POLYMORPHISM VITAMIN D RECEPTOR GENE (VDR) BSMI (RS1544410) CHRONIC PERIODONTITIS PATIENT IN JAVANESE BANYUMAS ETHNIC by Ryana Budi Purnama, Setiadi Warata Logamarta, Agung Dhartono

“…Genetic factors that cause chronic periodontitis, namely mutations in the form of a gene that functions to regulate calcium homeostasis, which is called the vitamin D receptor (VDR) gene. …”
Get full text

Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg Ischaemia by Teik K. Ho, X. Shiwen, D. Abraham, J. Tsui, D. Baker

“…The chemokine stromal-cell-derived factor-1 (SDF-1 aka CXCL12) is a constitutively expressed and inducible chemokine that regulates multiple physiological processes, including embryonic development and organ homeostasis. The biologic effects of SDF-1 are mediated by chemokine receptor CXCR4, a 352 amino acid rhodopsin-like transmembrane-specific G protein-coupled receptor (GPCR). …”
Get full text

Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases by Jiani Li, Chen Guo, Xiaofei Yang, Weinan Xie, Wenjing Mi, Chenglong Hua, Cheng Tang, Han Wang

“…Immunometabolic variations in macrophages critically influence their differentiation into pro-inflammatory or anti-inflammatory phenotypes, thereby contributing to immune homeostasis, defense against infection, and tissue repair. …”
Get full text

Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance by Shehnaz Bano, Shyam More, Dattatray S. Mongad, Abdul Khalique, Dhiraj P. Dhotre, Manoj K. Bhat, Vasudevan Seshadri

“…Glucose homeostasis is maintained by insulin. Insulin resistance is caused by multiple factors including hereditary factors and diet. …”
Get full text

Risk of poor glycemic control in tamsulosin versus finasteride users with type 2 diabetes mellitus by Minh-Ha Nguyen, Maxim S. Petrov, Jaelim Cho

“…Recent evidence has been inconsistent regarding the effect of BPH medications on glucose homeostasis. This study examined the risk of poor glycemic control associated with finasteride and tamsulosin use in individuals with type 2 diabetes. …”
Get full text

Hypernatremia in patients with neurological conditions in critical state by David Wilfredo Suàrez Prieto, Mairen Pèrez Fuentes, Elaine Teresa Gutièrrez Pèrez

“…<p><strong>Background:</strong> sodium disorders are the most common and least understood in patients with acute brain injury due to the major role played by the central nervous system in regulating sodium and water homeostasis, which can lead to serious complications and adverse outcomes, including death.…”
Get full text

Orexitropic Signaling Proteins in Obese Children by Ljiljana Saranac, Bojko Bjelakovic, Hristina Stamenkovic, Borislav Kamenov

“…Adipose tissue is not only the main organ for energy storage, but it also has endocrine properties, producing “adipokines” responsible for energy homeostasis, insulin sensitivity, and inflammation. …”
Get full text

The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications by Ranin Saad, Hagar Tadmor, Offir Ertracht, Nakhoul Nakhoul, Farid Nakhoul, Farber Evgeny, Shaul Atar

“…Autophagy plays a key role in the degradation of damaged intracellular proteins in order to maintain intracellular homeostasis and cell integrity. The disturbance of autophagy is involved in the pathogenesis of diabetic nephropathy. …”
Get full text

What Do Gases in the Large Intestine Have to Do with Health? by Klaudia Pawełek, Patrycja Kinga Marta, Filip Maciej Huzarski, Gabriela Monika Ferfecka, Magdalena Rosa-Bończak, Agata Ossolińska, Weronika Kłosowicz, Oliver Carlton, Lucyna Stolarska, Natalia Morawiecka

“…Gut microorganisms produce short-chain fatty acids (SCFAs), which play a significant role in regulating energy homeostasis and enteroendocrine hormone secretion. …”
Get full text

Taurine Prevented Biochemical Alterations in Chronic Restraint-Stressed Wistar Rats by Iliya, Ezekiel, Agnes Igimi, Odey, Stephen Olawale, Ajayi, Ejike, Daniel Eze, Obioha, Mary

“…Stress has the potential of altering physiological homeostasis. The body’s ability to cope under stressful stimuli is a vital determinant of health and disease conditions. …”
Get full text

Grain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Rats by Keneth Iceland, Kasozi, Namubiru, Sarah, Safiriyu, Abass Alao, Ninsiima, Herbert Izo, Nakimbugwe, Dorothy, Namayanja, Monica, Valladares, Miriela Betancourt

“…Grain amaranth exerts its antidiabetic properties through improved calcium homeostasis in blood, kidney, and liver.…”
Get full text

Sleeve gastrectomy reveals the plasticity of the human gastric epithelium by Amit Elad, Botros Moalem, Dana Sender, Aya Bardugo, Ki-Suk Kim, Yhara Arad, Haya Benhayon, Ayelet Gal Etzyoni, Nehemia Greenstein, Aviv Halfon, Sarah Knapp, Michelle Malis, Bailey Peck, Itia Samuel, Amram Kupietzky, Saleh Daher, Esther Forkosh, David Hakimian, Tiberiu Hershcovici, Nadav Ilani, Lior Katz, Moshe Rottenstreich, Elez Vainer, Yuval Ishay, Eitan Zlotnick, Abed Nasereddin, Idid Shiff, Ariel Benson, Ronit Grinbaum, Siddhartha Mishra, Shlomi Kotler, Linda C. Samuelson, Darleen A. Sandoval, Rachel Ben-Haroush Schyr, Danny Ben-Zvi

