Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols by Qi Ge, Liang Chen, Keping Chen

“…Additionally, certain polyphenols found in spices might improve glucose homeostasis and insulin resistance in diabetes patients, thereby constituting promising options for the treatment of type 2 diabetes.…”
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Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes by Armin Robubi, Klaus R. Huber, Walter Krugluger

“…Apart from toxic action on liver cells, adipocytes might be stimulated to take up extra fructose and generate new lipid vesicles, further dysregulating energy homeostasis.…”
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RNA folding kinetics control riboswitch sensitivity in vivo by David Z. Bushhouse, Jiayu Fu, Julius B. Lucks

“…Abstract Riboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in maintaining cellular homeostasis. Understanding how riboswitch sensitivity to ligand (EC50) is controlled is critical to explain how highly conserved aptamer domains are deployed in a variety of contexts with different sensitivity demands. …”
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ1 is a member of a large growth factor family including activins/inhibins and bone morphogenic proteins (BMPs) that have a potent growth regulatory and immunomodulatory functions in normal skin homeostasis, regulation of epidermal stem cells, extracellular matrix production, angiogenesis, and inflammation. …”
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Crosstalk between ferroptosis and autophagy: broaden horizons of cancer therapy by Xingyu Liu, Halahati Tuerxun, Yixin Zhao, Yawen Li, Shuhui Wen, Xi Li, Yuguang Zhao

“…Autophagy regulates the metabolic balance between synthesis, degradation and reutilization of cellular substances to maintain intracellular homeostasis. Numerous studies have demonstrated that both ferroptosis and autophagy play important roles in cancer pathogenesis and cancer therapy. …”
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The Role of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer by Joo-In Park, Jong-Young Kwak

“…Some nuclear hormone receptors play an important role in regulating nutrient metabolism and energy homeostasis. Among these receptors, special attention has been focused on the role of peroxisome proliferator-activated receptors (PPARs) in colorectal cancer, because PPARs are involved in regulation of lipid and carbohydrate metabolism. …”
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Aspects of the rhizospheric microbiota and their interactions with the soil ecosystem by El Amrani Belkacem

“…This review focuses on the main interactions between the indigenous soil microflora and the major constituents of the rhizosphere to understand, on the one hand, how microbial biodiversity can improve plant growth and maintain homeostasis of the rhizospheric ecosystem, on the other hand, how the maintenance and enrichment of plant biodiversity can contribute to the conservation of soil microbial diversity; knowing that these microorganisms are also controlled by the abiotic properties of the soil. …”
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Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation by Ulrike Gimsa, N. Avrion Mitchison, Monika C. Brunner-Weinzierl

“…They support differentiation and homeostasis of neurons and influence synaptic activity. …”
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The unexpected role of the STING protein in lipid metabolism by Vila, Isabelle K., Laguette, Nadine

“…However, recent work has revealed that STING is also a direct regulator of metabolic homeostasis. In particular, STING regulates lipid metabolism directly, a function that is conserved throughout evolution. …”
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Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools by Nur Alia Natasya Zabidi, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Tieng Yew Fu, Imilia Ismail, Muhammad Redha Abdullah Zawawi, Jodi Woan-Fei Law, Learn-Han Lee, Nurul-Syakima Ab Mutalib

“…SLC genes encode transporters that play vital roles in maintaining cellular homeostasis, and alterations in their DNA methylation can influence nutrient and metabolite transport, impacting cancer cell behavior. …”
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Diabetes in HFE Hemochromatosis by James C. Barton, Ronald T. Acton

“…Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. …”
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The Importance of Lung Innate Immunity During Health and Disease by Gusty Rizky Teguh Ryanto, Ratoe Suraya, Tatsuya Nagano

“…In this review, we discuss globally how the components of lung innate immunity are important not only for maintaining lung homeostasis but also during the pathophysiology of notable lung diseases beyond acute pulmonary infections, including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis.…”
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Proprotein Convertase Subtilisin/Kexin Type 9: From the Discovery to the Development of New Therapies for Cardiovascular Diseases by Nicola Ferri

“…The discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9), a secretory protein that posttranscriptionally regulates levels of low density lipoprotein receptor (LDLR) by inducing its degradation, has opened a new era of pharmacological modulation of cholesterol homeostasis. This paper summarizes the current knowledge of the basic molecular mechanism underlying the regulatory effect of LDLR expression by PCSK9 obtained from in vitro cell-cultured studies and the analysis of the crystal structure of PCSK9. …”
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Tumor-Associated Regulatory T Cells in Non-Small-Cell Lung Cancer: Current Advances and Future Perspectives by Jiaqi Liang, Guoshu Bi, Guangyao Shan, Xing Jin, Yunyi Bian, Qun Wang

“…Regulatory T cells (Tregs), a functional subset of T cells, maintain immunologic immunological self-tolerance and homeostasis. Accumulating evidence has uncovered their implicated roles in various cancers in recent years. …”
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Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission by Min Lin, Gonglin Hou, Ying Zhao, Ti-Fei Yuan

“…In conclusion, spontaneous recovery acts as an important mechanism in system homeostasis.…”
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Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics by Abdullahi Y. Muhammad, Malik Amonov, Atif A. Baig, Farrukh J. Alvi

“…Under normal health conditions, the gut commensals are in homeostasis with the host; while they inhabit the gut for their normal growth, they protect against invading pathogens through anticolonization mechanisms and contribute largely to the metabolism of several macromolecules in the gut. …”
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Detection of the WNT/Beta-Catenin Signaling Activity by Using Immunocytochemical Technique in Cervical Smears by Hanife Güler Dönmez, Şayeste Demirezen, Sinan Beksaç

“… OBJECTIVES: The Wnt/β-catenin signaling pathway controls cell fate and homeostasis of embryonic and adult tissues. The aim of the study is to evaluate the activity of Wnt/β-catenin signaling in cervical smears by using immunocytochemistry. …”
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Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection by Ali Vural, John H. Kehrl

“…Autophagy is a catabolic process that normally maintains cellular homeostasis in a lysosome-dependent manner, but it also functions as a cytoprotective response that intersects with a variety of general stress-response pathways. …”
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Unfolded protein responses in T cell immunity by Wencan Zhang, Xu Cao

“…The UPR, mediated by IRE1, PERK, and ATF6, is crucial for maintaining ER homeostasis and supporting T cell survival under stress. …”
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The role of the neurovascular unit in vascular cognitive impairment: Current evidence and future perspectives by Zhidong He, Jing Sun

“…The concept of an NVU emphasizes that interactions between different types of cells are essential for maintaining brain homeostasis. A stable NVU is the basis of normal brain function. …”
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