Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil by Ahmet Mehmet Somuncu, Busra Parlak Somuncu, Ahmet Duhan Ozbay, Ibrahim Cicek, Bahadir Suleyman, Renad Mammadov, Seval Bulut, Tugba Bal Tastan, Taha Abdulkadir Coban, Halis Suleyman, Aliyev Aydin

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Premalignant features of the prostate can be ameliorated by Uvaria chamae root extract: Modeling prostate cancer with cadmium and alternative treatment option in adult Wistar rats by Edem GD, Sakpa CL, Ezeuko VC

“…These histological features are often encountered in premalignant lesions of the prostate gland. …”
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Paediatric nephroblastoma at a South African tertiary hospital: A 21-year retrospective analysis by E Brits, E Gerber, I Iroka, L Mgidlana, J Willoughby, S Dhlamini, P Nxumalo, S Sefadi, A Mthembu, J B Sempa

“…Compared with similar SA studies, a higher stage IV disease rate (29.5%) was observed, and encouraging survival rates (59.4%) correlated with favourable preoperative histology and no relapse. In comparison, Lesotho patients experienced longer delays and presented with more severe disease. …”
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A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research by Max L. A. Ebert, Vanessa F. Schmidt, Osman Öcal, Anne von Thaden, Olaf Dietrich, Bastian Popper, Sandra Elges, Max Seidensticker, Jens Ricke, Melanie A. Kimm, Astrid Jeibmann, Moritz Wildgruber

“…The stent-retriever model resulted in less periprocedural morbidity (including expenditure, intubation time, anesthetics, and end-tidal CO2 level) and mortality (40% mortality in the conventional group compared to 0% in the stent-retriever model, p = 0.011), while generating lumen-narrowing atherosclerotic lesions with key features as compared to humans as revealed by time-of-flight magnetic resonance imaging and histology. Conclusion We developed a minimally invasive model of iliac atherosclerosis with high reproducibility and improved animal welfare for translational research. …”
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Efficacy and Prognostic Factors for Y-90 Radioembolization (Y-90) in Metastatic Neuroendocrine Tumors with Liver Metastases by Erica S. Tsang, Jonathan M. Loree, Janine M. Davies, Sharlene Gill, David Liu, Stephen Ho, Daniel J. Renouf, Howard J. Lim, Hagen F. Kennecke

“…Longer overall survival (OS) was associated with resection of primary tumor, well-differentiated histology, and low Ki-67. Median OS was 27.2 months (95% CI 8.0–46.5).Conclusions. …”
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Prevalence and antimicrobial resistance of extended spectrum beta-lactamase (ESBL) producing Klebsiella spp. in poultry meat by Fatema Yeasmin Tanni, Md. Shahidur Rahman Chowdhury, Hemayet Hossain, Md. Atik Faysal, Md. Anisur Rahman, Ahsan Al Emon, Mashuka Nahida Asha, Md. Mukter Hossain, Md. Mahfujur Rahman

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Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients: Preliminary Results of Surgery plus Prophylactic HIPEC by Paolo Sammartino, Simone Sibio, Daniele Biacchi, Maurizio Cardi, Fabio Accarpio, Pietro Mingazzini, Maria Sofia Rosati, Tommaso Cornali, Angelo Di Giorgio

“…The study included patients with colonic cancer with clinical T3/T4, any N, M0, and mucinous or signet ring cell histology. The 25 patients in the experimental group underwent hemicolectomy, omentectomy, bilateral adnexectomy, hepatic round ligament resection, and appendectomy, followed by HIPEC. …”
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Neurodevelopmental Disorders and Connective Tissue-Related Symptoms: An Exploratory Case-Control Study in Children by Leonardo Zoccante, Gianfranco Di Gennaro, Erika Rigotti, Marco Luigi Ciceri, Andrea Sbarbati, Marco Zaffanello

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Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats by Izzet Emir, Seval Bulut, Bahadır Suleyman, Renad Mammadov, Nurinisa Yucel, Betul Cicek, Gulce Naz Yazici, Durdu Altuner, Murat Gunay, Halis Suleyman

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Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation by Zengkai Wu, Tunike Mulatibieke, Mengya Niu, Bin Li, Juanjuan Dai, Xin Ye, Yan He, Congying Chen, Li Wen, Guoyong Hu

“…Pancreatitis was confirmed by histology and serum amylase and lipase. Expression of pancreatic proinflammatory mediators and NF-κB activation were assessed. …”
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Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease by Maria Galluzzo, Elisa Ciraolo, Monica Lucattelli, Eriola Hoxha, Martina Ulrich, Carlo Cosimo Campa, Giuseppe Lungarella, Gerd Doring, Zhe Zhou-Suckow, Marcus Mall, Emilio Hirsch, Virginia De Rose

“…Tissue damage was assessed by histology and morphometry and inflammatory cell number was evaluated in bronchoalveolar lavage fluid (BALF). …”
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Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism by Eman A. E. Farrag, Mona H. Askar, Zienab Abdallah, Safinaz M. Mahmoud, Eman A. Abdulhai, Eman Abdelrazik, Eman Mohamad El Nashar, Faten Mohammed Alasiri, Asma Nasser Saeed Alqahtani, Mamdouh Eldesoqui, Ali M. Eldib, Alshimaa Magdy