“…Mathematical modeling showed that pH homeostasis by gastrin is analogous to non-linear proportional and integral control, that drives adaptation of the epithelium to acid-secretion demand. …”
Get full text

The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface by Claudio Costantini, Giorgia Renga, Vasilis Oikonomou, Giuseppe Paolicelli, Monica Borghi, Marilena Pariano, Antonella De Luca, Matteo Puccetti, Claudia Stincardini, Paolo Mosci, Andrea Bartoli, Teresa Zelante, Luigina Romani

“…The scenario that is emerging unveils a delicate equilibrium that balances the effector functions of mast cells to guarantee host protection without compromising tissue homeostasis. Among the environmental components able to mold mast cells and fine-tune their effector functions, the microorganisms that colonize the human body, collectively known as microbiome, certainly play a key role. …”
Get full text

All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III by C. M. Durward, T. J. Hartman, S. M. Nickols-Richardson

“…Metabolic health was defined as: (1) homeostasis model assessment-insulin resistance (HOMA-IR) <2.5; (2) ≤2 Adult Treatment Panel (ATP) III metabolic syndrome criteria; (3) combined definition using ≤1 of the following: HOMA-IR ≥1.95 (or diabetes medications), triglycerides ≥1.7 mmol/L, HDL-C <1.04 mmol/L (males) or <1.30 mmol/L (females), LDL-C ≥2.6 mmol/L, and total cholesterol ≥5.2 mmol/L (or cholesterol-lowering medications). …”
Get full text

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Cristian Scheau, Ioana Anca Badarau, Raluca Costache, Constantin Caruntu, Gratiela Livia Mihai, Andreea Cristiana Didilescu, Carolina Constantin, Monica Neagu

“…The auto- and cross-activation of MMPs may complicate this issue, as pinpointing the extent of implication of each MMP may be extremely difficult. The homeostasis between MMPs and their tissue inhibitors is essential in preventing tumor progression, and the disturbance of this stability is another entailed factor in the EMT of HCC, which is addressed herein.…”
Get full text

Calponin 3 Regulates Myoblast Proliferation and Differentiation Through Actin Cytoskeleton Remodeling and YAP1-Mediated Signaling in Myoblasts by Mai Thi Nguyen, Quoc Kiet Ly, Thanh Huu Phan Ngo, Wan Lee

“…An actin-binding protein, known as Calponin 3 (CNN3), modulates the remodeling of the actin cytoskeleton, a fundamental process for the maintenance of skeletal muscle homeostasis. Although the roles of CNN3 in actin remodeling have been established, its biological significance in myoblast differentiation remains largely unknown. …”
Get full text

Salt stress and its eco-friendly management using biostimulants in grain legumes: a review by Narayan Singh, Vasudha Maurya, Kriti Gupta, Indu Sharma, Ashutosh Sharma, Rahul Kumar

“…The application of biostimulants in grain legumes alleviates the salt stress-induced toxicity by improving the seed germination, seedling growth, rate of photosynthesis, nitrogen fixation, absorption and uptake of minerals, grain development, yield, ROS homeostasis and osmoregulation. Many of the reviews have lacked the assessment of the effect of these ecofriendly biostimulants on mitigation of salt stress in grain legumes. …”
Get full text

Gut Mesenchymal Stromal Cells in Immunity by Valeria Messina, Carla Buccione, Giulia Marotta, Giovanna Ziccheddu, Michele Signore, Gianfranco Mattia, Rossella Puglisi, Benedetto Sacchetti, Livia Biancone, Mauro Valtieri

“…Among their multiple functions, MSCs closely interact with immune cells, orchestrating their activity to maintain overall homeostasis. The phenotype of tissue MSCs residing in the bowel overlaps with myofibroblasts, lining the bottom walls of intestinal crypts (pericryptal) or interspersed within intestinal submucosa (intercryptal). …”
Get full text

Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae. by Hilary T Brewis, Peter C Stirling, Michael S Kobor

“…We also observed that apo-SWR1-C contributed to gene expression defects in the htz1Δ mutant, particularly for genes involved in phosphate homeostasis regulation. Furthermore, mapping H2A.Z incorporation before and after treatment with HU revealed that decreases in H2A.Z enrichment at transcription start sites was correlated with, but generally not required for, the upregulation of genes during HU exposure. …”
Get full text

Molecular Age-Related Changes in the Anterior Segment of the Eye by Luis Fernando Hernandez-Zimbron, Rosario Gulias-Cañizo, María F. Golzarri, Blanca Elizabeth Martínez-Báez, Hugo Quiroz-Mercado, Roberto Gonzalez-Salinas

“…We also introduce and propose potential roles of autophagy, an important mechanism responsible for maintaining homeostasis and proteostasis under stress conditions in the anterior segment during aging.…”
Get full text