Erasing Synapses in Sleep: Is It Time to Be SHY? by Marcos Gabriel Frank

“…An elegant idea that may explain how sleep accomplishes this role is the “synaptic homeostasis hypothesis (SHY).” According to SHY, sleep promotes net synaptic weakening which offsets net synaptic strengthening that occurs during wakefulness. …”
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Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians by Xuhui Chen

“…Positional information in muscle cells governs the polarity and patterning of the body plan during homeostasis and regeneration. For planarians, removal of neoblasts disables the regenerative feats and disruption of positional information results in the regeneration of inappropriate missing body regions, only the combination of neoblasts and positional information enables regeneration. …”
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Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities by Ran Zhang, Bo Li, Heng Li

“…Accumulating studies have demonstrated that ECM stiffness, a type of mechanical forces, exerts a pivotal influence on regulating organogenesis, tissue homeostasis, and the occurrence and development of miscellaneous diseases. …”
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Thiazolidinediones on PPARγ: The Roles in Bone Remodeling by Wei Wei, Yihong Wan

“…This paper will focus on current new developments that implicate potential mechanisms for how PPARγ modulates skeletal homeostasis and how TZDs exert bone-loss side effects.…”
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Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug by S. A. Bulgakov

“…The therapeutic effect of dalargin at various gastro-intestinal diseases is determined by its bioregulator properties maintaining body homeostasis up to standard. Conclusion. Dalargin has demonstrated high therapeutic efficacy and safety for almost 30 years of application in practical gastroenterology and significantly expanded facilities of gastroenterologists in treatment of digestive diseases.…”
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The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases by Carmela Rita Balistreri, Calogero Caruso, Giuseppina Candore

“…Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. …”
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Substrates, regulation, cellular functions, and disease associations of P4-ATPases by Hye-Won Shin, Hiroyuki Takatsu

“…In this review, we highlight the emerging evidence related to substrate diversity, the regulation of cellular localization, enzymatic activities, and their impact on organism homeostasis and diseases.…”
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Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations by Masahiro Murakami

“…Hence, blood vessel maintenance is fundamental to controlling vascular homeostasis and tissue functions. This paper discusses signaling pathways essential for vascular maintenance and clinical conditions caused by deterioration of vessel integrity.…”
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Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases by Claire J. Wiggins, Susan Y. Chon

“…Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. …”
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Role of serotonin in physiology and diseases of gastro-intestinal tract by E. F. Barinov, O. N. Sulayeva

“…To analyze the information published in scientific literature on a role of serotonin in regulation of structural homeostasis of gastro-intestinal tract (GIT) organs, realizations of compensatory-adaptive and pathological processes at ulcerogenesis in gastroduodenal zone.Original positions. …”
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Antioxidants and the Integrity of Ocular Tissues by Marcela P. Cabrera, Ricardo H. Chihuailaf

“…This paper reviews the role of oxidative stress in the onset and progression of damage in different eye structures, the involvement of the antioxidant network in protecting and maintaining the homeostasis of this organ, and the potential assessment methodologies used in research and in some cases in clinical practice.…”
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Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries by Cheng Ji

“…Potential mechanisms that trigger the alcoholic ER stress response are directly or indirectly related to alcohol metabolism, which includes toxic acetaldehyde and homocysteine, oxidative stress, perturbations of calcium or iron homeostasis, alterations of S-adenosylmethionine to S-adenosylhomocysteine ratio, and abnormal epigenetic modifications. …”
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The future of G protein‐coupled receptor therapeutics: Apelin receptor acts as a prototype for the advancement of precision drug design by Wei‐Wei Wang, Su‐Yu Ji, Ping Xu, Yan Zhang, Yan Zhang

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Cerebral Venous Sinus Thrombosis Linked to Dietary Supplement Use in a Bodybuilder: A Case Report by Sondos K. Khalil, Zahra B. Yousif, Jawaher Baraka, Israa Al‐Hashimi, Moaz O. Moursi, Abdalla Fadul, Wanis Ibrahim

“…ABSTRACT Many dietary supplements commonly used by bodybuilders and athletes carry thrombogenic risks, potentially leading to life‐threatening conditions like arterial and venous thrombosis by either elevating testosterone levels or directly interfering with homeostasis. Increased awareness and further research are crucial for consumer safety and supplement regulation.…”
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The Evolution of Rehabilitation and Return to Sport Following Cartilage Surgery by Snehal Patel, William Marrone

“…This clinical viewpoint discusses the evolution of knee cartilage rehabilitation characterized by early but progressive weightbearing and early ROM while maintaining early homeostasis in the knee, and then its progression to return to sport and performance in the higher-level athlete…”
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Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia by Korry J. Hintze, James P. McClung

“…The effects of hypoxia on iron balance have been attributed to hepcidin, a central regulator of iron homeostasis. This paper will focus on the molecular mechanisms by which hypoxia affects hepcidin expression, to include a review of the hypoxia inducible factor (HIF)/hypoxia response element (HRE) system, as well as recent evidence indicating that localized adipose hypoxia due to obesity may affect hepcidin signaling and organismal iron metabolism.…”
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Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular n... by Liu Chang, Yu Hao, Xia Hongyi, Wang Ziwei, Li Bolin, Xue Hongmei, Jin Sheng, Xiao Lin, Wu Yuming, Guo Qi

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Integrated metabolomics and proteomics revealed astragaloside IV inhibiting Pdxk-mediated vitamin B6 metabolism based on liquid chromatography-tandem mass spectrometry combined wit... by Shi Qiu, Sifan Guo, Zhibo Wang, Ying Cai, Dandan Xie, Wanying Sun, Aihua Zhang

“…In short, the integrated metabolomics and proteomics approach could reveal ASIV inhibits Pdxk as a potential target by regulating AA metabolic homeostasis and laying a new paradigm for precision treatment of future diseases.…”
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Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice by Caroline Daems, Sophie Welsch, Hasnae Boughaleb, Juliette Vanderroost, Annie Robert, Etienne Sokal, Philippe A. Lysy

“…Islets from EMPA-treated mice were also less subjected to ER (endoplasmic reticulum) stress and inflammation, as shown by qPCR analysis. Glucose homeostasis parameters and islet area/pancreas area ratio improved, as compared to diabetic controls, when T1D mice were treated for three weeks with GABA and EMPA. …”
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Trade-Off Between Enzymatic Antioxidant Defense and Accumulation of Organic Metabolite Affects Salt Tolerance of White Clover Associated with Redox, Water, and Metabolic Homeostase... by Min Zhou, Yuting Wu, Yuchen Yang, Yan Yuan, Junnan Lin, Long Lin, Zhou Li

“…These organic metabolites helped to maintain osmotic adjustment, energy supply, reactive oxygen species homeostasis, and cellular metabolic homeostasis with regard to salt stress. …”
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