Brain-derived neurotrophic factor – a key player in the gastrointestinal system by Arjun Singh

“…In addition, current evidence on the diverse physiologic and pathophysiologic roles of BDNF in the control of intestinal peristalsis, mucosal transport processes, visceral sensation, neuroimmune interactions, gastrointestinal mucosal healing, and enteric nervous system homeostasis are discussed. Finally, the therapeutic potential of targeting BDNF for the treatment of functional GI diseases is explored. …”
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Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia by Alessio Molfino, Gianfranco Gioia, Filippo Rossi Fanelli, Alessandro Laviano

“…Robust data indicate that, during cancer, functional modifications within brain areas regulating energy homeostasis contribute to the onset of anorexia, reduced food intake, and increased catabolism of muscle mass and adipose tissue. …”
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Heat Shock Protein 70 Neutralizes Apoptosis-Inducing Factor by Guido Kroemer

“…Its normal function is essential both for embryonic development and for maintenance of adult tissue homeostasis. Deficient apoptosis participates in cancerogenesis, whereas excessive apoptosis leads to unwarranted cell loss accounting for disparate diseases including neurodegeneration and AIDS. …”
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A Pilot Proteomic Analysis of Huntington’s Disease by Functional Capacity by Andrew McGarry, Ruin Moaddel

“…<b>Results</b>: Our exploratory data reveal correlations between progression and several processes including inflammation, ECM homeostasis and NAD⁺ metabolism. <b>Conclusions:</b> Consistently identified targets that correlate with phenotype or progression may have value, if validated, as enrichment tools in clinical trials and potentially as markers of therapeutic response.…”
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Skin Acute Wound Healing: A Comprehensive Review by Luis Cañedo-Dorantes, Mara Cañedo-Ayala

“…Once this is completed, the inflammatory phase is resolved and homeostasis is restored. The aim of the proliferative phase, the second phase, is to repair wound damage and begin tissue remodeling. …”
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DNA methylation: a cause and consequence of type 2 diabetes by Mirang Kim

“…Because metabolic intermediates are key factors of DNA methylation and demethylation, perturbations in metabolic homeostasis can trigger alterations in cell-specific patterns of DNA methylation and contribute to disease development, including type 2 diabetes (T2D). …”
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Peroxisome Proliferator-Activated Receptors in Lung Cancer by Venkateshwar G. Keshamouni, ShouWei Han, Jesse Roman

“…Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis; the regulation of cell differentiation, proliferation, and apoptosis; and the modulation of important biological and pathological processes related to inflammation, among others. …”
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Research on Energy Supply System Applied to Autonomous Underwater Observation Vehicles by Chunjie Wang, Yugeng Chai, Lin Cui

“…The operating principle and homeostasis property of the proposed converter are analyzed in detail. …”
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Total Body Sodium Balance in Chronic Kidney Disease by Kylie Martin, Sven-Jean Tan, Nigel D. Toussaint

“…Tissue sodium represents an extrarenal influence on sodium homeostasis with demonstrated clinical associations of hypertension and inflammation. …”
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Research Progress on the Interaction between Taurine Metabolism and the Gut Microbiota by YANG Xinyu, WU Qingjie, MI Shengquan, ZHANG Yanzhen, GUO Junxia

“…This article provides an overview of the gut microbiota and the sources and transformation of taurine in the body, and focuses on the interaction between taurine and the gut microbiota and the effect of taurine supplementation on reshaping gut microbiota homeostasis. The aim is to provide a scientific basis for the development of preventive and therapeutic measures for diseases related to gut microbiota imbalance.…”
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Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming by Androniki Kretsovali, Christiana Hadjimichael, Nikolaos Charmpilas

“…Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. …”
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The Mechanosensory Role of Primary Cilia in Vascular Hypertension by Surya M. Nauli, Xingjian Jin, Beerend P. Hierck

“…Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. …”
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ER Dysfunction and Protein Folding Stress in ALS by Soledad Matus, Vicente Valenzuela, Danilo B. Medinas, Claudio Hetz

“…The disruption of protein homeostasis due to chronic stress responses at the endoplasmic reticulum (ER) and the accumulation of abnormal protein inclusions are extensively described in ALS mouse models and patient-derived tissue. …”
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A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives by Jonathan W. Lowery, Brice Brookshire, Vicki Rosen

“…Appropriate regulation of canonical BMP signaling is critical for the development and homeostasis of numerous human organ systems, as aberrations in the BMP pathway or its regulation are increasingly associated with diverse human pathologies. …”
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Structure and Physiological Actions of Ghrelin by Christine Delporte

“…Ghrelin exerts wide physiological actions throughout the body, including growth hormone secretion, appetite and food intake, gastric secretion and gastrointestinal motility, glucose homeostasis, cardiovascular functions, anti-inflammatory functions, reproductive functions, and bone formation. …”
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The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency by Ryan C. Tsou, Kendra K. Bence

“…The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obesity and type 2 diabetes. …”
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AMPK-Dependent Metabolic Regulation by PPAR Agonists by Woo Hyung Lee, Sang Geon Kim

“…Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARα, PPARβ/δ, and PPARγ, regulate cell growth, morphogenesis, differentiation, and homeostasis. Agonists of each PPAR subtype exert their effects similarly or distinctly in different tissues such as liver, muscle, fat, and vessels. …”
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Thrombospondin-1: Multiple Paths to Inflammation by Zenaida Lopez-Dee, Kenneth Pidcock, Linda S. Gutierrez

“…If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. …”
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The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin. by Anhua Hu, Maximilian E Pickup, Maryam A Lawal, Hetal J Patel, Mohammed I Ahmed

“…Skin and hair development is regulated by multitude of programs of activation and silencing of gene expression to maintain normal skin and hair follicle (HF) development, homeostasis, and cycling. Here, we have identified E74-like factor 5 (Elf5) transcription factor, as a novel regulator of keratinocyte proliferation and differentiation processes in skin. …”
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Erythropoietin supplementation induces dysbiosis of the gut microbiota and impacts mucosal immunity in a non-diseased mouse model by Guillaume Sarrabayrouse, Corentin Joulain, Stéphanie Bessoles, Andrada S. Chiron, Andrada S. Chiron, Amine M. Abina, Salima Hacein-Bey-Abina, Salima Hacein-Bey-Abina

“…However, the impact of this therapeutic cytokine on the homeostasis of the intestinal tract has not previously been investigated in detail. …”
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