“…Biochemical analysis of TLR4, NF-κB, NOX-2, and ROS using ELISA, RT-PCR, WB, histological examination with hematoxylin and eosin and immunohistochemical study of CAS-3 were performed. …”
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Hyoid bone-based sex discrimination among Egyptians using a multidetector computed tomography: discriminant function analysis, meta-analysis, and artificial intelligence-assisted s... by Afaf Abdelkader, Susan A. Ali, Ahmed Abdeen, Ehab S. Taher, Asmaa Y. A. Hussein, Mamdouh Eldesoqui, Mohamed Abdo, Liana Fericean, Bănăţean-Dunea Ioan, Samah F. Ibrahim, Ashraf M. Said, Darine Amin, Elturabi E. Ebrahim, Amany M. Allam, Mihaela Ostan, Khaled A. Bayoumi, Tabinda Hasan, Ekramy M. Elmorsy

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Marital Status and Survival in Patients Diagnosed with Melanoma by J. A. Maas, A. J. Monreal, E. L. Diaz, G. Castro, P. Rodriguez de la Vega, M. Varella

“…Married patients were significantly more likely to survive than single patients (Hazard ratio (HR) = 0.65; 99% Confidence Interval (CI): 0.57–0.74; P<0.001) after adjusting for age, sex, race, ethnicity, geographic location, insurance status, tobacco use, primary site, stage, and histology. There was no evidence of effect modification by gender (P=0.189). …”
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Oligodendrocyte precursor cells facilitate neuronal lysosome release by Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff, Xianshu Bai

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Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial by Luz E. Gasca-Lozano, Silvia Lucano-Landeros, Héctor Ruiz-Mercado, Adriana Salazar-Montes, Ana Sandoval-Rodríguez, Jesus Garcia-Bañuelos, Arturo Santos-Garcia, Judith R. Davila-Rodriguez, José Navarro-Partida, Hiram Bojórquez-Sepúlveda, Juan Castañeda-Gomez, José Domínguez-Rosales, Myriam A. Ruiz-Arcos, María Guadalupe Sánchez-Parada, Juan Armendariz-Borunda

“…Healing score improved 4.5 points with PFD + M-DDO and 1.5 points with ketanserin compared to basal value. Histology analysis revealed few inflammatory cells and organized/ordered collagen fiber bundles in PFD + M-DDO. …”
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Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation by Tristan Whitmarsh, Wei Cope, Julia Carmona-Bozo, Roido Manavaki, Stephen-John Sammut, Ramona Woitek, Elena Provenzano, Emma L. Brown, Sarah E. Bohndiek, Ferdia A. Gallagher, Carlos Caldas, Fiona J. Gilbert, Florian Markowetz

“…We also performed a 3D histology analysis on a separate tumour sample as a proof of principle, providing a more comprehensive visualization of vasculature morphology compared to the standard 2D cross-section of a tissue sample. …”
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miR-223 and Chromogranin A Affect Inflammatory Immune Cell Activation in Liver Metastasis of Neuroendocrine Neoplasms by Lukas Geisler, Katharina Detjen, Teresa Hellberg, Marlene Kohlhepp, Carsten Grötzinger, Jana Knorr, Ines Eichhorn, Raphael Mohr, Theresa Holtmann, Bertram Wiedenmann, Frank Tacke, Christoph Roderburg, Alexander Wree

“…We performed flow cytometry of circulating neutrophils in a patient cohort (n = 10) with NEN, microdissection and histology of tumor tissue. Subsequently, in vitro transfections using the well-established human pancreatic NEN cell line (BON), and co-culture experiments with primary macrophages and neutrophils were performed. …”
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Establishment and internal validation of a model to predict the efficacy of Adalimumab in Crohn’s disease by Fang Wang, He Zhou, Yujie Zhang, Yu Da, Tiantian Zhang, Yanting Shi, Tong Wu, Jie Liang

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Egyptian Novel Goose Parvovirus in Immune Organs of Naturally Infected Ducks: Next-Generation Sequencing, Immunohistochemical Signals, and Comparative Analysis of Pathological Chan... by Mohamed A. Lebdah, Amal A. M. Eid, Reham M. ElBakrey, Abd Elgalil. El-Gohary, Mohamed G. Seadawy, Mohamed R. Mousa, Hagar F. Gouda, Nehal I. A. Goda, Mostafa F. El-Hosseny, Ahmed S. El-tahlawy, Rokayya Sami, Rasha A. Al-Eisa, Sarah S. Helal

“…Microscopically, the pathological impact of the virus was exhibited by a necrotic thymic cortex with Hassall’s corpuscle disintegration, the disappearance of normal bursal histological morphology accompanied by atrophied follicles and lymphocytic depletion, and apoptosis of B-lymphocytes in lymphoid follicles of the spleen. …”
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