Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism by Tsuyoshi Goto, Nobuyuki Takahashi, Shizuka Hirai, Teruo Kawada

“…Because PPARs are dietary lipid sensors that control energy homeostasis, daily eating of these terpenoids might be useful for the management for obesity-induced metabolic disorders, such as type 2 diabetes, hyperlipidemia, insulin resistance, and cardiovascular diseases.…”
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Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading by Chuanxin Zhang, Jun Zhu, Yiqin Zhou, Bhavani P. Thampatty, James H-C. Wang

“…In addition, the effects of such interactions on the maintenance of tendon homeostasis and the initiation of tendon pathological conditions are discussed. …”
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Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower. by Mingzhu Zhao, Bing Yi, Xiaohong Liu, Dexing Wang, Dianxiu Song, Enyu Sun, Liangji Cui, Jingang Liu, Liangshan Feng

“…Most of DEGs were enriched in cell wall organisation, protein kinase activity, hormone, transcription factor activities, redox homeostasis, immune response, and secondary metabolism. …”
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Math-Phys-Chem Approaches to Life by Hitomi Kitaojima, Shigeru Kanemitsu

“…Thus comes our definition, “life is a one way flow along the intrinsic time axis toward the ultimate heat death, of denumerably many metabolic reactions, each at local equilibrium in view of homeostasis”. However, our disposition is not of reductionismic as have been most of approaches, but it is to the effect that such a complicated dynamic system as lives are not feasible for modelling or reducing to minor fragments, but rather belongs to the whole-ism. …”
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New insights into constitutive neutrophil death by Tong Chen, Qian Ren, Fengxia Ma

“…Constitutive neutrophil death (CND) contributes to neutrophil homeostasis and inflammation resolution. CND has long been considered to be apoptotic until our findings reveal that it was a heterogeneous combination of diverse death. …”
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Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant by Béla Dénes, István Fodor, William H. R. Langridge

“…Data presented here demonstrate multifunctional vaccination strategies that harness vaccinia virus mediated delivery of a gene encoding an immunoenhanced diabetes autoantigen in combination with complete Freund’s adjuvant (CFA) that can maintain safe and durable immunologic homeostasis in NOD mice. Systemic coinoculation of prediabetic mice with recombinant vaccinia virus rVV-CTB::GAD and undiluted or 10-fold diluted CFA demonstrated a significant decrease in hyperglycemia and pancreatic islet inflammation in comparison with control animals during 17–61 and 17–105 weeks of age, respectively. …”
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Lipid Chaperones and Metabolic Inflammation by Masato Furuhashi, Shutaro Ishimura, Hideki Ota, Tetsuji Miura

“…Several inflammatory cytokines as well as lipids and metabolic stress pathways can activate metaflammation, which targets metabolically critical organs and tissues including adipocytes and macrophages to adversely affect systemic homeostasis. On the other hand, inside the cell, fatty acid-binding proteins (FABPs), a family of lipid chaperones, as well as endoplasmic reticulum (ER) stress, and reactive oxygen species derived from mitochondria play significant roles in promotion of metabolically triggered inflammation. …”
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Peroxisome Proliferator-Activated Receptor Alpha Target Genes by Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, Sander Kersten

“…The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. PPARα serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. …”
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The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

“…Astrocytes regulate neuronal homeostasis, excitability, and synaptic plasticity, playing key roles in maintaining the blood–brain barrier (BBB) and mediating neuroinflammatory responses. …”
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A Car-Following Model Based on Safety Margin considering ADAS and Driving Experience by Yugang Wang, Nengchao Lyu

“…In this study, we established a car-following model based on risk homeostasis theory, which uses safety margin (SM) as the risk level quantization parameter. …”
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Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes by Xuebao Zhang, Kezhong Zhang

“…Pancreatic β cell is the only insulin-secreting cell type that has highly developed endoplasmic reticulum (ER) to cope with high demands of insulin synthesis and secretion. Therefore, ER homeostasis is crucial to the proper function of insulin signaling. …”
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PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis by Lina Sabatino, Alessandra Fucci, Massimo Pancione, Vittorio Colantuoni

“…Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. …”
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A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence. by Frédéric J Veyrier, Ivo G Boneca, Mathieu F Cellier, Muhamed-Kheir Taha

“…The present work thus points to new clues about Mn homeostasis, its interplay with Fe metabolism and the influence on N. meningitidis physiology and pathogenicity.…”
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The role of gut microbiota and its metabolites short-chain fatty acids in food allergy by Chen Chen, Chenglong Liu, Ke Zhang, Wentong Xue

“…Gut microbiota played a vital role in maintaining the homeostasis of the immune system and the dysbiosis of gut microbiota promoted the occurrence of FA. …”
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Forward programming of hPSCs to neutrophils using chemically defined media by Hayley E. Hall, Xiaoping Bao, Cheng Dong, Xiaojun Lance Lian

“…Due to their terminally differentiated state, PMNs possess a short lifespan and exhibit limited proliferative potential, which makes continuous replenishment from the bone marrow essential for maintaining immune homeostasis. This demand underscores the need for efficient, reliable, and robust methods of PMN production. …”
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Transmission of unfolded protein response—a regulator of disease progression, severity, and spread in virus infections by Vibhu Prasad

“…ABSTRACT The unfolded protein response (UPR) is a cell-autonomous stress response aimed at restoring homeostasis due to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). …”
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Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics by Monica Profir, Robert Mihai Enache, Oana Alexandra Roşu, Luciana Alexandra Pavelescu, Sanda Maria Creţoiu, Bogdan Severus Gaspar

“…Targeted nutritional therapies combined with prebiotic, probiotic, and postbiotic administration can restore the immune response in the intestine and the host’s homeostasis.…”
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Mechanisms of Rhodopsin-Related Inherited Retinal Degeneration and Pharmacological Treatment Strategies by Maria Azam, Beata Jastrzebska

“…The progression of this disease involves complex cellular responses to restore cellular homeostasis, including the unfolded protein response (UPR) signaling, autophagy, and various cell death pathways. …”
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Keratinized Gingiva Determines a Homeostatic Behavior of Gingival Sulcus through Transudation of Gingival Crevice Fluid by Maria Luiza P. Lagos, Adriana Campos Passanezi Sant'Ana, Sebastião Luiz Aguiar Greghi, Euloir Passanezi

“…The results suggest that KG plays a role in marginal periodontal homeostasis.…”
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Sarcopenia and Age-Related Endocrine Function by Kunihiro Sakuma, Akihiko Yamaguchi

“…Since sarcopenia is largely attributed to various molecular mediators affecting fiber size, mitochondrial homeostasis, and apoptosis, numerous targets exist for drug discovery. …”
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