Clinical and laboratory characteristics of solitary rectal ulcer syndrome: a retrospective analysis of 36 case by Furkan Ali Uygur, Muhammed Emin Göktepe, Gökhan Aydın, Enes Ağırman, Ahmet Cumhur Dülger

“…Laboratory findings revealed significant abnormalities, including mean hemoglobin levels of 10.0 ± 2.4 g/dL and mean CRP levels of 56.7 ± 65.4 mg/L. Histopathological analysis showed that 38.9% of patients had normal biopsy results, whereas inflammation and dysplasia were observed in 41.7% and 2.8% of cases, respectively. …”
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Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways by Randa Ismail, Heba A. Habib, Aliaa F. Anter, Amr Amin, Gehan H. Heeba

“…MCP enhanced the cytotoxicity of MTX in Nalm6 and JEG3 and did not interfere with its cytotoxicity in the MCF7 cell lines.DiscussionMCP attenuated MTX-induced liver and lung toxicity through antioxidant, anti-fibrotic, anti-inflammatory, and anti-apoptotic influences, as demonstrated by the improved histopathological changes induced by MTX in pulmonary and hepatic tissues. …”
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Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer by Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon

“…Further, we induced xenograft tumors in nude mice. The histopathological analysis confirmed the aggressive nature of resistant tumors and showed the presence of necrotic core which could be implicated to EMT. …”
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Enhanced Detection of Residual Breast Cancer Post-Excisional Biopsy: Comparative Analysis of Contrast-Enhanced MRI with and Without Diffusion-Weighted Imaging by Han Song Mun, Bong Joo Kang, Sung Hun Kim, Ga Eun Park

“…The apparent diffusion coefficient (ADC) values were measured, and the diagnostic outcomes of CE-MRI, CE-MRI with DWI, mammography (MG), and ultrasound (US) were compared with clinical and histopathological data. Results: A total of 152 lesions were analyzed, with 36.2% showing residual malignancy. …”
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MM-HiFuse: multi-modal multi-task hierarchical feature fusion for esophagus cancer staging and differentiation classification by Xiangzuo Huo, Shengwei Tian, Long Yu, Wendong Zhang, Aolun Li, Qimeng Yang, Jinmiao Song

“…The staging and differentiation of esophageal cancer are crucial factors in determining the prognosis and surgical treatment plan for patients, as well as improving their chances of survival. Endoscopy and histopathological examination are considered as the gold standard for esophageal cancer diagnosis. …”
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Surgical Quality in Rectal Cancer Management: What Can Be Achieved by a Voluntary Observational Study? by Łukasz Dziki, Ronny Otto, Hans Lippert, Paweł Mroczkowski, Olof Jannasch

“…The distribution of histopathological stage, anastomotic leakage, and in-hospital mortality did not change significantly. …”
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Comparison of Clinico-pathologic features and outcomes of ANCA negative and ANCA positive pauci immune crescentic glomerulonephritis: A single centre study by Pallav Gupta, Vinant Bhargava, Manish Malik, Anurag Gupta, Anil K. Bhalla, Ashwini Gupta, Vaibhav Tiwari, Devinder S. Rana, Ramesh L. Sapra

“…The present study compared clinico-pathologic features, Brix’s renal risk score, Berden’s histopathological classes and differences in outcome between ANCAnegative vs ANCA positive PICN patients. …”
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Bilosomal Co-Encapsulated Tamoxifen and Propranolol for Potentiated Anti-Breast Cancer Efficacy: In Vitro and In Vivo Investigation by Toka T. Elebyary, Amal A. Sultan, Sally E. Abu-Risha, Gamal M. El Maghraby, Manna Amin

“…Oral administration of combined TAM/PRO bilosomes showed a significant reduction in tumor growth volume compared to that recorded following naked drug administration. Histopathological investigations reflected a significant decline in tumor giant cells and mitotic figures, implying the in vivo capability of the TAM/PRO combination to interfere with cancer cell proliferation and persistence. …”
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Submucosal Tunnel Endoscopic Resection for Esophageal Submucosal Tumors: A Multicenter Study by Sufang Tu, Silin Huang, Guohua Li, Xiaowei Tang, Haitao Qing, Qiaoping Gao, Jingwen Fu, Guoping Du, Wei Gong

“…Regarding complications, there were 9 (7.8%) cases of perforation, 2 (1.7%) cases of pneumothorax, and 9 (7.8%) cases of subcutaneous emphysema. Histopathological results revealed 113 (95.0%) cases of leiomyoma, 5 (4.2%) cases of gastrointestinal stromal tumors, and 1 (0.8%) case of a granular cell tumor. …”
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Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways by Amany Abdlrehim Bekhit, Olivia N. Beshay, Michael A. Fawzy, Sara Mohamed Naguib Abdel-Hafez, Gaber El-Saber Batiha, Farid S. Ataya, Moustafa Fathy

