Expanding Yarrowia lipolytica’s metabolic potential for detoxification of cyanogenic glycosides in edible plants by Fidelis Azi, Zhiyu Li, Peng Xu

“…The engineered strain repressed fatty acid production to optimize energy production and activated the cyanide-resistant respiratory (AOX) pathway to circumvent HCN toxicity and maintain cellular homeostasis. It upregulated ribosome biogenesis, the sec-dependent protein export pathway, and the sulfur relay system to facilitate the production and transmembrane efflux of the secreted GH1 hydrolase. …”
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Interkingdom signaling between gastrointestinal hormones and the gut microbiome by Xinyu Zhao, Ye Qiu, Lanfan Liang, Xiangsheng Fu

“…The distributions of the gut microbiota and gastrointestinal hormones are anatomically intertwined, and close interactions between the gut microbiota and gastrointestinal hormones are crucial for maintaining gastrointestinal homeostasis. Interventions leveraging the interplay between the gut microbiota and gastrointestinal hormones have been employed in the clinical management of metabolic diseases and inflammatory bowel diseases, such as bariatric surgery and fecal microbiota transplantation, offering promising targets for the treatment of dysbiosis-related diseases.…”
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The role of acetylation and deacetylation in cancer metabolism by Cuicui Wang, Xiaoxin Ma

“…Abstract As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to adapt to and promote the complex biological processes of abnormal growth and proliferation. …”
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Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice by Lubna Danish, Riffat Siddiq, Sarwat Jahan, Mehwish Taneez, Manzoor Khan, Marva Sandhu

“…Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. …”
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miRNA changes associated with differentiation of human embryonic stem cells into human retinal ganglion cells by Maryam Esmaeili, Daniel A. Smith, Ben Mead

“…Abstract miRNA, short non-coding RNA, are rapidly emerging as important regulators in cell homeostasis, as well as potential players in cellular degeneration. …”
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Bile acids and incretins as modulators of obesity-associated atherosclerosis by Andrijana Kirsch, Juergen Gindlhuber, Diana Zabini, Elena Osto, Elena Osto

“…This mini review highlights the current knowledge about dysregulations in BA homeostasis in obesity with a special focus on atherosclerosis as well as athero-modulating roles of incretins and currently available incretin-based therapies.…”
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Exploring novel pharmacological trends: Natural compounds in dry eye disease management by Rák Tibor, Csutak Adrienne

“…Dry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like tear film instability, hyperosmolarity, inflammation, and neurosensory abnormalities. …”
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Spinal NGF Restores Opioid Sensitivity in Neuropathic Rats: Possible Role of NGF as a Regulator of CCK-Induced Anti-Opioid Effects by Catherine M Cahill, Terence J Coderre

“…The authors hypothesize that NGF is critical in maintaining neurochemical homeostasis in the spinal cord of nociceptive neurons, and that supplementation may be beneficial in restoring and/or maintaining opioid analgesia in chronic pain conditions resulting from traumatic nerve injury.…”
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Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers by Li Lai, Yohannes T. Ghebremariam

“…The generation of NO by the NOS enzymes is known to contribute to vascular homeostasis including insulin-mediated skeletal muscle vasodilation and insulin sensitivity. …”
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Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection by Maša Ždralević, Nicoletta Guaragnella, Lucia Antonacci, Ersilia Marra, Sergio Giannattasio

“…Cell homeostasis results from the balance between cell capability to adapt or succumb to environmental stress. …”
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Diversity of Epithelial Stem Cell Types in Adult Lung by Feng Li, Jinxi He, Jun Wei, William C. Cho, Xiaoming Liu

“…In order to maintain its homeostasis and normal functions following injuries caused by varied extraneous and intraneous insults, such as inhaled environmental pollutants and overwhelming inflammatory responses, the respiratory epithelium normally undergoes regenerations by the proliferation and differentiation of region-specific epithelial stem/progenitor cells that resided in distinct niches along the airway tree. …”
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MS-1 by Sofia M. Pereira PhD, Steve R. Williams PhD, Patricia Murray PhD, Arthur Taylor PhD

