PPARγ and the Innate Immune System Mediate the Resolution of Inflammation by Amanda Croasdell, Parker F. Duffney, Nina Kim, Shannon H. Lacy, Patricia J. Sime, Richard P. Phipps

“…Resolution represents not only an increase in anti-inflammatory actions, but also a paradigm shift in immune cell function to restore homeostasis. PPARγ, a ligand activated transcription factor, has long been studied for its anti-inflammatory actions, but an emerging body of literature is investigating the role of PPARγ and its ligands (including thiazolidinediones, prostaglandins, and oleanolic acids) in all phases of resolution. …”
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Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention by Xuan Lu, Ying Chen, Yue Shi, Yi Shi, Xianbin Su, Peijie Chen, Die Wu, Hui Shi

“…By stimulating the secretion of these exerkines, exercise supports healthy longevity by promoting tissue homeostasis and metabolic balance. Additionally, the integration of exercise-induced exerkines into therapeutic strategies represents a promising approach to mitigating age-related pathologies at the molecular level. …”
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Association between Sarcopenia and Insulin-Like Growth Factor-1, Myostatin, and Insulin Resistance in Elderly Patients Undergoing Hemodialysis by Novira Widajanti, SoebagijoAdi Soelistijo, Usman Hadi, Mochammad Thaha, null Aditiawardana, null Widodo, Hadiq Firdausi, YafanitaIzzati Nurina, MiraDelima Asikin, Hersih Srinowati, NoerHalimatus Syakdiyah

“…There were differences between the two groups in hemoglobin levels, IGF-1 levels, myostatin levels, homeostasis model assessment-insulin resistance (HOMA-IR) levels, muscle mass, handgrip strength, body mass index status, mini nutritional assessment status, and physical activity scale for elderly status (all p < 0.05). …”
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Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions by Alexis M. Stranahan, Bronwen Martin, Wayne Chadwick, Sung-Soo Park, Liyun Wang, Kevin G. Becker, William H. WoodIII, Yongqing Zhang, Stuart Maudsley

“…This suggests that challenges to metabolic homeostasis regulate distinct hypothalamic gene sets in diabetic and non-diabetic animals. …”
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Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice. by Avigail Ehrlich, Graziano Pelli, Bernard Foglia, Filippo Molica, Brenda R Kwak

“…The lymphatic system ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells to draining lymph nodes, thereby potentially affecting atherogenesis. …”
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The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…Taken together, the presented data suggest that the PTP1B inhibition strategy and the use of its specific inhibitor MSI-1436 represents a promising option for the improvement of liver tissue integrity and homeostasis in the course of EMS and adds more insights for ongoing clinical trials for human MetS management.…”
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Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…Similarly, PDE5 dysregulation disrupts nitric oxide (NO) signaling and protein kinase G (PKG) pathways, which are involved in cerebrovascular homeostasis, recovery after ischemic events, and neurodegenerative processes in Alzheimer’s, Parkinson’s, and Huntington’s diseases. …”
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Menopausal Hormone Therapy: Its Role in the Prevention of Cardiovascular Diseases and the Risk of Breast Cancer in Women by Tam Thai Thanh Tran, Thu Minh Phung, Anh Thi Mai Do, Quynh Tran Mai Ly, Tin Hoang Nguyen

“…Mechanism: Estrogen deficiency, altered energy homeostasis, adipocyte changes, inflammation, and insulin resistance are responsible for the development of metabolic syndrome and CVDs. …”
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Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress by Linmin Zhong, Qiling Yang, Yiming Shao, Shanwen Hu, Lianxian Guo

“…Herein, we hypothesize that H. pylori infection may exacerbate the intestinal flora imbalance and hepatic metabolic disturbances caused by arsenic exposure, which may disrupt enterohepatic homeostasis and potentially increase biological susceptibility to heavy metal toxicity.…”
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Smart estimation of protective antioxidant enzymes’ activity in savory (Satureja rechingeri L.) under drought stress and soil amendments by Amin Taheri-Garavand, Mojgan Beiranvandi, Abdolreza Ahmadi, Nikolaos Nikoloudakis

