bacillus paralichenifromis</i> BL-1 and Its Potential Application in Producing Bioflocculants Using Phenol Saline Wastewater by Tao Zhang, Rongkai Guo, Fanshu Liu, Lei Zhang, Linxiao Li, Rongfei Zhang, Chaogang Shao, Junbo Zhou, Fan Ding, Lan Yu

“…A further investigation suggested that salinity stress resulted in the down-regulated expression of the genes involved in iron homeostasis. Therefore, alleviating iron limitation by supplying excess iron could improve cell growth and, thus, increase the phenol removal rate and flocculating activity. …”
Get full text

Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway by Laura La Paglia, Angela Listì, Stefano Caruso, Valeria Amodeo, Francesco Passiglia, Viviana Bazan, Daniele Fanale

“…Subsequently, ANGPTL4 has been shown to be involved in several nonmetabolic and metabolic conditions, both physiological and pathological, including angiogenesis and vascular permeability, cell differentiation, tumorigenesis, glucose homoeostasis, lipid metabolism, energy homeostasis, wound healing, inflammation, and redox regulation. …”
Get full text

Autophagy activation alleviates annulus fibrosus degeneration via the miR-2355-5p/mTOR pathway by Zilin Yu, Chunyang Fan, Yubo Mao, Xiexing Wu, Haiqing Mao

“…Autophagy, a vital process for cellular homeostasis, involves the lysosomal degradation of cytoplasmic proteins and organelles. …”
Get full text

The Gut Microbiota-Related Antihyperglycemic Effect of Metformin by Izabela Szymczak-Pajor, Józef Drzewoski, Małgorzata Kozłowska, Jan Krekora, Agnieszka Śliwińska

“…It is critical to sustain the diversity of the microbiota to maintain host homeostasis and health. Growing evidence indicates that changes in gut microbial biodiversity may be associated with the development of several pathologies, including type 2 diabetes mellitus (T2DM). …”
Get full text

Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis by Azael Torales-Cardeña, Isaí Martínez-Torres, Sandra Rodríguez-Martínez, Fernando Gómez-Chávez, Juan C. Cancino-Díaz, Ernesto A. Vázquez-Sánchez, Mario E. Cancino-Díaz

“…Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia-inducible factor 1-alpha” (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.…”
Get full text

Oxidative stress and reactive oxygen species in otorhinolaryngological diseases: insights from pathophysiology to targeted antioxidant therapies by Linghui Meng, Shengyang Liu, Jinfeng Luo, Yanyi Tu, Tao Li, Ping Li, Jinzhuang Yu, Li Shi

“…Recent studies have highlighted the potential of antioxidant therapies to mitigate oxidative stress and restore homeostasis, offering promising avenues for alleviating symptoms in these diseases. …”
Get full text

Molecular, Physical, and Technical Performance Response After a Competitive Match in Male Professional Soccer Players by Alessandra Modesti, Rosamaria Militello, Alice Tanturli, Alice Santi, Massimo Gulisano, Cristian Petri, Luca Pengue, Alessio Pellegrino, Pietro Amedeo Modesti, Simone Luti

“…Background: Male professional soccer players frequently compete in multiple matches weekly, and each match significantly impacts their homeostasis, health, and performance. This study evaluates players response at 48 h post-match by combining biological and GPS data. …”
Get full text

Redox proteomics reveal a role for peroxiredoxinylation in stress protection by Gerhard Seisenbacher, Zrinka Raguz Nakic, Eva Borràs, Eduard Sabidó, Uwe Sauer, Eulalia de Nadal, Francesc Posas

“…Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. …”
Get full text

The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole. by Marie Seveno, Manon N Loubens, Laurence Berry, Arnault Graindorge, Maryse Lebrun, Catherine Lavazec, Mauld H Lamarque

“…First, we provide further evidence that PP1 controls the homeostasis of the second messenger cGMP by modulating the basal activity of guanylyl cyclase alpha and consequently the PKG-dependent downstream Ca2+ signaling. …”
Get full text

The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study by Xiao-Hua Liang, Lun Xiao, Jing-Yu Chen, Ping Qu, Xian Tang, Yuwei Wang

“…Subjects with an urban residence, no pubertal development, dyslipidemia in 2014, higher family income, and higher parental education had significantly elevated fasting insulin (FI) or homeostasis model assessment of insulin resistance (HOMA-IR) levels; subjects with female sex, no pubertal development, dyslipidemia in 2014, obesity, gestational hypertension, maternal weight gain above Institute of Medicine guidelines, and single parents had increased triglyceride or triglyceride/high-density lipoprotein (HDL). …”
Get full text