“…Although it has been suggested that magA is involved in iron transport, when expressed in HEK cells, it does not affect the transcription of endogenous genes related to iron homeostasis. Furthermore, the magA -induced enhancement in iron uptake in HEK cells is insignificant, suggesting this gene is a poor reporter even for cell types that can tolerate its expression. …”
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Hormonal Changes in Menopause and Orexin-A Action by Giovanni Messina, Andrea Viggiano, Vincenzo De Luca, Antonietta Messina, Sergio Chieffi, Marcellino Monda

“…Orexins are hypothalamic neuropeptides recently discovered, involved in the regulation of feeding behaviour, sleep-wakefulness rhythm, and neuroendocrine homeostasis. Orexins might offer the missing link between postmenopausal hypoestrogenism and other manifestations of the menopausal syndrome, including appetite and weight changes and increase in cardiovascular risk.…”
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Homeostatic model and job-organization related factors as predictors of subjective wellbeing of Mizan-Tepi university teachers by Michael Emru adesse

“…Accordingly, the study employed the homeostasis theory of SWB as a theoretical framework and tested two major hypotheses. …”
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Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases by Asako Otomo, Lei Pan, Shinji Hadano

“…Among such mechanisms, ones that are associated with disturbances of protein homeostasis, the ubiquitin-proteasome system and autophagy, have recently been highlighted. …”
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Escherichia coli growing under antimicrobial gallium nitrate stress reveals new processes of tolerance and toxicity by Daniel A. Salazar-Alemán, Raymond J. Turner

“…Some of the affected biological systems identified in our analysis include iron homeostasis, sulfate metabolism, oxidative and nitrosative stress response, cysteine biosynthesis, anaerobic respiration, toxin-antitoxin interactions, and DNA repair. …”
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Cambios morfofisiológicos celulares durante la reanimación cardiopulmocerebral by Ana María Barcia Armas, Claudia Díaz de la Rosa, Jeisy Rivero Morey, Víctor René Navarro Machado

“…Las células realizan transformaciones estructurales y metabólicas ante situaciones de estrés, lo que les permite mantener una adecuada homeostasis y evitar la muerte. La presente revisión bibliográfica tuvo como objetivo describir los principales cambios morfofisiológicos celulares que acontecen en la parada cardiaca y reanimación cardiopulmocerebral. …”
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Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways by Shannon M. Ruppert, Ben A. Falk, S. Alice Long, Paul L. Bollyky

“…Moreover, we found that inhibition of HA synthesis impairs Treg homeostasis but that this effect could be overcome with exogenous IL-2 or CD44-cross-linking. …”
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Denosumab-Induced Hypocalcemia after Billroth II Gastric Bypass Surgery by Abigail M. Schmucker, Dina E. Green, Philip M. Montemuro

“…Osteoporosis is commonly treated with denosumab, though denosumab can exacerbate underlying abnormalities in calcium homeostasis. We present the case of a 59-year-old female with severe hypocalcemia who had been treated with denosumab for osteoporosis three months before and had Billroth II gastric bypass surgery 15 years before, for bariatric purposes. …”
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Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Existing in Direct Proximity with the Distal End of the Arrector Pili Muscle by N. Torkamani, N. W. Rufaut, L. Jones, R. Sinclair

“…Keratinocytes in the epidermal stem cell niche express K15, MCSP, and α6 integrin. α5 integrin marks the distal end of the APM colocalized with basal keratinocytes expressing stem cell markers located in a well-protected and nourished environment at the lowermost point of the epidermis; these cells are hypothesized to participate directly in epidermal renewal and homeostasis and also indirectly in wound healing through communication with the hair follicle bulge epithelial stem cell population through the APM. …”
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