Adaptive potential of winter rye cultivars developed at VIR in the context of their grain protein content in the environments of Leningrad province by N. I. Aniskov, I. V. Safonova, V. I. Horeva

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Mina53 catalyzes arginine demethylation of p53 to promote tumor growth by Lixiao Zhou, Liyang Yu, Shushu Song, Yong Wang, Qiang Zhu, Meng Li, Yutong Sha, Liang Xu, Xin Shu, Qingqing Liao, Ting Wu, Bing Yang, Siyuan Chai, Bingyi Lin, Liming Wu, Ruhong Zhou, Xiaotao Duan, Chenggang Zhu, Yuanyuan Ruan, Wen Yi

“…Thus, our study reveals a regulatory mechanism of p53 homeostasis and activity and, more broadly, defines a paradigm for dynamic arginine methylation in controlling important biological functions.…”
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ERBB4 selectively amplifies TGF-β pro-metastatic responses by Peihong Luo, Huanyu Hong, Baoling Zhang, Jie Li, Shuyi Zhang, Chaomin Yue, Jin Cao, Jia Wang, Yuhan Dai, Qingqing Liao, Pinglong Xu, Bing Yang, Xia Liu, Xia Lin, Yi Yu, Xin-Hua Feng

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Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts by Linwei Fan, Yuanjun Tang, Jian Liu, Yueqi Liu, Yiwei Xu, Jiayu Liu, Han Liu, Wei Pang, Yuxuan Guo, Weijuan Yao, Tao Zhang, Qin Peng, Jing Zhou

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Harnessing the power of structure‐based design: A new lease on life for cardiovascular drug development with apelin receptor modulators by Junxia Zhang, Erdan Dong, Yan Zhang, Yan Zhang

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Sleep Deprivation Influences Circadian Gene Expression in the Lateral Habenula by Beilin Zhang, Yanxia Gao, Yang Li, Jing Yang, Hua Zhao

“…Sleep is governed by homeostasis and the circadian clock. Clock genes play an important role in the generation and maintenance of circadian rhythms but are also involved in regulating sleep homeostasis. …”
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Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer by Patrizia Pellegrini, Ida Contasta, Tiziana Del Beato, Fabiana Ciccone, Anna Maria Berghella

“…Our results show that the interferon (IFN)γ production pathway for immune response homeostasis is specific to men whilst the interleukin- (IL-) 6 production pathway for immune response homeostasis is specific to women. …”
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Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review by Natalia Drabińska

“…The shift in metabolism occurring in ketosis can affect the reactive oxygen species (ROS)-producing pathways and influence the expression of enzymes involved in redox homeostasis. Therefore, this review summarizes and discusses existing knowledge about KD and ROS homeostasis. …”
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Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease by Katherine Luo, Stewart Siyan Cao

“…In eukaryotic cells, perturbation of protein folding homeostasis in the endoplasmic reticulum (ER) causes accumulation of unfolded and misfolded proteins in the ER lumen, which activates intracellular signaling pathways termed the unfolded protein response (UPR). …”
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Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus by Stephen A. Myers, Alex Nield, Mark Myers

“…Cellular homeostasis requires mechanisms that tightly control the uptake, storage, and distribution of zinc. …”
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Mitochondria as a Therapeutic Target: Focusing on Traumatic Brain Injury by Randhall Bruce Carteri

“…Mitochondria are organelles of eukaryotic cells delimited by two membranes and cristae that consume oxygen to produce adenosine triphosphate (ATP), and are involved in the synthesis of vital metabolites, calcium homeostasis, and cell death mechanisms. Strikingly, normal mitochondria function as an integration center between multiple conditions that determine neural cell homeostasis, whereas lesions that lead to mitochondrial dysfunction can desynchronize cellular functions, thus contributing to the pathophysiology of traumatic brain injury (TBI). …”
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2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks by Jinah Park, Sunmi Lee, Sanghyuk Lee, Sang Won Kang

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Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis by Yinuo Fan, Zhiwen Chen, Haixing Wang, Mengyu Jiang, Hongduo Lu, Yangwenxiang Wei, Yunhao Hu, Liang Mo, Yuhao Liu, Chi Zhou, Wei He, Zhenqiu Chen

“…We found an imbalance in mitochondrial homeostasis and ferroptosis-induced impairment of osteogenic capacity in SIONFH. …”
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Activated receptors for peroxisomic proliferators. Its role in the atherosclerosis, obesity and high blood pressure. by Mikhail Benet Rodríguez, Yosvel Curbelo Pérez

“…PPAR receptors regulate the expressions of a great variety of genes that codify the proteins that are implied in the lipid metabolism, the energetic homeostasis, the cellular differentiation and the formation of tumours. …”
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Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Metabolism by Michelle M Pluhator, Alan BR Thomson, Richard N Fedorak

“…In addition, numerous unknowns surround the intricacies of bodily zinc homeostasis. Part two of this five-part review presents current views on the normal intestinal absorption, intracellular and extracellular metabolism, transport, excretion and homeostasis of zinc in the human body. …”
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Mechanistic insights into connexin-mediated neuroglia crosstalk in neurodegenerative diseases by Simona Denaro, Simona D’Aprile, Nunzio Vicario, Rosalba Parenti

“…This review explores mechanistic insights of Cxs-mediated intercellular communication in the progression of neurodegenerative diseases and discusses the therapeutic potential of targeting Cxs to restore cellular homeostasis.…”
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Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions by Rodrigo Bibiloni, Eduardo J. Schiffrin

“…The close interaction between host-symbiotic microbiota at the mucosal level poses important challenges since microbial breaches through the gut barrier can result in the breakdown of gut homeostasis. In this paper, hosts-integrated components that help to preserve intestinal homeostasis including barrier and immune function are discussed. …”
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Escherichia coli stress response systems and their reaction to terahertz radiation by S. E. Peltek, E. V. Demidova, V. M. Popik, T. N. Goryachkovskaya

“…The obtained data indicate that exposure to nonthermal terahertz radiation induces E. сoli gene networks of oxidative stress and copper ion homeostasis, but does not activate those responding to antibiotics, protonophores, or superoxide anions. …”
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The Impact of Incretin-Based Medications on Lipid Metabolism by Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…In the current review, how these antidiabetic medications can regulate lipid homeostasis and the possible cellular pathways involved are discussed, incorporating related clinical evidence about incretin effects on lipid homeostasis.…”
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Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice by Thomas Guerbette, Vincent Ciesielski, Manon Brien, Daniel Catheline, Roselyne Viel, Mégane Bostoën, Jean-Baptiste Perrin, Agnès Burel, Régis Janvier, Vincent Rioux, Annaïg Lan, Gaëlle Boudry

“…However, diet-induced obesity (DIO) may impair mitochondrial activity of IEC and consequently, intestinal homeostasis. The aim of the project was to determine whether DIO alters the mitochondrial function of IEC, and what are the consequences on intestinal homeostasis. …”
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