“…Assessment of reactive oxygen species, malondialdehyde, and glutathione contents, and superoxide dismutase activity and histopathological evaluations were done on hepatic tissue. …”
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Advances in colorectal cancer diagnosis using optimal deep feature fusion approach on biomedical images by Sultan Refa Alotaibi, Manal Abdullah Alohali, Mashael Maashi, Hamed Alqahtani, Moneerah Alotaibi, Ahmed Mahmud

“…Pathology diagnoses complemented with predictive and prognostic biomarker information is the first step for personalized treatment. Histopathological image (HI) analysis is the benchmark for pathologists to rank colorectal cancer of various kinds. …”
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Comparing the Rates of Further Resection After Intraoperative MRI Visualisation of Residual Tumour Between Brain Tumour Subtypes: A 17-Year Single-Centre Experience by Daniel Madani, R. Dineth Fonseka, Sihyong Jake Kim, Patrick Tang, Krishna Muralidharan, Nicholas Chang, Johnny Wong

“…Patients were identified using SurgiNet and were grouped according to their histopathological diagnosis in accordance with the WHO 2021 classification. …”
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Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression by Mingyan Chen, Yanfang Zhang, Yangbo Zhao, Kewei Cao, Ruiyan Niu, Dongguang Guo, Zilong Sun

“…Our findings revealed significant damage to the thymus and spleen that was proportional to the dose administered, as evidenced by changes in organ indices and histopathological abnormalities. We observed mitochondrial swelling, chromatin condensation, and nuclear structure disruptions in these organs. …”
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Prevalence and clinicopathological Spectrum of Auto-Immune Liver Diseases & Overlap syndrome by Annapoorani Varadarajan, Archana Rastogi, Rakhi Maiwall, Chhagan Bihari, Sherin Thomas, Vikrant Sood, Saggere Muralikrishna Shasthry

“…Two pathologists independently reviewed the liver biopsies and reassessed 18 histopathological parameters. Results: During the study period, 17664 liver biopsies were received, out of which 1060 (6%) biopsies of AILD were identified. …”
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Metformin and Probiotics Interplay in Amelioration of Ethanol-Induced Oxidative Stress and Inflammatory Response in an In Vitro and In Vivo Model of Hepatic Injury by Farhin Patel, Kirti Parwani, Dhara Patel, Palash Mandal

“…In vivo, combined administration of probiotic V and Met ameliorated the histopathological changes, inflammatory response, hepatic markers (liver enzymes), and lipid metabolism induced by ethanol. …”
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Unraveling the Beneficial Role of Resveratrol in Fructose-Induced Non-Alcoholic Steatohepatitis with a Focus on the AMPK/Nrf2 Signaling Axis by Soha S. Zakaria, Safaa M. Hanafy

“…<i>Results</i>: Resveratrol effectively alleviated the biochemical and histopathological abnormalities associated with NASH, improving autophagy by raising Beclin 1 levels while reducing inflammation by decreasing IL-6 levels. …”
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Single-Cell RNA Sequencing Analysis of Steroidogenesis and Spermatogenesis Impairment in the Testis of db/db Mice by Yun Hu, Ting-Ting Cai, Reng-Na Yan, Bing-Li Liu, Bo Ding, Jian-Hua Ma

“…The differentially expressed genes were then confirmed by real-time PCR. The histopathological characteristics of testis in db/db mice and C57BL/6J control were also performed. …”
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Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain by Jun Xu, Sijie Li, Alexandra Wehbe, Xunming Ji, Yong Yang, Yu Yang, Linhui Qin, Feng-Yong Liu, Yuchuan Ding, Changhong Ren

“…Serum, hippocampus, and left ventricle tissue samples were then subjected to biochemical and histopathological analyses. Results. AAO-induced I/R injury had no effect on cell necrosis, cell apoptosis, or ROS production. …”
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Neuroprotective Effects of the Ethanolic Leaf Extract of Crassocephalum crepidioides (Asteracaeae) on Diazepam-Induced Amnesia in Mice by Beppe Galba Jean, Folefack Alice Irène, Atsamo Albert Donatien, Ngatanko Aïbassou Hervé-Hervé, Barga Mpoo Bertrand, Allah-Doum Nanou Gael, Nguedia Ymele Merline, Zemo Gamo Franklik, Dongmo Alain Bertrand, Dimo Théophile

“…Moreover, compared to the negative control group, the extract significantly (p<0.01) increased superoxide dismutase activity and significantly (p<0.01) decreased malondialdehyde levels. The histopathological analysis of hippocampi showed that the cc extract increased cell density when compared with the negative control. …”
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Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet by Ayman Mohammed El-Anany, Rehab Farouk M. Ali

“…The lipid parameter of the serum was recorded and liver and kidney function tests were conducted. Finally, a histopathological assay was performed on the liver and kidney tissues of the rats fed the tested diets. …”
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