Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders by Hao Qian, Na Luo, Yuling Chi

“…Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. …”
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The Role of MicroRNAs in Regulatory T Cells by Chao Liu, Nannan Li, Guijian Liu

“…Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. …”
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Aerobic Endurance Development in 13 and 14 Year-Old Swimmers by C. Tartalranu, D. Ortanescu

“…Sporting physical effort determines the modification of homeostasis, stabilizing it in a certain period of time, at a higher level. …”
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Mitochondria-Associated Endoplasmic Reticulum Membranes in Microglia: One Contact Site to Rule Them all by Elisa Navarro, Jorge Montesinos

“…Microglia, the resident immune cells of the central nervous system (CNS), play a crucial role in maintaining tissue homeostasis by monitoring and responding to environmental changes through processes such as phagocytosis, cytokine production or synapse remodeling. …”
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Fever by Tamas Bartfai, Bruno Conti

“…We also show how fever research provided new insights into temperature and energy homeostasis, and into treatment of infection and inflammation.…”
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Innate Immunity and Neuroinflammation by Abhishek Shastri, Domenico Marco Bonifati, Uday Kishore

“…Innate immune system consisting of pattern-recognition receptors, macrophages, and complement system plays a key role in CNS homeostasis following injury and infection. Here, we discuss how innate immune components can also contribute to neuroinflammation and neurodegeneration.…”
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Alternative Argets Within the Endocannabinoid System for Future Treatment of Gastrointestinal Diseases by Rudolf Schicho, Martin Storr

“…The ECS in the gastrointestinal tract quickly responds to homeostatic disturbances by de novo synthesis of its components to maintain homeostasis, thereby offering many potential targets for pharmacological intervention. …”
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Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling by Luca Genovese, Andrea Brendolan

“…Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. …”
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Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins by Amy W. Lin, Heng-Ye Man

“…An increasing number of studies have established ubiquitination and proteasome-mediated degradation as universal mechanisms in the control of synaptic protein homeostasis. In this paper, we focus on the role of the ubiquitin-proteasome system (UPS) in the turnover of major neurotransmitter receptors, including glutamatergic and nonglutamatergic receptors, as well as postsynaptic receptor-interacting proteins.…”
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Interleukin-7 and Immunosenescence by Vanloan Nguyen, Andrew Mendelsohn, James W. Larrick

“…Interleukin-7 (IL-7) plays a central, critical role in the homeostasis of the immune system. Recent studies support a critical role for IL-7 in the maintenance of a vigorous healthspan. …”
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Pneumatosis Coli Formation via Counterperfusion Supersaturation in a Patient with Severe Diarrhea by Eric Vecchio, Sehrish Jamot, Jason Ferreira

“…We propose counterperfusion supersaturation as the etiology for this patient’s pneumatosis coli via disruption of homeostasis between nitrogen and hydrogen normally present in the bowel. …”
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IPEX as a Result of Mutations in FOXP3 by Hans J. J. van der Vliet, Edward E. Nieuwenhuis

“…Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by mutations in the FOXP3 gene that result in the defective development of CD4+CD25+ regulatory T cells which constitute an important T cell subset involved in immune homeostasis and protection against autoimmunity. Their deficiency is the hallmark of IPEX and leads to severe autoimmune phenomena including autoimmune enteropathy, dermatitis, thyroiditis, and type 1 diabetes, frequently resulting in death within the first 2 years of life. …”
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Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview by Nurulmuna Mohd Ghozali, Nelli Giribabu, Naguib Salleh

“…Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.…”
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Effects of Exercise or Mechanical Stimulation on Bone Development and Bone Repair by Lidan Song

“…The immune cells in the environment interact with bone cells to maintain homeostasis and facilitate bone regeneration. Investigation of the mechanism by which these cells sense and respond to mechanical signals in bone is fundamental for optimal clinical intervention in bone injury healing. …”
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Heart Rate Variability: Why Chaos can be healthy by Jorge Cancino

“…Body autonomic interactions, mediated by sympathetic-parasympathetic balance, have been widely associated with stress and internal homeostasis. The acquisition of data, otherwise hidden in the signal from RR interval duration in heart rate, has given scientists access to the quantification of autonomic balance in humans, as long as the appropriate mathematical analyses are performed. …”
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Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms by Tamás Rőszer

“…The alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling. Today the M2 macrophages are identified based on the expression pattern of a set of M2 markers. …”
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Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism by Annelies Peeters, Myriam Baes

“…PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. …”
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Expression Profiling and Functional Implications of a Set of Zinc Finger Proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in Primary Osteoarthritic Articular Chondrocytes by Maria Mesuraca, Olimpio Galasso, Leonardo Guido, Emanuela Chiarella, Stefania Scicchitano, Renaud Vatrinet, Giovanni Morrone, Heather M. Bond, Giorgio Gasparini

“…These results suggest a role for ZNF423 and ZNF521 in the regulation of chondrocyte homeostasis and warrant further investigations to elucidate their mechanism of action.…”
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Mechanism of action of Xipayimaizibizi oral liquid on outlet obstruction-induced overactive bladder: An integrated study by Menglu Wang, Yang Yang, Yuhang Du, Jiamei Xie, Yige Zhao, Yongcheng An, Ziyi Shan, Shenyujun Wang, Meng Hao, Baosheng Zhao

“…It can also reduce the overexpression of Ca2+ caused by agonists, inhibit targets such as transient receptor potential vanilloid type 1, and participate in calcium signaling pathways to maintain Ca2+ homeostasis. Conclusion: These results suggest that XP inhibited bladder overactivity by maintaining Ca2+ homeostasis and regulating the parasympathetic nervous system.…”
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Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…Potential threats to homeostasis might occur as early as during in utero life, potentially leaving a lasting mark on the developing organism. …”
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