Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

“…Cytotoxicity was determined by microscopy, cell-based assays and histology. The cell death mode was analyzed by applying specific inhibitors followed by immunofluorescence or qPCR analyses of cell death markers. …”
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The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission by Bahia Belatar, Abdallah Elabidi, Malika Barkiyou, Mamoun El Faroudi, Rachid Eljaoudi, Laila Lahlou, Saad Kabbaj, Wajdi Maazouzi

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Basic research for ultrasound-guided injection into skeletal muscle lesions in an experimental animal model by KiyomitsuFujimoto, TakashiKanamoto, ShunyaOtani, RyoMiyazaki, KosukeEbina, KenNakata

“…Histological analysis showed that ultrasound-guided injection could successfully deliver Fast Green solution around the myofibres at the site of injury. …”
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Combined effects of co-exposure to microcystin-LR and polystyrene microplastics on growth, brain pathology and thyroid hormone homeostasis in adult zebrafish by Wang Lin, Ling Liao, Ling Ling, Huimin Luo, Ying Jiang, Xinru Li, Yilong Yao, Pinhong Yang

“…Alterations in brain histology, thyroid hormone (TH) levels, and the transcription levels of hypothalamic-pituitary-thyroid (HPT)-axis genes were used to assess the thyroid function. …”
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Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) by Liliana Ferreira, Edite Teixeira-de-Lemos, Filipa Pinto, Belmiro Parada, Cristina Mega, Helena Vala, Rui Pinto, Patrícia Garrido, José Sereno, Rosa Fernandes, Paulo Santos, Isabel Velada, Andreia Melo, Sara Nunes, Frederico Teixeira, Flávio Reis

“…Glucose, HbA1c, insulin, Total-c, TGs, IL-1β, TNF-α, CRPhs, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart. Pancreatic histology was also evaluated. Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRPhs and IL-1β. …”
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Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition by Zsolt Tamás Papp, Polett Ribiczey, Erzsébet Kató, Zsuzsanna E. Tóth, Zoltán V. Varga, Zoltán Giricz, Adrienn Hanuska, Mahmoud Al-Khrasani, Ákos Zsembery, Tibor Zelles, Laszlo G. Harsing, László Köles

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Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma by Melody J. Xu, Tara J. Wu, Annemieke van Zante, Ivan H. El-Sayed, Alain P. Algazi, William R. Ryan, Patrick K. Ha, Sue S. Yom

“…Multimodality therapy, age, and histopathologic features (size, margins, solid histology, lymphovascular or perineural invasion) were not associated with PFS or OS. …”
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Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report by Evangelos Koumasopoulos, Evangelia-Anna Spiteri, Aigli G Vakrakou, Panagiotis Toulas, Georgios Velonakis, George Stranjalis, Leonidas Stefanis, Maria-Eleptheria Evangelopoulos, Maria Anagnostouli

“…The patient presented with primary central nervous system B-cell lymphoma 3 years after the initial diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Brain tissue histology was indicative of diffuse giant B cells, Epstein–Barr virus positive, and non-Hodgkin lymphoma. …”
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RNA-Seq-Based Gene Expression Pattern and Morphological Alterations in Chick Thymus during Postnatal Development by Zhouyiyuan Xue, Abdur Rahman Ansari, Xing Zhao, Kun Zang, Yu Liang, Lei Cui, Yafang Hu, Ranran Cheng, Xiaolong Zhang, Juming Zhong, Huazhen Liu

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Clinicopathological characteristics and survival outcomes of women aged ≤45 and >45 years with endometrial adenocarcinoma in tertiary referral hospital: a 21-year cohort study by Tarinee Manchana, Pinyada Panyavaranant, Juthamas Rattanachaipipat

“…Independent prognostic factors consist of non-endometrioid histology, involvement of the lower uterine segment and cervix, omental metastasis, lymphovascular invasion and advanced stage.Conclusions Young patients with endometrial cancer exhibit distinct favourable clinicopathological characteristics associated with better oncological outcomes compared with older patients. …”
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Correlation between White Globe Appearance and Clinicopathologic Characteristics in Early Gastric Cancer by Dae Jin Jung, Gwang Ha Kim, Kyungbin Kim, Hye Kyung Jeon, Dong Chan Joo, Moon Won Lee, Bong Eun Lee

