Thyroid Nodules Located in the Lower Pole Have a Higher Risk of Malignancy than Located in the Isthmus: A Single-Center Experience by Gulhan Duman, Baris Sariakcali

“…Ultrasonography provides very valuable information in the evaluation of TNs, but it does not correlate perfectly with histopathologic findings. Therefore, studies that will include new diagnostic methods that can improve these unknowns can be welcomed gratefully. …”
Get full text

A Case of Neuromyelitis Optica: Puerto Rican Woman with an Increased Time Lag to Diagnosis and a High Response to Eculizumab Therapy by Ramón Vega, Benjamín González, Kiara Ortiz, Viviana Martínez, David Carmona, Ivonne Vicente, Javier Chapa, Ángel Chinea

“…This case illustrates the efficacy of eculizumab therapy and the importance of differentiating the clinical, histopathological, and neuroimaging characteristics that separate demyelinating autoimmune inflammatory disorders, such as NMOSD and multiple sclerosis (MS).…”
Get full text

Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma by Yasuo Otsuka, Yoriaki Komeda, Masayuki Takeda, Takayuki Takahama, Masashi Kono, Mamoru Takenaka, Satoru Hagiwara, Naoshi Nishida, Hiroshi Kashida, Masatoshi Kudo

“…In addition, ascites and nodules were observed in the abdominal cavity. Histopathological examination of a biopsy specimen revealed peritoneal invasion of atypical epithelioid cells with trabecular and glandular patterns. …”
Get full text

Evaluation of the Diagnostic Performance of Physical Examination Combined with Transvaginal Ultrasonography in Patients with Endometriosis by Talha Tiryaki, Tolga Karacan, Seyma Yesiralioglu, Eser Ozyurek, Huseyin Kiyak, Engin Oral

“…Results: The number of patients reported to have endometriosis histopathologically was 138;132 were in the premenopausal period (symptomatic group n=101, asymptomatic group n=31) and 6 were in the postmenopausal period (symptomatic group n=1, asymptomatic group n=5). …”
Get full text

Etoricoxib–NLC Mitigates Radiation-Induced Ovarian Damage in Rats: Insights into Pro-Inflammatory Cytokines, Antioxidant Activity, and Hormonal Responses by Sahar Khateeb

“…Twenty-four female rats were randomly assigned to four groups: a control group receiving normal saline, a group exposed to a single dose of whole-body gamma radiation (6 Gy), a group treated with etoricoxib (10 mg/kg) post-radiation, and a group treated with ETO-NLC for 14 days following radiation. Histopathological evaluations and oxidative stress biomarker assessments were conducted, including ELISAs for reactive oxygen species (ROS), pro-inflammatory cytokines (IL-1β, TNF-α), and signaling molecules (PI3K, AKT, P38MAPK, AMH). …”
Get full text

Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats by Zahra Moslemi, Izadpanah Gheitasi, Amir Hossein Doustimotlagh

“…However, in agreement with renal function tests, SP extract had no significant effects on histopathological examinations. Conclusion. It seems that SP extract employs renoprotective effects on renal damage induced by I/R, possibly by improving of oxidant-antioxidant status in favor of the antioxidant system.…”
Get full text

Two Rare Cases of Feline Toxic Epidermal Necrolysis: A Novel Therapeutic Approach With Medical-Grade Honey by Alexandra Peteoacă, Niels A. J. Cremers, Linsey J. F. Peters

“…TEN was confirmed via histopathological examination. The suspected cause of TEN in both cases was the iodine present in the surgical scrub. …”
Get full text

Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-κB Signaling by Jiangrui Liu, Liangpan Shi, Wenchang Huang, Zhihua Zheng, Xiaohui Huang, Yibin Su

“…Body weight, colon length, disease activity index (DAI), and histopathological change were examined. The relative contents of interleukin- (IL-) 1β, tumor necrosis factor- (TNF-) α, IL-6, and the chemokine (C-C motif) ligand 2 (CCL2) in the colon tissues and HHT-treated RAW264.7 cells were detected with the enzyme-linked immunosorbent assay. …”
Get full text

Corrigendum to “Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake” by James A. Edwards, Dirk Cremer

“…Subchronic OECD guideline studies with mice and rats receiving beadlet formulations of high-purity synthetic zeaxanthin in the diet at dosages up to 1000 mg/kg body weight (bw)/day, and in dogs at over 400 mg/kg bw/day, produced no adverse effects or histopathological changes. In developmental toxicity studies, there was no evidence of fetal toxicity or teratogenicity in rats or rabbits at dosages up to 1000 or 400 mg/kg bw/day, respectively. …”
Get full text

Effect of Uncaria rhynchophylla against Thioacetamide-Induced Acute Liver Injury in Rat by Mi-Rae Shin, Min Ju Kim, Jin A Lee, Seong-Soo Roh

