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441
Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission
Published 2018-01-01“…In conclusion, spontaneous recovery acts as an important mechanism in system homeostasis.…”
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442
Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics
Published 2024-01-01“…Under normal health conditions, the gut commensals are in homeostasis with the host; while they inhabit the gut for their normal growth, they protect against invading pathogens through anticolonization mechanisms and contribute largely to the metabolism of several macromolecules in the gut. …”
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443
Detection of the WNT/Beta-Catenin Signaling Activity by Using Immunocytochemical Technique in Cervical Smears
Published 2013-08-01“… OBJECTIVES: The Wnt/β-catenin signaling pathway controls cell fate and homeostasis of embryonic and adult tissues. The aim of the study is to evaluate the activity of Wnt/β-catenin signaling in cervical smears by using immunocytochemistry. …”
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444
Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection
Published 2014-01-01“…Autophagy is a catabolic process that normally maintains cellular homeostasis in a lysosome-dependent manner, but it also functions as a cytoprotective response that intersects with a variety of general stress-response pathways. …”
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445
Different Levels of Autophagy Activity in Mesenchymal Stem Cells Are Involved in the Progression of Idiopathic Pulmonary Fibrosis
Published 2024-01-01“…Autophagy is a lysosome-dependent pathway that mediates the degradation and recycling of intracellular material and is an efficient way to renew the nonnuclear (cytoplasmic) part of eukaryotic cells, which is essential for maintaining cellular homeostasis and is a potential target for regulating MSCs function. …”
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446
Mitochondrial Dynamics: Biogenesis, Fission, Fusion, and Mitophagy in the Regulation of Stem Cell Behaviors
Published 2019-01-01“…Through coordinated cellular behaviors (self-renewal, proliferation, and differentiation), stem cells are also pivotal to the homeostasis, repair, and regeneration of many adult tissues/organs and thus of great importance in regenerative medicine. …”
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447
Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity
Published 2011-01-01“…Here, we review the current understanding of the role of Id2 in lymphopoiesis and in the development of the adaptive immune response required for maintaining immune homeostasis and immune protection.…”
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448
A Case of Acute Psychosis in an Adolescent Male
Published 2014-01-01“…Primary hyperparathyroidism (PHPT) is a disorder of calcium homeostasis. We report the case of a 17-year-old adolescent male, who presented with an acute psychosis coinciding with severe hypercalcemia and markedly elevated intact parathyroid hormone (iPTH) level and low vitamin D level. …”
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449
The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments
Published 2025-01-01“…The signals then proceed to third- and fourth-order neurons that activate complex responses aimed at maintaining whole-body energy homeostasis. During the last 30 years, since the identification of leptin in 1994, there has been a great advance in the unveiling of the hypothalamic and extra-hypothalamic neuronal networks that control energy balance. …”
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450
Neuroprotection Caused by Hyperoxia Preconditioning in Animal Stroke Models
Published 2011-01-01“…Neuroprotection induced by HO exhibits specific adaptation responses that involve a number of cellular and biochemical alterations, including metabolic homeostasis and reprogramming of gene expression. The changes in the metabolic pathways are generally short lived and reversible, while the consequences of gene expression are a long-term process and may lead to the permanent alteration in the pattern of gene expression. …”
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451
Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses
Published 2018-01-01“…Its deficiency causes growth retardation, immunodeficiency, and neuronal degeneration. Zinc homeostasis is tightly regulated by zinc transporters and metallothioneins that control zinc concentration and its distribution in individual cells and contributes to zinc signaling. …”
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452
Sugar-Sweetened Beverage Intake Trends in US Adolescents and Their Association with Insulin Resistance-Related Parameters
Published 2010-01-01“…Main outcome measures included SSB consumption trends, a homeostasis model assessment of insulin resistance, blood pressure, waist circumference, body mass index, and fasting concentrations of total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides. …”
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453
Peroxisome proliferator–activated receptor delta and liver diseases
Published 2025-02-01“…Unlike PPAR-alpha and PPAR-gamma, PPAR-delta is ubiquitously expressed, and its activity is key to maintaining proper metabolic homeostasis within the liver. PPAR-delta not only regulates physiologic processes of lipid, glucose, and bile acid metabolism but also attenuates pathologic responses to alcohol metabolism, inflammation, fibrosis, and carcinogenesis, and is considered an important therapeutic target in liver diseases. …”
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454
Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage
Published 2024-12-01“…The intestinal barrier plays a key role in preventing harmful substance invasions and maintaining intestinal homeostasis, with tight junction proteins being essential for maintaining the integrity of the intestinal barrier. …”
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455
Regenerative Applications Using Tooth Derived Stem Cells in Other Than Tooth Regeneration: A Literature Review
Published 2016-01-01“…Considering their original function in development and the homeostasis of tooth structures, many applications of these cells in dentistry have aimed at tooth structure regeneration; however, the application in other than tooth structures has been attempted extensively. …”
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456
Association of p53 with Neurodegeneration in Parkinson’s Disease
Published 2022-01-01“…p53 is a vital transcriptional protein implicated in regulating diverse cellular processes, including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis, autophagy, senescence, and apoptosis. Recent studies have revealed that p53 levels and activity are substantially increased in affected neurons in cellular and animal models of Parkinson’s disease (PD) as well as in the brains of PD patients. p53 activation in response to neurodegenerative stress is closely associated with the degeneration of dopaminergic neurons accompanied by mitochondrial dysfunction, reactive oxygen species (ROS) production, abnormal protein aggregation, and impairment of autophagy, and these pathogenic events have been implicated in the pathogenesis of PD. …”
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457
Single-cell and spatial transcriptomics in endocrine research
Published 2024-02-01“…Accumulating evidence suggests that cellular heterogeneity in organs and cell-cell and tissue-tissue interactions are crucial for maintaining physical homeostasis and disease progression. Endocrine organs also exhibit cellular heterogeneity and comprise multiple cell types. …”
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458
(Pro)renin Receptor in Kidney Development and Disease
Published 2011-01-01“…The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. …”
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459
Iron-regulatory liver hormone hepcidin and its place in the system of congenital immunity
Published 2010-11-01“…Unique properties of hepcidin allow to consider this peptide as a part, linking two major systems of homeostasis maintenance – nonspecific protection of the body and iron metabolism.…”
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460
Drosophila melanogaster as an alternative animal model in fat metabolism studies
Published 2024-07-01“…It is discovered that Drosophila accommodates a range of cell types and organs which entail lipid metabolism and related energy homeostasis similar to those of mammals. Fat storage in Drosophila occurs in the form of lipid droplets carrying cholesterol and triacylglycerol which are accumulated primarily in the fat body – the analogous Drosophila organ to mammalian adipose tissue. …”
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