“…Conclusions: WGA was associated with small tumor size, differentiated-type histology, and middle-third tumor location, and was more frequently observed in lesions with an oval/tubular MS and fine-network MV patterns and the absence of WOS.…”
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Factors associated with the formation of neutralizing antibodies post-vaccination: a lesson from COVID-19 vaccination by Hana Ratnawati, Fen Tih, Grace Puspasari, Allen A. Pelapelapon, Steven Felim

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Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein by Paula Andréa Malveira Cavalcante, Natalia Alenina, Alexandre Budu, Leandro Ceotto Freitas-Lima, Thaís Alves-Silva, Juan Sebastian Henao Agudelo, Fatimunnisa Qadri, Niels Olsen Saraiva Camara, Michael Bader, Ronaldo Carvalho Araújo

“…We examined the kidneys of TGM123-FVB/N animals to assess macrophage polarization and end-organ damage. mRNA expression was evaluated using real-time PCR, and protein levels were assessed through ELISA, CBA, Western blot, and immunofluorescence. Histology confirmed high levels of renal collagen. …”
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Effect of <italic>Shaoyao Gancao</italic> Decoction on Inflammatory Injury of Posterior Cervical Muscle Based on miR-146a Regulation of NF-κB Signaling Pathway by Jincheng CHEN, Rong LIN, Yuanfang ZHANG, Jiquan DONG, Weilin LIU, Zheng JIANG, Shaoqing CHEN, Xiangbin WANG, Jian HE

“…Objective:To investigate the effect of <italic>Shaoyao Gancao</italic> decoction on the injury of rabbit cervical posterior myoinflammation and its possible mechanism from histology and molecular level, and provided experimental basis for the clinical application of <italic>Shaoyao Gancao</italic> decoction in the treatment of cervical spondylopathy.Methods:A total of thirty 6-month-old New Zealand white rabbits were randomly divided into high dose group, medium dose group, low dose group, model group and normal group, with 6 rabbits in each group. …”
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Utilization of cardiopulmonary bypass at radical nephrectomy for renal cell carcinoma with tumour thrombus by Chalairat Suk‐Ouichai, Mitchell M. Huang, Clayton Neill, Christopher K. Mehta, Ashley E. Ross, Shilajit D. Kundu, Kent T. Perry Jr, Duc T. Pham, Hiten D. Patel

“…Inclusion criteria included RCC histology and preoperative imaging available for thrombus‐level categorization based on the Mayo Clinic grading system. …”
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Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling by Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

“…We combined single-cell RNA sequencing, NichetNet analysis and histology to determine the role of mural cell dysfunction in HFpEF. …”
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Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation by Sara Querido, Henrique Silva Sousa, Tiago Assis Pereira, Rita Birne, Patrícia Matias, Cristina Jorge, André Weigert, Teresa Adragão, Margarida Bruges, Domingos Machado

“…Colonoscopy showed haemorrhagic patches in the colon and the rectum; histology diagnosis was Kaposi sarcoma (KS). A skin biopsy revealed cutaneous involvement of KS. …”
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Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status by Luca Formichella, Laura Romberg, Hannelore Meyer, Christian Bolz, Michael Vieth, Michael Geppert, Gereon Göttner, Christina Nölting, Wolfgang Schepp, Arne Schneider, Kurt Ulm, Petra Wolf, Ingrid Lisanne Holster, Ernst J. Kuipers, Bernd Birkner, Erwin Soutschek, Markus Gerhard

“…Here, we evaluate the H. pylori recomLine test for risk stratification of infected patients by comparing the test score and immune recognition of type I or type II strains defined by the virulence factors CagA, VacA, GroEL, UreA, HcpC, and gGT with patient’s disease status according to histology. Moreover, the immune responses of eradicated individuals from two different populations were analysed. …”
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Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer by Tytti-Maria Uurasmaa, Pauline Bourdin, Wail Nammas, Shiva Latifi, Heidi Liljenbäck, Antti Saraste, Olli Eskola, Johan Rajander, Anne Roivainen, Helene Rundqvist, Anu Autio, Ilkka Heinonen, Katja Anttila

“…Mice underwent 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography and echocardiography after two and four DOX-doses. The cardiac histology, oxidative stress, maximal metabolic enzyme activities, and mitochondrial respiration were analyzed. …”
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The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma by Andrew C. Kidd, Gordon W. Cowell, Geoffrey A. Martin, Jenny Ferguson, Dean A. Fennell, Matt Evison, Kevin G. Blyth

“…No associations were observed with tumour volume, histology, weight, inflammatory markers. Conclusion: T4 muscle indices were feasible in all cases and outperformed L3 values in prognostication. …”
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