Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…Potential threats to homeostasis might occur as early as during in utero life, potentially leaving a lasting mark on the developing organism. …”
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AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis by Manikandan Palrasu, Khadija Kakar, Amarnath Marudamuthu, Hamida Hamida, Shruthi Thada, Yin Zhong, Shanieka Staley, Philip Brandon Busbee, Jie Li, Monica Garcia-Buitrago, Mitzi Nagarkatti, Prakash Nagarkatti

“…Our data identify a novel signaling pathway in which AhR acts as a transcription factor for α-defensin 1, leading to regulation of homeostasis between gut microbiota, intestinal mucosa, and mucosal immunity.…”
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TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

“…Single-cell RNA-seq revealed that loss of p63γ increases the expression of SCD1, a rate-limiting enzyme for synthesis of monounsaturated fatty acids, leading to altered lipid homeostasis. Together, our data indicate that TP63γ is the primary isoform of TP63 for tumor suppression but not development by maintaining normal inflammatory response and lipid homeostasis.…”
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Functional Status of Pancreatic α and β Cells in Type 2 Diabetes Mellitus Patients with Different Plasma Triglyceride Levels: A Retrospective Analysis by Hang Guo, Chunlei Ma, Xiaoming Wu, Congqing Pan

“…In addition to the increase in TG levels, the insulin sensitivity index (ISI), homeostasis model assessment for β-cell function index (HOMA-β), ΔI30/ΔG30, and AUCI displayed a reducing trend. …”
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Prion protein promotes copper toxicity in Wilson disease by Raffaella Petruzzelli, Federico Catalano, Roberta Crispino, Elena V. Polishchuk, Mariantonietta Elia, Antonio Masone, Giada Lavigna, Anna Grasso, Maria Battipaglia, Lucia Vittoria Sepe, Banu Akdogan, Quirin Reinold, Eugenio Del Prete, Diego Carrella, Annalaura Torella, Vincenzo Nigro, Enrico Caruso, Nicole Innocenti, Emiliano Biasini, Ludmila V. Puchkova, Alessia Indrieri, Ekaterina Y. Ilyechova, Pasquale Piccolo, Hans Zischka, Roberto Chiesa, Roman S. Polishchuk

“…Unfortunately, the molecular targets for normalizing Cu homeostasis in Wilson disease remain poorly understood. …”
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The Mla pathway promotes Vibrio cholerae re-expansion from stationary phase by Deborah R. Leitner, Franz G. Zingl, Alexander A. Morano, Hailong Zhang, Matthew K. Waldor

“…Our findings suggest that the defects in cellular energy homeostasis that emerge in the absence of the Mla pathway underlie its importance in maintaining V. cholerae culturability.…”
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Bilateral Simultaneous Avulsion Fractures of the Proximal Tibia in a 14-Year-Old Athlete with Vitamin-D Deficiency by Ziad Harb, Arfan Malhi

“…Vitamin-D plays a vital role in bone homeostasis and its deficiency has an impact on fracture risk and healing. …”
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Inflammasome in Intestinal Inflammation and Cancer by Tiago Nunes, Heitor S. de Souza

“…Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens.…”
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The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases by Simon J. Conway, Thomas Doetschman, Mohamad Azhar

“…Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.…”
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Oxi-Inflamm-Aging: a New Theory with Practical Implications by Ángel Julio Romero Cabrera, Leocadia Amores Hernández

“…Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune <em>dysregulation</em> leads to a <em>chronic low-grade inflammatory state</em> in aging. …”
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A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation by Elena Tarabra, Stella Pelengaris, Michael Khan

“…Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. …”
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Loss and Dysregulation of Th17 Cells during HIV Infection by Sandra L. Bixler, Joseph J. Mattapallil

“…T helper 17 (Th17) cells are a unique lineage of T helper cells that are enriched in mucosal tissues and are thought to play a central role in protecting the integrity of the mucosal barrier and maintaining immune homeostasis at mucosal sites. Th17 cells are lost very early during the course of HIV infection, and their loss has been shown to correlate with bacterial translocation. …”
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Nutrition – facts and myths by Verbanac Donatella, Maleš Željan, Barišić Karmela

“…By following the main principles of a healthy diet, the physiological homeostasis can be managed, as well as faster recovery from disease achieved.…”
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Insights into the Roles of B Cells in Patients with Sepsis by Xijie Dong, Hao Tu, Shuang Qin, Xiangjun Bai, Fan Yang, Zhanfei Li

“…Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper the numbers and function of B cells, which mediate innate and adaptive immune responses to maintain immune homeostasis. Dysfunction of B cells, along with aggravated immunosuppression, are closely related to poor prognosis. …”
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Tolerance in Kidney Transplantation: What Is on the B Side? by Laura Carreras-Planella, Francesc E. Borràs, Marcella Franquesa

“…Regulatory B cells (Breg) are in the spotlight for their role in immune homeostasis maintenance and tolerance achievement as in the last years the correlation with functional and increased Breg numbers in autoimmune diseases and transplantation has been extensively proven. …”
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Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases by D. Dreymueller, K. Theodorou, M. Donners, A. Ludwig

“…Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. …”
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Erasing Synapses in Sleep: Is It Time to Be SHY? by Marcos Gabriel Frank

“…An elegant idea that may explain how sleep accomplishes this role is the “synaptic homeostasis hypothesis (SHY).” According to SHY, sleep promotes net synaptic weakening which offsets net synaptic strengthening that occurs during wakefulness. …”
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Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians by Xuhui Chen

“…Positional information in muscle cells governs the polarity and patterning of the body plan during homeostasis and regeneration. For planarians, removal of neoblasts disables the regenerative feats and disruption of positional information results in the regeneration of inappropriate missing body regions, only the combination of neoblasts and positional information enables regeneration. …”
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Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities by Ran Zhang, Bo Li, Heng Li

“…Accumulating studies have demonstrated that ECM stiffness, a type of mechanical forces, exerts a pivotal influence on regulating organogenesis, tissue homeostasis, and the occurrence and development of miscellaneous diseases. …”
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Thiazolidinediones on PPARγ: The Roles in Bone Remodeling by Wei Wei, Yihong Wan

“…This paper will focus on current new developments that implicate potential mechanisms for how PPARγ modulates skeletal homeostasis and how TZDs exert bone-loss side effects.…”
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