“…Specifically, using biochar and superabsorbent led to improved homeostasis under water deficit as reflected by lower MDA levels. …”
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Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome by Agnieszka Adamska, Agnieszka Łebkowska, Małgorzata Jacewicz, Anna Krentowska, Justyna Hryniewicka, Sławomir Wołczyński, Maria Górska, Irina Kowalska

“…Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). …”
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Spontaneous Complete Regression of Colon Cancer Liver Metastases in a Lung Transplant Patient: A Case Report by Koen Zwart, Dieuwertje Ruigrok, Magda de Graaf-Bos, Roel Goldschmeding, Miriam Koopman, Guus M. Bol

“…This case underscores the huge impact that temporary relief from immunosuppressive therapy could have on tumor homeostasis. Balanced management of care for organ transplant recipients with malignancies requires a multidisciplinary approach involving medical oncologists and transplant physicians to reach the best quality of care in these complex cases.…”
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The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review by Wiktoria Maria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Jakub Kurasz, Wojciech Maj, Wiktoria Podlasiewicz, Katarzyna Pala, Piotr Dudziak, Anna Nowak, Maria Golińska

“…It also exerts a beneficial influence on the intestinal microbiota, promoting the proliferation of beneficial bacterial species, such as Faecalibacterium prausnitzii, which play a role in mitigating disease relapses and sustaining immune homeostasis. Although vitamin D supplementation demonstrates potential in reducing inflammation and improving clinical outcomes, the observed effects remain varied and require further investigation. …”
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Clinical profile of stress hyperglycemia in medical intensive care units by Geethanjali Ganesan, Sudha Vidyasagar, Nandakrishna Bolanthakodi, Cynthia Amrutha Sukumar

“…Introduction: Stress hyperglycemia (SH) is a transient increase in blood glucose during acute physiological stress in the absence of glucose homeostasis dysfunction. In the setting of medical intensive care units (ICU), it significantly contributes to patient morbidity and mortality.It initates a cascade of pathophysiological responses that in turn increase blood glucose and insulin resistance. …”
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Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures by Yán Wāng

“…Mitochondria, endoplasmic reticulum, and lysosomes emerge as pivotal organelles in the disruption of cellular homeostasis, with mitochondrial dysfunction particularly implicated in metabolic dysregulation and the activation of pro-apoptotic pathways. …”
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A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…IL-1β is a strong regulator of Brain Natriuretic Peptide (BNP), a hormone involved in cardiovascular homeostasis by guanylyl cyclase Natriuretic Peptide Receptor (NPR-1). …”
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Effect of opercular deformity on morphological and transcriptomic profiling of gills in golden pompano (Trachinotus ovatus) by Yuwei Wu, Qian Ma, Dihao Huang, Liuyong Wang, Qiling Zhou, Chunli Ran, Gang Chen

“…These enrichment analysis results suggest that functions associated with immunity and disease, ion homeostasis, energy metabolism, and apoptosis may be influenced by the opercular deformity.…”
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Advances in Microengineered Platforms for Skin Research by Sireesh Kumar Teertam, Vijayasaradhi Setaluri, Jose M. Ayuso

“…Disruption of this homeostasis leads to numerous skin disorders. Human and animal skin differ significantly, limiting the translational potential of animal-based investigations to advance therapeutics to human skin diseases. …”
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Mesenchymal Progenitors Derived from Different Locations in Long Bones Display Diverse Characteristics by Weiguang Lu, Bo Gao, Jing Fan, Pengzhen Cheng, Yaqian Hu, Qiang Jie, Zhuojing Luo, Liu Yang

“…Mesenchymal progenitors within bone marrow have multiple differentiation potential and play an essential role in the maintenance of adult skeleton homeostasis. Mesenchymal progenitors located in bone regions other than the bone marrow also display bone-forming properties. …”
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Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings by Rushika Conroy, Gerardo Febres, Donald J. McMahon, Michael O. Thorner, Bruce D. Gaylinn, Irene Conwell, Louis Aronne, Judith Korner

“…Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent of weight loss. …”
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