PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling by Maria Moreno, Assunta Lombardi, Elena Silvestri, Rosalba Senese, Federica Cioffi, Fernando Goglia, Antonia Lanni, Pieter de Lange

“…Peroxisome proliferator-activated receptors (PPARs), which are known to regulate lipid homeostasis, are tightly controlled by nutrient availability, and they control nutrient handling. …”
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Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release Hepcidin In Vivo by Lisa Tussing-Humphreys, Keith N. Frayn, Steven R. Smith, Mark Westerman, A. Louise Dennis, Elizabeta Nemeth, Jessica Thomson, Cenk Pusatcioglu

“…Hepcidin is the main regulator of systemic iron homeostasis and is primarily produced by the liver but is also expressed, at the mRNA-level, in periphery tissues including the subcutaneous and visceral adipose tissue. …”
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Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy by Shiori Kawai, Hajime Yamakage, Kazuhiko Kotani, Mitsuhiko Noda, Noriko Satoh-Asahara, Koshi Hashimoto

“…Serum adiponectin levels also negatively correlated with the area of subcutaneous adipose tissue (SAT) and Homeostasis model assessment (HOMA)-R in the MHO group, but not in the MUO group. …”
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Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases by Makoto Ishikawa

“…Glutamate excess is primarily attributed to perturbation in the homeostasis of the glutamate metabolism. Major pathway of glutamate metabolism consists of glutamate uptake by glutamate transporters followed by enzymatic conversion of glutamate to nontoxic glutamine by glutamine synthetase. …”
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The Role of Hyaluronan in Innate Defense Responses of the Intestine by Carol A. de la Motte, Sean P. Kessler

“…Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating innate host defense mechanisms. …”
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Remodeling of ER Membrane Contact Sites During Cell Division by Fang Yu, Khaled Machaca

“…Membrane contact sites (MCS) provide specialized conduits for inter-organelle communications to maintain cellular homeostasis. Most organelles are interconnected, which supports their coordination and function. …”
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Role of Apoptosis in HIV Pathogenesis by Cyril Jabea Ekabe, Njinju Asaba Clinton, Eugene Kusi Agyei, Jules Kehbila

“…The apoptotic pathway is an important cell death pathway that contributes to the maintenance of homeostasis in living systems. However, variations in apoptosis have been linked to many diseases such as cancers and chronic infections. …”
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IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex by Tae Sik Goh, Yuna Jo, Byunghyuk Lee, Geona Kim, Hyunju Hwang, Eunhee Ko, Seung Wan Kang, Sae-Ock Oh, Sun-Yong Baek, Sik Yoon, Jung Sub Lee, Changwan Hong

“…IL-7 signaling via IL-7Rα and common γ-chain (γc) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-7Rα and γc in the absence or presence of IL-7 remains unclear. …”
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Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice by Nitin Puri, Yevgeniy Arefiev, Robert Chao, David Sacerdoti, Hibba Chaudry, Alexandra Nichols, Krithika Srikanthan, Athar Nawab, Dana Sharma, Vishal Hari Lakhani, Rebecca Klug, Komal Sodhi, Stephen J. Peterson

“…We investigated the effects of HO-1 induction on hepatic hepcidin levels and on iron homeostasis in hepatic tissues from lean and obese mice. …”
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APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs by Yong Wang, Xinping Liu, Zheng Liu, Shasha Hua, Kai Jiang

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Transient Neonatal Zinc Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 (SLC30A2) Gene in the Mother Highlighting the Importance of Zn2+ for Normal... by Maria Consolata Miletta, Andreas Bieri, Kristin Kernland, Martin H. Schöni, Vibor Petkovic, Christa E. Flück, Andrée Eblé, Primus E. Mullis

“…Thus the coordinated action of both is essential for the maintenance of Zn2+ homeostasis in the cytoplasm, and accumulating evidence suggests that this is also true for the secretory pathway of growth hormone.…”
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Associations of CAG repeat polymorphism in the androgen receptor gene with steroid hormone levels and anthropometrics among men: the role of the ethnic factor by L. V. Osadchuk, G. V. Vasiliev, A. V. Osadchuk

“…Androgens are required for stimulation and maintenance of skeletal growth and bone homeostasis. Physiological functions of androgens are mediated through the androgen receptor (AR). …”
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Involvement of RBP4 in Diabetic Atherosclerosis and the Role of Vitamin D Intervention by Wan Zhou, Shan-Dong Ye, Chao Chen, Wei Wang

“…The levels of serum and adipose RBP4, fasting insulin (FINS), fasting plasma glucose (FPG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), 25-hydroxyvitamin D [25(OH)D], C-reactive protein (CRP), and systolic blood pressure (SBP) were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment β-cell function index (HOMA-β), and atherogenic indexes (AI) were calculated. …”
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The enriched gut commensal Faeciroseburia intestinalis contributes to the anti-metabolic disorders effects of the Ganoderma meroterpene derivative by Shanshan Qiao, Kai Wang, Chang Liu, Nan Zhou, Li Bao, Jun Wang, Shuangjiang Liu, Hongwei Liu

“…Treatment with F. intestinalis effectively enhanced the level of gut butyrate, which subsequently ameliorated the intestinal barrier function and activated epithelial PPAR-γ signaling pathway to regulate microbiome homeostasis in gut. Our study demonstrated that the causal relationship between the butyrate-producing bacteria and the GMD's therapeutic effects and confirmed the important function of the butyrate-producing F. intestinalis in maintaining host metabolism homeostasis.…”
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Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2 by Qi Dong, Haoyuan Fu, Wenxiao Li, Xinyu Ji, Yingchao Yin, Yiran Zhang, Yanbo Zhu, Guoqiang Li, Huiyang Jia, Heng Zhang, Haofei Wang, Jinglue Hu, Ganggang Wang, Zhihao Wu, Yingze Zhang, Sujuan Xu, Zhiyong Hou

“…Abstract The delicate balance between bone formation by osteoblasts and bone resorption by osteoclasts maintains bone homeostasis. Nuclear receptors (NRs) are now understood to be crucial in bone physiology and pathology. …”
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Liver GlucokinaseA456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase by Anna Vidal-Alabró, Alícia G. Gómez-Valadés, Andrés Méndez-Lucas, Jordi Llorens, Ramon Bartrons, Jordi Bermúdez, Jose C. Perales

“…Recent reports point out the importance of the complex GK-GKRP in controlling glucose and lipid homeostasis. Several GK mutations affect GKRP binding, resulting in permanent activation of the enzyme. …”
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Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model by Suresh Kumar

“…Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis. In structural genomics, prediction of metal binding proteins help in the selection of suitable growth medium for overexpression’s studies and also help in obtaining the functional protein. …”
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PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia by Sarawin Harnchoowong, Poonkiat Suchonwanit

“…PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. …”
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Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation by Erin E. Mulvihill, Murray W. Huff

“…Molecular studies will add significantly to the concept of these flavonoids as viable and promising therapeutic agents to treat the dysregulation of lipid homeostasis, metabolic disease, and its cardiovascular complications.…”
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A Different Perspective for Management of Diabetes Mellitus: Controlling Viral Liver Diseases by Yingying Zhao, Huichun Xing

“…Through participating in synthesis and catabolism of glycogen, the liver helps to regulate glucose homeostasis. Viral related liver diseases are associated with glycometabolism disorders, which means effective management of viral liver diseases may be a therapeutic strategy for DM. …”
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