Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells by Mariagrazia Valentini, Alessia Piermattei, Gabriele Di Sante, Giuseppe Migliara, Giovanni Delogu, Francesco Ria

“…In fact the immune system plays an essential role in maintaining the homeostasis with the microbiota that normally resides in the gut, while, at the same time, the gut microbiota influences the immune system, modulating number and function of effector and regulatory T cells. …”
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Immunomodulatory effects of Lactiplantibacillus plantarum CCFM8661 + stachyose on cyclophosphamide-induced immunosuppression mice by Weiwei Ma, Hang Sun, Lian Lian, Lidong Guo, Yanyan Wang, Lili Huang

“…Additionally, it restored intestinal microbiota diversity by increasing the abundance of Muribaculaceae while reducing Lachnospiraceae, potentially promoting intestinal homeostasis.DiscussionThe combination of Lactiplantibacillus plantarum CCFM8661 and stachyose has immune-enhancing effects, potentially achieved by regulating inflammation levels and maintaining intestinal homeostasis.…”
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Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives by Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li

“…Disruption of pseudouridylation impairs cellular homeostasis, contributing to pathological alterations. …”
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Role of transforming growth factor-β1 in regulating adipocyte progenitors by Nguyen Quynh Phuong, Muhammad Bilal, Allah Nawaz, Le Duc Anh, Memoona, Muhammad Rahil Aslam, Sana Khalid, Tomonobu Kado, Yoshiyuki Watanabe, Ayumi Nishimura, Yoshiko Igarashi, Keisuke Okabe, Kenichi Hirabayashi, Seiji Yamamoto, Takashi Nakagawa, Hisashi Mori, Isao Usui, Shiho Fujisaka, Ryuji Hayashi, Kazuyuki Tobe

“…Abstract Adipose tissue (AT) metabolism involves coordinating various cells and cellular processes to regulate energy storage, release, and overall metabolic homeostasis. Therein, macrophage and its cytokine are important in controlling tissue homeostasis. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Abstract Background The small intestine harbors a rich array of intestinal intraepithelial lymphocytes (IELs) that interact with structural cells to collectively sustain gut immune homeostasis. Dysregulation of gut immune homeostasis was implicated in the pathogenesis of multiple autoimmune diseases, however, whether this homeostasis is disrupted in a lupus autoimmune background remains unclear. …”
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Thymus ad astra, or spaceflight-induced thymic involution by Wataru Muramatsu, Wataru Muramatsu, Maria Maryanovich, Maria Maryanovich, Maria Maryanovich, Taishin Akiyama, Taishin Akiyama, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis

“…The thymus is particularly sensitive to spaceflight conditions, as its role in maintaining immune homeostasis is tightly regulated by a balance of systemic and local factors easily disrupted in space. …”
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High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus by Yoshiichi Takagi, Taichi Sugimoto, Masaya Kobayashi, Mitsuyuki Shirai, Fumitoshi Asai

“…High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. …”
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Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility by Maurizio Vitti, Giovanna Di Emidio, Michela Di Carlo, Gaspare Carta, Andrea Antonosante, Paolo Giovanni Artini, Annamaria Cimini, Carla Tatone, Elisabetta Benedetti

“…PPARs act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism, energy homeostasis, inflammation, and cell proliferation and differentiation. …”
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The protein tyrosine phosphatase, nonreceptor type 22-1858C->T (rs2476601) polymorphism is not a genetic risk factor for systemic lupus erythematosus in Indian Tamils by Panneer Devaraju, Reena Gulati, Durga Prasanna Misra, Vir Singh Negi

“…Background: Systemic lupus erythematosus (SLE), a systemic autoimmune disease, occurs due to disruption of immune homeostasis against self-antigens. The etiology of SLE is complex and multiple genetic factors contribute to disease susceptibility and clinical phenotypes. …”
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The Effect of Long-Term Exercise on the Production of Osteoclastogenic and Antiosteoclastogenic Cytokines by Peripheral Blood Mononuclear Cells and on Serum Markers of Bone Metabol... by J. Kelly Smith, Rhesa Dykes, David S. Chi

