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481
A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis
Published 2008-01-01“…Its role in the regulation of skeletal muscle fatty acid catabolism, glucose homeostasis, and cellular differentiation has been established in multiple studies. …”
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482
Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body?
Published 2012-01-01“…Vitamin D (VitD), although originally described as an essential hormone for bone and mineral homeostasis, appears to have an active role in regulating specific facets of human immunity. …”
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483
Endothelium-Derived Hyperpolarizing Factor and Vascular Function
Published 2011-01-01“…Endothelial function refers to a multitude of physiological processes that maintain healthy homeostasis of the vascular wall. Exposure of the endothelium to cardiac risk factors results in endothelial dysfunction and is associated with an alteration in the balance of vasoactive substances produced by endothelial cells. …”
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484
Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective
Published 2025-01-01“…Normally, the microbiome, intestinal epithelium, and immune system interact to maintain intestinal homeostasis. However, when this equilibrium is disturbed, a harmful cycle of dysbiosis, immune dysregulation, and inflammation emerges, resulting in intestinal barrier dysfunction and UC progression. …”
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485
Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold
Published 2013-01-01“…PEA is synthesized and metabolized in animal cells via a number of enzymes and exerts a multitude of physiological functions related to metabolic homeostasis. Research on PEA has been conducted for more than 50 years, and over 350 papers are referenced in PubMed describing the physiological properties of this endogenous modulator and its pharmacological and therapeutical profile. …”
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486
Organoid Models for Salivary Gland Biology and Regenerative Medicine
Published 2021-01-01“…The salivary gland is composed of an elegant epithelial network that secrets saliva and maintains oral homeostasis. While cell lines and animal models furthered our understanding of salivary gland biology, they cannot replicate key aspects of the human salivary gland tissue, particularly the complex architecture and microenvironmental features that dictate salivary gland function. …”
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487
Enhancing sleep quality in synucleinopathies through physical exercise
Published 2025-01-01“…During sleep, several crucial processes for brain homeostasis occur, including the rearrangement of synaptic connections, which is essential for memory formation and updating. …”
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488
Autophagy-associated signal pathways of functional foods for chronic diseases
Published 2019-03-01“…Once the cells are in the stress environment, the induced autophagy will accelerate the clearance of cellular damaged or toxic protein aggregates or dysfunctional cellular organelles to maintain homeostasis in cells. In this article, we summarize several widely investigated bioactive components used as functional foods, such as resveratrol, epigallocatechin-3-gallate, curcumin and trehalose, with the regulatory function for autophagy during the intervention of chronic diseases, which will provide the references or novel thoughts for the development of functional foods with the modulation of autophagy. …”
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489
Adropin as an indicator of T2DM and its complications
Published 2022-11-01“…As a secreted peptide, adropin is identified as a useful regulator associated with insulin sensitivity and energy homeostasis. It has the potential for regulating metabolic diseases including obesity and T2DM. …”
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490
Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells
Published 2016-01-01“…Although monocytes maintain several tissue-specific populations of immune cells in homeostasis, their contribution to populations of dendritic cells, macrophages, and osteoclasts is significantly increased in inflammation. …”
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491
Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease
Published 2015-01-01“…The possible mechanisms assigned for these neuroprotective actions of HDAC inhibitors involve transcriptional activation of neuronal survival genes and maintenance of histone acetylation homeostasis, both of which have been shown to be dysregulated in PD. …”
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492
Immune conversations at the border: meningeal immunity in health and disease
Published 2025-01-01“…The meninges host diverse resident immune cells and serve as a critical interface with peripheral immunity, playing multifaceted roles in maintaining central nervous system homeostasis, responding to pathogenic threats, and neurological disorders. …”
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493
Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis
Published 2025-01-01“…Concurrently, the gut microbiota, known to affect systemic immunity and neurological health, emerges as an important regulator of iron homeostasis and inflammatory responses, thereby influencing ferroptotic pathways. …”
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494
Climate change and the single cell
Published 2024-12-01“…Stomata act as crucial regulatory components of a water hypercycle that contributes to the homeostasis of a warming planet by regulating evaporative cooling and reflective cloud cover generated by vast tropical rainforests of the South and the equally vast arboreal forests of the North. …”
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495
Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases
Published 2025-01-01“…Regulatory T cells (Tregs), which maintain immune homeostasis in immunometabolism, play crucial regulatory roles. …”
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496
Prostanoid Receptors in the Human Vascular Wall
Published 2007-01-01“…The mechanisms involved in vascular homeostasis and disease are mostly dependent on the interactions between blood, vascular smooth muscle, and endothelial cells. …”
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497
Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases
Published 2023-01-01“…It mediates the information exchange between different cellular pathways in cellular homeostasis and stress response and regulates the differentiation, plasticity, and neurotransmission of neurons. …”
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498
Protocol for the site-specific isolation of mouse endothelial cells using the modified Häutchen technique
Published 2025-03-01“…Summary: Endothelial cells (ECs) play a major role in vascular homeostasis and pathology. They show a pronounced heterogeneity between different organs as well as within the same organ. …”
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499
Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue
Published 2018-01-01“…Metabolic syndrome can be defined as a state of disturbed metabolic homeostasis characterized by visceral obesity, atherogenic dyslipidemia, arterial hypertension, and insulin resistance. …”
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500
A Highly Selective Fluorescent Probe for Hypochlorous Acid in Living Cells Based on a Naphthalene Derivative
Published 2022-01-01“…Hypochlorous acid (HOCl) was crucial for maintaining the homeostasis in cells and plays vital roles in many physiological and pathological processes. …”
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