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481
Associations of combined exposure to selected metal mixtures with thyroid hormones in children: a cross-sectional study in China
Published 2025-01-01“…BackgroundExposure to several metal elements has been found to be associated with thyroid hormone homeostasis. However, evidence for combined exposure is inconclusive, especially for children.ObjectiveTo examine the individual and joint effects of blood metal elements on thyroid hormones in children.MethodsA total of 12,470 children aged 0–14 were collected from January 2018 to December 2021 in Hunan Children's Hospital. …”
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482
Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
Published 2025-01-01“…Abstract Mitochondrial homeostasis plays a crucial role in the pathogenesis of osteoarthritis (OA), a chronic musculoskeletal disorder characterized by articular cartilage degeneration and chondrocyte apoptosis. …”
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483
Reshaping lipid metabolism with long-term alternate day feeding in type 2 diabetes mice
Published 2025-02-01“…These studies support that long-term IF can improve glucose homeostasis and dramatically altered lipid metabolism in the absence of weight loss.…”
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484
Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees
Published 2025-01-01“…The present study aims to detect the effects of acute sublethal tebuconazole exposure focusing on the redox homeostasis of honey bee flight muscles. The results show that the redox homeostasis, especially the glutathione system, of the exposed animals is severely impaired by the treatment, but flight muscles are able to successfully counteract the detrimental effects by the effective activation of protective processes. …”
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485
Self-healable and pH-responsive spermidine/ferrous ion complexed hydrogel Co-loaded with CA inhibitor and glucose oxidase for combined cancer immunotherapy through triple ferroptos...
Published 2025-05-01“…Highly expressed carbonic anhydrases (CA) in tumor that maintaining the delicate metabolic homeostasis is thus the most potential target to be modulated to resolve the therapeutic tolerability. …”
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486
Mast Cell Degranulation Decreases Lipopolysaccharide-Induced Aortic Gene Expression and Systemic Levels of Interleukin-6 In Vivo
Published 2019-01-01“…In conclusion, in an in vivo setting, mast cells appear to partially and transiently regulate systemic IL-6 homeostasis. This effect may be regulated through increased systemic IL-10 and/or aortic overexpression of SOCS-1.…”
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487
TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State
Published 2012-01-01“…This paper summarizes the neoplastic alterations of the TCA cycle enzymes focusing on the generation of pseudohypoxic phenotype and the alteration of epigenetic homeostasis as the main tumor-promoting effects of the TCA cycle affecting defects. …”
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488
Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators
Published 2012-01-01“…Heat shock proteins, also called damage-associated molecular patterns (DAMPs), are rapidly released following nonprogrammed cell death, are key effectors of the innate immune system, and critically restore homeostasis by promoting the reconstruction of the effected tissue. …”
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489
Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer
Published 2025-01-01“…These findings highlight the importance of paradoxical genes in resisting tumor progression and maintaining cellular homeostasis, offering new avenues for targeted cancer therapy.…”
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490
Sex Differences in Energy Metabolism Need to Be Considered with Lifestyle Modifications in Humans
Published 2011-01-01“…Moreover, elucidating the regulatory role of hormones in energy homeostasis is important for understanding the pathogenesis of obesity and perhaps in the future may lead to ways to reduce body fat with less energy restriction.…”
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491
HOMEOKİNETİK CANLILIK TEORİSİ
Published 2023-10-01“…Canlıdaki dengenin betimlenmesi maksadıyla, homeostasis yerine homeokinesis teriminin kullanılması önerilmektedir.…”
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492
Role and interactions of organelle stress in septic cardiomyopathy
Published 2024-12-01“…The excessive inflammatory response, immune dysfunction, and dysregulation of homeostasis induced by sepsis can trigger abnormal stress responses in organelles such as endoplasmic reticulum, mitochondria, and Golgi apparatus, regulating the pathophysiological progression of SCM. …”
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493
An Analytic Contemplation of the Conspicuous Vicissitudes in the Histomorphology of Corpuscles of Stannius of a Freshwater Catfish Mystus tengara (Hamilton, 1822) due to the Exposu...
Published 2015-01-01“…Mystus tengara, exposed to ZnS nanoparticles, responded to hypoxia with varied behavioural, physiological, and cellular responses in order to maintain homeostasis and organ function in an oxygen-depleted environment. …”
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494
Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases
Published 2009-01-01“…MTs exert a central position in zinc homeostasis, modulate the activation of the transcription factor nuclear factor (NF)-𝜅B, and serve as antioxidants. …”
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495
GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism
Published 2025-02-01“…G-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly in the regulation of food intake and energy metabolism. …”
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496
Coronary Microvascular Function and Beyond: The Crosstalk between Hormones, Cytokines, and Neurotransmitters
Published 2015-01-01“…A dynamic communication between the heart and other organs takes place constantly to maintain cardiovascular homeostasis. The current understanding highlights the importance of the endocrine, immune, and nervous factors to fine-tune the crosstalk of the cardiovascular system with the entire body. …”
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497
PPARγ and Its Role in Cardiovascular Diseases
Published 2017-01-01“…Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. …”
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498
Mitochondria as a Potential Regulator of Myogenesis
Published 2013-01-01“…Understanding how mitochondria are involved in myogenesis will provide a valuable insight into the underlying mechanisms that regulate the maintenance of cellular homeostasis. Here, we will summarize the current knowledge regarding the role of mitochondria as a potential regulator of myogenesis.…”
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499
Is There a Role for Probiotics in Liver Disease?
Published 2014-01-01“…Alteration in its healthy homeostasis may result in the development of numerous liver disorders including complications of liver cirrhosis. …”
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500
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Published 2025-01-01“…A bidirectional nucleus-mitochondria communication is essential for homeostasis and stress. By acting as critical molecules, the nuclear-encoded lncRNAs (nulncRNAs) have been implicated in the nucleus-to-mitochondria anterograde regulation. …”
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