“…In addition, the histopathological analysis showed that the liver tissue lesions were improved obviously by UR treatment. …”
Get full text

Protective and anti-inflammatory effects of caffeic acid phenethyl ester on arsenic-induced vasculitis in vivo by Yasser Kofiah, Eman A.A. Abdallah, Mohamed F. El-Refaei

“…Immunohistochemical examination for proliferating cell nuclear antigen indicated mild immunoreactivity in the aorta cells. Furthermore, histopathological inspection of the aortas revealed significantly less distortion of the wall and fewer rounded nuclei in group IV-treated rats. …”
Get full text

Wedelolactone Mitigates Alcoholic Steatohepatitis via Modulating the TLR4/MyD88/NF-κB Pathway by Tao Jiang, Bingde Hu, Yongxia Li, Shuihong Yu

“…The serum levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 in the ethanol + WEL group exhibited a dose-dependent decrease. Histopathological evaluations revealed that WEL mitigated liver injury, lipid accumulation, and macrophage infiltration provoked by alcohol consumption and a high-fat diet in mice. …”
Get full text

Prevalence of Esophageal Eosinophilia, Eosinophilic Esophagitis, and Lymphocytic Gastritis in Children with Celiac Disease: A Saudi Tertiary Center Experience by Meshari A. Alaifan, Ammar Khayat, Rana Y. Bokhary, Abdulhameed Ibrahim, Yagoub Bin-Taleb, Bakr H. Alhussaini, Omar I. Saadah

“…The study examined clinical, demographic, endoscopic, and histopathological data. Results. Seventy-five patients with CD were included in the analysis. …”
Get full text

Dynamic evaluation of vertebral alveolar echinococcosis using MR T2 mapping by Jinhuan Han, Yushan Chang, Hui Guo

“…Two rabbits with positive imaging results were randomly selected every 2 months for histopathological examination to evaluate the severity and pathological features of the rabbit model with Echinococcus multilocular infection. …”
Get full text

The Rare Large Common Peroneal Nerve’s Schwannoma—A Case Report and Literature Review by Rudiansyah Harahap, Nurmaliannysa Dwinandia Harahap

“…The encapsulated operation to remove the tumor was carried out with a size measuring 5 cm×4.5 cm×4 cm. The histopathological examination showed schwannoma. After surgery, the pain disappeared, hypoesthesia and a slight drop in the foot underwent physiotherapy, and stimulation with the result gradually improved. …”
Get full text

Laser Excisional Biopsy of Bleeding Tumor near Newly Erupted Tooth in an 11-Month-Old Patient under General Anesthesia by Amir Mansour Shirani, Parnian Tadayonnezhad, Sarah Arzani, Seyed Omid Kiansadr, Nasser Kaviani

“…Several treatment options exist for PG lesions, which apply after a final diagnosis specified by biopsy and histopathological investigations. Surgical excision is the most common treatment choice for PG lesions. …”
Get full text

Trichoscopic Features of Lichen Planopilaris versus Frontal Fibrosing Alopecia: A Systematic Review by Shreya K. Gowda, Enzo Errichetti, Biswanath Behera, Vishal Thakur

“…Conclusion: This article provides a comprehensive literature review, correlating dermoscopic features with histopathological findings and the similarities, differences, and peculiarities of LPP and FFA. …”
Get full text

The Initial Experience of Trans-Rectal Ultrasound and Biopsy in Diagnosis of Carcinoma Prostate In Gezira Hospital For Renal Disease And Surgery (GHRDS) by Walaa Eldin Ibraheem, Sami Mahjoub Taha, Mustafa Omran Mansour, Mohammed El Imam Mohamed Ahmed

“…Transrectal U/S findings well correlated to the histopathological results, where abnormal findings (like hypo-echoic lesions or calcifications and cysts) showed higher incidence of malignancy in 46 patients constitute 52.8% of the abnormal U/S findings. …”
Get full text

Pseudomyxoma Peritonei Originating from Transverse Colon Mucinous Adenocarcinoma: A Case Report and Literature Review by Yingbo Gong, Xin Wang, Zhi Zhu

“…We did an extensive literature review in order to describe the clinical characteristics, histopathological findings, genetic profile, and potential treatments of PMP caused by nonappendiceal mucinous adenocarcinoma.…”
Get full text

MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice by Jun Hu, Hui Du, Yinglin Yuan, Peipei Guo, Junxia Yang, Xinru Yin, Jin Liu, Shengwang Wu, Jingyuan Wan, Xia Gong

“…Using methionine and choline deficient (MCD) diet-fed mice, we found MFG-E8 knockout exacerbated hepatic damage and steatosis as indicated by increased plasma transaminases activities and hepatic histopathologic change, higher hepatic triglycerides (TGs), and lipid accumulation. …”
Get full text