“…We also measured lymphocyte phenotypes and serum markers of bone formation (osteocalcin), bone resorption (C-terminal telopeptides of Type I collagen), and bone homeostasis (25 (OH) vitamin D, estradiol, testosterone, parathyroid hormone, and insulin-like growth factor 1). …”
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Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice by Ayana N. Martin, Martha Alexander-Miller, Barbara K. Yoza, Vidula Vachharajani, Charles E. McCall

“…Resistance and tolerance to infection are two universal fitness and survival strategies used by inflammation and immunity in organisms and cells to guard homeostasis. During sepsis, however, both strategies fail, and animal and human victims often die from combined innate and adaptive immune suppression with persistent bacterial and viral infections. …”
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Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function by Atenea A. Perez-Serna, Daniel Guzman-Llorens, Reinaldo S. Dos Santos, Laura Marroqui

“…However, over the years, they have been implicated in many other cellular processes, including intracellular Ca²⁺ homeostasis and the regulation of mitochondrial metabolism. …”
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Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents by Mar Quiñones, Cintia Folgueira, Estrella Sánchez-Rebordelo, Omar Al-Massadi

“…Our findings indicate that serum irisin levels are not modulated by different physiological settings associated to alterations in energy homeostasis. These results suggest that in rodents circulating levels of irisin are not involved in the pathophysiology of obesity and could be unrelated to metabolic status; however, further studies should clarify its precise role in states of glucose homeostasis imbalance.…”
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Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice by Ravneet K. Boparai, Oge Arum, Johanna G. Miquet, Michal M. Masternak, Andrzej Bartke, Romesh K. Khardori

“…Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. …”
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Rac1-dependent regulation of osteoclast and osteoblast differentiation by developmentally regulated GTP-binding 2 by Jung Ha Kim, Semun Seong, Kabsun Kim, Inyoung Kim, Jeong Woo Park, Jeong-Tae Koh, Nacksung Kim

“…Abstract Multiple small GTPases play crucial roles in bone homeostasis by regulating the differentiation and function of bone cells, including osteoclasts and osteoblasts. …”
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Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction by Subhra Karmakar, Sangita Majumdar, Anasuya Maiti, Monalisa Choudhury, Aniruddha Ghosh, Asankur S. Das, Chandan Mitra

“…Also, several bone parameters (bone density, bone tensile strength, bone mineral content, and bone histology) and calcium homeostasis were checked. Results. Results indicated that HFD-induced alterations in urinary, serum, and bone parameters as well as calcium homeostasis, all could be significantly ameliorated by BTE supplementation. …”
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Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan by Seishi Furukawa, Yoichi Kobayashi

“…The cut-off value of the homeostasis model assessment insulin resistance (HOMA-IR) for detecting GDM was determined. …”
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Effect of Stress on Autonomic and Cardiovascular Systems in Military Population: A Systematic Review by Álvaro Bustamante-Sánchez, José Francisco Tornero-Aguilera, Valentín E. Fernández-Elías, Alberto J. Hormeño-Holgado, Athanasios A. Dalamitros, Vicente Javier Clemente-Suárez

“…A multifactorial response usually leads to significant behavioural modifications and alterations on homeostasis and physical and psychological status. Moreover, stress is an emotional response that can lead to psychosocial and psychophysiological adversity. …”
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Dopamine Suppresses Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells via AKT/GSK-3β/β-Catenin Signaling Pathway by Zhili Kuang, Zheng Chen, Shaoqin Tu, Zhihui Mai, Lin Chen, Xiaoning Kang, Xiaochuan Chen, Jiaming Wei, Yuxuan Wang, Yun Peng, Hong Ai

“…Our study provides new insights into the role of neurotransmitters in bone homeostasis.…”
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Association between exposure to ambient air pollutants and metabolic syndrome in the vicinity of the Taklamakan Desert by Zhe Wang, Weidong Ji, Yushan Wang, Lin Li, Kai Wang, Hongze Liu, Yining Yang, Yi Zhou

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