Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease by Cui Zhang, Weigang Shu, Guangxi Zhou, Jian Lin, Feifei Chu, Huili Wu, Zhanju Liu

“…These data indicate that TNF-α plays a critical role in the induction of mucosal inflammatory response, and that blockade of TNF-α modulates intestinal homeostasis through balancing immune responses of neutrophils.…”
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Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications by Meng Cai, Gopi K. Kolluru, Asif Ahmed

“…Unlike siRNA, microRNAs are “fine-tuners” rather than “switches” in the regulation of gene expression; thus they play key roles in maintaining tissue homeostasis. The aberrant microRNA expression is implicated in the disease process. …”
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The Role of PPARs in Placental Immunology: A Systematic Review of the Literature by Stefan Hutter, Julia Knabl, Ulrich Andergassen, Udo Jeschke

“…They are expressed in most human organs and their function extends from regulating metabolism, homeostasis, and carcinogenesis to immune response. …”
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De novo biosynthesis of nylon 12 monomer ω-aminododecanoic acid by Jiawei Ge, Ting Wang, Hongwei Yu, Lidan Ye

“…Through modular pathway engineering, redesign and dimerization enhancement of the rate-limiting P450, reconstruction of redox and energy homeostasis, and enhancement of oxidative stress tolerance, we achieve a production level of 471.5 mg/L ω-AmDDA from glucose in shake flasks. …”
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Microenvironment Dependent Photobiomodulation on Function-Specific Signal Transduction Pathways by Timon Cheng-Yi Liu, De-Feng Wu, Ling Zhu, P. Peng, Long Liu, Xiang-Bo Yang

“…The signal transduction pathways maintaining a normal function in its function-specific homeostasis (FSH), resisting the activation of many other irrelative signal transduction pathways, are so sparse that it can be supposed that there may be normal function-specific signal transduction pathways (NSPs). …”
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Physiology-informed regularisation enables training of universal differential equation systems for biological applications. by Max de Rooij, Balázs Erdős, Natal A W van Riel, Shauna D O'Donovan

“…Systems biology tackles the challenge of understanding the high complexity in the internal regulation of homeostasis in the human body through mathematical modelling. …”
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Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells by Huiling Hu, Zhijun Luo, Xiuli Liu, Lisi Huang, Xiaoxia Lu, Rui Ding, Chaohui Duan, Yuqing He

“…Sestrin2 is a highly conserved stress-inducible protein, acting as a crucial part in regulating homeostasis in response to various stress conditions in the cell. …”
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Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases by Wuhao Li, Peiyang Cai, Ye Xu, Weihong Tian, Licong Jing, Qiaoyi Lv, Yangjing Zhao, Hui Wang, Qixiang Shao

“…To maintain metabolic homeostasis, mitochondria dynamically adjust their morphology, distribution, and mass via biogenesis, fusion and fission, translocation, and mitophagy. …”
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Anthropometric indicators in identification of insulin resistance in elderly men by Pamella Cristine Anunciação, Rita de Cássia Lanes Ribeiro

“…IR was determined by homeostasis model assessment (HOMA-IR). Statistical analysis consisted of correlation coefficient. …”
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17β-estradiol promotes osteogenic differentiation of BMSCs by regulating mitophagy through ARC by Jingcun Shi, Jin Wen, Longwei Hu

“…To sum up, 17β-estradiol can modulate bone homeostasis by adjusting ARC expression. ARC stimulates mitophagy in BMSCs via MAPK/Akt pathway, identifying ARC as a promising therapeutic target for postmenopausal osteoporosis (PMOP) treatment.…”
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INTENSITY OF NITRIC OXIDE SYNTHESIS IN THE BLOOD OF RATS UNDER THE INFLUENCE OF SODIUM FLUORIDE by I.L. Kolisnyk

“…At low NO concentrations, direct effects aimed at maintaining homeostasis, such as the vascular, respiratory, and nervous systems, predominate; at high concentrations of NO, indirect effects prevail, due primarily to the formation of peroxynitrite. …”
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Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding by B. Glueck, Y. Han, G. A. M. Cresci

“…The gut microbiome is known to contribute to the maintenance of intestinal homeostasis, and disturbances are associated with pathology. …”
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Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients by Yu Zhou, Deli Ye, Xiaofen Yuan, Yonglie Zhou, Jun Xia

“…Serum BAs regulate glucose homeostasis, but have no special value in the pathogenesis of LADA patients. …”
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Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus by Lusha Cen, Fengling Xing, Liying Xu, Yi Cao

“…The ability of NFAT5 to maintain cell homeostasis and proliferation is impaired in patients with diabetes. …”
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Impact of the Ketogenic Diet on Neurological Diseases: A Review by Carmen Rubio, Alejandro López-Landa, Hector Romo-Parra, Moisés Rubio-Osornio

“…Thus, the KD represents a broad and promising strategy that involves both neurons and glial cells, with a molecular impact on brain metabolism and neuroinflammatory homeostasis. Conclusion: Multiple molecular mechanisms have been identified to explain the benefits of the KD in neurological diseases; however, further experimental and clinical studies are needed to address various molecular pathways in order to achieve conclusive results.…”
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PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products by Chuanxiang Zhao, Shan Lin

“…The intestinal epithelium, beyond its role in absorption and digestion, serves as a critical protective mechanical barrier that delineates the luminal contents and the gut microbiota from the lamina propria within resident mucosal immune cells to maintain intestinal homeostasis. The barrier is manifested as a contiguous monolayer of specialized intestinal epithelial cells (IEC), interconnected through tight junctions (TJs). …”
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Genetic, Functional, and Immunological Study of ZnT8 in Diabetes by Qiong Huang, Jie Du, Chengfeng Merriman, Zhicheng Gong

“…Zinc participates in insulin synthesis, storage, and secretion by functioning as a “cellular second messenger” in the insulin signaling pathway and glucose homeostasis. The highest zinc concentration is in the pancreas islets. …”
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Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases by Yinyin Xie, Wenlin Sun, Aoya Han, Xinru Zhou, Shijie Zhang, Changchang Shen, Yi Xie, Cui Wang, Nanchang Xie

“…Mitochondria and lysosomes are critical for neuronal homeostasis, as highlighted by their dysfunction in various neurological diseases. …”
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Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models by Everardo Macias, Dharanija Rao, John DiGiovanni

“…Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. …”
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Combining robust state estimation with nonlinear model predictive control to regulate the acute inflammatory response to pathogen by Gregory Zitelli, Seddik M. Djouadi, Judy D. Day

“…The inflammatory responseaims to restore homeostasis by means of removing a biological stress, such as an invading bacterial pathogen.In cases of acute systemic inflammation, the possibility of collateral tissuedamage arises, which leads to a necessary down-regulation of the response.A reduced ordinary differential equations (ODE) model of acute inflammation was presented and investigated in [10]. …”
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